AR074514A1 - Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR074514A1 AR074514A1 ARP090104752A ARP090104752A AR074514A1 AR 074514 A1 AR074514 A1 AR 074514A1 AR P090104752 A ARP090104752 A AR P090104752A AR P090104752 A ARP090104752 A AR P090104752A AR 074514 A1 AR074514 A1 AR 074514A1
- Authority
- AR
- Argentina
- Prior art keywords
- application
- derivatives
- preparation
- morfina
- glucuronido
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- -1 C 1- haloalkyl 4 Chemical group 0.000 abstract 1
- GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical class O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente solicitud se refiere a derivados de morfina-6-glucurónido de fórmula (1) en la que R1 es un grupo heteroaromático de 5 eslabones eventualmente sustituido con uno o varios sustituyentes elegidos entre átomos de halógeno y los grupos alquilo C1-4, halógeno, hidroxilo, haloalquilo C1-4, haloalcoxi C1-4, alquiloxi C1-4, aril-alquilo C1-4 y arilo, estando dicho grupo arilo eventualmente sustituido con uno o varios grupos elegidos entre los grupos alquilo C1-4, haloalquilo C1-4, hidroxilo y alquiloxi C1-4; en el estado de base o de sal de adición a un ácido así como en el estado de hidrato o de solvato. La presente solicitud se refiere también a su procedimiento de preparación y a su aplicación en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0806949A FR2939437B1 (fr) | 2008-12-10 | 2008-12-10 | Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR074514A1 true AR074514A1 (es) | 2011-01-19 |
Family
ID=41031604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104752A AR074514A1 (es) | 2008-12-10 | 2009-12-09 | Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8461122B2 (es) |
| EP (1) | EP2376512B1 (es) |
| JP (1) | JP5616356B2 (es) |
| KR (1) | KR20110104486A (es) |
| CN (1) | CN102317301B (es) |
| AR (1) | AR074514A1 (es) |
| AU (1) | AU2009326909B2 (es) |
| BR (1) | BRPI0922733A2 (es) |
| CA (1) | CA2746429A1 (es) |
| CL (1) | CL2011001399A1 (es) |
| CR (1) | CR20110306A (es) |
| EA (1) | EA019053B1 (es) |
| EC (1) | ECSP11011110A (es) |
| ES (1) | ES2468990T3 (es) |
| FR (1) | FR2939437B1 (es) |
| HN (1) | HN2011001601A (es) |
| IL (1) | IL213381A (es) |
| MA (1) | MA32952B1 (es) |
| MX (1) | MX2011006252A (es) |
| MY (1) | MY152978A (es) |
| NI (1) | NI201100115A (es) |
| NZ (1) | NZ593344A (es) |
| PE (1) | PE20120260A1 (es) |
| SG (1) | SG172068A1 (es) |
| TN (1) | TN2011000266A1 (es) |
| TW (1) | TW201026312A (es) |
| UA (1) | UA104302C2 (es) |
| WO (1) | WO2010067010A2 (es) |
| ZA (1) | ZA201104305B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103421063B (zh) * | 2012-05-23 | 2016-04-06 | 宜昌人福药业有限责任公司 | 一种合成吗啡-6-β-D-葡萄糖醛酸苷的方法 |
| CN111346104B (zh) * | 2018-12-21 | 2022-06-10 | 宜昌人福药业有限责任公司 | 一种吗啡-6-葡萄糖醛酸苷透皮给药的药物组合物及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3766188A (en) | 1971-06-28 | 1973-10-16 | Yamanouchi Pharma Co Ltd | Carbonyldioxymorphinan derivatives |
| GB9116909D0 (en) | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
| GB2282758A (en) | 1993-08-23 | 1995-04-19 | Euro Celtique Sa | Oral morphine-6-glucuronide compositions |
| DK0975648T3 (da) * | 1997-04-14 | 2003-09-29 | Ufc Ltd | Morfinderivater |
| JP2002517504A (ja) | 1998-06-06 | 2002-06-18 | セネス リミティド | モルフィン−６−グルクロニドの合成 |
| GB0218811D0 (en) * | 2002-08-14 | 2002-09-18 | Cenes Ltd | Salts of morphine-6-glucuronide |
| FR2864082B1 (fr) * | 2003-12-22 | 2006-03-10 | Synt Em | Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur |
| US8481501B2 (en) * | 2004-05-28 | 2013-07-09 | Human Biomolecular Research Institute | Synthesis of metabolically stable analgesics, pain medications and other agents |
| FR2907121B1 (fr) * | 2006-10-12 | 2012-05-04 | Neorphys | Nouveaux derives morphiniques |
-
2008
- 2008-12-10 FR FR0806949A patent/FR2939437B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-08 MY MYPI20112600 patent/MY152978A/en unknown
- 2009-12-08 JP JP2011540163A patent/JP5616356B2/ja not_active Expired - Fee Related
- 2009-12-08 WO PCT/FR2009/052448 patent/WO2010067010A2/fr not_active Ceased
- 2009-12-08 MX MX2011006252A patent/MX2011006252A/es active IP Right Grant
- 2009-12-08 ES ES09801748.6T patent/ES2468990T3/es active Active
- 2009-12-08 EP EP09801748.6A patent/EP2376512B1/fr active Active
- 2009-12-08 AU AU2009326909A patent/AU2009326909B2/en not_active Ceased
- 2009-12-08 SG SG2011042314A patent/SG172068A1/en unknown
- 2009-12-08 NZ NZ593344A patent/NZ593344A/xx not_active IP Right Cessation
- 2009-12-08 UA UAA201108592A patent/UA104302C2/ru unknown
- 2009-12-08 CN CN200980156457.9A patent/CN102317301B/zh not_active Expired - Fee Related
- 2009-12-08 EA EA201170792A patent/EA019053B1/ru not_active IP Right Cessation
- 2009-12-08 CA CA2746429A patent/CA2746429A1/fr not_active Abandoned
- 2009-12-08 KR KR1020117013142A patent/KR20110104486A/ko not_active Ceased
- 2009-12-08 PE PE2011001199A patent/PE20120260A1/es not_active Application Discontinuation
- 2009-12-08 BR BRPI0922733A patent/BRPI0922733A2/pt not_active IP Right Cessation
- 2009-12-08 MA MA33999A patent/MA32952B1/fr unknown
- 2009-12-09 AR ARP090104752A patent/AR074514A1/es unknown
- 2009-12-09 TW TW098142109A patent/TW201026312A/zh unknown
-
2011
- 2011-05-24 TN TN2011000266A patent/TN2011000266A1/fr unknown
- 2011-06-05 IL IL213381A patent/IL213381A/en not_active IP Right Cessation
- 2011-06-06 EC EC2011011110A patent/ECSP11011110A/es unknown
- 2011-06-06 CR CR20110306A patent/CR20110306A/es not_active Application Discontinuation
- 2011-06-08 US US13/155,655 patent/US8461122B2/en not_active Expired - Fee Related
- 2011-06-08 NI NI201100115A patent/NI201100115A/es unknown
- 2011-06-09 CL CL2011001399A patent/CL2011001399A1/es unknown
- 2011-06-09 ZA ZA2011/04305A patent/ZA201104305B/en unknown
- 2011-06-09 HN HN2011001601A patent/HN2011001601A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |