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PE20110999A1 - Compuestos derivados de 6-piperazin-1-il-9h-purina - Google Patents

Compuestos derivados de 6-piperazin-1-il-9h-purina

Info

Publication number
PE20110999A1
PE20110999A1 PE2011001219A PE2011001219A PE20110999A1 PE 20110999 A1 PE20110999 A1 PE 20110999A1 PE 2011001219 A PE2011001219 A PE 2011001219A PE 2011001219 A PE2011001219 A PE 2011001219A PE 20110999 A1 PE20110999 A1 PE 20110999A1
Authority
PE
Peru
Prior art keywords
methyl
purine
piperazin
compounds derived
tertahydro
Prior art date
Application number
PE2011001219A
Other languages
English (en)
Inventor
Peter Charles Astles
Rossella Guidetti
Michael Wade Tidwell
Sean Patrick Hollinshead
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20110999A1 publication Critical patent/PE20110999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

REFERIDA A UN DERIVADO DE PURINA DE FORMULA (I), DONDE R1 ES H, F, Cl, ALQUILO C1-C2, ENTRE OTROS; R2 ES TETRAHIDROFURANILO, TETRAHIDROPIRANILO, ENTRE OTROS; R3 ES H O EN COMBINACION CON R4 FORMA UNA PIRROLIN-2-ONA FUSIONADA; R4 ES ALQUILO C1-C2, FLUOROALQUILO C1-C2, CICLOPROPILO O COCH3; R5 ES H, CH3 O CF3; n ES 0 O 1; X1 Y X3 SON N, CH O CR6; X2 ES CH O CR6; R6 ES F, Cl, CF3, OCH3 U OCF3. SON COMPUESTOS PREFERIDOS: 8-(2-CLORO-PIRIDIN-3-IL)-2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(R)-TETRAHIDRO-FURAN-3-IL-9H-PURINA, 2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(TERTAHIDRO-PIRAN-4-IL)-8-(2-TRIFLUOROMETIL-FENIL)-9H-PURINA, 2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(R)-TERTAHIDRO-FURAN-3-IL-8-(2-TRIFLUOROMETIL-FENIL)-9H-PURINA, ENTRE OTROS. TAMBIEN ESTA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECPETOR CANABINOIDE CB2 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR
PE2011001219A 2008-12-18 2009-12-09 Compuestos derivados de 6-piperazin-1-il-9h-purina PE20110999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13858908P 2008-12-18 2008-12-18

Publications (1)

Publication Number Publication Date
PE20110999A1 true PE20110999A1 (es) 2012-01-16

Family

ID=41719189

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001219A PE20110999A1 (es) 2008-12-18 2009-12-09 Compuestos derivados de 6-piperazin-1-il-9h-purina

Country Status (29)

Country Link
US (1) US8252798B2 (es)
EP (1) EP2379555B1 (es)
JP (1) JP5559812B2 (es)
KR (1) KR101319630B1 (es)
CN (1) CN102256977B (es)
AR (1) AR075104A1 (es)
AU (1) AU2009335997B2 (es)
BR (1) BRPI0923195A2 (es)
CA (1) CA2746740C (es)
CL (1) CL2011001464A1 (es)
CO (1) CO6390101A2 (es)
CR (1) CR20110340A (es)
DO (1) DOP2011000196A (es)
EA (1) EA018386B1 (es)
EC (1) ECSP11011151A (es)
ES (1) ES2536880T3 (es)
HN (1) HN2011001700A (es)
IL (1) IL213167A (es)
MA (1) MA32904B1 (es)
MX (1) MX2011006442A (es)
NZ (1) NZ593088A (es)
PA (1) PA8851501A1 (es)
PE (1) PE20110999A1 (es)
SG (1) SG172253A1 (es)
TN (1) TN2011000291A1 (es)
TW (1) TWI376378B (es)
UA (1) UA104010C2 (es)
WO (1) WO2010080306A1 (es)
ZA (1) ZA201103943B (es)

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JP5647998B2 (ja) * 2009-03-13 2015-01-07 カトリーケ ユニバーシテイト ルーヴェン、ケー．ユー． ルーヴェン アール アンド ディー 免疫抑制剤としてのチアゾロピリミジン調節因子
JP5746698B2 (ja) 2009-08-28 2015-07-08 アリーナ ファーマシューティカルズ， インコーポレイテッド カンナビノイド受容体モジュレーター
RU2012141536A (ru) * 2010-03-17 2014-04-27 Ф. Хоффманн-Ля Рош Аг Имидазопиридины, композиции и способы применения
MX2012011164A (es) * 2010-03-31 2012-11-12 Lilly Co Eli Compuesto de purina usados como agonistas de cb2.
AR080711A1 (es) * 2010-03-31 2012-05-02 Lilly Co Eli Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor
WO2012035039A1 (en) 2010-09-15 2012-03-22 F. Hoffmann-La Roche Ag Azabenzothiazole compounds, compositions and methods of use
CA2817785A1 (en) 2010-11-19 2012-05-24 Toby Blench Pyrazolopyridines and pyrazolopyridines and their use as tyk2 inhibitors
CA2827057C (en) 2011-02-25 2022-06-07 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of condensed azacycles (cannabinoid receptor modulators)
US9597340B2 (en) 2011-02-25 2017-03-21 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
EP3385252B8 (en) 2011-02-25 2022-10-26 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
RU2014113236A (ru) * 2011-09-20 2015-10-27 Ф. Хоффманн-Ля Рош Аг Соединения имидазопиридина, композиции и способы применения
US9067943B2 (en) * 2011-11-25 2015-06-30 Hoffmann-La Roche Inc. [1,2,3]triazolo[4,5-D]pyrimidine derivatives
KR20150042834A (ko) * 2012-08-16 2015-04-21 얀센 파마슈티카 엔.브이. N형 칼슘 채널 차단제로서의 치환된 피라졸
WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
AU2014261546B2 (en) * 2013-05-02 2018-01-18 F. Hoffmann-La Roche Ag Pyrrolo[2,3-d]pyrimidine derivatives as CB2 receptor agonists
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
WO2017052394A1 (en) * 2015-09-23 2017-03-30 Uniwersytet Jagielloński Imidazopyridine compounds and their use as 5-ht6 receptor ligands
WO2018137176A1 (en) * 2017-01-25 2018-08-02 Eli Lilly And Company Treatment for nonalcoholic steatohepatitis and fibrosis
WO2017181317A1 (en) * 2016-04-18 2017-10-26 Eli Lilly And Company Treatment for nonalcoholic steatohepatitis and fibrosis
WO2017184412A1 (en) 2016-04-18 2017-10-26 Eli Lilly And Company Purine cannabinoid agonist for treating nonalcoholic steatohepatitis and fibrosis
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WO2024017227A1 (zh) * 2022-07-21 2024-01-25 长春金赛药业有限责任公司 取代的稠环大麻素受体化合物及其应用

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Also Published As

Publication number Publication date
CA2746740C (en) 2014-01-14
CL2011001464A1 (es) 2012-01-20
JP2012512873A (ja) 2012-06-07
NZ593088A (en) 2012-12-21
UA104010C2 (en) 2013-12-25
EA201170832A1 (ru) 2011-12-30
DOP2011000196A (es) 2011-10-31
AU2009335997A1 (en) 2011-06-23
CN102256977B (zh) 2014-04-16
MX2011006442A (es) 2011-07-19
SG172253A1 (en) 2011-07-28
KR101319630B1 (ko) 2013-10-17
PA8851501A1 (es) 2010-07-27
AR075104A1 (es) 2011-03-09
ECSP11011151A (es) 2011-07-29
MA32904B1 (fr) 2011-12-01
TWI376378B (en) 2012-11-11
BRPI0923195A2 (pt) 2016-02-16
JP5559812B2 (ja) 2014-07-23
ZA201103943B (en) 2012-11-28
CR20110340A (es) 2011-09-16
IL213167A0 (en) 2011-07-31
ES2536880T3 (es) 2015-05-29
IL213167A (en) 2013-11-28
TN2011000291A1 (en) 2012-12-17
EP2379555B1 (en) 2015-02-25
AU2009335997B2 (en) 2012-05-10
EA018386B1 (ru) 2013-07-30
CA2746740A1 (en) 2010-07-15
HN2011001700A (es) 2013-05-06
US20100160288A1 (en) 2010-06-24
CO6390101A2 (es) 2012-02-29
TW201024296A (en) 2010-07-01
WO2010080306A1 (en) 2010-07-15
KR20110084459A (ko) 2011-07-22
US8252798B2 (en) 2012-08-28
EP2379555A1 (en) 2011-10-26
CN102256977A (zh) 2011-11-23

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