PE20110777A1 - Nuevas lactamas como inhibidores de beta secretasa - Google Patents
Nuevas lactamas como inhibidores de beta secretasaInfo
- Publication number
- PE20110777A1 PE20110777A1 PE2011001066A PE2011001066A PE20110777A1 PE 20110777 A1 PE20110777 A1 PE 20110777A1 PE 2011001066 A PE2011001066 A PE 2011001066A PE 2011001066 A PE2011001066 A PE 2011001066A PE 20110777 A1 PE20110777 A1 PE 20110777A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- alkyl
- halogen
- secretase inhibitors
- compounds
- Prior art date
Links
- 239000002439 beta secretase inhibitor Substances 0.000 title 1
- 150000003951 lactams Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- -1 4-HYDROXY-3-ISOPROPOXY-BENZYL Chemical class 0.000 abstract 2
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 2
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 2
- JUXAVSAMVBLDKO-UHFFFAOYSA-N 1-(1-azabicyclo[2.2.2]octan-3-yl)-3-[3-(1h-indol-3-yl)-1-oxo-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-yl]urea Chemical compound C1N(CC2)CCC2C1NC(=O)NC(C(=O)N1CCC2(C3=CC=CC=C3CC2)CC1)CC1=CNC2=CC=CC=C12 JUXAVSAMVBLDKO-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ESPIROPIPERIDINA DE FORMULA (I) DONDE B ES ALQUILO, ARILO, CICLOALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON R3, EN DONDE R3 ES HALOGENO, CN, OH, ENTRE OTROS; A ES ARILO, HETEROARILO, CICLOALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON R4, EN DONDE R4 ES ALQUILO, HALOGENO, CN, ENTRE OTROS; CUANDO ---- ES UN ENLACE SENCILLO R1a Y R1b SON CADA UNO H, ALQUILO, ALQUENILO, ENTRE OTROS; Y CUANDO ---- ES UN DOBLE ENLACE R1b ESTA AUSENTE Y R1a ES H, ALQUILO, (CH2)t-CICLOALQUILO, ENTRE OTROS, DONDE t ES DE 0 A 3; n ES DE 1 A 3; R2 ES ALQUILO, CICLOALQUILO O ALQUENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, OH O CN. SON COMPUESTOS PREFERIDOS: (5R,7S)-8-(4-HIDROXI-3-ISOPROPOXI-BENCIL)-7-METIL-1-FENIL-1,8-DIAZA-ESPIRO[4,5]DECAN-2-ONA; N-{4-[(5R,7S)-8-(4-HIDROXI-3-ISOPROPOXI-BENCIL)-7-METIL-2-OXO-1,8-DIAZA-ESPIRO[4,5]DEC-1-IL]-FENIL}-ACETAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA BETA-SECRETASA (BACE) SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, ISQUEMIA CEREBRAL, DEMENCIA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11722508P | 2008-11-23 | 2008-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110777A1 true PE20110777A1 (es) | 2011-10-29 |
Family
ID=41481076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001066A PE20110777A1 (es) | 2008-11-23 | 2009-11-12 | Nuevas lactamas como inhibidores de beta secretasa |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20110224231A1 (es) |
| EP (1) | EP2370439A1 (es) |
| JP (2) | JP4932065B2 (es) |
| KR (1) | KR20110086769A (es) |
| CN (1) | CN102317289A (es) |
| AP (1) | AP2011005725A0 (es) |
| AU (1) | AU2009318855A1 (es) |
| BR (1) | BRPI0922799A2 (es) |
| CA (1) | CA2743584A1 (es) |
| CL (1) | CL2011001147A1 (es) |
| CO (1) | CO6361924A2 (es) |
| CR (1) | CR20110269A (es) |
| CU (1) | CU20110113A7 (es) |
| DO (1) | DOP2011000134A (es) |
| EA (1) | EA201170722A1 (es) |
| EC (1) | ECSP11011073A (es) |
| GE (1) | GEP20135806B (es) |
| IL (1) | IL212869A0 (es) |
| MA (1) | MA32929B1 (es) |
| MX (1) | MX2011005346A (es) |
| NI (1) | NI201100096A (es) |
| NZ (1) | NZ592823A (es) |
| PE (1) | PE20110777A1 (es) |
| SV (1) | SV2011003916A (es) |
| TN (1) | TN2011000252A1 (es) |
| UA (1) | UA99787C2 (es) |
| WO (1) | WO2010058333A1 (es) |
| ZA (1) | ZA201103738B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| US8633212B2 (en) | 2009-03-13 | 2014-01-21 | Vitae Pharmaceuticals, Inc. | Inhibitors of beta-secretase |
| WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| ES2689149T3 (es) | 2011-01-25 | 2018-11-08 | Bayer Cropscience Ag | Procedimiento para la preparación de derivados de 1-H-pirrolidin-2,4-diona |
| WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
| TWI557112B (zh) | 2012-03-05 | 2016-11-11 | 百靈佳殷格翰國際股份有限公司 | β－分泌酶抑制劑 |
| WO2014052398A1 (en) | 2012-09-28 | 2014-04-03 | Vitae Pharmaceuticals, Inc. | Inhibitor of beta-secretase |
| JP2017521440A (ja) * | 2014-07-14 | 2017-08-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 腎髄質外層カリウムチャンネルの阻害剤 |
| WO2016008064A1 (en) * | 2014-07-14 | 2016-01-21 | Merck Sharp & Dohme Corp. | Inhibitors of renal outer medullary potassium channel |
| WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
| WO2016100823A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
| CN113045484B (zh) * | 2019-12-27 | 2024-01-26 | 南京药石科技股份有限公司 | 一种2-氨基-2-(1-甲基-4-哌啶基)丙烷-1-醇的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876260A (en) * | 1987-10-28 | 1989-10-24 | State Of Israel, Israel Institute Of Biological Research | Oxathiolanes |
| US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
| FR2824901B1 (fr) * | 2001-05-21 | 2003-09-12 | Poudres & Explosifs Ste Nale | Procede et installation de destruction de fusee montee sur une munition |
| MXPA06007210A (es) * | 2003-12-22 | 2006-08-18 | Schering Corp | Composiciones farmaceuticas. |
| WO2005077814A1 (de) * | 2004-02-17 | 2005-08-25 | Herm. Sprenger Gmbh & Co. Kg | Doppelt gebrochenes gebiss für pferde |
| US7659264B2 (en) * | 2004-10-07 | 2010-02-09 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| AU2005295814A1 (en) * | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of Alzhermer's disease |
| GB0504556D0 (en) * | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
| US20080234252A1 (en) * | 2005-05-18 | 2008-09-25 | Pfizer Inc | Compounds Useful in Therapy |
| AU2006270084B2 (en) * | 2005-07-18 | 2011-08-25 | Merck Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease |
| RU2382589C2 (ru) * | 2005-09-20 | 2010-02-27 | Ска Хайджин Продактс Аб | Распределительное устройство |
| BRPI0712166A2 (pt) * | 2006-05-26 | 2012-01-24 | Eisai R&D Man Co Ltd | composto, composição farmacêutica, método para o tratamento de esclerose múltipla em um mamìfero, uso de um composto, e, método para o tratamento de artrite reumatóide em um mamìfero |
| ATE474574T1 (de) * | 2006-05-26 | 2010-08-15 | Eisai R&D Man Co Ltd | Imidazoazephinonverbindungen |
| CA2655203A1 (en) * | 2006-06-14 | 2007-12-21 | Virochem Pharma Inc. | Spirotropane compounds |
| CA2662776A1 (en) * | 2006-09-07 | 2008-03-13 | Merck And Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| ATE549923T1 (de) * | 2006-10-06 | 2012-04-15 | Merck Sharp & Dohme | Makrozyklische spiropiperidin-beta-sekretase- hemmer zur behandlung von morbus alzheimer |
| EP2091328B1 (en) * | 2006-10-30 | 2011-12-28 | Merck Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
-
2009
- 2009-11-12 US US13/130,192 patent/US20110224231A1/en not_active Abandoned
- 2009-11-12 KR KR1020117014375A patent/KR20110086769A/ko not_active Abandoned
- 2009-11-12 WO PCT/IB2009/055043 patent/WO2010058333A1/en not_active Ceased
- 2009-11-12 UA UAA201106359A patent/UA99787C2/ru unknown
- 2009-11-12 MX MX2011005346A patent/MX2011005346A/es not_active Application Discontinuation
- 2009-11-12 MA MA33879A patent/MA32929B1/fr unknown
- 2009-11-12 EA EA201170722A patent/EA201170722A1/ru unknown
- 2009-11-12 CN CN2009801552711A patent/CN102317289A/zh active Pending
- 2009-11-12 BR BRPI0922799A patent/BRPI0922799A2/pt not_active IP Right Cessation
- 2009-11-12 AP AP2011005725A patent/AP2011005725A0/xx unknown
- 2009-11-12 GE GEAP200912232A patent/GEP20135806B/en unknown
- 2009-11-12 AU AU2009318855A patent/AU2009318855A1/en not_active Abandoned
- 2009-11-12 NZ NZ592823A patent/NZ592823A/xx not_active IP Right Cessation
- 2009-11-12 PE PE2011001066A patent/PE20110777A1/es not_active Application Discontinuation
- 2009-11-12 CA CA2743584A patent/CA2743584A1/en not_active Abandoned
- 2009-11-12 JP JP2011536976A patent/JP4932065B2/ja not_active Expired - Fee Related
- 2009-11-12 EP EP09764055A patent/EP2370439A1/en not_active Withdrawn
-
2011
- 2011-05-11 NI NI201100096A patent/NI201100096A/es unknown
- 2011-05-12 DO DO2011000134A patent/DOP2011000134A/es unknown
- 2011-05-12 IL IL212869A patent/IL212869A0/en unknown
- 2011-05-17 CL CL2011001147A patent/CL2011001147A1/es unknown
- 2011-05-17 CU CU20110113A patent/CU20110113A7/es unknown
- 2011-05-17 TN TN2011000252A patent/TN2011000252A1/fr unknown
- 2011-05-20 ZA ZA2011/03738A patent/ZA201103738B/en unknown
- 2011-05-23 SV SV2011003916A patent/SV2011003916A/es unknown
- 2011-05-23 EC EC2011011073A patent/ECSP11011073A/es unknown
- 2011-05-23 CR CR20110269A patent/CR20110269A/es not_active Application Discontinuation
- 2011-05-24 CO CO11063882A patent/CO6361924A2/es not_active Application Discontinuation
-
2012
- 2012-01-20 JP JP2012009735A patent/JP2012107029A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP4932065B2 (ja) | 2012-05-16 |
| KR20110086769A (ko) | 2011-07-29 |
| JP2012509310A (ja) | 2012-04-19 |
| ECSP11011073A (es) | 2011-06-30 |
| GEP20135806B (en) | 2013-04-10 |
| AU2009318855A1 (en) | 2010-05-27 |
| CR20110269A (es) | 2011-07-04 |
| EA201170722A1 (ru) | 2011-10-31 |
| UA99787C2 (en) | 2012-09-25 |
| JP2012107029A (ja) | 2012-06-07 |
| CL2011001147A1 (es) | 2011-09-30 |
| NZ592823A (en) | 2012-12-21 |
| AP2011005725A0 (en) | 2011-06-30 |
| US20110224231A1 (en) | 2011-09-15 |
| WO2010058333A1 (en) | 2010-05-27 |
| CO6361924A2 (es) | 2012-01-20 |
| TN2011000252A1 (fr) | 2012-12-17 |
| ZA201103738B (en) | 2012-01-25 |
| CA2743584A1 (en) | 2010-05-27 |
| CU20110113A7 (es) | 2012-01-31 |
| CN102317289A (zh) | 2012-01-11 |
| IL212869A0 (en) | 2011-07-31 |
| MA32929B1 (fr) | 2012-01-02 |
| DOP2011000134A (es) | 2011-07-31 |
| MX2011005346A (es) | 2011-06-16 |
| BRPI0922799A2 (pt) | 2019-09-24 |
| EP2370439A1 (en) | 2011-10-05 |
| NI201100096A (es) | 2011-10-31 |
| SV2011003916A (es) | 2011-07-28 |
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