[go: up one dir, main page]

PE20110939A1 - Agente preventivo/terapeutico contra el cancer - Google Patents

Agente preventivo/terapeutico contra el cancer

Info

Publication number
PE20110939A1
PE20110939A1 PE2011001293A PE2011001293A PE20110939A1 PE 20110939 A1 PE20110939 A1 PE 20110939A1 PE 2011001293 A PE2011001293 A PE 2011001293A PE 2011001293 A PE2011001293 A PE 2011001293A PE 20110939 A1 PE20110939 A1 PE 20110939A1
Authority
PE
Peru
Prior art keywords
alkyl
group
preventive
therapeutic agent
against cancer
Prior art date
Application number
PE2011001293A
Other languages
English (en)
Inventor
Hisanori Matsui
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42025816&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110939(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20110939A1 publication Critical patent/PE20110939A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

REFERIDA A UN DERIVADO DE METASTINA DE FORMULA (IV), DONDE V' ES UN GRUPO DE FORMULA P-NZ1-R1-(C=Z2)-NH-CHQ1, P-W1(Z1)n-W2Q1- O P-W1(P')n-; n ES 0 O 1; W1 ES N, CH U O; W2 ES N O CH; Z1, Z3, Z5 Y Z7 SON H O ALQUILO C1-C3; Z2, Z4, Z6 Y Z8 SON H O S; R1 ES H, ALQUILO C1-C8, ENTRE OTROS; R2 ES H, ALQUILO C1-C10, ENTRE OTROS; R3 ES ALQUILO C1-C8, UN GRUPO ARALQUILO, ENTRE OTROS; R4 ES ALQUILO C1-C4, UN GRUPO HETEROCICLICO AROMATICO DE 5 A 14 MIEMBROS CON HETEROATOMOS SELECCIONADOS DE N, O Y S, ENTRE OTROS; Q1 ES ALQUILO C1-C4, UN GRUPO HETEROCICLICO AROMATICO DE 5 A 14 MIEMBROS CON HETEROATOMOS SELECCIONADOS DE N, O Y S, ENTRE OTROS; Q2 ES CH2, NH, O, ENTRE OTROS; Y ES CONH, CSNH, CH2NH, ENTRE OTROS; Z9 ES H, O O S; P Y P' SON H O UN RESIDUO DE AMINOACIDO DE SECUENCIA SEQ ID NO:1 J1-J2-C(J3)(Q3)Y1C(J4)(Q4)Y2C(J5)(Q5)Y3C(J6)(Q6)C(=Z10)-; J1 ES H, ACILO C1-C15, ALQUILO C1-C15, ENTRE OTROS; J2 ES NH, CH2, O, ENTRE OTROS; J3 A J6 SON H O ALQUILO C1-C3; Q3 A Q6 SON ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON AMINO, OH, UN GRUPO GUANIDINO, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DEL CANCER, PARTICULARMENTE, CANCER DE PROSTATA INDEPENDIENTE DE ANDROGENOS
PE2011001293A 2008-12-29 2009-12-28 Agente preventivo/terapeutico contra el cancer PE20110939A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20388708P 2008-12-29 2008-12-29

Publications (1)

Publication Number Publication Date
PE20110939A1 true PE20110939A1 (es) 2012-01-19

Family

ID=42025816

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001293A PE20110939A1 (es) 2008-12-29 2009-12-28 Agente preventivo/terapeutico contra el cancer

Country Status (26)

Country Link
US (1) US20110312898A1 (es)
EP (1) EP2379053A1 (es)
JP (1) JP2012513982A (es)
KR (1) KR20110111420A (es)
CN (1) CN102333520B (es)
AR (1) AR074918A1 (es)
AU (1) AU2009334235A1 (es)
BR (1) BRPI0923663A2 (es)
CA (1) CA2748517A1 (es)
CL (1) CL2011001519A1 (es)
CO (1) CO6382105A2 (es)
CR (1) CR20110374A (es)
DO (1) DOP2011000163A (es)
EA (1) EA019738B1 (es)
EC (1) ECSP11011166A (es)
GE (1) GEP20146001B (es)
IL (1) IL212913A0 (es)
MA (1) MA32935B1 (es)
MX (1) MX2011006170A (es)
NZ (1) NZ593381A (es)
PE (1) PE20110939A1 (es)
TN (1) TN2011000250A1 (es)
TW (1) TW201029660A (es)
UY (1) UY32367A (es)
WO (1) WO2010076896A1 (es)
ZA (1) ZA201103627B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139298A1 (ja) * 2008-04-30 2009-11-19 国立大学法人京都大学 メタスチン誘導体およびその用途
ES2434315T3 (es) * 2009-12-22 2013-12-16 Takeda Pharmaceutical Company Limited Formulación de liberación sostenida
WO2011162413A1 (en) * 2010-06-25 2011-12-29 Takeda Pharmaceutical Company Limited Sustained-release formulation
JP6253146B2 (ja) * 2014-02-04 2017-12-27 国立大学法人山口大学 新規なペプチド誘導体及びこれを含有する医薬
EA201700154A1 (ru) * 2014-10-20 2017-08-31 Товарищество С Ограниченной Ответственностью "Фармацевтическая Компания "Ромат" Фармацевтический состав лечебно-профилактического действия и способ его приготовления
IL265696B2 (en) 2016-09-30 2024-08-01 Sumitomo Pharma Switzerland Gmbh 2-(n-acetyl-d-tyrosyl-trans-4-hydroxy-l-prolyl-l-asparaginyl-l-threonyl-l-phenylalanyl) hydrazinocarbonyl-l-leucyl-nω-methyl-l-arginyl-l-tryptophanamide, for use in assisted reproductive technology.
WO2024206577A1 (en) * 2023-03-28 2024-10-03 Radionetics Oncology, Inc. Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof
WO2025217074A1 (en) 2024-04-08 2025-10-16 Radionetics Oncology, Inc. Kisspeptin receptor (kiss1r) targeted therapeutics and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1577323B1 (en) 2002-12-26 2013-07-10 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
US6800611B2 (en) * 2003-01-06 2004-10-05 Takeda Chemical Industries, Ltd. Metastin derivatives and their use
NZ552029A (en) * 2004-06-25 2009-01-31 Takeda Pharmaceutical Metastin derivatives and use thereof
ZA200610820B (en) * 2004-06-25 2008-08-27 Takeda Pharmaceutical Metastin derivatives and use thereof
AR058584A1 (es) * 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos

Also Published As

Publication number Publication date
DOP2011000163A (es) 2011-07-31
NZ593381A (en) 2013-01-25
AU2009334235A1 (en) 2010-07-08
MX2011006170A (es) 2011-06-27
WO2010076896A1 (en) 2010-07-08
CN102333520A (zh) 2012-01-25
CO6382105A2 (es) 2012-02-15
CL2011001519A1 (es) 2012-03-16
IL212913A0 (en) 2011-07-31
KR20110111420A (ko) 2011-10-11
CA2748517A1 (en) 2010-07-08
EA201100882A1 (ru) 2011-12-30
US20110312898A1 (en) 2011-12-22
EA019738B1 (ru) 2014-05-30
EP2379053A1 (en) 2011-10-26
GEP20146001B (en) 2014-01-10
BRPI0923663A2 (pt) 2016-01-19
CN102333520B (zh) 2013-11-06
JP2012513982A (ja) 2012-06-21
ZA201103627B (en) 2012-09-26
TW201029660A (en) 2010-08-16
MA32935B1 (fr) 2012-01-02
ECSP11011166A (es) 2011-07-29
TN2011000250A1 (en) 2012-12-17
UY32367A (es) 2010-07-30
CR20110374A (es) 2011-09-19
AR074918A1 (es) 2011-02-23

Similar Documents

Publication Publication Date Title
PE20110939A1 (es) Agente preventivo/terapeutico contra el cancer
US8653124B2 (en) Inhibition of bacterial biofilms with imidazole derivatives
PE20090649A1 (es) DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1
CO6270184A2 (es) Compuestos aromaticos y sus derivados con actividad biolëgica potenciadas contra la perdida de flujo intestinal
PE20081596A1 (es) Derivados fluorinados de deferiprona
BRPI0412761A (pt) inibidores de serino proteases, particularmente a protease ns3-ns4a do vhc
PE20091201A1 (es) AMIDAS SUSTITUIDAS COMO INHIBIDORES DE LA TIROSINA QUINASA DE BRUTON (Btk)
US7662856B2 (en) Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine
PE20061073A1 (es) Compuestos derivados de piperidinilamida como agentes inhibidores de quinasas
PE20080714A1 (es) DERIVADOS HETEROCICLICOS COMO MODULADORES DE LA ACTIVIDAD DE LA ESTEARIL-CoA-DESATURASA
PE20070983A1 (es) COMPUESTOS DERIVADOS DE 3-DESAZAPURINA COMO AGONISTAS DEL RECEPTOR Toll-LIKE (TLR7)
CY1105579T1 (el) Kαρβαμιδο - υποκατεστημενες πυραζολοπυριδινες
ATE282410T1 (de) Thyromimetika als mittel gegen fettleibigkeit
PE20070367A1 (es) Compuestos de espiropiperidina como inhibidores de la enzima beta secretasa
RU2008119842A (ru) Производные триазола в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы-1
PE20060297A1 (es) Nuevos derivados fluoroglicosidicos de pirazoles como inhibidores de sglt 1
TW200614983A (en) 5-substituted-2-phenylamino benzamides as MEK inhibitors
AR062409A1 (es) Compuesto y composicion farmaceutica, utiles como agentes terapeuticos en el tratamiento, prevencion o mejoramiento de enfermedad o trastorno caracterizado por depositos o niveles de b-amiloide elevados o para inhibir o elucidar la enzima b-secretasa, y proceso para la preparacion del compuesto
PE20061130A1 (es) Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a
RU2008129096A (ru) Композиция для лечения волос
BRPI0409921A (pt) derivados de éster e amida de ácido 2-cianopropanóico e métodos de seu uso
PE20060875A1 (es) Derivados de triazol sustituidos como antagonistas de oxitocina
PE20081169A1 (es) Compuestos tipo pirazol y triazol sustituidos como inhibidores de ksp
TW200700069A (en) Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives
ES397786A1 (es) Procedimiento para la obtencion de derivados piperidinicos.

Legal Events

Date Code Title Description
FC Refusal