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PE20100053A1 - Compuestos heterociclicos como inhibidores de la adn girasa - Google Patents

Compuestos heterociclicos como inhibidores de la adn girasa

Info

Publication number
PE20100053A1
PE20100053A1 PE2009000778A PE2009000778A PE20100053A1 PE 20100053 A1 PE20100053 A1 PE 20100053A1 PE 2009000778 A PE2009000778 A PE 2009000778A PE 2009000778 A PE2009000778 A PE 2009000778A PE 20100053 A1 PE20100053 A1 PE 20100053A1
Authority
PE
Peru
Prior art keywords
girase
inhibitors
alyl
pyridin
alkyl
Prior art date
Application number
PE2009000778A
Other languages
English (en)
Inventor
Manoj Ganpat Kale
Mohamed Shahul Hameed Peer
Anadkumar Venkobachar Raichurkar
Sandeep Raghunath Ghorpade
David Charles Mckinney
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40872366&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100053(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20100053A1 publication Critical patent/PE20100053A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I) DONDE Y ES S U O; Q ES C(=O)NR4, C(=S)NR5, C(=O)O, ENTRE OTROS, DONDE R4 Y R5 SON CADA UNO H, OH, ALQUIL(C1-C4) O CICLOALQUIL(C3-C6); R1 ES ALQUIL(C1-C6), ALQUENIL(C2-C6), ALQUINIL(C2-C6), ALCOXI(C1-C6), ENTRE OTROS; X ES N O CRa, DONDE Ra ES H, F, CH3, ENTRE OTROS; m ES DE 0 A 5; A ES UN SISTEMA DE ANILLOS CARBOCICLICO O HETEROCICLICO DE HASTA 12 ATOMOS; R3 ES H, HALO, NITRO, CN, ENTRE OTROS; R2 ES H, ALQUIL(C1-C6), ALQUENIL(C2-C6), ALCOXI(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-ALIL-3-(6-CLORO-TIAZOLO[5,4-b]PIRIDIN-2-IL)-UREA, 1-ALIL-3-(6-BROMO-5-METIL-TIAZOLO[5,4-b]PIRIDIN-2-IL)-UREA, 5-[2-(3-ALIL-UREIDO)-5-METIL-TIAZOLO[5,4-b]PIRIDIN-6-IL]-N,N-DIMETIL-NICOTINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ADN GIRASA BACTERIANA SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
PE2009000778A 2008-06-04 2009-06-04 Compuestos heterociclicos como inhibidores de la adn girasa PE20100053A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5874808P 2008-06-04 2008-06-04

Publications (1)

Publication Number Publication Date
PE20100053A1 true PE20100053A1 (es) 2010-02-25

Family

ID=40872366

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000778A PE20100053A1 (es) 2008-06-04 2009-06-04 Compuestos heterociclicos como inhibidores de la adn girasa

Country Status (16)

Country Link
US (1) US20100137303A1 (es)
EP (1) EP2303894A1 (es)
JP (1) JP2011522024A (es)
KR (1) KR20110031419A (es)
CN (1) CN102056932A (es)
AR (1) AR072047A1 (es)
AU (1) AU2009254928A1 (es)
BR (1) BRPI0913300A2 (es)
CA (1) CA2725689A1 (es)
CL (1) CL2009001346A1 (es)
MX (1) MX2010013249A (es)
PE (1) PE20100053A1 (es)
RU (1) RU2010154499A (es)
TW (1) TW201002723A (es)
UY (1) UY31860A (es)
WO (1) WO2009147431A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103599798B (zh) 2007-05-09 2015-11-18 国际壳牌研究有限公司 环氧化催化剂及其制备方法和生产环氧烷、1,2-二醇、1,2-二醇醚、1,2-碳酸酯或烷醇胺的方法
CN102844305B (zh) 2010-03-31 2014-07-02 埃科特莱茵药品有限公司 抗菌异喹啉-3-基脲衍生物
CN103124496B (zh) 2010-10-06 2016-03-30 葛兰素史密丝克莱恩有限责任公司 作为pi3激酶抑制剂的苯并咪唑衍生物
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
EP2721026B1 (en) * 2011-06-20 2016-03-02 Vertex Pharmaceuticals Incorporated Phosphate esters of gyrase and topoisomerase inhibitors
JP2015514063A (ja) * 2012-03-22 2015-05-18 ビオタ ヨーロッパ リミテッドＢｉｏｔａ Ｅｕｒｏｐｅ Ｌｔｄ 抗菌化合物
KR102178590B1 (ko) 2012-07-18 2020-11-13 유니버시티 오브 노트르 담 듀락 5,5-헤테로방향족 항-감염 화합물
KR101602559B1 (ko) * 2014-04-29 2016-03-10 경북대학교 산학협력단 2,5,6,7-사중치환 티아졸로[4,5-b]피리딘 유도체 및 이의 용도
CN104788473B (zh) * 2015-03-25 2017-03-15 石家庄学院 一种具有抗菌能力的化合物及其制备方法与用途
CN104744493B (zh) * 2015-04-08 2017-01-25 石家庄学院 3‑苯甲酰基‑5,7‑二苯基‑5H‑噻唑并[3,2‑a]嘧啶类衍生物及其应用
EP3544978B1 (de) 2016-11-23 2020-11-04 Bayer CropScience Aktiengesellschaft 2-[3-(alkylsulfonyl)-2h-indazol-2-yl]-3h-imidazo[4,5-b]pyridin-derivate und ähnliche verbindungen als schädlingsbekämpfungsmittel
WO2018174288A1 (ja) 2017-03-24 2018-09-27 大正製薬株式会社 ２（１ｈ）－キノリノン誘導体
RU2725886C1 (ru) 2017-03-30 2020-07-07 ЭксДабл-Ю ЛЭБОРЕТРИЗ ИНК. Бициклические гетероарильные производные и их получение и применение
WO2020048949A1 (en) 2018-09-03 2020-03-12 Univerza V Ljubljani New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria
US20250002455A1 (en) 2020-12-17 2025-01-02 Univerza V Ljubljani New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity
WO2022165198A1 (en) * 2021-01-29 2022-08-04 Board Of Trustees Of Michigan State University Therapeutic compounds and uses thereof
KR20250005373A (ko) 2022-04-22 2025-01-09 버텍스 파마슈티칼스 인코포레이티드 통증 치료를 위한 헤테로아릴 화합물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1341769B1 (en) * 2000-12-15 2007-10-17 Vertex Pharmaceuticals Incorporated Bacterial gyrase inhibitors and uses thereof
KR20060079098A (ko) * 2004-12-31 2006-07-05 주식회사 엘지생명과학 신규한([1,3]티아졸로[5,4-ｂ]피리딘-2-일)-2-카르복사마이드유도체
GB0724342D0 (en) * 2007-12-13 2008-01-30 Prolysis Ltd Anitbacterial compositions
MX2010011370A (es) * 2008-04-16 2010-12-15 Vertex Pharma Inhibidores de fosfatidilinositol 3-cinasa.

Also Published As

Publication number Publication date
AU2009254928A1 (en) 2009-12-10
KR20110031419A (ko) 2011-03-28
WO2009147431A1 (en) 2009-12-10
EP2303894A1 (en) 2011-04-06
MX2010013249A (es) 2010-12-21
UY31860A (es) 2010-01-29
JP2011522024A (ja) 2011-07-28
CN102056932A (zh) 2011-05-11
US20100137303A1 (en) 2010-06-03
BRPI0913300A2 (pt) 2018-05-22
CL2009001346A1 (es) 2010-07-02
CA2725689A1 (en) 2009-12-10
TW201002723A (en) 2010-01-16
AR072047A1 (es) 2010-08-04
RU2010154499A (ru) 2012-07-20

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