PE20131137A1 - Composiciones nasales de vitamina b12 - Google Patents
Composiciones nasales de vitamina b12Info
- Publication number
- PE20131137A1 PE20131137A1 PE2013000547A PE2013000547A PE20131137A1 PE 20131137 A1 PE20131137 A1 PE 20131137A1 PE 2013000547 A PE2013000547 A PE 2013000547A PE 2013000547 A PE2013000547 A PE 2013000547A PE 20131137 A1 PE20131137 A1 PE 20131137A1
- Authority
- PE
- Peru
- Prior art keywords
- vitamin
- nasal compositions
- composition
- ehylucene
- ehylucenables
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 title 1
- -1 GUAR GUM Substances 0.000 abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract 1
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 abstract 1
- YEYKMVJDLWJFOA-UHFFFAOYSA-N 2-propoxyethanol Chemical compound CCCOCCO YEYKMVJDLWJFOA-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 102000004856 Lectins Human genes 0.000 abstract 1
- 108090001090 Lectins Proteins 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000002523 lectin Substances 0.000 abstract 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 235000010987 pectin Nutrition 0.000 abstract 1
- 239000001814 pectin Substances 0.000 abstract 1
- 229920001277 pectin Polymers 0.000 abstract 1
- 229960000292 pectin Drugs 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000000661 sodium alginate Substances 0.000 abstract 1
- 235000010413 sodium alginate Nutrition 0.000 abstract 1
- 229940005550 sodium alginate Drugs 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 235000010356 sorbitol Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000811 xylitol Substances 0.000 abstract 1
- 235000010447 xylitol Nutrition 0.000 abstract 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 abstract 1
- 229960002675 xylitol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
REFERIDA A UNA COMPOSICION ACUOSA INTRANASAL QUE COMPRENDE METILCOBALAMINA, CO-SOLVENTES/SOLUBILIZADORES TALES COMO GLICOFUROL, PROPILGLICOL, POLIETILENGLICOL O MEZCLAS DE LOS MISMOS EN AGUA Y, OPCIONALMENTE, PRESERVANTES TALES COMO CLORURO DE BENZALCONIO, METILPARABENO, ETILPARABENO, ENTRE OTROS, AGENTES MUCOADHESIVOS TALES COMO ALGINATO DE SODIO, PECTINA, GOMA GUAR, LECTINA, ENTRE OTROS, QUELANTES, HUMECTANTES TALES COMO GLICERINA, SORBITOL, XILITOL, ENTRE OTROS, ANTIOXIDANTES, DONDE DICHA COMPOSICION POSEE UN PH DE ENTRE 5 A 7
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2169MU2010 | 2010-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20131137A1 true PE20131137A1 (es) | 2013-10-03 |
Family
ID=45350421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013000547A PE20131137A1 (es) | 2010-10-29 | 2011-10-28 | Composiciones nasales de vitamina b12 |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP2632430B1 (es) |
| JP (1) | JP5843873B2 (es) |
| CN (1) | CN103384513B (es) |
| AP (1) | AP3814A (es) |
| AR (1) | AR083658A1 (es) |
| BR (1) | BR112013010049B1 (es) |
| CO (1) | CO6801717A2 (es) |
| CU (1) | CU24142B1 (es) |
| DK (1) | DK2632430T3 (es) |
| EA (1) | EA024475B1 (es) |
| ES (1) | ES2686299T3 (es) |
| HU (1) | HUE039349T2 (es) |
| MX (1) | MX337365B (es) |
| MY (1) | MY163106A (es) |
| PE (1) | PE20131137A1 (es) |
| PH (1) | PH12013500631B1 (es) |
| PL (1) | PL2632430T3 (es) |
| PT (1) | PT2632430T (es) |
| UA (1) | UA111342C2 (es) |
| WO (1) | WO2012056299A1 (es) |
| ZA (1) | ZA201303024B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3474842A4 (en) * | 2016-06-24 | 2020-01-29 | Opiant Pharmaceuticals, Inc. | COMPOSITIONS, DEVICES AND METHODS FOR TREATING ALKOHOL CONSUMPTION |
| IL312012A (en) | 2016-11-18 | 2024-06-01 | Opiant Pharmaceuticals Inc | Compositions and methods for the treatment of opioid overdose |
| MY202277A (en) | 2017-02-06 | 2024-04-22 | Torrent Pharmaceuticals Ltd | Intranasal composition of methylcobalamin |
| EP3634413A1 (en) | 2017-06-09 | 2020-04-15 | Exelixis, Inc. | Liquid dosage forms to treat cancer |
| GB202013645D0 (en) | 2020-08-31 | 2020-10-14 | Innotesto Bvba | Pharmacetical compositions for the nasal administration of a colbalamin compound |
| AU2022323269A1 (en) | 2021-08-04 | 2024-02-29 | Indivior Inc. | Compositions and methods for the treatment of opioid overdose |
| CN120884544A (zh) * | 2025-09-28 | 2025-11-04 | 湖南状元制药有限公司 | 甲钴胺组合物及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT376879B (de) * | 1982-10-27 | 1985-01-10 | Gerot Pharmazeutika | Verfahren zur herstellung einer injektionsloesung |
| US4724231A (en) * | 1985-04-16 | 1988-02-09 | Nastech Pharmaceutical, Inc. | Nasel compositions containing vitamin B12 |
| ES2074396B1 (es) * | 1993-03-24 | 1996-04-01 | Farmalider Sa | Sistema de administracion nasal de cianocobalamina (vitamina b12). |
| BE1007839A6 (nl) * | 1993-12-20 | 1995-10-31 | Merkus Franciscus W H M Prof | Farmaceutische compositie voor de nasale toediening van hydroxocobalamine. |
| US7229636B1 (en) * | 2003-03-04 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery |
| ES2356242T3 (es) * | 2003-05-07 | 2011-04-06 | EISAI R&D MANAGEMENT CO., LTD. | Preparación liofilizada conteniendo metilcobalamina y procedimiento de producción de esta preparación. |
| JP2009504767A (ja) * | 2005-08-17 | 2009-02-05 | フレミング・アンド・カンパニー・ファーマシューティカルズ | ビタミンｂ１２鼻用スプレーおよび使用方法 |
| CN101600729A (zh) * | 2006-06-23 | 2009-12-09 | 帕尔医疗公司 | 用于鼻内递送的氰钴胺低粘度水性制剂 |
| US20090012039A1 (en) * | 2007-03-16 | 2009-01-08 | Stan Kurtz | Use of methylcobalamin nasal spray to treat disorders |
| DE102007012644A1 (de) * | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Stabilisierung von Vitamin B12 |
-
2011
- 2011-10-28 UA UAA201306483A patent/UA111342C2/uk unknown
- 2011-10-28 BR BR112013010049-4A patent/BR112013010049B1/pt active IP Right Grant
- 2011-10-28 MX MX2013004846A patent/MX337365B/es active IP Right Grant
- 2011-10-28 EP EP11797111.9A patent/EP2632430B1/en active Active
- 2011-10-28 HU HUE11797111A patent/HUE039349T2/hu unknown
- 2011-10-28 WO PCT/IB2011/002546 patent/WO2012056299A1/en not_active Ceased
- 2011-10-28 PT PT11797111T patent/PT2632430T/pt unknown
- 2011-10-28 PL PL11797111T patent/PL2632430T3/pl unknown
- 2011-10-28 PH PH1/2013/500631A patent/PH12013500631B1/en unknown
- 2011-10-28 MY MYPI2013000794A patent/MY163106A/en unknown
- 2011-10-28 PE PE2013000547A patent/PE20131137A1/es active IP Right Grant
- 2011-10-28 JP JP2013535525A patent/JP5843873B2/ja active Active
- 2011-10-28 EA EA201390623A patent/EA024475B1/ru unknown
- 2011-10-28 ES ES11797111.9T patent/ES2686299T3/es active Active
- 2011-10-28 DK DK11797111.9T patent/DK2632430T3/en active
- 2011-10-28 CN CN201180057382.6A patent/CN103384513B/zh active Active
- 2011-10-28 CU CU20130062A patent/CU24142B1/es unknown
- 2011-10-28 AP AP2013006837A patent/AP3814A/en active
- 2011-10-31 AR ARP110104028A patent/AR083658A1/es not_active Application Discontinuation
-
2013
- 2013-04-25 ZA ZA2013/03024A patent/ZA201303024B/en unknown
- 2013-05-24 CO CO13128213A patent/CO6801717A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA201390623A1 (ru) | 2013-09-30 |
| CN103384513A (zh) | 2013-11-06 |
| MX337365B (es) | 2016-02-29 |
| PH12013500631A1 (en) | 2013-05-06 |
| WO2012056299A1 (en) | 2012-05-03 |
| EP2632430B1 (en) | 2018-06-06 |
| AP3814A (en) | 2016-09-30 |
| BR112013010049B1 (pt) | 2021-07-13 |
| MY163106A (en) | 2017-08-15 |
| BR112013010049A2 (pt) | 2018-01-09 |
| JP2013540805A (ja) | 2013-11-07 |
| ZA201303024B (en) | 2014-01-29 |
| JP5843873B2 (ja) | 2016-01-13 |
| AP2013006837A0 (en) | 2013-04-30 |
| CU24142B1 (es) | 2015-12-23 |
| CN103384513B (zh) | 2016-01-13 |
| PH12013500631B1 (en) | 2019-03-27 |
| CU20130062A7 (es) | 2013-10-29 |
| PL2632430T3 (pl) | 2018-11-30 |
| ES2686299T3 (es) | 2018-10-17 |
| PT2632430T (pt) | 2018-10-19 |
| EP2632430A1 (en) | 2013-09-04 |
| HUE039349T2 (hu) | 2018-12-28 |
| CO6801717A2 (es) | 2013-11-29 |
| AR083658A1 (es) | 2013-03-13 |
| MX2013004846A (es) | 2013-10-01 |
| UA111342C2 (uk) | 2016-04-25 |
| DK2632430T3 (en) | 2018-09-17 |
| EA024475B1 (ru) | 2016-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |