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UA99284C2 - ИНГИБИТОРЫ р70 S6-КИНАЗЫ - Google Patents

ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Info

Publication number
UA99284C2
UA99284C2 UAA200911422A UAA200911422A UA99284C2 UA 99284 C2 UA99284 C2 UA 99284C2 UA A200911422 A UAA200911422 A UA A200911422A UA A200911422 A UAA200911422 A UA A200911422A UA 99284 C2 UA99284 C2 UA 99284C2
Authority
UA
Ukraine
Prior art keywords
kinase inhibitors
formula
methods
provides
present
Prior art date
Application number
UAA200911422A
Other languages
English (en)
Ukrainian (uk)
Inventor
Роберт Дін Даллі
Цзяньпін Хуан
Саджан Джоузеф
Тімоті Алан Шеперд
Крістіан Л. Холст
Original Assignee
Елі Ліллі Енд Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані filed Critical Елі Ліллі Енд Компані
Publication of UA99284C2 publication Critical patent/UA99284C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Это изобретение предлагает ингибиторы р70 S 6-киназы формулы: , фармацевтические композиции, которые их содержат, и их применение.
UAA200911422A 2007-05-11 2008-01-05 ИНГИБИТОРЫ р70 S6-КИНАЗЫ UA99284C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11

Publications (1)

Publication Number Publication Date
UA99284C2 true UA99284C2 (ru) 2012-08-10

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200911422A UA99284C2 (ru) 2007-05-11 2008-01-05 ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Country Status (33)

Country Link
US (2) US8093383B2 (ru)
EP (1) EP2148880B1 (ru)
JP (1) JP5503532B2 (ru)
KR (1) KR101088219B1 (ru)
CN (1) CN101679439B (ru)
AR (1) AR066344A1 (ru)
AU (1) AU2008251692B2 (ru)
BR (1) BRPI0811212A2 (ru)
CA (1) CA2687265C (ru)
CL (1) CL2008001230A1 (ru)
CO (1) CO6241109A2 (ru)
CR (1) CR11106A (ru)
DK (1) DK2148880T3 (ru)
DO (1) DOP2009000257A (ru)
EA (1) EA016445B1 (ru)
EC (1) ECSP099721A (ru)
ES (1) ES2483726T3 (ru)
GT (1) GT200900292A (ru)
HR (1) HRP20140611T1 (ru)
IL (1) IL201564A (ru)
MA (1) MA31433B1 (ru)
MX (1) MX2009012075A (ru)
MY (1) MY154898A (ru)
NZ (1) NZ580423A (ru)
PE (1) PE20090887A1 (ru)
PL (1) PL2148880T3 (ru)
PT (1) PT2148880E (ru)
RS (1) RS53451B (ru)
SI (1) SI2148880T1 (ru)
TN (1) TN2009000446A1 (ru)
TW (1) TWI423805B (ru)
UA (1) UA99284C2 (ru)
WO (1) WO2008140947A1 (ru)

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PL2396307T3 (pl) 2009-02-11 2015-03-31 Merck Patent Gmbh Nowe aminowe azaheterocykliczne karboksyamidy
ES2654332T3 (es) 2009-08-07 2018-02-13 Merck Patent Gmbh Nuevos compuestos azaheterocíclicos
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KR101942212B1 (ko) 2010-02-03 2019-01-24 시그날 파마소티칼 엘엘씨 Ｔｏｒ 키나제 억제자에 대한 민감성 예측 바이오마커로서 ｌｋｂ1 돌연변이의 동정
UA110113C2 (xx) 2010-07-29 2015-11-25 Біциклічні азагетероциклічні карбоксаміди
BR112013002212A2 (pt) 2010-07-29 2017-09-26 Merck Patent Gmbh carboxamidas aza-heterocíclicas de aminas cíclicas
WO2012069146A1 (en) 2010-11-24 2012-05-31 Merck Patent Gmbh Quinazoline carboxamide azetidines
BR112014005468A2 (pt) 2011-09-12 2017-03-21 Merck Patent Gmbh derivados de aminopiridina para uso como moduladores de atividade quinase
LT2755965T (lt) 2011-09-12 2017-11-10 Merck Patent Gmbh Naujieji imidazolo aminai kaip kinazės aktyvumo moduliatoriai
MX2015002887A (es) 2012-09-06 2015-07-06 Plexxikon Inc Compuestos y metodos para la modulacion de cinasas, e indicaciones para ello.
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
AU2013344552B2 (en) 2012-11-16 2018-03-15 Xiaoling Chen Novel heterocyclic derivatives as modulators of kinase activity
ES2656096T3 (es) 2012-11-16 2018-02-23 Merck Patent Gmbh Nuevos derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa
EP2925747B1 (en) 2012-11-29 2020-06-24 Merck Patent GmbH Azaquinazoline carboxamide derivatives
KR20150124957A (ko) * 2013-03-11 2015-11-06 메르크 파텐트 게엠베하 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체
EP2986298A1 (en) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Treatment of cancer with dihydropyrazino-pyrazines
US9359364B2 (en) 2013-04-17 2016-06-07 Signal Pharmaceuticals, Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one
SG10201801965RA (en) 2013-04-17 2018-04-27 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
SG11201508302PA (en) 2013-04-17 2015-11-27 Signal Pharm Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
HK1221144A1 (zh) 2013-04-17 2017-05-26 西格诺药品有限公司 用於治疗癌症的包含tor激酶抑制剂和胞苷类似物的组合疗法
KR102240356B1 (ko) 2013-04-17 2021-04-14 시그날 파마소티칼 엘엘씨 Ｔｏｒ 키나제 억제제와 5-치환된 퀴나졸리논 화합물을 포함하는 암 치료용 조합 요법
CA2909579A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
CN105407892B (zh) 2013-05-29 2019-05-07 西格诺药品有限公司 一种化合物的药物组合物、其固体形式及它们的使用方法
WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
KR102410696B1 (ko) 2014-04-03 2022-06-17 메르크 파텐트 게엠베하 암 치료법의 조합
EP3131551A4 (en) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
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WO2016164641A1 (en) 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
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EP4243819A1 (en) 2020-11-16 2023-09-20 Merck Patent GmbH Kinase inhibitor combinations for cancer treatment

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EP1750727A2 (en) * 2004-04-23 2007-02-14 Exelixis, Inc. Kinase modulators and methods of use
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
US7994172B2 (en) 2004-12-28 2011-08-09 Exelixis, Inc. [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
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UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Also Published As

Publication number Publication date
NZ580423A (en) 2012-02-24
CR11106A (es) 2010-04-12
SI2148880T1 (sl) 2014-07-31
CA2687265C (en) 2012-12-04
CA2687265A1 (en) 2008-11-20
TWI423805B (zh) 2014-01-21
JP5503532B2 (ja) 2014-05-28
AU2008251692B2 (en) 2012-10-11
US20120071490A1 (en) 2012-03-22
EA200971051A1 (ru) 2010-06-30
CN101679439B (zh) 2013-09-11
HK1140767A1 (en) 2010-10-22
ES2483726T3 (es) 2014-08-07
MX2009012075A (es) 2009-11-19
PL2148880T3 (pl) 2014-10-31
IL201564A0 (en) 2010-05-31
EP2148880B1 (en) 2014-05-28
AU2008251692A1 (en) 2008-11-20
IL201564A (en) 2014-08-31
TN2009000446A1 (en) 2011-03-31
KR20100005710A (ko) 2010-01-15
PT2148880E (pt) 2014-08-28
DOP2009000257A (es) 2010-03-31
RS53451B (sr) 2014-12-31
EA016445B1 (ru) 2012-05-30
ECSP099721A (es) 2009-12-28
CN101679439A (zh) 2010-03-24
US20090163714A1 (en) 2009-06-25
MA31433B1 (fr) 2010-06-01
CO6241109A2 (es) 2011-01-20
HRP20140611T1 (hr) 2014-08-15
CL2008001230A1 (es) 2009-05-22
US8093383B2 (en) 2012-01-10
WO2008140947A1 (en) 2008-11-20
DK2148880T3 (da) 2014-06-16
JP2010526814A (ja) 2010-08-05
MY154898A (en) 2015-08-28
KR101088219B1 (ko) 2011-11-30
TW200848053A (en) 2008-12-16
BRPI0811212A2 (pt) 2014-10-29
PE20090887A1 (es) 2009-07-13
GT200900292A (es) 2011-06-24
AR066344A1 (es) 2009-08-12
EP2148880A1 (en) 2010-02-03

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