PE20151726A1 - Formulaciones veterinarias estables de combinacion de lactonas macrociclicas e imidazotiazoles - Google Patents
Formulaciones veterinarias estables de combinacion de lactonas macrociclicas e imidazotiazolesInfo
- Publication number
- PE20151726A1 PE20151726A1 PE2015002122A PE2015002122A PE20151726A1 PE 20151726 A1 PE20151726 A1 PE 20151726A1 PE 2015002122 A PE2015002122 A PE 2015002122A PE 2015002122 A PE2015002122 A PE 2015002122A PE 20151726 A1 PE20151726 A1 PE 20151726A1
- Authority
- PE
- Peru
- Prior art keywords
- imidazothiazoles
- combination
- macrocyclic lactones
- veterinary formulations
- stable veterinary
- Prior art date
Links
- 150000002596 lactones Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 1
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 230000002141 anti-parasite Effects 0.000 abstract 1
- 239000003096 antiparasitic agent Substances 0.000 abstract 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 abstract 1
- 229960003997 doramectin Drugs 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 229960002442 glucosamine Drugs 0.000 abstract 1
- 150000002337 glycosamines Chemical class 0.000 abstract 1
- 229960001614 levamisole Drugs 0.000 abstract 1
- 229960003194 meglumine Drugs 0.000 abstract 1
- YZBLFMPOMVTDJY-CBYMMZEQSA-N moxidectin Chemical compound O1[C@H](C(\C)=C\C(C)C)[C@@H](C)C(=N/OC)\C[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YZBLFMPOMVTDJY-CBYMMZEQSA-N 0.000 abstract 1
- 229960004816 moxidectin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
Referida a una composicion para el tratamiento de infecciones parasitarias en animales, que comprende: una lactona macrociclica tal como doramectina o moxidectina en una cantidad de entre 0,1% p/p a 1% p/p, de 4,0% p/p a 24% p/p de levamisol, un potenciador de estabilidad de aminoazucar tal como glucosamina o meglumina en una cantidad de entre 0,01% p/p a 0,2% p/p, un vehiculo farmaceutica o veterinariamente aceptable y al menos un agente antiparasitario adicional tal como benzimidazol
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361811138P | 2013-04-12 | 2013-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20151726A1 true PE20151726A1 (es) | 2015-11-18 |
Family
ID=50694063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015002122A PE20151726A1 (es) | 2013-04-12 | 2014-04-10 | Formulaciones veterinarias estables de combinacion de lactonas macrociclicas e imidazotiazoles |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10307405B2 (es) |
| EP (1) | EP2983712B1 (es) |
| BR (1) | BR112015025875B1 (es) |
| CL (1) | CL2015002976A1 (es) |
| CR (1) | CR20150508A (es) |
| ES (1) | ES2846820T3 (es) |
| MX (1) | MX364170B (es) |
| NZ (1) | NZ712345A (es) |
| PE (1) | PE20151726A1 (es) |
| PL (1) | PL2983712T3 (es) |
| WO (1) | WO2014169092A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR102017010598A2 (pt) * | 2017-05-19 | 2018-12-04 | Flavio Alves Da Rocha | composições veterinárias de liberação retardada para controle de ovos e larvas de helmintos nas fezes dos ruminantes, uso das composições, uso de antelmínticos com essa finalidade |
| EP3713413A1 (en) | 2017-11-23 | 2020-09-30 | Ceva Sante Animale | Composition for treating parasites infestations |
| DK3846786T3 (da) * | 2018-09-05 | 2024-12-02 | Zoetis Services Llc | Velsmagende antiparasitære formuleringer |
| SI3815677T1 (sl) | 2019-10-30 | 2023-12-29 | Krka, D.D., Novo Mesto | Stabilni veterinarski sestavek, ki obsega moksidektin in imidakloprid |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
| EP0165900A3 (de) | 1984-06-08 | 1986-05-28 | Ciba-Geigy Ag | Neue Lactone, Verfahren zu ihrer Herstellung und ihre Verwendung in der Schädlingsbekämpfung |
| US4916154A (en) | 1986-09-12 | 1990-04-10 | American Cyanamid Company | 23-Imino derivatives of LL-F28249 compounds |
| DK1276748T3 (da) | 2000-04-27 | 2006-03-20 | Sankyo Lifetech Company Ltd | 13-substituerede milbemycinderivater, deres fremstilling og deres anvendelse over for insekter og andre skadedyr |
| US7348417B2 (en) | 2003-08-07 | 2008-03-25 | Wyeth | Method of purifying moxidectin through crystallization |
| US7671034B2 (en) * | 2003-12-19 | 2010-03-02 | Merial Limited | Stabilized formulation of ivermectin feed premix with an extended shelf life |
| WO2006006021A2 (en) * | 2004-06-28 | 2006-01-19 | Glenmark Pharmaceuticals Limited | Stabilized pharmaceutical compositions of preferably a statin |
| WO2006069580A1 (en) * | 2004-12-30 | 2006-07-06 | Cheminova A/S | Oil-in-water formulation of avermectins |
| US7840123B2 (en) * | 2007-06-21 | 2010-11-23 | S.C. Johnson & Son, Inc. | Diffusion device |
| BRPI0819849B8 (pt) | 2007-11-26 | 2021-05-25 | Merial Ltd | sistemas de solvente para formulações pour on para combater parasitas |
| AU2009283313C1 (en) * | 2008-08-18 | 2014-07-31 | Intervet Ineternational B.V. | Anthelmintic compositions |
| UA108641C2 (uk) * | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| WO2011143479A1 (en) | 2010-05-12 | 2011-11-17 | Merial Limited | Injectable parasiticidal formulations of levamisole and macrocyclic lactones |
| PL3351546T3 (pl) * | 2011-12-02 | 2024-09-09 | Boehringer Ingelheim Vetmedica Gmbh | Długodziałające wstrzykiwalne postaci moksydektyny |
-
2014
- 2014-04-10 NZ NZ712345A patent/NZ712345A/en unknown
- 2014-04-10 BR BR112015025875-1A patent/BR112015025875B1/pt active IP Right Grant
- 2014-04-10 EP EP14723640.0A patent/EP2983712B1/en active Active
- 2014-04-10 US US14/779,045 patent/US10307405B2/en active Active
- 2014-04-10 WO PCT/US2014/033599 patent/WO2014169092A1/en not_active Ceased
- 2014-04-10 PL PL14723640T patent/PL2983712T3/pl unknown
- 2014-04-10 MX MX2015014310A patent/MX364170B/es active IP Right Grant
- 2014-04-10 PE PE2015002122A patent/PE20151726A1/es not_active Application Discontinuation
- 2014-04-10 ES ES14723640T patent/ES2846820T3/es active Active
-
2015
- 2015-09-28 CR CR20150508A patent/CR20150508A/es unknown
- 2015-10-06 CL CL2015002976A patent/CL2015002976A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2015002976A1 (es) | 2016-05-06 |
| BR112015025875A2 (pt) | 2017-07-25 |
| WO2014169092A1 (en) | 2014-10-16 |
| MX2015014310A (es) | 2016-02-16 |
| ES2846820T3 (es) | 2021-07-29 |
| US20160051524A1 (en) | 2016-02-25 |
| BR112015025875B1 (pt) | 2021-06-29 |
| EP2983712A1 (en) | 2016-02-17 |
| NZ712345A (en) | 2016-04-29 |
| EP2983712B1 (en) | 2020-11-25 |
| MX364170B (es) | 2019-04-15 |
| CR20150508A (es) | 2015-11-18 |
| PL2983712T3 (pl) | 2021-05-31 |
| US10307405B2 (en) | 2019-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |