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PE20130246A1 - COMPUESTOS DEL COMPLEJO DE Fe(III) PARA EL TRATAMIENTO Y PROFILAXIS DE LOS SINTOMAS DE DEFICIENCIA DE HIERRO Y LAS ANEMIAS POR DEFICIENCIA DE HIERRO - Google Patents

COMPUESTOS DEL COMPLEJO DE Fe(III) PARA EL TRATAMIENTO Y PROFILAXIS DE LOS SINTOMAS DE DEFICIENCIA DE HIERRO Y LAS ANEMIAS POR DEFICIENCIA DE HIERRO

Info

Publication number
PE20130246A1
PE20130246A1 PE2012001611A PE2012001611A PE20130246A1 PE 20130246 A1 PE20130246 A1 PE 20130246A1 PE 2012001611 A PE2012001611 A PE 2012001611A PE 2012001611 A PE2012001611 A PE 2012001611A PE 20130246 A1 PE20130246 A1 PE 20130246A1
Authority
PE
Peru
Prior art keywords
iron deficiency
alkyl
compounds
iii
complex
Prior art date
Application number
PE2012001611A
Other languages
English (en)
Inventor
Thomas Gunter Bark
Wilm Buhr
Susanna Elena Burckhardt
Michael Burgert
Camillo Canclini
Franz Daniel Durrenberger
Felix Funk
Peter Otto Geisser
Aris Kalogerakis
Simona Mayer
Erik Gerhard Phillip
Stefan Markus Johannes Reim
Diana Manuela Sieber
Jorg Simon Schmitt
Katrin Schwarz
Original Assignee
Vifor Int Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42710524&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130246(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vifor Int Ag filed Critical Vifor Int Ag
Publication of PE20130246A1 publication Critical patent/PE20130246A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DEL COMPLEJO DE HIERRO (III) BETA- CETOAMIDA DE FORMULA (II) DONDE: R1 ES ALQUILO C1-6, ALCOXI (C1-C4)-ALQUILO (C1-C4), HIDROXI-ALQUILO C1-4, ENTRE OTROS; R2 ES H, ALQUILO C1-6, HALOGENO, ENTRE OTROS; R1 Y R2 JUNTOS FORMAN UN GRUPO PROPILENO (-CH2-CH2-CH2-)- O UN GRUPO BUTILENO (-CH2-CH2-CH2-CH2)- EN EL CUAL METILENO PUEDE SER REEMPLAZADO CON O, NH, ENTRE OTROS; R3 Y R4 SON IGUALES O DIFERENTES Y SE SELECCIONAN DE H, ALQUILO C1-6, ALCOXI (C1-C4)-ALQUILO (C1-C4), HIDRO-ALQUILO C1-4, ENTRE OTROS; R3 Y R4 JUNTOS FORMAN UN GRUPO ETILENO (-CH2-CH2-)-, UN GRUPO BUTILENO (-CH2-CH2-CH2-CH2)- EN EL CUAL METILENO PUEDE SER REEMPLAZADO CON O, NH, ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA Y A UN METODO DE PREPARACION. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE LA ANEMIA
PE2012001611A 2010-03-23 2011-03-22 COMPUESTOS DEL COMPLEJO DE Fe(III) PARA EL TRATAMIENTO Y PROFILAXIS DE LOS SINTOMAS DE DEFICIENCIA DE HIERRO Y LAS ANEMIAS POR DEFICIENCIA DE HIERRO PE20130246A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10157387 2010-03-23

Publications (1)

Publication Number Publication Date
PE20130246A1 true PE20130246A1 (es) 2013-04-07

Family

ID=42710524

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012001611A PE20130246A1 (es) 2010-03-23 2011-03-22 COMPUESTOS DEL COMPLEJO DE Fe(III) PARA EL TRATAMIENTO Y PROFILAXIS DE LOS SINTOMAS DE DEFICIENCIA DE HIERRO Y LAS ANEMIAS POR DEFICIENCIA DE HIERRO

Country Status (25)

Country Link
US (2) US9394324B2 (es)
EP (1) EP2549991B1 (es)
JP (1) JP5648120B2 (es)
KR (1) KR101529273B1 (es)
CN (1) CN102892415B (es)
AR (1) AR080802A1 (es)
AU (1) AU2011231710B2 (es)
BR (1) BR112012023780A2 (es)
CA (1) CA2793153C (es)
CL (1) CL2012002624A1 (es)
CO (1) CO6630090A2 (es)
CR (1) CR20120478A (es)
DO (1) DOP2012000250A (es)
ES (1) ES2660202T3 (es)
MA (1) MA34067B1 (es)
MX (1) MX2012010950A (es)
NZ (1) NZ602289A (es)
PE (1) PE20130246A1 (es)
PH (1) PH12012501814A1 (es)
RU (1) RU2589710C2 (es)
SG (1) SG183972A1 (es)
TN (1) TN2012000457A1 (es)
TW (1) TWI426900B (es)
WO (1) WO2011117225A1 (es)
ZA (1) ZA201207550B (es)

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ES2548407T3 (es) * 2011-05-31 2015-10-16 Vifor (International) Ag Compuestos de complejos de 2,4-dioxo-1-carbonilo de Fe(III) para su uso en el tratamiento y la profilaxis de estados de deficiencia de hierro y anemias por deficiencia de hierro
CN103974702A (zh) * 2011-10-12 2014-08-06 思佰益药业股份有限公司 癌性贫血改善/预防剂
EP2604617A1 (de) * 2011-12-12 2013-06-19 Sika Technology AG Eisen(III)-Komplexverbindungen als Katalysatoren für Polyurethan-Zusammensetzungen
EP2604618A1 (de) * 2011-12-12 2013-06-19 Sika Technology AG Metall-Komplexverbindungen als Katalysatoren für Polyurethan-Zusammensetzungen
EP2604615A1 (de) * 2011-12-12 2013-06-19 Sika Technology AG Bismuthaltiger Katalysator für Polyurethan-Zusammensetzungen
US9452152B2 (en) * 2012-12-21 2016-09-27 Vifor (International) Ag Fe(III) complex compounds for the treatment and prophylaxis of iron deficiency symptoms and iron deficiency anemias
WO2014154797A1 (de) * 2013-03-28 2014-10-02 Vifor (International) Ag Fe(iii)-komplexverbindungen zur behandlung und prophylaxe von eisenmangelerscheinungen und eisenmangelanämien
CN103819425A (zh) * 2014-03-05 2014-05-28 南通惠康国际企业有限公司 一种树脂固化剂n-乙酰乙酰基吗啉的制备方法
WO2015198304A1 (en) 2014-06-22 2015-12-30 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
ES2985990T3 (es) 2018-05-16 2024-11-08 Ceva Sante Animale Composiciones veterinarias y usos de las mismas para controlar deficiencias de hierro en mamíferos no humanos
EP4021956A4 (en) * 2019-08-30 2023-04-26 Dow Global Technologies LLC METHODS FOR REDUCING ALDEHYDE EMISSIONS IN POLYETHER POLYOLS AND POLYURETHANE FOAM
US20230165278A1 (en) * 2020-05-01 2023-06-01 North Carolina State University Nutritional supplements comprising dietary metal complexes in a matrix of cellulosic materials
RU2763135C1 (ru) * 2021-04-23 2021-12-27 Виктор Павлович Ремез Фармакологическая композиция для лечения железодефицитной анемии
EP4405362A2 (en) * 2021-09-20 2024-07-31 Novaled GmbH Compound, semiconductor layer comprising compound and organic electronic device
KR102623739B1 (ko) * 2022-07-28 2024-01-11 주식회사 페라메드 시트르산과 철을 포함하는 착화합물 및 그를 포함하는 식품 조성물
CN116199572B (zh) * 2023-03-02 2025-01-14 南京师范大学 一种铁催化酮α位溴化的方法

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Also Published As

Publication number Publication date
WO2011117225A1 (de) 2011-09-29
NZ602289A (en) 2014-01-31
EP2549991B1 (de) 2017-11-22
US9394324B2 (en) 2016-07-19
CN102892415B (zh) 2016-10-19
RU2589710C2 (ru) 2016-07-10
CL2012002624A1 (es) 2013-02-01
JP5648120B2 (ja) 2015-01-07
KR20130031250A (ko) 2013-03-28
BR112012023780A2 (pt) 2018-07-24
CR20120478A (es) 2013-03-11
CA2793153A1 (en) 2011-09-29
TN2012000457A1 (en) 2014-01-30
PH12012501814A1 (en) 2012-12-10
RU2012144844A (ru) 2014-04-27
JP2013522343A (ja) 2013-06-13
US20130109662A1 (en) 2013-05-02
TW201136583A (en) 2011-11-01
US9943498B2 (en) 2018-04-17
ES2660202T3 (es) 2018-03-21
TWI426900B (zh) 2014-02-21
SG183972A1 (en) 2012-10-30
EP2549991A1 (de) 2013-01-30
AR080802A1 (es) 2012-05-09
CA2793153C (en) 2016-03-29
AU2011231710A1 (en) 2012-09-27
DOP2012000250A (es) 2013-02-15
CO6630090A2 (es) 2013-03-01
US20160310459A1 (en) 2016-10-27
KR101529273B1 (ko) 2015-06-16
MX2012010950A (es) 2012-11-12
CN102892415A (zh) 2013-01-23
ZA201207550B (en) 2013-06-26
MA34067B1 (fr) 2013-03-05
AU2011231710B2 (en) 2013-07-25

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