PE20121495A1 - Combinacion de un agente quimioterapeutico y un inhibidor del sistema tgf-beta - Google Patents
Combinacion de un agente quimioterapeutico y un inhibidor del sistema tgf-betaInfo
- Publication number
- PE20121495A1 PE20121495A1 PE2012000130A PE2012000130A PE20121495A1 PE 20121495 A1 PE20121495 A1 PE 20121495A1 PE 2012000130 A PE2012000130 A PE 2012000130A PE 2012000130 A PE2012000130 A PE 2012000130A PE 20121495 A1 PE20121495 A1 PE 20121495A1
- Authority
- PE
- Peru
- Prior art keywords
- tgf
- beta
- chemotherapeutic agent
- inhibitor
- combination
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 4
- 239000000074 antisense oligonucleotide Substances 0.000 abstract 4
- 238000012230 antisense oligonucleotides Methods 0.000 abstract 4
- -1 DACARBACIN Chemical compound 0.000 abstract 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 abstract 1
- 239000012829 chemotherapy agent Substances 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960004964 temozolomide Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE: A) UN AGENTE QUIMIOTERAPEUTICO TAL COMO GEMCITABINA, 5-FLUOROURACILO, TEMOZOLOMIDA, DACARBACINA, DOCETAXEL, CISPLATINO, ENTRE OTROS; Y B) UN OLIGONUCLEOTIDO ANTISENTIDO CONTRA TGF-BETA 2 DE SEQ ID Nº 22 A 48, UN OLIGONUCLEOTIDO ANTISENTIDO CONTRA TGF-BETA 1 DE SEQ ID Nº 1 A 21 O UN OLIGONUCLEOTIDO ANTISENTIDO CONTRA TGF-BETA 3 DE SEQ ID Nº 49 A 78, EN DONDE EL OLIGONUCLEOTIDO ANTISENTIDO REDUCE LA CONCENTRACION INHIBITORIA IC50 DE LA CITOTOXICIDAD DEL AGENTE QUIMIOTERAPEUTICO EN UN 5% A 95%
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09166893 | 2009-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121495A1 true PE20121495A1 (es) | 2012-11-19 |
Family
ID=41278403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000130A PE20121495A1 (es) | 2009-07-30 | 2010-07-30 | Combinacion de un agente quimioterapeutico y un inhibidor del sistema tgf-beta |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8476246B2 (es) |
| EP (1) | EP2340308B1 (es) |
| JP (1) | JP2013500313A (es) |
| KR (1) | KR20120107456A (es) |
| CN (1) | CN102712924A (es) |
| AU (1) | AU2010277554B2 (es) |
| BR (1) | BR112012002102A2 (es) |
| CA (1) | CA2769618A1 (es) |
| CL (1) | CL2012000247A1 (es) |
| CO (1) | CO6511199A2 (es) |
| EC (1) | ECSP12011689A (es) |
| IL (1) | IL217821A0 (es) |
| IN (1) | IN2012DN00969A (es) |
| MX (1) | MX2012001244A (es) |
| PE (1) | PE20121495A1 (es) |
| RU (1) | RU2012107535A (es) |
| WO (1) | WO2011012713A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2307942T3 (es) | 2002-01-17 | 2008-12-01 | The University Of British Columbia | Oligonucleotidos antisentido biespecificos que inhiben igfbp-2 e igfbp-5 y metodos de uso. |
| EP2625292B1 (en) | 2010-10-07 | 2018-12-05 | The General Hospital Corporation | Biomarkers of cancer |
| TWI454281B (zh) * | 2011-10-06 | 2014-10-01 | Nat Univ Tsing Hua | 硼酸於硼中子捕獲治療肝癌之用途 |
| WO2013124869A2 (en) * | 2012-02-21 | 2013-08-29 | Amrita Vishwa Vidyapeetham University | The art, method,manner process and system of fibrous bio-degradable polymeric wafers for the local delivery of therapeutic agents in combinations |
| US20140275214A1 (en) * | 2013-03-14 | 2014-09-18 | Teva Pharmaceutical Industries, Ltd. | Custirsen treatment with reduced toxicity |
| ES2753580T3 (es) * | 2014-05-23 | 2020-04-13 | Inst Nat Sante Rech Med | Procedimientos para determinar si un paciente logrará una respuesta después de la radioterapia |
| EP3161159B1 (en) | 2014-06-25 | 2020-08-05 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
| WO2016081503A1 (en) * | 2014-11-17 | 2016-05-26 | City Of Hope | Tki permeability enhancers |
| HK1256603A1 (zh) | 2015-06-26 | 2019-09-27 | 贝斯以色列女执事医疗中心股份有限公司 | 靶向髓样衍生的抑制细胞中的四跨膜蛋白33(tspan33)的癌症疗法 |
| US9758786B2 (en) | 2016-02-09 | 2017-09-12 | Autotelic, Llc | Compositions and methods for treating pancreatic cancer |
| WO2017138924A1 (en) | 2016-02-09 | 2017-08-17 | Autotelic Llc | Compositions and methods for treating pancreatic cancer |
| WO2017138925A1 (en) | 2016-02-09 | 2017-08-17 | Autotelic Llc | Antitumour combinations of antisense oligonucleotides and anticancer agents |
| CA3037046A1 (en) | 2016-10-31 | 2018-05-03 | University Of Massachusetts | Targeting microrna-101-3p in cancer therapy |
| US11471515B2 (en) | 2016-11-09 | 2022-10-18 | The Brigham And Women's Hospital, Inc. | Restoration of tumor suppression using MRNA-based delivery system |
| AU2019217875A1 (en) | 2018-02-06 | 2020-08-20 | Icahn School Of Medicine At Mount Sinai | Repeat RNA as biomarkers of tumor immune response |
| KR20210139237A (ko) * | 2019-03-14 | 2021-11-22 | 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 | 변형된 마이크로rna 및 암 치료에 있어서의 이의 용도 |
| GB201908012D0 (en) * | 2019-06-05 | 2019-07-17 | Io Biotech Aps | TGF-Beta vaccine |
| CN112933238A (zh) * | 2021-02-02 | 2021-06-11 | 石河子大学 | 抑制TGF-βR1基因表达的物质与顺铂在治疗和/或预防食管癌中的应用 |
| CN113425855B (zh) * | 2021-06-28 | 2023-11-07 | 深圳瑞吉生物科技有限公司 | 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用 |
| WO2025193774A1 (en) * | 2024-03-12 | 2025-09-18 | The Regents Of The University Of California | Methods of identifying and treating an immune poor cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| AU568067B2 (en) | 1981-10-23 | 1987-12-17 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and methods of making same |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| EP0856579A1 (en) * | 1997-01-31 | 1998-08-05 | BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH | An antisense oligonucleotide preparation method |
| US7795232B1 (en) | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| US6809118B2 (en) * | 2002-07-25 | 2004-10-26 | Yih-Lin Chung | Methods for therapy of radiation cutaneous syndrome |
| DE112004001603T5 (de) * | 2003-09-04 | 2006-07-06 | Nihon University | TGF-β-Genexpressionsinhibitor |
| CA2542215A1 (en) * | 2003-11-13 | 2005-06-02 | Genentech, Inc. | Screening assays and methods of tumor treatment |
| ZA200602941B (en) * | 2003-11-13 | 2007-07-25 | Genentech Inc | Screening assays and methods of tumor treatment |
| WO2005059133A2 (en) | 2003-12-19 | 2005-06-30 | Antisense Pharma Gmbh | Combination therapy associating a tgf-breta antagonist with a chemiotherapeutic agent |
| US20070155685A1 (en) * | 2004-02-27 | 2007-07-05 | Karl-Hermann Schlingensiepen | Pharmaceutical composition |
| US20090186076A1 (en) * | 2006-02-01 | 2009-07-23 | Kazunori Kataoka | Combined Use of TGF-Beta Signaling Inhibitor and Antitumor Agent |
| JP5322476B2 (ja) * | 2008-03-31 | 2013-10-23 | テルモ株式会社 | リポソームの製造装置およびリポソームの製造方法 |
-
2010
- 2010-07-30 BR BR112012002102A patent/BR112012002102A2/pt not_active IP Right Cessation
- 2010-07-30 JP JP2012522185A patent/JP2013500313A/ja active Pending
- 2010-07-30 AU AU2010277554A patent/AU2010277554B2/en not_active Ceased
- 2010-07-30 RU RU2012107535/15A patent/RU2012107535A/ru not_active Application Discontinuation
- 2010-07-30 CA CA2769618A patent/CA2769618A1/en not_active Abandoned
- 2010-07-30 EP EP10737580.0A patent/EP2340308B1/en not_active Not-in-force
- 2010-07-30 IN IN969DEN2012 patent/IN2012DN00969A/en unknown
- 2010-07-30 CN CN2010800436805A patent/CN102712924A/zh active Pending
- 2010-07-30 US US13/059,623 patent/US8476246B2/en active Active
- 2010-07-30 MX MX2012001244A patent/MX2012001244A/es active IP Right Grant
- 2010-07-30 WO PCT/EP2010/061152 patent/WO2011012713A1/en not_active Ceased
- 2010-07-30 PE PE2012000130A patent/PE20121495A1/es not_active Application Discontinuation
- 2010-07-30 KR KR1020127005337A patent/KR20120107456A/ko not_active Withdrawn
-
2012
- 2012-01-29 IL IL217821A patent/IL217821A0/en unknown
- 2012-01-30 CL CL2012000247A patent/CL2012000247A1/es unknown
- 2012-02-23 EC ECSP12011689 patent/ECSP12011689A/es unknown
- 2012-02-29 CO CO12035227A patent/CO6511199A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2340308A1 (en) | 2011-07-06 |
| BR112012002102A2 (pt) | 2017-05-02 |
| CL2012000247A1 (es) | 2013-07-05 |
| MX2012001244A (es) | 2012-03-26 |
| US8476246B2 (en) | 2013-07-02 |
| AU2010277554B2 (en) | 2015-02-19 |
| CA2769618A1 (en) | 2011-02-03 |
| RU2012107535A (ru) | 2013-09-10 |
| CO6511199A2 (es) | 2012-08-31 |
| IL217821A0 (en) | 2012-03-29 |
| AU2010277554A1 (en) | 2012-03-01 |
| JP2013500313A (ja) | 2013-01-07 |
| US20120027873A1 (en) | 2012-02-02 |
| CN102712924A (zh) | 2012-10-03 |
| KR20120107456A (ko) | 2012-10-02 |
| EP2340308B1 (en) | 2014-12-24 |
| IN2012DN00969A (es) | 2015-04-10 |
| ECSP12011689A (es) | 2012-06-29 |
| WO2011012713A1 (en) | 2011-02-03 |
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