PE20121682A1 - Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents
Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienenInfo
- Publication number
- PE20121682A1 PE20121682A1 PE2012000242A PE2012000242A PE20121682A1 PE 20121682 A1 PE20121682 A1 PE 20121682A1 PE 2012000242 A PE2012000242 A PE 2012000242A PE 2012000242 A PE2012000242 A PE 2012000242A PE 20121682 A1 PE20121682 A1 PE 20121682A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation procedure
- dihydro
- oxazolobenzodiazepinones
- derivatives
- contain
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 6-QUINOLINYL Chemical class 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000003104 endogenous depression Diseases 0.000 abstract 1
- 208000037870 generalized anxiety Diseases 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- 239000002858 neurotransmitter agent Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1 ES H O UN GRUPO ALQUILO (C1-4) LINEAL O RAMIFICADO; R2 ES UN GRUPO ALQUILO (C1-4) LINEAL O RAMIFICADO Y R3 ES UN GRUPO ARILO O HETEROARILO. SON COMPUESTOS PREFERIDOS: 5-(4-FLUORO-1-BENZOTIEN-2-IL)-8-METIL-1,9-DIHIDRO-2H-[1,3]OXAZOLO[4,5-h][2,3]-BENZODIAZEPIN-2-ONA; 8-METIL-5-(6-QUINOLINIL)-1,9-DIHIDRO-2H-[1,3]OXAZOLO[4,5-h][2,3]BENZODIAZEPIN-2-ONA; ENTRE OTROS. REFERIDO ADEMAS A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS DISMINUYEN LOS EFECTOS DEL NEUROTRANSMISOR GABA SIENDO UTILES PARA EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, ESQUIZOFRENIA, DEPRESION UNIPOLAR, ANSIEDAD GENERALIZADA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1100682A FR2972454B1 (fr) | 2011-03-08 | 2011-03-08 | Nouveaux derives dihydro-oxazolobenzodiazepinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121682A1 true PE20121682A1 (es) | 2012-12-08 |
Family
ID=44004482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000242A PE20121682A1 (es) | 2011-03-08 | 2012-02-22 | Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen |
Country Status (44)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU230684B1 (hu) | 2014-01-21 | 2017-08-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Új dihidro-oxazino-benzodiazepin vegyületek és eljárás ezek elõállítására, illetve az ezeket tartalmazó gyógyászati készítmények |
| DE102016005291B4 (de) | 2016-04-29 | 2024-01-11 | Ksg Austria Gmbh | Verfahren zur Herstellung eines elektronischen Gerätes in der Form eines Spritzgußteils mit eingelegter Leiterplatte |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3370616D1 (en) | 1982-08-06 | 1987-05-07 | Ube Industries | Process for producing phenylacetones |
| US5891871A (en) * | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
| UA67749C2 (uk) * | 1997-08-12 | 2004-07-15 | Егіш Дьйодьсердьяр Рт. | Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування |
| CA2300142A1 (en) * | 1997-08-12 | 1999-02-18 | Peter Kotay Nagy | 1,3-dioxolo/4,5-h//2,3/benzodiazepine derivatives as ampa/kainate receptor inhibitors |
| GB9900222D0 (en) * | 1999-01-06 | 1999-02-24 | Merck Sharp & Dohme | Therapeutic compounds |
| HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
| CA2627757A1 (en) * | 2005-10-26 | 2007-05-03 | The Regents Of The University Of Michigan | Therapeutic compositions and methods |
| HU230760B1 (hu) * | 2005-12-30 | 2018-03-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Dihidro-2,3-benzodiazepin-származékok optikai izomerjei, eljárás ezek sztereoszelektív szintézisére, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények és az eljárás közbenső termékei |
| EP2298296A1 (en) * | 2009-08-25 | 2011-03-23 | CNRS Centre National De La Recherche Scientifique | Composition and method for treating cognitive impairments in down syndrome subjects |
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2011
- 2011-03-08 FR FR1100682A patent/FR2972454B1/fr active Active
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2012
- 2012-02-20 IL IL218215A patent/IL218215A/en active IP Right Grant
- 2012-02-21 JO JO201236A patent/JO2948B1/en active
- 2012-02-22 PH PH1/2012/000035A patent/PH12012000035A1/en unknown
- 2012-02-22 AU AU2012201031A patent/AU2012201031B2/en not_active Ceased
- 2012-02-22 SG SG2012012340A patent/SG184633A1/en unknown
- 2012-02-22 PE PE2012000242A patent/PE20121682A1/es active IP Right Grant
- 2012-02-24 MY MYPI2012700036A patent/MY162537A/en unknown
- 2012-02-27 CL CL2012000496A patent/CL2012000496A1/es unknown
- 2012-02-28 UY UY0001033927A patent/UY33927A/es unknown
- 2012-03-02 MA MA34658A patent/MA33641B1/fr unknown
- 2012-03-05 CA CA2771189A patent/CA2771189C/fr not_active Expired - Fee Related
- 2012-03-05 GE GEAP201212613A patent/GEP20146017B/en unknown
- 2012-03-06 AP AP2012006149A patent/AP3344A/xx active
- 2012-03-06 CR CR20120109A patent/CR20120109A/es unknown
- 2012-03-06 EC ECSP12011711 patent/ECSP12011711A/es unknown
- 2012-03-06 MX MX2012002788A patent/MX2012002788A/es active IP Right Grant
- 2012-03-07 EA EA201200267A patent/EA021125B1/ru not_active IP Right Cessation
- 2012-03-07 DK DK12290077.2T patent/DK2497774T3/da active
- 2012-03-07 TW TW101107763A patent/TWI428342B/zh not_active IP Right Cessation
- 2012-03-07 ZA ZA2012/01681A patent/ZA201201681B/en unknown
- 2012-03-07 HN HN2012000485A patent/HN2012000485A/es unknown
- 2012-03-07 ES ES12290077.2T patent/ES2442293T3/es active Active
- 2012-03-07 WO PCT/FR2012/000080 patent/WO2012120206A1/fr not_active Ceased
- 2012-03-07 AR ARP120100728A patent/AR085691A1/es unknown
- 2012-03-07 US US13/413,977 patent/US8778932B2/en not_active Expired - Fee Related
- 2012-03-07 NZ NZ598625A patent/NZ598625A/xx not_active IP Right Cessation
- 2012-03-07 UA UAA201202760A patent/UA112153C2/uk unknown
- 2012-03-07 RS RS20130492A patent/RS53032B/sr unknown
- 2012-03-07 NI NI201200039A patent/NI201200039A/es unknown
- 2012-03-07 EP EP12290077.2A patent/EP2497774B1/fr active Active
- 2012-03-07 SI SI201230017T patent/SI2497774T1/sl unknown
- 2012-03-07 JP JP2012050550A patent/JP5475816B2/ja not_active Expired - Fee Related
- 2012-03-07 SA SA112330231A patent/SA112330231B1/ar unknown
- 2012-03-07 PT PT122900772T patent/PT2497774E/pt unknown
- 2012-03-07 PL PL12290077T patent/PL2497774T3/pl unknown
- 2012-03-07 BR BRBR102012005137-0A patent/BR102012005137A2/pt not_active Application Discontinuation
- 2012-03-07 RU RU2013144824/04A patent/RU2572556C2/ru not_active IP Right Cessation
- 2012-03-07 SA SA112330331A patent/SA112330331B1/ar unknown
- 2012-03-08 CU CUP2012000041A patent/CU24134B1/es unknown
- 2012-03-08 GT GT201200066A patent/GT201200066A/es unknown
- 2012-03-08 KR KR1020120023935A patent/KR101477991B1/ko not_active Expired - Fee Related
- 2012-03-08 CN CN201210063418.8A patent/CN102675341B/zh not_active Expired - Fee Related
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2013
- 2013-12-13 CY CY20131101128T patent/CY1114729T1/el unknown
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2014
- 2014-01-16 HR HRP20140050AT patent/HRP20140050T1/hr unknown
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Legal Events
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| FG | Grant, registration |