PE20131116A1 - Compuestos heterociclicos potenciadores de ampa - Google Patents
Compuestos heterociclicos potenciadores de ampaInfo
- Publication number
- PE20131116A1 PE20131116A1 PE2013000244A PE2013000244A PE20131116A1 PE 20131116 A1 PE20131116 A1 PE 20131116A1 PE 2013000244 A PE2013000244 A PE 2013000244A PE 2013000244 A PE2013000244 A PE 2013000244A PE 20131116 A1 PE20131116 A1 PE 20131116A1
- Authority
- PE
- Peru
- Prior art keywords
- thadiazine
- dihydropyride
- ring
- ampa
- enhancing
- Prior art date
Links
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- -1 4-PHENOXYPHENYL Chemical class 0.000 abstract 3
- 206010020772 Hypertension Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- UUDAMDVQRQNNHZ-UHFFFAOYSA-N (S)-AMPA Chemical compound CC=1ONC(=O)C=1CC(N)C(O)=O UUDAMDVQRQNNHZ-UHFFFAOYSA-N 0.000 abstract 1
- KEIFWROAQVVDBN-UHFFFAOYSA-N 1,2-dihydronaphthalene Chemical compound C1=CC=C2C=CCCC2=C1 KEIFWROAQVVDBN-UHFFFAOYSA-N 0.000 abstract 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003334 potential effect Effects 0.000 abstract 1
- 239000004576 sand Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE EL ANILLO A ES UN HETEROCICLO DE 5 A 7 MIEMBROS OPCIONALMENTE SUSTITUIDO; EL ANILLO B ES UN HETEROCICLO DE 5 A 8 MIEMBROS OPCIONALMENTE SUSTITUIDO; EL ANILLO D ES CICLOALCANO C3-C7, ARENO C6-C14, DIHIDRONAFTALENO, ENTRE OTROS; W ES ALQUILENO C1-C3 O ALQUENILENO C2-C3 OPCIONALMENTE SUSTITUIDOS; L ES UN ENLACE, O, O-CH2, CO-NH, ENTRE OTROS; n ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: 2,2-DIOXIDO DE 9-(4-FENOXIFENIL)-3,4-DIHIDROPIRIDO[2,1-c][1,2,4]TIADIAZINA, 2,2-DIOXIDO DE 9-[4-(4-METILFENOXI)FENIL]-3,4-DIHIDROPIRIDO[2,1-c][1,2,4]TIADIAZINA, 2,2-DIOXIDO DE 9-[4-(CICLOHEXILOXI)FENIL]-3,4-DIHIDROPIRIDO[2,1-c][1,2,4]TIADIAZINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACCION POTENCIADORA DEL RECEPTOR DE AMPA (ACIDO ALFA-AMINO-3-HIDROXI-5-METIL-4-ISOXAZOLPROPIONICO) Y SON UTILES EN EL TRATAMIENTO DE LA DEPRESION, ESQUIZOFRENIA, ENFERMEDAD DE ALZHEIMER, TRANSTORNO DE HIPERACTIVIDAD, ENTRE OTRAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010179577 | 2010-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20131116A1 true PE20131116A1 (es) | 2013-10-24 |
Family
ID=44534564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013000244A PE20131116A1 (es) | 2010-08-10 | 2011-08-09 | Compuestos heterociclicos potenciadores de ampa |
Country Status (39)
| Country | Link |
|---|---|
| US (11) | US8575154B2 (es) |
| EP (1) | EP2603513B1 (es) |
| JP (2) | JP5788496B2 (es) |
| KR (1) | KR101852215B1 (es) |
| CN (2) | CN103180326B (es) |
| AR (1) | AR082618A1 (es) |
| AU (1) | AU2011290126B2 (es) |
| BR (1) | BR112013002250B1 (es) |
| CA (1) | CA2807460C (es) |
| CL (1) | CL2013000380A1 (es) |
| CO (1) | CO6680700A2 (es) |
| CR (1) | CR20130066A (es) |
| CY (1) | CY1123507T1 (es) |
| DK (1) | DK2603513T3 (es) |
| DO (1) | DOP2013000030A (es) |
| EA (1) | EA022078B1 (es) |
| EC (1) | ECSP13012478A (es) |
| ES (1) | ES2793723T3 (es) |
| GE (1) | GEP20156216B (es) |
| HR (1) | HRP20200844T1 (es) |
| HU (1) | HUE049460T2 (es) |
| IL (1) | IL224452A (es) |
| LT (1) | LT2603513T (es) |
| MA (1) | MA34509B1 (es) |
| MX (1) | MX349470B (es) |
| MY (1) | MY165908A (es) |
| NZ (1) | NZ607593A (es) |
| PE (1) | PE20131116A1 (es) |
| PH (1) | PH12013500247A1 (es) |
| PL (1) | PL2603513T3 (es) |
| PT (1) | PT2603513T (es) |
| RS (1) | RS60311B1 (es) |
| SG (1) | SG187656A1 (es) |
| SI (1) | SI2603513T1 (es) |
| TW (1) | TWI504604B (es) |
| UA (1) | UA111594C2 (es) |
| UY (1) | UY33551A (es) |
| WO (1) | WO2012020848A1 (es) |
| ZA (1) | ZA201301120B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2603513T (pt) * | 2010-08-10 | 2020-06-08 | Takeda Pharmaceuticals Co | Composto heterocíclico e sua utilização como modulador alostérico positivo do recetor de ampa |
| JP5976011B2 (ja) * | 2011-04-05 | 2016-08-23 | 武田薬品工業株式会社 | スルホンアミド誘導体およびその用途 |
| JP6134654B2 (ja) * | 2012-02-08 | 2017-05-24 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| BR112015031249A2 (pt) * | 2013-06-13 | 2017-07-25 | Veroscience Llc | método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica |
| PT3421462T (pt) | 2013-06-27 | 2023-06-29 | Pfizer | Compostos heteroaromáticos e a sua utilização como ligandos de d1 de dopamina |
| US11589583B2 (en) | 2013-12-03 | 2023-02-28 | Fmc Corporation | Pyrrolidinones herbicides |
| KR102395827B1 (ko) | 2013-12-03 | 2022-05-10 | 에프엠씨 코포레이션 | 제초제로서의 피롤리디논 |
| US9944602B2 (en) | 2014-07-02 | 2018-04-17 | E. I. Du Pont De Nemours And Company | Piperidinone herbicides |
| KR102542215B1 (ko) | 2014-12-08 | 2023-06-12 | 에프엠씨 코포레이션 | 3-옥소-3-(아릴아미노)프로파노에이트, 이의 제조방법 및 피롤리디논 제조에 있어서 이의 용도 |
| AU2016246410B2 (en) | 2015-04-10 | 2020-11-05 | Fmc Corporation | Substituted cyclic amides as herbicides |
| EP3288928B1 (en) | 2015-04-27 | 2021-10-13 | FMC Corporation | Butyrolactones as herbicides |
| MA41988B1 (fr) * | 2015-04-29 | 2021-03-31 | Janssen Pharmaceutica Nv | Azabenzimidazoles et leur utilisation comme modulateurs du recepteur ampa |
| AU2016255431B2 (en) * | 2015-04-29 | 2020-05-07 | Janssen Pharmaceutica Nv | Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators |
| EP3294743B1 (en) | 2015-05-12 | 2019-08-21 | FMC Corporation | Aryl substituted bicyclic compounds as herbicides |
| BR112017022743B1 (pt) | 2015-05-29 | 2022-02-22 | Fmc Corporation | Composto, composições herbicidas, mistura de herbicidas e método para controlar o crescimento de vegetação indesejada |
| CN107709310B (zh) | 2015-06-02 | 2021-09-24 | Fmc公司 | 取代的环酰胺及其作为除草剂的用途 |
| WO2017023515A1 (en) | 2015-07-31 | 2017-02-09 | E. I. Du Pont De Nemours And Company | Cyclic n-carboxamide compounds useful as herbicides |
| HRP20191589T1 (hr) * | 2015-08-06 | 2019-12-13 | Hoffmann La Roche | Postupci za pripravu derivata galnac kiseline |
| US20170181292A1 (en) * | 2015-12-16 | 2017-06-22 | Rohm And Haas Electronic Materials Llc | Method for forming organic coating on nickel surface |
| CN105669731B (zh) * | 2016-01-10 | 2017-06-30 | 沧州普瑞东方科技有限公司 | 一种4‑(4‑烷基环己氧基)苯硼酸的合成方法 |
| ES2958741T3 (es) | 2016-12-21 | 2024-02-14 | Fmc Corp | Herbicidas de nitrona |
| CN107892697B (zh) | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| JP7548697B2 (ja) | 2017-03-21 | 2024-09-10 | エフ エム シー コーポレーション | 除草剤混合物、組成物、及び方法 |
| EP3599854A4 (en) | 2017-03-21 | 2020-12-23 | FMC Corporation | PYRROLIDINONES AND PROCESS FOR PREPARING THEM |
| AR111967A1 (es) | 2017-05-30 | 2019-09-04 | Fmc Corp | Amidas herbicidas |
| AR111839A1 (es) | 2017-05-30 | 2019-08-21 | Fmc Corp | Lactamas 3-sustituidas herbicidas |
| JP7250686B2 (ja) * | 2017-10-06 | 2023-04-03 | 武田薬品工業株式会社 | 複素環化合物 |
| US11447488B2 (en) | 2017-10-06 | 2022-09-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
| EP4031552B1 (en) | 2019-09-16 | 2024-11-06 | Takeda Pharmaceutical Company Limited | Azole-fused pyridazin-3(2h)-one derivatives |
| WO2021229294A1 (en) * | 2020-05-15 | 2021-11-18 | Takeda Pharmaceutical Company Limited | Treatment for depression |
| CN113943294A (zh) * | 2020-07-15 | 2022-01-18 | 成都海博为药业有限公司 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
| WO2025226591A1 (en) | 2024-04-22 | 2025-10-30 | Neurocrine Biosciences, Inc. | Methods of administering 9-[4-(cyclohexyloxy)phenyl]-7-methyl-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide without side effects |
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| DE19704923A1 (de) | 1997-02-10 | 1998-08-13 | Hoechst Schering Agrevo Gmbh | Klebstoffhaltige Schädlingsbekämpfungsmittel |
| AU5271900A (en) | 1999-11-04 | 2001-05-14 | Colorado State University Research Foundation | Method and device for attracting insects |
| FR2801587B1 (fr) | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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| FR2854634B1 (fr) * | 2003-05-05 | 2005-07-08 | Servier Lab | Nouveaux derives de thiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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| WO2009119088A1 (ja) | 2008-03-25 | 2009-10-01 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2009248543A (ja) * | 2008-04-11 | 2009-10-29 | Fujifilm Corp | 光情報記録媒体および情報記録方法 |
| TW201012803A (en) * | 2008-06-06 | 2010-04-01 | Organon Nv | Heterocyclic derivatives |
| WO2010054067A1 (en) | 2008-11-06 | 2010-05-14 | Schering Corporation | Gamma secretase modulators |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| FR2943342B1 (fr) | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO2010140339A1 (ja) | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
| JPWO2011007756A1 (ja) | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| WO2011036889A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| WO2011036885A1 (ja) | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| PT2603513T (pt) * | 2010-08-10 | 2020-06-08 | Takeda Pharmaceuticals Co | Composto heterocíclico e sua utilização como modulador alostérico positivo do recetor de ampa |
-
2011
- 2011-08-09 PT PT117499442T patent/PT2603513T/pt unknown
- 2011-08-09 AR ARP110102905A patent/AR082618A1/es active IP Right Grant
- 2011-08-09 PE PE2013000244A patent/PE20131116A1/es active IP Right Grant
- 2011-08-09 EP EP11749944.2A patent/EP2603513B1/en active Active
- 2011-08-09 KR KR1020137006113A patent/KR101852215B1/ko active Active
- 2011-08-09 CA CA2807460A patent/CA2807460C/en active Active
- 2011-08-09 LT LTEP11749944.2T patent/LT2603513T/lt unknown
- 2011-08-09 SI SI201131887T patent/SI2603513T1/sl unknown
- 2011-08-09 PL PL11749944T patent/PL2603513T3/pl unknown
- 2011-08-09 US US13/206,113 patent/US8575154B2/en active Active
- 2011-08-09 BR BR112013002250-7A patent/BR112013002250B1/pt active IP Right Grant
- 2011-08-09 TW TW100128311A patent/TWI504604B/zh active
- 2011-08-09 NZ NZ607593A patent/NZ607593A/en unknown
- 2011-08-09 ES ES11749944T patent/ES2793723T3/es active Active
- 2011-08-09 HR HRP20200844TT patent/HRP20200844T1/hr unknown
- 2011-08-09 DK DK11749944.2T patent/DK2603513T3/da active
- 2011-08-09 CN CN201180048970.3A patent/CN103180326B/zh active Active
- 2011-08-09 HU HUE11749944A patent/HUE049460T2/hu unknown
- 2011-08-09 SG SG2013007463A patent/SG187656A1/en unknown
- 2011-08-09 JP JP2013506362A patent/JP5788496B2/ja active Active
- 2011-08-09 EA EA201390222A patent/EA022078B1/ru not_active IP Right Cessation
- 2011-08-09 US US13/816,137 patent/US9150591B2/en active Active
- 2011-08-09 MA MA35708A patent/MA34509B1/fr unknown
- 2011-08-09 AU AU2011290126A patent/AU2011290126B2/en active Active
- 2011-08-09 RS RS20200574A patent/RS60311B1/sr unknown
- 2011-08-09 PH PH1/2013/500247A patent/PH12013500247A1/en unknown
- 2011-08-09 UY UY0001033551A patent/UY33551A/es not_active Application Discontinuation
- 2011-08-09 WO PCT/JP2011/068497 patent/WO2012020848A1/en not_active Ceased
- 2011-08-09 MY MYPI2013000428A patent/MY165908A/en unknown
- 2011-08-09 GE GEAP201113021A patent/GEP20156216B/en unknown
- 2011-08-09 CN CN201510259936.0A patent/CN104926837A/zh active Pending
- 2011-08-09 MX MX2013001614A patent/MX349470B/es active IP Right Grant
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2014
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