[go: up one dir, main page]

PE20120495A1 - 3-ciclopentilamino-2,2-difluor-propanoato de etilo como intermediario en la preparacion de pirimidodiazepinas - Google Patents

3-ciclopentilamino-2,2-difluor-propanoato de etilo como intermediario en la preparacion de pirimidodiazepinas

Info

Publication number
PE20120495A1
PE20120495A1 PE2011001933A PE2011001933A PE20120495A1 PE 20120495 A1 PE20120495 A1 PE 20120495A1 PE 2011001933 A PE2011001933 A PE 2011001933A PE 2011001933 A PE2011001933 A PE 2011001933A PE 20120495 A1 PE20120495 A1 PE 20120495A1
Authority
PE
Peru
Prior art keywords
cyclopentilamino
difluor
propanoate
intermediary
preparation
Prior art date
Application number
PE2011001933A
Other languages
English (en)
Inventor
Shaoqing Chen
Peter Michael Wovkulich
Kin-Chun Thomas Luk
Xin-Jie Chu
Jianping Cai
Kang Le
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120495(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20120495A1 publication Critical patent/PE20120495A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA AL COMPUESTO 3-CICLOPENTILAMINO-2,2-DIFLUOR-PROPANOATO DE ETILO DE FORMULA (I), EL CUAL ES UN INTERMEDIARIO EN LA PREPARACION DE DERIVADOS DE PIRIMIDODIAZEPINAS INHIBIDORES DE LA PLK1
PE2011001933A 2007-03-22 2008-03-19 3-ciclopentilamino-2,2-difluor-propanoato de etilo como intermediario en la preparacion de pirimidodiazepinas PE20120495A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91935807P 2007-03-22 2007-03-22

Publications (1)

Publication Number Publication Date
PE20120495A1 true PE20120495A1 (es) 2012-05-12

Family

ID=39415299

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001933A PE20120495A1 (es) 2007-03-22 2008-03-19 3-ciclopentilamino-2,2-difluor-propanoato de etilo como intermediario en la preparacion de pirimidodiazepinas

Country Status (23)

Country Link
US (1) US7517873B2 (es)
EP (1) EP2139892B1 (es)
JP (1) JP5087640B2 (es)
KR (1) KR101157848B1 (es)
CN (2) CN102746175B (es)
AR (1) AR065794A1 (es)
AT (1) ATE524472T1 (es)
AU (1) AU2008228303B2 (es)
BR (1) BRPI0809088A2 (es)
CA (1) CA2680757A1 (es)
CL (1) CL2008000785A1 (es)
CY (1) CY1112102T1 (es)
DK (1) DK2139892T3 (es)
ES (1) ES2371832T3 (es)
HR (1) HRP20110807T1 (es)
IL (1) IL200617A (es)
MX (1) MX2009010034A (es)
PE (1) PE20120495A1 (es)
PL (1) PL2139892T3 (es)
PT (1) PT2139892E (es)
SI (1) SI2139892T1 (es)
TW (1) TWI363629B (es)
WO (1) WO2008113711A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101952291A (zh) 2007-08-15 2011-01-19 弗特克斯药品有限公司 用作人蛋白激酶plk1至plk4的抑制剂以治疗增殖疾病的4-(9-(3,3-二氟环戊基)-5,7,7-三甲基-6-氧代-6,7,8,9-四氢-5h-嘧啶并[4,5-b][1,4]二氮杂䓬-2-基氨基)-3-甲氧基苯甲酰胺衍生物
ES2488966T3 (es) * 2007-09-25 2014-09-01 Takeda Pharmaceutical Company Limited Inhibidores de cinasa de tipo Polo
CA2700979C (en) 2007-09-28 2017-06-20 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
WO2009067547A1 (en) * 2007-11-19 2009-05-28 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
EP2303889A1 (en) 2008-06-18 2011-04-06 F. Hoffmann-La Roche AG Halo-substituted pyrimidodiazepines as plkl inhibitors
TW201639852A (zh) 2008-12-09 2016-11-16 吉李德科學股份有限公司 用於製備可用作類鐸受體調節劑之化合物的中間體化合物
WO2010080712A2 (en) * 2009-01-06 2010-07-15 Dana Farber Cancer Institute Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
KR102050712B1 (ko) 2009-06-17 2019-12-02 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
ES2661850T3 (es) 2009-09-14 2018-04-04 Gilead Sciences, Inc. Moduladores de receptores del tipo toll
WO2012083117A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9676792B2 (en) 2013-03-15 2017-06-13 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
BR112016001457A2 (pt) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc Inibidores de fatores de transcrição e usos dos mesmos
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
PL3068776T3 (pl) 2013-11-13 2019-10-31 Vertex Pharma Inhibitory replikacji wirusów grypy
KR102338461B1 (ko) 2013-11-13 2021-12-13 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제 억제제의 제조 방법
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
EP3099677A4 (en) 2014-01-31 2017-07-26 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
BR112017002369A2 (pt) 2014-08-08 2017-12-05 Dana Farber Cancer Inst Inc derivados de diazepana e usos dos mesmos
ES2845205T3 (es) 2014-09-16 2021-07-26 Gilead Sciences Inc Métodos para preparar moduladores de receptores tipo Toll
CA2960436C (en) 2014-09-16 2021-01-05 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
US10702527B2 (en) 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
US10881668B2 (en) 2015-09-11 2021-01-05 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazolodiazepines and uses thereof
CA2996974A1 (en) 2015-09-11 2017-03-16 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
SG10201913450PA (en) 2015-11-25 2020-03-30 Dana Farber Cancer Inst Inc Bivalent bromodomain inhibitors and uses thereof
US11155556B2 (en) * 2016-04-07 2021-10-26 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
EP4034132A4 (en) * 2019-09-27 2023-10-11 Dana-Farber Cancer Institute, Inc. Erk5 degraders as therapeutics in cancer and inflammatory diseases
WO2021194321A1 (en) * 2020-03-27 2021-09-30 Uppthera Benzimidazole thiophene derivative compounds inducing selective degradation of plk1
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체
JP2024530195A (ja) * 2021-08-10 2024-08-16 オップテラ インコーポレイテッド 新規ｐｌｋ１分解誘導化合物
GB202313514D0 (en) 2023-09-05 2023-10-18 Cambridge Entpr Ltd Treatment of inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60037455T2 (de) * 1999-09-17 2008-11-27 Abbott Gmbh & Co. Kg Kinaseinhibitoren als arzneimittel
EP1427730B1 (de) * 2001-09-04 2006-07-12 Boehringer Ingelheim Pharma GmbH & Co.KG Neue dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
NZ570530A (en) * 2006-02-14 2011-09-30 Vertex Pharma Pharmaceutical compositions comprising 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives
TW200808325A (en) * 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
WO2008113711A1 (en) 2008-09-25
KR20090119913A (ko) 2009-11-20
ATE524472T1 (de) 2011-09-15
CL2008000785A1 (es) 2009-03-27
AU2008228303B2 (en) 2012-04-19
CY1112102T1 (el) 2015-11-04
PL2139892T3 (pl) 2012-03-30
JP5087640B2 (ja) 2012-12-05
DK2139892T3 (da) 2011-12-12
CN101636399A (zh) 2010-01-27
PT2139892E (pt) 2011-11-21
CN102746175A (zh) 2012-10-24
TW200843781A (en) 2008-11-16
EP2139892B1 (en) 2011-09-14
AU2008228303A1 (en) 2008-09-25
TWI363629B (en) 2012-05-11
HRP20110807T1 (hr) 2011-12-31
HK1139936A1 (en) 2010-09-30
IL200617A0 (en) 2010-05-17
ES2371832T3 (es) 2012-01-10
US7517873B2 (en) 2009-04-14
CN102746175B (zh) 2014-01-15
CN101636399B (zh) 2012-04-18
BRPI0809088A2 (pt) 2014-09-09
AR065794A1 (es) 2009-07-01
SI2139892T1 (sl) 2011-12-30
KR101157848B1 (ko) 2012-07-11
EP2139892A1 (en) 2010-01-06
IL200617A (en) 2014-02-27
MX2009010034A (es) 2009-10-12
JP2010521514A (ja) 2010-06-24
US20080234255A1 (en) 2008-09-25
CA2680757A1 (en) 2008-09-25

Similar Documents

Publication Publication Date Title
PE20120495A1 (es) 3-ciclopentilamino-2,2-difluor-propanoato de etilo como intermediario en la preparacion de pirimidodiazepinas
CY1119515T1 (el) Οξαζολο υποκατεστημενα ινδαζολια ως αναστολεις ρι3-κινασης
EA201490912A1 (ru) Производные [1,2,3]триазоло[4,5-d]пиримидина в качестве агонистов каннабиноидного рецептора 2
CO6321282A2 (es) Derivados de piperidinilindol como inhibidores de aldosterona sintasa
CO6491116A2 (es) Derivados de 5-fluoropirimidinona
SV2011003853A (es) Compuestos organicos
ATE542813T1 (de) 6-substituierte 2- heterocyclylaminopyrazinverbindungen als chk-1- inhibitoren
CY1113131T1 (el) Τα παραγωγα ινδολης ως αγωνιστες υποδοχεων s1p1
CR20120295A (es) Triazolopiridinas
UY32292A (es) Agonistas de s1p1 y métodos de preparación y uso
UY33337A (es) DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
MA35664B1 (fr) Nouveaux dérivés bicycliques de la dihydroisoquinoline-1-one
CR20130349A (es) COMPUESTOS SUSTITUIDOS DE N-(1H- INDAZOL-4-IL) IMIDAZO [1,2-a] PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE LA TIROSINA QUINASA RECEPTORA DE TIPO III
CR20120348A (es) Nuevos compuestos tricíclicos
CR20140132A (es) Derivados de pirrolopirimidina y purina
ECSP11011411A (es) Derivados de prolina como inhibidores de catepsina
SV2010003472A (es) Compuestos de pirazol
CR20120121A (es) Compuestos de benzoxazepina como inhibidores de la pi3k y métodos de uso
EA200970207A1 (ru) Соединения пиридо[2,3-d]пиримидинона и их применение в качестве pi3 ингибиторов
CR20120641A (es) Compuestos macrocìclicos como inhibidores de quinasa trk
EA201100503A1 (ru) Глюкозидные производные и их применения
ECSP11010889A (es) INHIBIDORES DE cMET
CR20110467A (es) Derivados de benzofuranilo como inhibidores de la glucoquinasa
DOP2011000009A (es) Amidofenoxiindazoles utiles como inhibidores de c-met
CO6362015A2 (es) Derivados de acido 1-amino-2ciclobutiletilboronico

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed