PE20120894A1 - Derivados de isoxazolidina - Google Patents
Derivados de isoxazolidinaInfo
- Publication number
- PE20120894A1 PE20120894A1 PE2012000303A PE2012000303A PE20120894A1 PE 20120894 A1 PE20120894 A1 PE 20120894A1 PE 2012000303 A PE2012000303 A PE 2012000303A PE 2012000303 A PE2012000303 A PE 2012000303A PE 20120894 A1 PE20120894 A1 PE 20120894A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxy
- halogen
- isoxazolidine
- compounds
- fenantren
- Prior art date
Links
- 150000002546 isoxazolidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- -1 2-HYDROXY-ACETYL Chemical class 0.000 abstract 2
- CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 abstract 1
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 239000003862 glucocorticoid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940037128 systemic glucocorticoids Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0068—Nitrogen and oxygen at position 16(17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ISOXAZOLIDINA DE FORMULA (I) DONDE R1 ES (CH2)n-Z-(CH2)n'-R4, EN DONDE n Y n' SON CADA UNO DE 0 A 2; Z ES UNA UNION SIMPLE, S, O, CO, ENTRE OTROS; R4 ES H, HALOGENO, OH, CN, ARILALQUILO(C1-C6), ENTRE OTROS; R2 ES H, ALQUILO(C2-C6), (CH2)mR5, ENTRE OTROS, EN DONDE R5 ES HETEROARILO OPCIONALMENTE SUSTITUIDO CON OXO, OH, HALOGENO, CN, ENTRE OTROS; m ES DE 0 A 6; X E Y SON CADA UNO H O HALOGENO. SON COMPUESTOS PREFERIDOS: (4aR,4bS,5S,6aS,6bR,9aS,10aS,10bS)-8-FURAN-3-ILMETIL-5-HIDROXI-6b-(2-HIDROXI-ACETIL)-4a,6a-DIMETIL-4a,4b,5,6,6a,6b,8,9,9a,10,10a,10b,11,12-TETRADECAHIDRO-7-OXA-8-AZA-PENTALENO[2,1-a]FENANTREN-2-ONA; (4aS,4bR,5S,6aS,6bR,9aS,10aS,10bS,12S)-4b,12-DIFLUORO-8-FURAN-2-ILMETIL-5-HIDROXI-6b-(2-HIDROXI-ACETIL)-4a,6a-DIMETIL-4a,4b,5,6,6a,6b,8,9,9a,10,10a,10b,11,12-TETRADECAHIDRO-7-OXA-8-AZA-PENTALENO[2,1-a]FENANTREN-2-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON GLUCOCORTICOIDES SIENDO UTILES EN EL TRATAMIENTO DE ASMA, BRONQUITIS CRONICA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09011665 | 2009-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120894A1 true PE20120894A1 (es) | 2012-08-13 |
Family
ID=41666572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000303A PE20120894A1 (es) | 2009-09-11 | 2010-09-01 | Derivados de isoxazolidina |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8637662B2 (es) |
| EP (2) | EP2993178A1 (es) |
| JP (1) | JP2013504524A (es) |
| KR (1) | KR101451486B1 (es) |
| CN (2) | CN102482318B (es) |
| AR (2) | AR078164A1 (es) |
| AU (1) | AU2010294598B2 (es) |
| BR (1) | BR112012005503B1 (es) |
| CA (1) | CA2773594C (es) |
| CL (1) | CL2012000450A1 (es) |
| CO (1) | CO6511204A2 (es) |
| EA (1) | EA025191B1 (es) |
| GE (1) | GEP20146135B (es) |
| IL (1) | IL218539A (es) |
| JO (1) | JO3760B1 (es) |
| MA (1) | MA33561B1 (es) |
| ME (1) | ME01331B (es) |
| MX (1) | MX2012002967A (es) |
| MY (1) | MY164842A (es) |
| NZ (1) | NZ598662A (es) |
| PE (1) | PE20120894A1 (es) |
| SG (2) | SG10201608490VA (es) |
| TN (1) | TN2012000077A1 (es) |
| TW (1) | TWI494318B (es) |
| UA (1) | UA108858C2 (es) |
| WO (1) | WO2011029547A2 (es) |
| ZA (1) | ZA201201705B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20120894A1 (es) * | 2009-09-11 | 2012-08-13 | Chiesi Farma Spa | Derivados de isoxazolidina |
| TW201139369A (en) * | 2010-02-05 | 2011-11-16 | Chiesi Farma Spa | Pyrrolidine derivatives |
| EP2686332A2 (en) * | 2011-03-15 | 2014-01-22 | Chiesi Farmaceutici S.p.A. | Isoxazolidine derivatives |
| KR20140039161A (ko) | 2011-03-15 | 2014-04-01 | 키에시 파르마슈티시 엣스. 피. 에이. | 이소옥사졸리딘 유도체 |
| CN103814043A (zh) * | 2011-08-01 | 2014-05-21 | 奇斯药制品公司 | 在16，17位与吡咯烷环稠合的抗炎类固醇 |
| US9155747B2 (en) * | 2012-09-13 | 2015-10-13 | Chiesi Farmaceutici S.P.A. | Isoxazolidine derivatives |
| SI3231444T1 (sl) | 2014-05-12 | 2020-04-30 | Verona Pharma Plc | Novo zdravljenje |
| CN113332439A (zh) | 2014-09-03 | 2021-09-03 | 理森制药股份公司 | 包含双重PI3Kδ-γ激酶抑制剂和皮质类固醇的治疗方法及组合物 |
| CN104262440B (zh) * | 2014-09-10 | 2016-08-17 | 江西赣亮医药原料有限公司 | 一种16ɑ-羟基泼尼松龙的制备方法 |
| CN109206471B (zh) * | 2017-06-30 | 2022-07-12 | 天津药业研究院股份有限公司 | 一种哈西奈德的制备方法 |
| CN109575096B (zh) * | 2019-01-20 | 2021-01-01 | 湖南科瑞生物制药股份有限公司 | 一种制备16a-羟基泼尼松龙产品的新方法 |
| CN112142820A (zh) * | 2019-06-29 | 2020-12-29 | 天津药业研究院股份有限公司 | 曲安奈德的合成方法 |
| CN117050128A (zh) * | 2023-08-15 | 2023-11-14 | 黄冈人福药业有限责任公司 | 一种11β-羟基-孕甾-1,4,16-三烯-3,20-二酮-21-醋酸酯的制备方法和设备 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1131213B (de) * | 1958-06-13 | 1962-06-14 | Syntex Sa | Verfahren zur Herstellung neuer Pregnanverbindungen |
| US3048581A (en) * | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
| BR6678983D0 (pt) * | 1965-05-04 | 1973-09-18 | Merck & Co Inc | Processo para preparar 21-fosfato esteroides |
| SE307576B (es) * | 1966-01-27 | 1969-01-13 | Bofors Ab | |
| IL31997A (en) * | 1968-05-03 | 1974-03-14 | Lepetit Spa | Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes |
| GB1302572A (es) * | 1969-05-05 | 1973-01-10 | ||
| US3996359A (en) * | 1972-05-19 | 1976-12-07 | Ab Bofors | Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith |
| SE378110B (es) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| US4018774A (en) * | 1976-02-13 | 1977-04-19 | E. R. Squibb & Sons, Inc. | Steroidal [16α,17-d]isoxazolidines |
| DE3133631A1 (de) * | 1981-08-21 | 1983-03-03 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue kortikoide ihre herstellung und verwendung |
| US5200518A (en) * | 1991-02-21 | 1993-04-06 | Kangweon National University | Anti-inflammatory carboxycyclic acetal pregnane derivatives |
| JP2749778B2 (ja) * | 1994-09-05 | 1998-05-13 | 日清食品株式会社 | トリアムシノロン誘導体 |
| WO2005028495A1 (en) * | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Anti-inflammatory glucocorticoids |
| GB0415747D0 (en) * | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| WO2006138212A1 (en) * | 2005-06-14 | 2006-12-28 | Gilead Sciences, Inc. | SUBSTITUTED PHENYLPHOSPHATES AS MUTUAL PRODRUGS OF STEROIDS AND β -AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION |
| PE20091525A1 (es) * | 2007-12-21 | 2009-09-25 | Schering Corp | Agonista del receptor glucocorticoide c-20-c21 sustituido |
| WO2009108118A1 (en) * | 2008-02-27 | 2009-09-03 | Astrazeneca Ab | 16 alpha, 17 alpa-acetal glucocorticosteroidal derivatives and their use |
| PE20120894A1 (es) * | 2009-09-11 | 2012-08-13 | Chiesi Farma Spa | Derivados de isoxazolidina |
-
2010
- 2010-09-01 PE PE2012000303A patent/PE20120894A1/es active IP Right Grant
- 2010-09-01 AU AU2010294598A patent/AU2010294598B2/en not_active Ceased
- 2010-09-01 BR BR112012005503-8A patent/BR112012005503B1/pt not_active IP Right Cessation
- 2010-09-01 ME MEP-2012-28A patent/ME01331B/me unknown
- 2010-09-01 GE GEAP201012612A patent/GEP20146135B/en unknown
- 2010-09-01 MY MYPI2012001059A patent/MY164842A/en unknown
- 2010-09-01 CN CN201080040085.6A patent/CN102482318B/zh not_active Withdrawn - After Issue
- 2010-09-01 CA CA2773594A patent/CA2773594C/en active Active
- 2010-09-01 CN CN201510690091.0A patent/CN105175479B/zh not_active Expired - Fee Related
- 2010-09-01 NZ NZ598662A patent/NZ598662A/en not_active IP Right Cessation
- 2010-09-01 EA EA201290091A patent/EA025191B1/ru not_active IP Right Cessation
- 2010-09-01 SG SG10201608490VA patent/SG10201608490VA/en unknown
- 2010-09-01 KR KR1020127006312A patent/KR101451486B1/ko not_active Expired - Fee Related
- 2010-09-01 SG SG2012016473A patent/SG179055A1/en unknown
- 2010-09-01 WO PCT/EP2010/005366 patent/WO2011029547A2/en not_active Ceased
- 2010-09-01 UA UAA201202764A patent/UA108858C2/ru unknown
- 2010-09-01 JP JP2012528250A patent/JP2013504524A/ja active Pending
- 2010-09-01 MX MX2012002967A patent/MX2012002967A/es active IP Right Grant
- 2010-09-01 EP EP15185573.1A patent/EP2993178A1/en not_active Withdrawn
- 2010-09-01 EP EP10754274.8A patent/EP2475676B1/en active Active
- 2010-09-08 JO JOP/2010/0313A patent/JO3760B1/ar active
- 2010-09-09 US US12/878,113 patent/US8637662B2/en active Active
- 2010-09-09 AR ARP100103307A patent/AR078164A1/es not_active Application Discontinuation
- 2010-09-09 TW TW099130461A patent/TWI494318B/zh not_active IP Right Cessation
-
2012
- 2012-02-17 TN TNP2012000077A patent/TN2012000077A1/en unknown
- 2012-02-21 CL CL2012000450A patent/CL2012000450A1/es unknown
- 2012-03-01 CO CO12036474A patent/CO6511204A2/es not_active Application Discontinuation
- 2012-03-02 MA MA34659A patent/MA33561B1/fr unknown
- 2012-03-08 IL IL218539A patent/IL218539A/en active IP Right Grant
- 2012-03-08 ZA ZA2012/01705A patent/ZA201201705B/en unknown
-
2020
- 2020-02-17 AR ARP200100437A patent/AR118123A2/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |