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PE20110276A1 - Procedimiento para modificar la formacion de un cristal de acido micofenolico y micofenolato - Google Patents

Procedimiento para modificar la formacion de un cristal de acido micofenolico y micofenolato

Info

Publication number
PE20110276A1
PE20110276A1 PE2011000069A PE2011000069A PE20110276A1 PE 20110276 A1 PE20110276 A1 PE 20110276A1 PE 2011000069 A PE2011000069 A PE 2011000069A PE 2011000069 A PE2011000069 A PE 2011000069A PE 20110276 A1 PE20110276 A1 PE 20110276A1
Authority
PE
Peru
Prior art keywords
crystal
modify
procedure
mycophenolate
formation
Prior art date
Application number
PE2011000069A
Other languages
English (en)
Inventor
Sabine Pfeffer
Dierk Wieckhusen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9951448&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110276(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20110276A1 publication Critical patent/PE20110276A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA UN PROCEDIMIENTO PARA MODIFICAR UN CRISTAL DE FARMACO ACICULAR QUE COMPRENDE SUSPENDER EL FARMACO CRISTALINO EN UN SISTEMA DE SOLVENTE METANOL/AGUA EN UNA RELACION DE ENTRE 98:2 Y 90:10 Y SOMETER LA SUSPENSION A OSCILACION DE TEMPERATURA EN FORMA DE ZIGZAG, DONDE EL FARMACO ACICULAR ES LA SAL DE MICOFENOLATO DE SODIO, LA TEMPERATURA MAXIMA Y MINIMA DE OSCILACION ES 42ºC A 47ºC +/- 5ºC A 7ºC, EL PERIODO DE OSCILACION ES DE 110 A 160 MINUTOS, EL NUMERO DE OSCILACIONES ES DE 6 A 16 Y OPCIONALMENTE SE APLICA AGITACION
PE2011000069A 2003-01-20 2004-01-19 Procedimiento para modificar la formacion de un cristal de acido micofenolico y micofenolato PE20110276A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0301259.8A GB0301259D0 (en) 2003-01-20 2003-01-20 Organic compounds

Publications (1)

Publication Number Publication Date
PE20110276A1 true PE20110276A1 (es) 2011-05-27

Family

ID=9951448

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2004000074A PE20040826A1 (es) 2003-01-20 2004-01-19 Procedimiento para modificar formacion de cristal de farmaco
PE2011000069A PE20110276A1 (es) 2003-01-20 2004-01-19 Procedimiento para modificar la formacion de un cristal de acido micofenolico y micofenolato

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2004000074A PE20040826A1 (es) 2003-01-20 2004-01-19 Procedimiento para modificar formacion de cristal de farmaco

Country Status (31)

Country Link
US (3) US20060122265A1 (es)
EP (2) EP2308471A1 (es)
JP (1) JP4549976B2 (es)
KR (5) KR100855149B1 (es)
CN (2) CN101333201A (es)
AR (2) AR043343A1 (es)
AT (1) ATE546132T1 (es)
AU (1) AU2004206731B2 (es)
BR (1) BRPI0406827A (es)
CA (2) CA2706900A1 (es)
CL (1) CL2004000073A1 (es)
CO (1) CO5580738A2 (es)
CY (1) CY1112772T1 (es)
DK (1) DK1592401T3 (es)
EC (1) ECSP055918A (es)
ES (1) ES2382035T3 (es)
GB (1) GB0301259D0 (es)
IL (1) IL169484A (es)
MX (1) MXPA05007691A (es)
MY (1) MY148297A (es)
NO (1) NO20053846L (es)
NZ (1) NZ541073A (es)
PE (2) PE20040826A1 (es)
PL (2) PL376525A1 (es)
PT (1) PT1592401E (es)
RU (1) RU2388757C2 (es)
SG (1) SG155046A1 (es)
SI (1) SI1592401T1 (es)
TW (1) TWI325785B (es)
WO (1) WO2004064806A2 (es)
ZA (1) ZA200504442B (es)

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GB0301259D0 (en) 2003-01-20 2003-02-19 Novartis Ag Organic compounds
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US20050250773A1 (en) 2004-04-27 2005-11-10 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
DE602005020014D1 (de) 2004-07-20 2010-04-29 Teva Gyogyszergyar Zartkoeruen Kristallines mycophenolat-natrium
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CN103880800A (zh) * 2010-11-16 2014-06-25 北京京卫信康医药科技发展有限公司 麦考酚酸钠的新晶型及其制备方法
KR101913587B1 (ko) 2011-04-13 2018-10-31 얀센 파마슈티카 엔.브이. Sglt2의 억제제로서 유용한 화합물의 제조 방법
TWI582078B (zh) * 2013-01-23 2017-05-11 北京貝美拓新藥研發有限公司 抑制脯氨酸羥化酶活性的化合物的晶型及其應用
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN108368096B (zh) * 2015-12-21 2021-12-10 詹森药业有限公司 用于获得坎格列净半水合物晶体的结晶程序
AU2018222747A1 (en) 2017-02-16 2019-09-05 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
CN110520124A (zh) 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
CN108727317A (zh) * 2017-04-25 2018-11-02 鲁南制药集团股份有限公司 一种麦考酚酸的晶型物
CN108727318A (zh) * 2017-04-25 2018-11-02 鲁南制药集团股份有限公司 麦考酚酸的晶型物
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
CN110922371B (zh) * 2019-12-27 2020-08-11 广东蓝宝制药有限公司 一种m2晶型麦考酚钠的制备方法
CN120172955A (zh) 2020-05-18 2025-06-20 诺华股份有限公司 Lnp023的结晶形式
US20250296904A1 (en) * 2022-05-31 2025-09-25 Honshu Chemical Industry Co., Ltd. Crystal of 4,4'-bis(1,1-bis(4-hydroxy-3-methylphenyl)ethyl)biphenyl and method for producing the same

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Also Published As

Publication number Publication date
US20060122265A1 (en) 2006-06-08
HK1084874A1 (en) 2006-08-11
PL393385A1 (pl) 2011-03-14
PL376525A1 (pl) 2006-01-09
RU2388757C2 (ru) 2010-05-10
ATE546132T1 (de) 2012-03-15
AU2004206731A8 (en) 2004-08-05
JP4549976B2 (ja) 2010-09-22
US20090209639A1 (en) 2009-08-20
KR20090115898A (ko) 2009-11-09
PL213192B1 (pl) 2013-01-31
GB0301259D0 (en) 2003-02-19
EP1592401A2 (en) 2005-11-09
NO20053846L (no) 2005-08-16
IL169484A (en) 2016-03-31
CN1738605A (zh) 2006-02-22
KR100855149B1 (ko) 2008-08-28
NZ541073A (en) 2008-12-24
KR20090115821A (ko) 2009-11-06
ZA200504442B (en) 2006-02-22
MY148297A (en) 2013-03-29
IL169484A0 (en) 2007-07-04
AR103711A2 (es) 2017-05-31
PE20040826A1 (es) 2004-12-23
AU2004206731A1 (en) 2004-08-05
TW200505505A (en) 2005-02-16
TWI325785B (en) 2010-06-11
JP2006515016A (ja) 2006-05-18
ES2382035T3 (es) 2012-06-04
PT1592401E (pt) 2012-05-10
BRPI0406827A (pt) 2005-12-27
KR20050096940A (ko) 2005-10-06
US20110288313A1 (en) 2011-11-24
AU2004206731B2 (en) 2008-03-20
AR043343A1 (es) 2005-07-27
US8124795B2 (en) 2012-02-28
CA2509796A1 (en) 2004-08-05
CN100595199C (zh) 2010-03-24
ECSP055918A (es) 2005-11-22
WO2004064806A3 (en) 2004-10-28
CY1112772T1 (el) 2016-02-10
SG155046A1 (en) 2009-09-30
KR20100120321A (ko) 2010-11-15
CN101333201A (zh) 2008-12-31
CA2706900A1 (en) 2004-08-05
DK1592401T3 (da) 2012-05-21
US8008511B2 (en) 2011-08-30
KR101129105B1 (ko) 2012-04-12
EP1592401B1 (en) 2012-02-22
MXPA05007691A (es) 2005-09-30
CL2004000073A1 (es) 2005-01-14
RU2005126328A (ru) 2006-07-27
SI1592401T1 (sl) 2012-05-31
KR20070087181A (ko) 2007-08-27
WO2004064806A2 (en) 2004-08-05
CA2509796C (en) 2010-09-14
CO5580738A2 (es) 2005-11-30
EP2308471A1 (en) 2011-04-13

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