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PE20140020A1 - Analogos de buprenorfina - Google Patents

Analogos de buprenorfina

Info

Publication number
PE20140020A1
PE20140020A1 PE2013000548A PE2013000548A PE20140020A1 PE 20140020 A1 PE20140020 A1 PE 20140020A1 PE 2013000548 A PE2013000548 A PE 2013000548A PE 2013000548 A PE2013000548 A PE 2013000548A PE 20140020 A1 PE20140020 A1 PE 20140020A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
metanbenzofide
bencil
octahydro
Prior art date
Application number
PE2013000548A
Other languages
English (en)
Inventor
Donald J Kyle
Laykea Tafesse
Original Assignee
Purdue Pharma Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44903285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140020(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp
Publication of PE20140020A1 publication Critical patent/PE20140020A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A LOS COMPUESTOS ANALOGOS DE BUPRENORFINA DE FORMULA I, IA, IB, DONDE: R1 ES H, HETEROARIL, FENIL, BENCIL ENTRE OTROS; R2 ES H, (C1-C10) ALQUIL, (C2-C12) ALQUENIL, ENTRE OTROS; R8 ES H, FENIL, BENCIL ENTRE OTROS, R3A Y R3B SON INDEPENDIENTEMENTE (C2-C10) ALQUENIL, HIDROXI(C1-C6)ALQUIL ENTRE OTROS; X ES -OH,DIHIDROXI(C1-C6)ALQUIL, HALOGENO ENTRE OTROS; Q ES -(C1-C10)ALCOXI,-(C1-C10)ALQUIL; Z ES (CH2) m, DONDE m ES 1-6, G ES -OCO-, S, SO ENTRE OTROS; Y ES (CH2)n-CH, DONDE n ES 0-6 . SON COMPUESTOS PREFERIDOS: (4R, 4aS,6R,7R,7aR,12bS)-6-((BENCILOXI)METIL)-7-METOXI-3-METIL-1,2,3,4,5,6,7,7 a-OCTAHIDRO-4 a, 7-ETANO-4,12-METANBENZOFURO[3,2- ? ] ISOQUINOLIN-9-AMINO; (4R, 4aS,6R,7R,7aR,12 bS)-6-((BENCILOXI)METIL)-7-METOXI-3-METIL-9-VINIL-1,2,3,4,5,6,7,7 a-OCTAHIDRO-4 a, 7-ETANO-4,12-METANBENZOFURO[3,2- ? ] ISOQUINOLINA ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DEL DOLOR, LA CONSTIPACION Y OTRAS CONDICIONES MODULADAS POR LA ACTIVIDAD DE LOS RECEPTORES OPIOIDE Y ORL-1
PE2013000548A 2010-09-21 2011-09-20 Analogos de buprenorfina PE20140020A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38491210P 2010-09-21 2010-09-21
US201161503674P 2011-07-01 2011-07-01

Publications (1)

Publication Number Publication Date
PE20140020A1 true PE20140020A1 (es) 2014-01-31

Family

ID=44903285

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013000548A PE20140020A1 (es) 2010-09-21 2011-09-20 Analogos de buprenorfina

Country Status (34)

Country Link
US (1) US9221831B2 (es)
EP (1) EP2619212B1 (es)
JP (2) JP5977240B2 (es)
KR (2) KR101630912B1 (es)
CN (2) CN105399751A (es)
AR (1) AR083062A1 (es)
AU (1) AU2011306644B2 (es)
CA (1) CA2810356C (es)
CL (1) CL2013000732A1 (es)
CO (1) CO6690803A2 (es)
CR (1) CR20130129A (es)
CY (1) CY1117227T1 (es)
DK (1) DK2619212T3 (es)
DO (1) DOP2013000060A (es)
EA (1) EA201390422A1 (es)
EC (1) ECSP13012543A (es)
ES (1) ES2566828T3 (es)
HR (1) HRP20160281T1 (es)
HU (1) HUE027195T2 (es)
ME (1) ME02367B (es)
MX (1) MX2013003354A (es)
NI (1) NI201300032A (es)
NZ (1) NZ609200A (es)
PE (1) PE20140020A1 (es)
PH (1) PH12013500530A1 (es)
PL (1) PL2619212T3 (es)
RS (1) RS54579B1 (es)
SG (1) SG188300A1 (es)
SI (1) SI2619212T1 (es)
SM (1) SMT201600088B (es)
TW (2) TW201422621A (es)
UY (1) UY33618A (es)
WO (1) WO2012038813A1 (es)
ZA (1) ZA201301217B (es)

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US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2513060B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
HUE026619T2 (en) 2010-06-15 2016-06-28 Gruenenthal Gmbh Pharmaceutical combination for the treatment of pain
PL2707361T3 (pl) 2011-05-10 2018-01-31 Gilead Sciences Inc Skondensowane związki heterocykliczne stosowane jako modulatory kanału sodowego
TWI622583B (zh) 2011-07-01 2018-05-01 基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
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CA2890655A1 (en) 2012-11-09 2014-05-15 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
JP6317755B2 (ja) * 2012-12-07 2018-04-25 パーデュー、ファーマ、リミテッド、パートナーシップ オピオイド受容体モジュレーターとしてのブプレノルフィン類似体
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CN106414408A (zh) 2013-12-26 2017-02-15 普渡制药公司 缩合环吗啡喃和其用途
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EP3087079B1 (en) 2013-12-26 2019-04-03 Purdue Pharma LP Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
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GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
WO2015183780A1 (en) 2014-05-27 2015-12-03 Purdue Pharma L.P. Spirocyclic morphinans and use thereof
WO2015192053A1 (en) 2014-06-13 2015-12-17 Purdue Pharma L.P. Azamophinan derivatives and use thereof
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
KR20180080248A (ko) * 2015-10-26 2018-07-11 오르포메드, 인코포레이티드 부프레노르핀의 에틸렌 글리콜 에테르
BR112018014788B1 (pt) * 2016-03-22 2022-03-22 Helsinn Healthcare Sa Composto e uso de um composto
US10745402B2 (en) 2017-01-02 2020-08-18 Purdue Pharma L.P. Morphinan derivatives and use thereof
CA3063975A1 (en) 2017-05-19 2018-11-22 River Stone Biotech Aps Preparation of buprenorphine
JP2021104932A (ja) * 2018-03-30 2021-07-26 日本ケミファ株式会社 モルヒナン誘導体の製造方法
WO2024044179A1 (en) * 2022-08-23 2024-02-29 Virginia Commonwealth University Multiple targeting opioid receptor ligands as novel analgesics with minimum abuse liability
AU2024250576A1 (en) * 2023-04-04 2025-11-13 Board Of Regents, The University Of Texas System METHODS OF SYNTHESIZING 14-β-AMINOMORPHANS AND SALTS THEREOF

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WO2014102587A1 (en) 2012-12-28 2014-07-03 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs
US9056836B2 (en) 2013-01-31 2015-06-16 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015100092A2 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 7-beta analogs of orvinols
US9988392B2 (en) 2013-12-26 2018-06-05 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
WO2015099863A1 (en) 2013-12-27 2015-07-02 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
WO2015102682A1 (en) 2013-12-30 2015-07-09 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands

Also Published As

Publication number Publication date
TW201242968A (en) 2012-11-01
NZ609200A (en) 2015-01-30
CO6690803A2 (es) 2013-06-17
ES2566828T3 (es) 2016-04-15
US9221831B2 (en) 2015-12-29
HUE027195T2 (en) 2016-10-28
ECSP13012543A (es) 2013-06-28
HK1187045A1 (en) 2014-03-28
SMT201600088B (it) 2016-04-29
DK2619212T3 (en) 2016-03-21
JP2016102115A (ja) 2016-06-02
MX2013003354A (es) 2013-06-24
WO2012038813A1 (en) 2012-03-29
CA2810356A1 (en) 2012-03-29
CR20130129A (es) 2013-08-29
PH12013500530A1 (en) 2017-08-09
CN105399751A (zh) 2016-03-16
AU2011306644B2 (en) 2015-07-02
DOP2013000060A (es) 2013-04-30
CY1117227T1 (el) 2017-04-05
CN103154000A (zh) 2013-06-12
RS54579B1 (sr) 2016-06-30
EP2619212B1 (en) 2016-01-06
AR083062A1 (es) 2013-01-30
KR20130097210A (ko) 2013-09-02
US20140057931A1 (en) 2014-02-27
ZA201301217B (en) 2013-09-25
CA2810356C (en) 2016-06-14
KR20150027315A (ko) 2015-03-11
SG188300A1 (en) 2013-04-30
SI2619212T1 (sl) 2016-04-29
AU2011306644A1 (en) 2013-04-11
UY33618A (es) 2012-03-30
KR101630912B1 (ko) 2016-06-15
JP2013543488A (ja) 2013-12-05
NI201300032A (es) 2014-01-13
HRP20160281T1 (hr) 2016-04-08
EP2619212A1 (en) 2013-07-31
PL2619212T3 (pl) 2016-09-30
EA201390422A1 (ru) 2014-01-30
JP5977240B2 (ja) 2016-08-24
TW201422621A (zh) 2014-06-16
ME02367B (me) 2016-06-20
CL2013000732A1 (es) 2013-07-26

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