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PE20110100A1 - Procedimiento de preparacion de n-[trans-4-[4-(ciclopropilmetil)-1-piperazinil]ciclohexil]-4-[[(7r)-7-etil-5,6,7,8-tetrahidro-5-metil-8-(1-metiletil)-6-oxo-2-pteridinil]amino]-3-metoxi-benzamida - Google Patents

Procedimiento de preparacion de n-[trans-4-[4-(ciclopropilmetil)-1-piperazinil]ciclohexil]-4-[[(7r)-7-etil-5,6,7,8-tetrahidro-5-metil-8-(1-metiletil)-6-oxo-2-pteridinil]amino]-3-metoxi-benzamida

Info

Publication number
PE20110100A1
PE20110100A1 PE2010000509A PE2010000509A PE20110100A1 PE 20110100 A1 PE20110100 A1 PE 20110100A1 PE 2010000509 A PE2010000509 A PE 2010000509A PE 2010000509 A PE2010000509 A PE 2010000509A PE 20110100 A1 PE20110100 A1 PE 20110100A1
Authority
PE
Peru
Prior art keywords
methyl
ethyl
compound
methylethyl
pteridinyl
Prior art date
Application number
PE2010000509A
Other languages
English (en)
Inventor
Matthias Grauert
Guenter Linz
Rolf Schmid
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20110100A1 publication Critical patent/PE20110100A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA FABRICACION DEL COMPUESTO N-TRANS-4-[4-(CICLOPROPILMETIL)-1-PIPERAZINIL]CICLOHEXIL]-4-[[(7R)-7-ETIL-5,6,7,8-TETRAHIDRO-5-METIL-8-(1-METILETIL)-6-OXO-2-PTERIDINIL]AMINO]-3-METOXI-BENZAMIDA QUE COMPRENDE: A) SINTESIS DEL COMPUESTO DE FORMULA (15c). B) SINTESIS DEL COMPUESTO 2-CLORO-7-ETIL-7,8-DIHIDRO-5-METIL-8-(1-METILETIL)-(7R)-6(5H)-PTERIDINONA C) REACCION DE 23g DEL COMPUESTO SINTETIZADO EN A) CON 16,8g DEL COMPUESTO SINTETIZADO EN B) Y 28,3g DE ACIDO para-TOLUENSULFONICO EN 350mL DE SOLVENTE 2-METIL-4-PENTANOL. D) REFLUJO DE 22 HORAS. E) ADICION DE 300mL DE CLORURO METILENO Y 300mL DE AGUA DISMINERALIZADA. F) LAVADO CON AGUAY SECADO SOBRE SULAFTOM SODICO. G) EVAPORIZACION DEL SOLVENTE Y DISOLUCION DEL RESIDUO EN ACETATO DE ETILO. H) LA MEZCLA SE ENFRIO A 20ºC. I) SE FILTRO Y SE LAVO EL PRECIPITADO CON ACETATO DE ETILO. J) SECAR A 60ºC. DICHO PROCESO POSEE UN RENDIMIENTO DE AL MENOS 66% DE UN PRODUCTO CUYO PUNTO DE FUSION ES 182ºC. EL PRODUCTO ES UN INHIBIDOR DE CICLOQUINASAS
PE2010000509A 2006-02-08 2007-02-06 Procedimiento de preparacion de n-[trans-4-[4-(ciclopropilmetil)-1-piperazinil]ciclohexil]-4-[[(7r)-7-etil-5,6,7,8-tetrahidro-5-metil-8-(1-metiletil)-6-oxo-2-pteridinil]amino]-3-metoxi-benzamida PE20110100A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06101414 2006-02-08

Publications (1)

Publication Number Publication Date
PE20110100A1 true PE20110100A1 (es) 2011-02-18

Family

ID=38008126

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2010000509A PE20110100A1 (es) 2006-02-08 2007-02-06 Procedimiento de preparacion de n-[trans-4-[4-(ciclopropilmetil)-1-piperazinil]ciclohexil]-4-[[(7r)-7-etil-5,6,7,8-tetrahidro-5-metil-8-(1-metiletil)-6-oxo-2-pteridinil]amino]-3-metoxi-benzamida
PE2007000127A PE20071248A1 (es) 2006-02-08 2007-02-06 Sal especifica, forma anhidra y cristalina de un derivado de dihidropteridiona

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2007000127A PE20071248A1 (es) 2006-02-08 2007-02-06 Sal especifica, forma anhidra y cristalina de un derivado de dihidropteridiona

Country Status (21)

Country Link
US (3) US7439358B2 (es)
EP (2) EP1984367A1 (es)
JP (1) JP5134552B2 (es)
KR (2) KR101462879B1 (es)
CN (2) CN102093360B (es)
AR (1) AR059349A1 (es)
AU (1) AU2007213752B2 (es)
BR (1) BRPI0707604A8 (es)
CA (1) CA2635834C (es)
EA (2) EA018663B1 (es)
EC (1) ECSP088589A (es)
IL (2) IL193217A (es)
NO (1) NO20082610L (es)
NZ (2) NZ570987A (es)
PE (2) PE20110100A1 (es)
SG (2) SG10201404755SA (es)
TW (1) TW200738716A (es)
UA (2) UA101060C2 (es)
UY (1) UY30136A1 (es)
WO (1) WO2007090844A1 (es)
ZA (1) ZA200804587B (es)

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BRPI0707604A2 (pt) 2011-05-10
EP2543669A3 (en) 2013-05-15
UA101060C2 (ru) 2013-02-25
EP2543669A2 (en) 2013-01-09
EA200801769A1 (ru) 2009-02-27
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EA015389B1 (ru) 2011-08-30
UY30136A1 (es) 2007-09-28
US20120214995A1 (en) 2012-08-23
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KR20080093068A (ko) 2008-10-17
UA95625C2 (ru) 2011-08-25
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US20090030004A1 (en) 2009-01-29
IL236736A0 (en) 2015-02-26
IL193217A (en) 2017-06-29
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CN102093360B (zh) 2014-11-05
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AR059349A1 (es) 2008-03-26
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US8664222B2 (en) 2014-03-04
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