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PE20100258A1 - Aislamiento de ciclopamina - Google Patents

Aislamiento de ciclopamina

Info

Publication number
PE20100258A1
PE20100258A1 PE2009000912A PE2009000912A PE20100258A1 PE 20100258 A1 PE20100258 A1 PE 20100258A1 PE 2009000912 A PE2009000912 A PE 2009000912A PE 2009000912 A PE2009000912 A PE 2009000912A PE 20100258 A1 PE20100258 A1 PE 20100258A1
Authority
PE
Peru
Prior art keywords
alkaloid
plant
veratrum
cyclopamine
glycosylated
Prior art date
Application number
PE2009000912A
Other languages
English (en)
Inventor
Gamini Senerath Jayatilake
Steve L Richheimer
David A Mann
Original Assignee
Infinity Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Pharmaceuticals Inc filed Critical Infinity Pharmaceuticals Inc
Publication of PE20100258A1 publication Critical patent/PE20100258A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

SE REFIERE A UN PROCESO PARA AISLAR UN ALCALOIDE DEL VERATRUM DESGLICOSILADO (CICLOPAMINA) QUE COMPRENDE: (i) PROPORCIONAR UN MATERIAL DE LA PLANTA VERATRUM QUE COMPRENDE UN ALCALOIDE DEL VERATRUM GLICOSILADO; (ii) PONER EN CONTACTO EL MATERIAL DE LA PLANTA CON UNA SOLUCION ACUOSA TAMPONADA O NEUTRA CON UN PH ENTRE 4 A 8 Y A UNA TEMPERATURA MENOR A 100 ºC; (iii) EXTRAER EL MATERIAL DE LA PLANTA CON UN SOLVENTE SELECCIONADO DE METANOL, ACETATO DE ETILO, XILENOS, HEXANOS, ENTRE OTROS Y MEZCLA DE LOS MISMOS PARA PROPORCIONAR UN EXTRACTO QUE CONTIENE EL ALCALOIDE GLICOSILADO; (iv) DESGLICOSILACION CON LA ENZIMA -GLUCURONIDASA DE HELIX POMATIA. DICHO ALCALOIDE ES UTIL EN EL TRATAMIENTO DE CANCER
PE2009000912A 2008-07-02 2009-06-30 Aislamiento de ciclopamina PE20100258A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7770308P 2008-07-02 2008-07-02

Publications (1)

Publication Number Publication Date
PE20100258A1 true PE20100258A1 (es) 2010-04-21

Family

ID=41464684

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000912A PE20100258A1 (es) 2008-07-02 2009-06-30 Aislamiento de ciclopamina

Country Status (14)

Country Link
US (3) US20100003728A1 (es)
EP (1) EP2318027B1 (es)
JP (1) JP5607041B2 (es)
KR (1) KR20110028640A (es)
CN (1) CN102137679B (es)
AR (1) AR074524A1 (es)
AU (1) AU2009266993A1 (es)
BR (1) BRPI0913997A2 (es)
CA (1) CA2729110A1 (es)
CL (1) CL2009001479A1 (es)
IL (1) IL210149A (es)
PE (1) PE20100258A1 (es)
TW (1) TW201006484A (es)
WO (1) WO2010002970A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
WO2008109184A1 (en) 2007-03-07 2008-09-12 Infinity Pharmaceuticals, Inc. Heterocyclic cyclopamine analogs and methods of use thereof
CN104193797A (zh) 2007-03-07 2014-12-10 无限发现股份有限公司 环杷明内酰胺类似物及其使用方法
AU2008345151A1 (en) * 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Therapeutic cancer treatments
US20100297118A1 (en) * 2007-12-27 2010-11-25 Macdougall John Therapeutic Cancer Treatments
WO2009086451A1 (en) * 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
CA2636807A1 (en) * 2008-07-04 2010-01-04 Steven Splinter Methods for obtaining cyclopamine
DK2443229T3 (da) * 2009-06-18 2020-03-30 Phyton Holdings Llc Fremstilling af alkaloider med cellekultur fra Veratrum californicum
CA2769795C (en) 2009-08-05 2020-01-07 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
JP2013510180A (ja) * 2009-11-06 2013-03-21 インフィニティ ファーマスーティカルズ、インク． ヘッジホッグ経路阻害剤の経口製剤
US20110183948A1 (en) * 2010-01-15 2011-07-28 Infinity Pharmaceuticals, Inc. Treatment of fibrotic conditions using hedgehog inhibitors
WO2012037217A1 (en) 2010-09-14 2012-03-22 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
CN104861034B (zh) * 2014-02-24 2017-04-19 中国人民解放军第二军医大学 环巴胺类似物三元环环巴胺及其衍生物与制备和应用
AU2016271468B2 (en) 2015-06-04 2020-01-02 Sol-Gel Technologies Ltd. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6333341A (ja) * 1986-07-28 1988-02-13 Seitetsu Kagaku Co Ltd 配糖体の処理方法
US6993456B2 (en) * 1999-09-30 2006-01-31 Rockwell Automation Technologies, Inc. Mechanical-electrical template based method and apparatus
US6456928B1 (en) * 2000-12-29 2002-09-24 Honeywell International Inc. Prognostics monitor for systems that are subject to failure
JPWO2004000863A1 (ja) * 2002-06-20 2005-10-20 日本水産株式会社 プロドラッグ、その医薬としての使用、およびその製法
EP2082037A1 (en) * 2006-09-29 2009-07-29 Vib Vzw Plant cell lines established from the medicinal plant veratrum californicum
CA2636807A1 (en) * 2008-07-04 2010-01-04 Steven Splinter Methods for obtaining cyclopamine

Also Published As

Publication number Publication date
IL210149A (en) 2016-03-31
US20190263852A1 (en) 2019-08-29
AU2009266993A1 (en) 2010-01-07
TW201006484A (en) 2010-02-16
US20160168193A1 (en) 2016-06-16
EP2318027B1 (en) 2022-02-02
WO2010002970A2 (en) 2010-01-07
US20100003728A1 (en) 2010-01-07
CN102137679B (zh) 2013-04-24
WO2010002970A3 (en) 2010-05-06
AR074524A1 (es) 2011-01-26
BRPI0913997A2 (pt) 2015-10-20
IL210149A0 (en) 2011-03-31
CN102137679A (zh) 2011-07-27
CA2729110A1 (en) 2010-01-07
EP2318027A2 (en) 2011-05-11
CL2009001479A1 (es) 2010-01-04
KR20110028640A (ko) 2011-03-21
JP2011526921A (ja) 2011-10-20
JP5607041B2 (ja) 2014-10-15
EP2318027A4 (en) 2016-12-28

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