PE20131305A1 - Compuesto heterociclico y sus usos - Google Patents
Compuesto heterociclico y sus usosInfo
- Publication number
- PE20131305A1 PE20131305A1 PE2013000360A PE2013000360A PE20131305A1 PE 20131305 A1 PE20131305 A1 PE 20131305A1 PE 2013000360 A PE2013000360 A PE 2013000360A PE 2013000360 A PE2013000360 A PE 2013000360A PE 20131305 A1 PE20131305 A1 PE 20131305A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridin
- ring
- metoxy
- triazolo
- propan
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 4-CHLORO-3-FLUOROPHENOXY Chemical class 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE: EL ANILLO A ES OXAZOL, TRIAZOL, IMIDAZOL, ENTRE OTROS OPCIONALMENTE SUSTITUIDOS; EL ANILLO B ES UN ANILLO BENCENO, PIRIDINA O PIRIMIDINA OPCIONALMENTE SUSTITUIDOS; LA ESTRUCTURA PARCIAL (1) ES a) O b), R1 Y R2 SON IGUALES O DIFERENTES Y CADA UNO ES UN SUSTITUYENTE; DONDE R1 ES HIDROXI, ALCOXI (C1-C6), CARBOXI, ENTRE OTROS; R2 ES HALOGENO, UN GRUPO HETEROCICLICO, ENTRE OTROS; R3 ES UN SUSTITUYENTE; n ES UN ENTERO DE 0 A 6; L ES O, S, SO, SO2, ENTRE OTROS. ES UN COMPUESTO PREFERIDO: 2-{8-(4-CLORO-3-FLUOROFENOXI)-3-[3-METOXI-4-(2-METIL-1,3-OXAZOL-5-IL)FENIL]-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-8-IL}PROPAN-2-OL; 2-{(8R)-3-[6-METOXI-5-(4-METIL-1H-IMIDAZOL-1-IL)PIRIDIN-2-IL]-8-(3,4,5-TRIFLUOROFENOXI)-5,6,7,8-TETRAHIDRO[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-8-IL}PROPAN-2-OL; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010197064 | 2010-09-02 | ||
| JP2011143548 | 2011-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20131305A1 true PE20131305A1 (es) | 2013-10-31 |
Family
ID=45094181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013000360A PE20131305A1 (es) | 2010-09-02 | 2011-09-01 | Compuesto heterociclico y sus usos |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8822699B2 (es) |
| EP (1) | EP2611805A1 (es) |
| JP (1) | JP5871909B2 (es) |
| KR (1) | KR20130139895A (es) |
| CN (1) | CN103249733A (es) |
| AR (1) | AR082865A1 (es) |
| AU (1) | AU2011296887A1 (es) |
| BR (1) | BR112013004746A2 (es) |
| CA (1) | CA2809779A1 (es) |
| CL (1) | CL2013000575A1 (es) |
| DO (1) | DOP2013000051A (es) |
| EA (1) | EA201390333A1 (es) |
| EC (1) | ECSP13012535A (es) |
| MA (1) | MA34556B1 (es) |
| MX (1) | MX2013002511A (es) |
| PE (1) | PE20131305A1 (es) |
| PH (1) | PH12013500403A1 (es) |
| SG (1) | SG187917A1 (es) |
| TW (1) | TW201213327A (es) |
| UY (1) | UY33586A (es) |
| WO (1) | WO2012029991A1 (es) |
| ZA (1) | ZA201301929B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2011007756A1 (ja) * | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| BR112013004746A2 (pt) * | 2010-09-02 | 2016-06-07 | Takeda Pharmaceutical | "composto, medicamento, inibidor da produção de beta-amilóide, modulador de gama-secretase, métodos para inibir a produção de beta-amilóide, para modular gama-secretase, e para prevenir ou tratar deficiência cognitiva branda ou mal de alzheimer, e, uso do composto." |
| EP2687528A1 (en) * | 2012-07-17 | 2014-01-22 | Ares Trading S.A. | Fused triazole derivatives as gamma secretase modulators |
| RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
| EP3294743B1 (en) * | 2015-05-12 | 2019-08-21 | FMC Corporation | Aryl substituted bicyclic compounds as herbicides |
| US11512067B2 (en) * | 2017-09-14 | 2022-11-29 | Daiichi Sankyo Company, Limited | Compound having cyclic structure |
| US11603440B2 (en) * | 2019-09-12 | 2023-03-14 | Dupont Electronics, Inc. | Polyimide films and electronic devices |
| IL313039A (en) * | 2021-12-17 | 2024-07-01 | Athira Pharma Inc | Uses of bicyclic compounds for the treatment of diseases |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003523345A (ja) | 2000-02-17 | 2003-08-05 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環 |
| US7244739B2 (en) | 2003-05-14 | 2007-07-17 | Torreypines Therapeutics, Inc. | Compounds and uses thereof in modulating amyloid beta |
| CA2539811A1 (en) * | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
| MY149038A (en) | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
| AU2005297966B2 (en) | 2004-10-26 | 2010-12-23 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
| AU2007205066A1 (en) | 2006-01-11 | 2007-07-19 | Merck & Co., Inc. | Fused triazole tachykinin receptor antagonists |
| KR101464651B1 (ko) * | 2006-03-09 | 2014-11-24 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 다환식 신나미드 유도체 |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| TW200808800A (en) | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGluR5 modulators V |
| EP2119719A1 (en) | 2006-12-26 | 2009-11-18 | Daiichi Sankyo Company, Limited | Thiazepine derivative |
| US8143394B2 (en) | 2006-12-26 | 2012-03-27 | Gilead Sciences, Inc. | Pyrido(3,2-d)pyrimidines useful for treating viral infections |
| WO2008097538A1 (en) | 2007-02-08 | 2008-08-14 | Merck & Co., Inc. | Therapeutic agents |
| MX2010006243A (es) | 2007-12-06 | 2010-08-31 | Schering Corp | Moduladores de gamma secretasa. |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2010197064A (ja) | 2009-02-23 | 2010-09-09 | Chugoku Electric Power Co Inc:The | 直下位置測定装置 |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
| CN102333777B (zh) * | 2009-02-26 | 2014-06-25 | 卫材R&D管理有限公司 | 含氮的稠合杂环化合物及其作为β淀粉样蛋白生成抑制剂的用途 |
| WO2011002067A1 (ja) | 2009-07-02 | 2011-01-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JPWO2011007756A1 (ja) * | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| BR112012000915A2 (pt) | 2009-07-15 | 2019-09-24 | Janssen Pharmaceuticals Inc | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
| TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β－類澱粉生成之化合物 |
| US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| WO2011016559A1 (ja) | 2009-08-07 | 2011-02-10 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP2011143548A (ja) | 2010-01-12 | 2011-07-28 | Panasonic Corp | スクリーン印刷機及びスクリーン印刷方法 |
| CA2784765A1 (en) | 2010-01-15 | 2011-07-21 | Janssen Pharmaceuticals, Inc. | Novel substituted bicyclic triazole derivatives as gamma secretase modulators |
| BR112013004746A2 (pt) * | 2010-09-02 | 2016-06-07 | Takeda Pharmaceutical | "composto, medicamento, inibidor da produção de beta-amilóide, modulador de gama-secretase, métodos para inibir a produção de beta-amilóide, para modular gama-secretase, e para prevenir ou tratar deficiência cognitiva branda ou mal de alzheimer, e, uso do composto." |
-
2011
- 2011-09-01 BR BR112013004746A patent/BR112013004746A2/pt not_active IP Right Cessation
- 2011-09-01 PE PE2013000360A patent/PE20131305A1/es not_active Application Discontinuation
- 2011-09-01 PH PH1/2013/500403A patent/PH12013500403A1/en unknown
- 2011-09-01 MX MX2013002511A patent/MX2013002511A/es not_active Application Discontinuation
- 2011-09-01 EA EA201390333A patent/EA201390333A1/ru unknown
- 2011-09-01 CA CA2809779A patent/CA2809779A1/en not_active Abandoned
- 2011-09-01 WO PCT/JP2011/070419 patent/WO2012029991A1/en not_active Ceased
- 2011-09-01 MA MA35785A patent/MA34556B1/fr unknown
- 2011-09-01 US US13/223,455 patent/US8822699B2/en not_active Expired - Fee Related
- 2011-09-01 AR ARP110103195A patent/AR082865A1/es unknown
- 2011-09-01 AU AU2011296887A patent/AU2011296887A1/en not_active Abandoned
- 2011-09-01 SG SG2013012604A patent/SG187917A1/en unknown
- 2011-09-01 US US13/819,239 patent/US8901309B2/en not_active Expired - Fee Related
- 2011-09-01 UY UY0001033586A patent/UY33586A/es unknown
- 2011-09-01 TW TW100131443A patent/TW201213327A/zh unknown
- 2011-09-01 CN CN2011800518621A patent/CN103249733A/zh active Pending
- 2011-09-01 JP JP2013510386A patent/JP5871909B2/ja not_active Expired - Fee Related
- 2011-09-01 KR KR1020137008170A patent/KR20130139895A/ko not_active Withdrawn
- 2011-09-01 EP EP11791058.8A patent/EP2611805A1/en not_active Withdrawn
-
2013
- 2013-02-28 CL CL2013000575A patent/CL2013000575A1/es unknown
- 2013-03-01 DO DO2013000051A patent/DOP2013000051A/es unknown
- 2013-03-14 ZA ZA2013/01929A patent/ZA201301929B/en unknown
- 2013-03-28 EC ECSP13012535 patent/ECSP13012535A/es unknown
-
2014
- 2014-08-08 US US14/454,993 patent/US20140350260A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120059030A1 (en) | 2012-03-08 |
| BR112013004746A2 (pt) | 2016-06-07 |
| ECSP13012535A (es) | 2013-06-28 |
| US8822699B2 (en) | 2014-09-02 |
| JP2013536798A (ja) | 2013-09-26 |
| US20140350260A1 (en) | 2014-11-27 |
| AU2011296887A1 (en) | 2013-04-11 |
| EA201390333A1 (ru) | 2013-08-30 |
| DOP2013000051A (es) | 2013-04-30 |
| WO2012029991A1 (en) | 2012-03-08 |
| TW201213327A (en) | 2012-04-01 |
| CL2013000575A1 (es) | 2013-08-23 |
| AR082865A1 (es) | 2013-01-16 |
| SG187917A1 (en) | 2013-04-30 |
| US20130178497A1 (en) | 2013-07-11 |
| CA2809779A1 (en) | 2012-03-08 |
| CN103249733A (zh) | 2013-08-14 |
| UY33586A (es) | 2012-03-30 |
| PH12013500403A1 (en) | 2013-03-25 |
| MA34556B1 (fr) | 2013-09-02 |
| JP5871909B2 (ja) | 2016-03-01 |
| ZA201301929B (en) | 2013-11-27 |
| EP2611805A1 (en) | 2013-07-10 |
| US8901309B2 (en) | 2014-12-02 |
| MX2013002511A (es) | 2013-07-29 |
| KR20130139895A (ko) | 2013-12-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20131305A1 (es) | Compuesto heterociclico y sus usos | |
| PE20120172A1 (es) | Compuestos heterociclicos fusionados que contiene nitrogeno como inhibidores de la produccion de beta-amiloide | |
| PE20130234A1 (es) | Derivados de heteroaril imidazolona como inhibidores de jak | |
| PE20141938A1 (es) | Nuevos compuestos inhibidores de la fosfodiesterasa del tipo 10a | |
| PE20130346A1 (es) | Compuestos heterociclicos fusionados | |
| PE20090370A1 (es) | Derivados de heterociclo fusionado como inhibidores de quinasa | |
| PE20070752A1 (es) | Triazolopiridazinas como moduladores de quinasa | |
| PE20061424A1 (es) | Compuestos triciclicos de base 1,6-dihidro-1-3,5,6-tetraaza-as-indaceno y composiciones farmaceuticas que comprenden los mismos | |
| PE20121511A1 (es) | Novedosos derivados biciclicos de triazol sustituidos como moduladores de gamma secretasa | |
| PE20091068A1 (es) | Compuestos pirrolo[3,2-d]pirimidina y su uso como inhibidores de quinasa pi3 y quinasa mtor | |
| PE20151249A1 (es) | Derivados de pirazolopirimidina como inhibidores de jak quinasas | |
| PE20141010A1 (es) | Derivados de piridin-2(1h)-ona utiles como medicamentos para el tratamiento de transtornos mieloproliferativos, rechazo de transplantes, enfermedades mediadas por el sistema inmune y enfermedades inflamatorias | |
| PE20091833A1 (es) | Derivados heterociclicos espiro biciclicos o heterociclicos biciclicos, puenteados, de pirazolo [1,5-a]pirimidinas como inhibidores de quinasas raf y metodos para su preparacion | |
| PE20151251A1 (es) | Derivados [5,6] biciclicos de imidazo pirimidona con actividad sobre enzimas lp-pla2 | |
| PE20121438A1 (es) | Derivados de imidazopiridina o imidazopirimidina como inhibidores de fosfodiesterasa 10a | |
| PE20081612A1 (es) | Analogos de las pterinas | |
| PE20141557A1 (es) | Derivado de pirazoloquinolina | |
| PE20080520A1 (es) | Derivados de benzofuro- y benzotienopirimidina como moduladores del receptor de histamina h4 | |
| PE20120121A1 (es) | Derivados de imidazopirazina como inhibidores de syk | |
| EA201270498A1 (ru) | 8-этил-6-(арил)пиридо[2,3-d]пиримидин-7(8h)-оны для лечения заболеваний цнс | |
| NZ601687A (en) | Azaindoles useful as inhibitors of janus kinases | |
| PE20121312A1 (es) | Metodo para preparar compuestos macrociclicos inhibidores de serina proteasas de hepatitis c | |
| CA3091486A1 (en) | Oxadiazole transient receptor potential channel inhibitors | |
| BR112014032338A2 (pt) | cristais de sal | |
| PE20142293A1 (es) | Pirimidinas y triazinas fusionadas sustituidas y su uso |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |