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PE20091316A1 - Compuestos derivados de piridina como inhibidores de cinasa alk-5 - Google Patents

Compuestos derivados de piridina como inhibidores de cinasa alk-5

Info

Publication number
PE20091316A1
PE20091316A1 PE2009000022A PE2009000022A PE20091316A1 PE 20091316 A1 PE20091316 A1 PE 20091316A1 PE 2009000022 A PE2009000022 A PE 2009000022A PE 2009000022 A PE2009000022 A PE 2009000022A PE 20091316 A1 PE20091316 A1 PE 20091316A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
alk
pyridine
terpyridin
Prior art date
Application number
PE2009000022A
Other languages
English (en)
Inventor
Claire Adcock
Urs Baettig
Peter Hunt
Catherine Leblanc
Maude Nadine Pierrette Pipet
Katrin Spiegel
Robert Alexander Pulz
Nikolaus Johannes Stiefl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20091316A1 publication Critical patent/PE20091316A1/es

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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
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  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE T1 ES HETEROCICLO DE 4 A 14 MIEMBROS, CICLOALQUENILO DE 4 A 15 ATOMOS DE CARBONO OPCIONALMENTE SUSTITUIDOS CON CICLOALQUILO C3-C5, ALQUILTIO C1-C8, HALO, ENTRE OTROS; T2 ES HETEROCICLO DE 4-14 MIEMBROS OPCIONALMENTE SUSTITUIDO CON 1-3 ALQUILO C1-8, ARILO C6-C15, HETEROCICLO C4-C14, ENTRE OTROS; X ES CRc, N, O, S, CON LA CONDICION QUE CUANDO X SEA O, S, Ra ESTE AUSENTE; Ra Y Rb SON CADA UNO H, OH, NHR10; Rc ES H, OH, ALQUILO C1-C8, NHR10; R8 Y R9 SON CADA UNO H, HALO, OH, ENTRE OTROS; R10 ES H, ALQUILO C1-C8, ALQUENILO C2-C8, CICLOALQUILO C3-C8, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: METIL-{5''-[3-(4-METIL-PIPERAZIN-1-IL-METIL)-FENIL]-[2,2';4',3'']TERPIRIDIN-6'-IL}-AMINA; 4-ISOPROPIL-PIPERAZIN-1-IL-[4-(6-METILAMINO-[2.2';4'3'']TERPIRIDIN-5''-IL)-FENIL]-METANONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES INHIBIDOR DE CINASA (ALK-5), UTIL EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS U OBSTRUCTIVOS DE LAS VIAS RESPIRATORIAS, HIPERTENSION PULMONAR, ENTRE OTRAS
PE2009000022A 2008-01-11 2009-01-09 Compuestos derivados de piridina como inhibidores de cinasa alk-5 PE20091316A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150187 2008-01-11
EP08168207 2008-11-03

Publications (1)

Publication Number Publication Date
PE20091316A1 true PE20091316A1 (es) 2009-09-24

Family

ID=40689319

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000022A PE20091316A1 (es) 2008-01-11 2009-01-09 Compuestos derivados de piridina como inhibidores de cinasa alk-5

Country Status (22)

Country Link
US (1) US8343966B2 (es)
EP (1) EP2242742B1 (es)
JP (1) JP5566909B2 (es)
KR (1) KR20100101138A (es)
CN (1) CN101918362B (es)
AR (1) AR070519A1 (es)
AU (1) AU2009203681B2 (es)
BR (1) BRPI0907611A2 (es)
CA (1) CA2711803A1 (es)
CL (1) CL2009000029A1 (es)
CR (1) CR11490A (es)
EA (1) EA201001127A1 (es)
EC (1) ECSP10010336A (es)
ES (1) ES2562447T3 (es)
IL (1) IL206276A0 (es)
MA (1) MA31947B1 (es)
MX (1) MX2010007606A (es)
PE (1) PE20091316A1 (es)
TN (1) TN2010000255A1 (es)
TW (1) TW200938536A (es)
WO (1) WO2009087212A2 (es)
ZA (1) ZA201003929B (es)

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WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
BR112015009751A2 (pt) 2012-10-31 2017-07-11 Bayer Cropscience Ag novos compostos heterocíclicos como pesticidas
AP2016009368A0 (en) 2014-01-14 2016-08-31 Millennium Pharm Inc Heteroaryls and uses thereof
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JP6433509B2 (ja) 2014-04-24 2018-12-05 ノバルティス アーゲー ホスファチジルイノシトール３−キナーゼ阻害薬としてのアミノピラジン誘導体
BR112016024484A2 (pt) 2014-04-24 2017-08-15 Novartis Ag derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase
PL3134395T3 (pl) 2014-04-24 2018-07-31 Novartis Ag Pochodne pirazyny jako inhibitory 3-kinazy fosfatydyloinozytolu
MA45244A (fr) 2016-06-13 2019-04-17 Cancer Research Tech Ltd Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1
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RU2020124116A (ru) 2017-12-22 2022-01-25 Хиберселл, Инк. Производные арил-бипиридинамина в качестве ингибиторов фосфатидилинозитолфосфаткиназы
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KR102556500B1 (ko) * 2021-11-19 2023-07-19 하나제약 주식회사 피롤 유도체 또는 이의 약학적 또는 식품학적으로 허용 가능한 염, 및 이를 유효성분으로 포함하는 위장 질환의 예방, 개선 또는 치료용 조성물
AU2022405116A1 (en) 2021-12-09 2024-07-11 Deciphera Pharmaceuticals, Llc Raf kinase inhibitors and methods of use thereof
WO2023208986A1 (en) 2022-04-27 2023-11-02 Chiesi Farmaceutici S.P.A. Imidazole derivatives as alk5 inhibitors

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Publication number Publication date
WO2009087212A3 (en) 2009-09-24
TN2010000255A1 (en) 2011-11-11
US20090215776A1 (en) 2009-08-27
KR20100101138A (ko) 2010-09-16
CA2711803A1 (en) 2009-07-16
MA31947B1 (fr) 2010-12-01
JP2011509277A (ja) 2011-03-24
CL2009000029A1 (es) 2009-07-24
US8343966B2 (en) 2013-01-01
CN101918362B (zh) 2013-11-27
AU2009203681B2 (en) 2012-08-16
CR11490A (es) 2010-08-11
ZA201003929B (en) 2011-03-30
EA201001127A1 (ru) 2011-02-28
EP2242742B1 (en) 2015-12-02
WO2009087212A2 (en) 2009-07-16
CN101918362A (zh) 2010-12-15
JP5566909B2 (ja) 2014-08-06
EP2242742A2 (en) 2010-10-27
IL206276A0 (en) 2010-12-30
MX2010007606A (es) 2010-08-23
ECSP10010336A (es) 2010-08-31
ES2562447T3 (es) 2016-03-04
BRPI0907611A2 (pt) 2015-07-21
AR070519A1 (es) 2010-04-14
TW200938536A (en) 2009-09-16
AU2009203681A1 (en) 2009-07-16

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