PE20140860A1 - Compuestos de pirazol como antagonistas de crth2 - Google Patents
Compuestos de pirazol como antagonistas de crth2Info
- Publication number
- PE20140860A1 PE20140860A1 PE2013001586A PE2013001586A PE20140860A1 PE 20140860 A1 PE20140860 A1 PE 20140860A1 PE 2013001586 A PE2013001586 A PE 2013001586A PE 2013001586 A PE2013001586 A PE 2013001586A PE 20140860 A1 PE20140860 A1 PE 20140860A1
- Authority
- PE
- Peru
- Prior art keywords
- independently
- compounds
- benzyl
- carbonyl
- fluoro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000009389 Prostaglandin D receptors Human genes 0.000 title 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- -1 CARBONYL GROUP Chemical group 0.000 abstract 4
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001721 carbon Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical class N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000808 adrenergic beta-agonist Substances 0.000 abstract 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DE PIRAZOL DE FORMULA (Ia) O (Ib) DONDE: Ra Y Rb SON INDEPENDIENTEMENTE H, HIDROXI, ALCOXI C1-C6, ENTRE OTROS, O Ra Y Rb JUNTOS CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN GRUPO CARBONILO; Rc Y Rd SON INDEPENDIENTEMENTE H, HALOGENO, HALOALQUILO C1-6, ENTRE OTROS O Rc Y Rd JUNTOS CON EL ATOMO DE CARBONO AL QUE ESTAN UNIDOS FORMAN UN GRUPO CARBONILO, ENTRE OTROS; Y1, Y2, Y3, Y4 E Y5 SON INDEPENDIENTEMENTE N Y CRY, DONDE RY ES H, HIDROXI, CIANO, ENTRE OTROS; Z ES O, S, Y NRZ, DONDE RZ ES H, ALQUILO C1-C6 O BENCILO; R1 Y R2 ES INDEPENDIENTEMENTE H, FENILO, NAFTILO, ENTRE OTROS; n ES UN NUIMERO ENTERO ENTRE 0 A 3; R3 SI ESTA PRESENTE ES HALOGENO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ACIDO (1-(2-FLUORO-4-[(1H-INDOL-2-CARBONIL)AMINO]BENCIL)-3,5-DIMETIL-1H-PIRAZOL-4-IL)ACETICO; ACIDO (1-{4-[(5-FLUORO-3-METILBENZOFURAN-2-CARBONIL)AMINO]BENCIL}-3,5-DIMETIL-1H-PIRAZOL-4-IL)ACETICO; ENTRE OTROS. REFERIDO ADEMAS A FORMULACIONES FARMACEUTICAS QUE CONTIENEN DICHOS COMPUESTOS EN COMBINACION CON UNA O MAS SUSTANCIAS ACTIVAS TAL COMO BETAMIMETICOS, ANTICOLINERGICOS, CORTICOSTEROIDES, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11151876 | 2011-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140860A1 true PE20140860A1 (es) | 2014-07-20 |
Family
ID=43799503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013001586A PE20140860A1 (es) | 2011-01-24 | 2012-01-20 | Compuestos de pirazol como antagonistas de crth2 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US8759386B2 (es) |
| EP (1) | EP2668181B1 (es) |
| JP (1) | JP5695216B2 (es) |
| KR (2) | KR101923365B1 (es) |
| CN (4) | CN104961732B (es) |
| AP (1) | AP3343A (es) |
| AR (1) | AR084916A1 (es) |
| AU (1) | AU2012210718B2 (es) |
| BR (1) | BR112013017570B1 (es) |
| CA (1) | CA2825458C (es) |
| CL (1) | CL2013001945A1 (es) |
| CO (1) | CO6801731A2 (es) |
| CY (1) | CY1116012T1 (es) |
| DK (1) | DK2668181T3 (es) |
| EA (1) | EA022559B1 (es) |
| EC (1) | ECSP13012832A (es) |
| ES (1) | ES2529452T3 (es) |
| GE (1) | GEP20156332B (es) |
| HR (1) | HRP20150069T1 (es) |
| IL (1) | IL226920A (es) |
| MA (1) | MA34838B1 (es) |
| MX (1) | MX342830B (es) |
| MY (1) | MY163012A (es) |
| PE (1) | PE20140860A1 (es) |
| PH (2) | PH12013501356A1 (es) |
| PL (1) | PL2668181T3 (es) |
| PT (1) | PT2668181E (es) |
| RS (1) | RS53785B1 (es) |
| SG (1) | SG192096A1 (es) |
| SI (1) | SI2668181T1 (es) |
| TN (1) | TN2013000280A1 (es) |
| TW (1) | TWI527809B (es) |
| UA (1) | UA109696C2 (es) |
| UY (1) | UY33873A (es) |
| WO (1) | WO2012101043A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
| JP5999387B2 (ja) * | 2011-03-25 | 2016-09-28 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｒｔｈ２拮抗薬としてのピラゾール化合物 |
| US20140148492A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Bicyclosubstituted pyrazole compounds for treating hair loss |
| US20140148484A1 (en) * | 2012-11-23 | 2014-05-29 | Boehringer Ingelheim International Gmbh | Pyrazole compounds for treating hairloss |
| EA202092275A1 (ru) * | 2018-03-23 | 2021-02-09 | Палатин Текнолоджиз, Инк. | Составы пептидов, специфичных к рецептору меланокортина, и способы доставки в желудочно-кишечный тракт |
| ES2974634T3 (es) | 2018-12-21 | 2024-06-28 | Celgene Corp | Inhibidores de tienopiridinas de RIPK2 |
| WO2025009852A1 (ko) * | 2023-07-03 | 2025-01-09 | 주식회사 이노보테라퓨틱스 | 신규한 피라졸 유도체 및 이의 용도 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260322A (en) | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| JP3723071B2 (ja) | 1999-11-10 | 2005-12-07 | 武田薬品工業株式会社 | 含窒素５員複素環化合物 |
| PT1471057E (pt) | 2003-04-25 | 2006-05-31 | Actimis Pharmaceuticals Inc | Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2 |
| DE602004011966T2 (de) | 2003-10-24 | 2009-02-12 | Glaxo Group Ltd., Greenford | Heterocyclylverbindungen |
| WO2006066879A2 (en) * | 2004-12-21 | 2006-06-29 | Devgen N.V. | Compounds with kv4 ion channel activity |
| JP4950542B2 (ja) * | 2006-04-07 | 2012-06-13 | 岩手東芝エレクトロニクス株式会社 | 固体撮像装置およびその製造方法 |
| EP2040700B1 (en) | 2006-06-06 | 2010-11-24 | Glaxo Group Limited | N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration |
| UA92833C2 (en) * | 2006-11-27 | 2010-12-10 | Пфайзер Продактс Инк. | Pyrazole analogues |
| CN101874024A (zh) | 2007-09-25 | 2010-10-27 | 艾克提麦斯医药品有限公司 | 作为crth2拮抗剂的2-s-苄基取代的嘧啶 |
| CN101874023A (zh) | 2007-09-25 | 2010-10-27 | 艾克提麦斯医药品有限公司 | 作为crth2拮抗剂的烷硫基嘧啶 |
| JP2011088826A (ja) * | 2008-01-31 | 2011-05-06 | Astellas Pharma Inc | 芳香族カルボン酸化合物 |
| MX2010014172A (es) * | 2008-07-03 | 2011-02-22 | Amira Pharmaceuticals Inc | Antagonistas de receptores de prostaglandina d2. |
| GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010057118A2 (en) | 2008-11-17 | 2010-05-20 | Amira Pharmaceuticals, Inc. | Heterocyclic antagonists of prostaglandin d2 receptors |
| JP2012517405A (ja) * | 2009-02-09 | 2012-08-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器及び胃腸の疾患の治療のための新規医薬組成物 |
| CN108383789A (zh) * | 2010-01-27 | 2018-08-10 | 艾克提麦斯医药品有限公司 | 作为crth2拮抗剂的吡唑化合物 |
| WO2012013567A1 (en) * | 2010-07-28 | 2012-02-02 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition for treatment of respiratory and inflammatory diseases |
| US8759386B2 (en) * | 2011-01-24 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as CRTH2 antagonists |
-
2012
- 2012-01-19 US US13/353,621 patent/US8759386B2/en active Active
- 2012-01-19 TW TW101102302A patent/TWI527809B/zh not_active IP Right Cessation
- 2012-01-20 MY MYPI2013002719A patent/MY163012A/en unknown
- 2012-01-20 ES ES12700695.5T patent/ES2529452T3/es active Active
- 2012-01-20 EP EP12700695.5A patent/EP2668181B1/en active Active
- 2012-01-20 CA CA2825458A patent/CA2825458C/en active Active
- 2012-01-20 PL PL12700695T patent/PL2668181T3/pl unknown
- 2012-01-20 CN CN201510362688.2A patent/CN104961732B/zh not_active Expired - Fee Related
- 2012-01-20 MA MA36130A patent/MA34838B1/fr unknown
- 2012-01-20 PH PH1/2013/501356A patent/PH12013501356A1/en unknown
- 2012-01-20 PE PE2013001586A patent/PE20140860A1/es active IP Right Grant
- 2012-01-20 CN CN201410837969.4A patent/CN104628705B/zh not_active Expired - Fee Related
- 2012-01-20 KR KR1020137019577A patent/KR101923365B1/ko not_active Expired - Fee Related
- 2012-01-20 CN CN201280006303.3A patent/CN103339125B/zh not_active Expired - Fee Related
- 2012-01-20 WO PCT/EP2012/050830 patent/WO2012101043A1/en not_active Ceased
- 2012-01-20 SI SI201230126T patent/SI2668181T1/sl unknown
- 2012-01-20 UA UAA201310232A patent/UA109696C2/uk unknown
- 2012-01-20 DK DK12700695.5T patent/DK2668181T3/da active
- 2012-01-20 MX MX2013008082A patent/MX342830B/es active IP Right Grant
- 2012-01-20 KR KR1020187033824A patent/KR102251939B1/ko not_active Expired - Fee Related
- 2012-01-20 HR HRP20150069AT patent/HRP20150069T1/hr unknown
- 2012-01-20 CN CN201710440429.6A patent/CN107011332B/zh not_active Expired - Fee Related
- 2012-01-20 GE GEAP201213204A patent/GEP20156332B/en unknown
- 2012-01-20 RS RS20150037A patent/RS53785B1/sr unknown
- 2012-01-20 AP AP2013006942A patent/AP3343A/xx active
- 2012-01-20 BR BR112013017570-2A patent/BR112013017570B1/pt not_active IP Right Cessation
- 2012-01-20 JP JP2013549819A patent/JP5695216B2/ja not_active Expired - Fee Related
- 2012-01-20 AU AU2012210718A patent/AU2012210718B2/en not_active Ceased
- 2012-01-20 PT PT127006955T patent/PT2668181E/pt unknown
- 2012-01-20 SG SG2013056106A patent/SG192096A1/en unknown
- 2012-01-20 EA EA201300857A patent/EA022559B1/ru not_active IP Right Cessation
- 2012-01-23 AR ARP120100213A patent/AR084916A1/es active IP Right Grant
- 2012-01-24 UY UY0001033873A patent/UY33873A/es unknown
-
2013
- 2013-06-13 IL IL226920A patent/IL226920A/en active IP Right Grant
- 2013-06-28 TN TNP2013000280A patent/TN2013000280A1/fr unknown
- 2013-06-28 CL CL2013001945A patent/CL2013001945A1/es unknown
- 2013-07-26 CO CO13177740A patent/CO6801731A2/es active IP Right Grant
- 2013-08-15 EC ECSP13012832 patent/ECSP13012832A/es unknown
-
2015
- 2015-02-02 CY CY20151100103T patent/CY1116012T1/el unknown
-
2018
- 2018-07-18 PH PH12018501531A patent/PH12018501531A1/en unknown
Also Published As
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