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BRPI0815129B8 - composição radiofarmacêutica, e, métodos para preparação de uma composição radiofarmacêutica - Google Patents

composição radiofarmacêutica, e, métodos para preparação de uma composição radiofarmacêutica

Info

Publication number
BRPI0815129B8
BRPI0815129B8 BRPI0815129A BRPI0815129A BRPI0815129B8 BR PI0815129 B8 BRPI0815129 B8 BR PI0815129B8 BR PI0815129 A BRPI0815129 A BR PI0815129A BR PI0815129 A BRPI0815129 A BR PI0815129A BR PI0815129 B8 BRPI0815129 B8 BR PI0815129B8
Authority
BR
Brazil
Prior art keywords
radiopharmaceutical composition
preparing
methods
radiopharmaceutical
composition
Prior art date
Application number
BRPI0815129A
Other languages
English (en)
Inventor
Roed Line
Elizabeth Peterson Sarah
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of BRPI0815129A2 publication Critical patent/BRPI0815129A2/pt
Publication of BRPI0815129B1 publication Critical patent/BRPI0815129B1/pt
Publication of BRPI0815129B8 publication Critical patent/BRPI0815129B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

composição radiofarmacêutica, e, métodos para preparação de uma composição radiofarmacêutica, e para determinação da presença, localização e/ou quantidade de um ou mais depósitos de amilóide em um órgão ou área do corpo de um indivíduo a presente invenção refere-se a produtos radiofarmacêuticos e em particular a uma composição radiofarmacêutica contendo um composto de fórmula i: e polissorbato como um excipiente. a composição radiofarmacêutica da invenção reduz problemas encontrados com composições da arte anterior contendo a mesma classe de compostos. também é fornecido pela invenção um método para preparação da composição radiofarmacêutica da invenção. bem como usos particulares da composição radiofarmacêutica.
BRPI0815129A 2007-08-30 2008-08-28 composição radiofarmacêutica, e, métodos para preparação de uma composição radiofarmacêutica BRPI0815129B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96890407P 2007-08-30 2007-08-30
US60/968904 2007-08-30
PCT/EP2008/061275 WO2009027452A2 (en) 2007-08-30 2008-08-28 Radiopharmaceutical composition

Publications (3)

Publication Number Publication Date
BRPI0815129A2 BRPI0815129A2 (pt) 2015-02-03
BRPI0815129B1 BRPI0815129B1 (pt) 2021-01-12
BRPI0815129B8 true BRPI0815129B8 (pt) 2021-05-25

Family

ID=40029249

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815129A BRPI0815129B8 (pt) 2007-08-30 2008-08-28 composição radiofarmacêutica, e, métodos para preparação de uma composição radiofarmacêutica

Country Status (20)

Country Link
US (1) US8916131B2 (pt)
EP (1) EP2182988B1 (pt)
JP (1) JP5367708B2 (pt)
KR (1) KR101571572B1 (pt)
CN (1) CN101790387B (pt)
AU (1) AU2008292201B2 (pt)
BR (1) BRPI0815129B8 (pt)
CA (1) CA2694084C (pt)
DK (1) DK2182988T3 (pt)
ES (1) ES2464715T3 (pt)
HU (1) HUS1500007I1 (pt)
IL (1) IL203316A (pt)
MX (1) MX2010002196A (pt)
NO (1) NO2015006I1 (pt)
NZ (1) NZ583616A (pt)
PL (1) PL2182988T3 (pt)
PT (1) PT2182988E (pt)
RU (1) RU2475267C2 (pt)
WO (1) WO2009027452A2 (pt)
ZA (1) ZA201000718B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ600791A (en) * 2009-10-08 2014-02-28 Ge Healthcare Ltd Solid phase extraction purification technique
KR101930124B1 (ko) * 2012-04-10 2018-12-17 랜티우스 메디컬 이메징, 인크. 방사성제약 합성 방법
WO2016087653A1 (en) 2014-12-04 2016-06-09 Ge Healthcare Limited Method of removing acetaldehyde from radioactive pharmaceuticals
JP6485914B2 (ja) * 2015-10-28 2019-03-20 日本メジフィジックス株式会社 フルテメタモルの製造方法
JP6955347B2 (ja) 2017-02-28 2021-10-27 日本メジフィジックス株式会社 フルテメタモルの製造方法
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
EP4125599A1 (en) * 2020-03-27 2023-02-08 Jubilant Pharma Holdings Inc. Radiopharmaceutical dispensing system
KR102207372B1 (ko) * 2020-03-31 2021-01-27 재단법인 아산사회복지재단 방사성 의약품의 안정화제 및 이를 포함하는 방사성 의약 조성물
US11878081B1 (en) 2022-12-23 2024-01-23 Tap Pharmaceuticals Ag Pharmaceutical formulations of tafamidis
US11980685B1 (en) 2022-12-23 2024-05-14 Tap Pharmaceuticals, Ag Liquid pharmaceutical formulations of tafamidis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335095A (en) * 1979-03-21 1982-06-15 The Radiochemical Centre Limited Indium-111 oxine complex composition
GB9919673D0 (en) * 1999-08-20 1999-10-20 Cancer Res Campaign Tech 2-Arlybenzazole compounds
PT1334091E (pt) * 2000-08-24 2013-01-07 Univ Pittsburgh Derivados de tioflavina e seu uso no diagnóstico e terapia da doença de alzheimer
WO2003068269A1 (en) * 2002-02-13 2003-08-21 Amersham Plc Benzothiazole derivatives for in vivo imaging of amyloid plaques
CA2438032C (en) * 2003-03-14 2013-05-07 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
US20050043523A1 (en) * 2003-08-22 2005-02-24 University Of Pittsburgh Benzothiazole derivative compounds, compositions and uses
CN101137397A (zh) 2004-07-02 2008-03-05 匹兹堡大学高等教育联邦体系 淀粉样蛋白成像作为抗淀粉样蛋白疗法的功效的替代标记物
CN101060865B (zh) * 2004-07-02 2011-10-05 匹兹堡大学高等教育联邦体系 诊断淀粉样蛋白沉积相关疾病的前驱形式的方法
CA2617319A1 (en) 2005-06-24 2007-01-04 The Trustees Of The University Of Pennsylvania Radiolabeled-pegylation of ligands for use as imaging agents
GB0516564D0 (en) * 2005-08-12 2005-09-21 Ge Healthcare Ltd Fluorination process
JP2009519239A (ja) * 2005-12-01 2009-05-14 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション アミロイド生成性タンパク質の造影剤としての同位体標識ベンゾチアゾール化合物
WO2008134618A2 (en) 2007-04-27 2008-11-06 The General Hospital Corporation Novel imaging tracers for early detection and treatment of amyloid plaques caused by alzheimer's disease and related disorders

Also Published As

Publication number Publication date
WO2009027452A2 (en) 2009-03-05
PL2182988T3 (pl) 2015-02-27
CN101790387B (zh) 2013-03-20
US20110008254A1 (en) 2011-01-13
KR20100055440A (ko) 2010-05-26
MX2010002196A (es) 2010-03-18
KR101571572B1 (ko) 2015-11-24
AU2008292201A1 (en) 2009-03-05
IL203316A (en) 2015-02-26
JP5367708B2 (ja) 2013-12-11
BRPI0815129A2 (pt) 2015-02-03
WO2009027452A3 (en) 2009-09-03
ZA201000718B (en) 2010-10-27
DK2182988T3 (da) 2014-05-26
NO2015006I2 (pt) 2015-02-18
NZ583616A (en) 2012-06-29
JP2010536931A (ja) 2010-12-02
HK1146710A1 (en) 2011-07-08
RU2475267C2 (ru) 2013-02-20
CA2694084C (en) 2015-07-07
AU2008292201B2 (en) 2014-09-04
EP2182988A2 (en) 2010-05-12
NO2015006I1 (no) 2015-03-02
EP2182988B1 (en) 2014-04-16
US8916131B2 (en) 2014-12-23
HUS1500007I1 (hu) 2021-05-07
ES2464715T3 (es) 2014-06-03
CN101790387A (zh) 2010-07-28
CA2694084A1 (en) 2009-03-05
BRPI0815129B1 (pt) 2021-01-12
PT2182988E (pt) 2014-05-16
RU2010101935A (ru) 2011-10-10

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/01/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/08/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF