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PE20120260A1 - Derivados de morfina-6-glucuronido y su preparacion - Google Patents

Derivados de morfina-6-glucuronido y su preparacion

Info

Publication number
PE20120260A1
PE20120260A1 PE2011001199A PE2011001199A PE20120260A1 PE 20120260 A1 PE20120260 A1 PE 20120260A1 PE 2011001199 A PE2011001199 A PE 2011001199A PE 2011001199 A PE2011001199 A PE 2011001199A PE 20120260 A1 PE20120260 A1 PE 20120260A1
Authority
PE
Peru
Prior art keywords
cleutyl
morphin
xylopyranoside
beta
morphine
Prior art date
Application number
PE2011001199A
Other languages
English (en)
Inventor
Alain Dlubala
Isabelle Ripoche
Claire Trecant
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PE20120260A1 publication Critical patent/PE20120260A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE MORFINA-6-GLUCURONIDO DE FORMULA (I), DONDE R1 ES UN GRUPO HETEROCICLICO AROMATICO DE 5 ESLABONES TAL COMO IMIDAZOL, TIOFENO, TETRAZOL, OXAZOL, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON FLUOROMETILO, CLOROETILO, BUTOXIFENILO, ETOXIFENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: MORFIN-6-IL 5-C-(TETRAZOL-5-IL)-ALFA/BETA-D-XILOPIRANOSIDO, MORFIN-6-IL 5-C-(TETRAZOL-5-IL)-BETA-D-XILOPIRANOSIDO, MORFIN-6-IL 5-C-(2-METIL-1,3,4-OXADIAZOL-5-IL)-ALFA/BETA-D-XILOPIRANOSIDO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO Y PREVENCION DEL DOLOR
PE2011001199A 2008-12-10 2009-12-08 Derivados de morfina-6-glucuronido y su preparacion PE20120260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0806949A FR2939437B1 (fr) 2008-12-10 2008-12-10 Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20120260A1 true PE20120260A1 (es) 2012-04-13

Family

ID=41031604

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001199A PE20120260A1 (es) 2008-12-10 2009-12-08 Derivados de morfina-6-glucuronido y su preparacion

Country Status (29)

Country Link
US (1) US8461122B2 (es)
EP (1) EP2376512B1 (es)
JP (1) JP5616356B2 (es)
KR (1) KR20110104486A (es)
CN (1) CN102317301B (es)
AR (1) AR074514A1 (es)
AU (1) AU2009326909B2 (es)
BR (1) BRPI0922733A2 (es)
CA (1) CA2746429A1 (es)
CL (1) CL2011001399A1 (es)
CR (1) CR20110306A (es)
EA (1) EA019053B1 (es)
EC (1) ECSP11011110A (es)
ES (1) ES2468990T3 (es)
FR (1) FR2939437B1 (es)
HN (1) HN2011001601A (es)
IL (1) IL213381A (es)
MA (1) MA32952B1 (es)
MX (1) MX2011006252A (es)
MY (1) MY152978A (es)
NI (1) NI201100115A (es)
NZ (1) NZ593344A (es)
PE (1) PE20120260A1 (es)
SG (1) SG172068A1 (es)
TN (1) TN2011000266A1 (es)
TW (1) TW201026312A (es)
UA (1) UA104302C2 (es)
WO (1) WO2010067010A2 (es)
ZA (1) ZA201104305B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421063B (zh) * 2012-05-23 2016-04-06 宜昌人福药业有限责任公司 一种合成吗啡-6-β-D-葡萄糖醛酸苷的方法
CN111346104B (zh) * 2018-12-21 2022-06-10 宜昌人福药业有限责任公司 一种吗啡-6-葡萄糖醛酸苷透皮给药的药物组合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
GB2339196B (en) * 1997-04-14 2001-11-07 Salford Ultrafine Chem & Res Morphine derivatives
WO1999064430A2 (en) 1998-06-06 1999-12-16 Cenes Limited Morphine-6-glucuronide synthesis
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
ES2623362T3 (es) * 2004-05-28 2017-07-11 Human Biomolecular Research Institute Analgésicos metabólicamente estables y medicaciones para el dolor
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques

Also Published As

Publication number Publication date
US20110301107A1 (en) 2011-12-08
IL213381A (en) 2014-02-27
KR20110104486A (ko) 2011-09-22
HN2011001601A (es) 2013-09-16
EA019053B1 (ru) 2013-12-30
UA104302C2 (ru) 2014-01-27
WO2010067010A2 (fr) 2010-06-17
AR074514A1 (es) 2011-01-19
TN2011000266A1 (fr) 2012-12-17
NZ593344A (en) 2013-08-30
BRPI0922733A2 (pt) 2016-01-05
NI201100115A (es) 2011-12-14
SG172068A1 (en) 2011-07-28
ES2468990T3 (es) 2014-06-17
ECSP11011110A (es) 2011-07-29
MY152978A (en) 2014-12-15
MA32952B1 (fr) 2012-01-02
FR2939437B1 (fr) 2010-12-17
TW201026312A (en) 2010-07-16
MX2011006252A (es) 2011-11-04
EA201170792A1 (ru) 2012-01-30
EP2376512A2 (fr) 2011-10-19
HK1163110A1 (en) 2012-09-07
US8461122B2 (en) 2013-06-11
AU2009326909A1 (en) 2011-06-30
WO2010067010A3 (fr) 2011-06-30
CN102317301A (zh) 2012-01-11
ZA201104305B (en) 2012-10-31
FR2939437A1 (fr) 2010-06-11
CR20110306A (es) 2011-09-21
CN102317301B (zh) 2015-08-26
AU2009326909B2 (en) 2016-05-26
IL213381A0 (en) 2011-07-31
CL2011001399A1 (es) 2011-10-28
JP2012511553A (ja) 2012-05-24
EP2376512B1 (fr) 2014-02-26
CA2746429A1 (fr) 2010-06-17
JP5616356B2 (ja) 2014-10-29

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