[go: up one dir, main page]

PE20091195A1 - Nuevos moduladores de los puntos de control del ciclo celular y su uso en combinacion con inhibidores de quinasa de punto de control - Google Patents

Nuevos moduladores de los puntos de control del ciclo celular y su uso en combinacion con inhibidores de quinasa de punto de control

Info

Publication number
PE20091195A1
PE20091195A1 PE2008001894A PE2008001894A PE20091195A1 PE 20091195 A1 PE20091195 A1 PE 20091195A1 PE 2008001894 A PE2008001894 A PE 2008001894A PE 2008001894 A PE2008001894 A PE 2008001894A PE 20091195 A1 PE20091195 A1 PE 20091195A1
Authority
PE
Peru
Prior art keywords
kinase inhibitors
combination
cell cycle
control point
point kinase
Prior art date
Application number
PE2008001894A
Other languages
English (en)
Inventor
Timothy J Guzi
David A Parry
Marc A Labroli
Michael P Dwyer
Kristin E Rosner
Ruichao Shen
Janeta Popovici-Muller
Kamil Paruch
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40351703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091195(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20091195A1 publication Critical patent/PE20091195A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE G ES H, HALO, ALQUILO; X, Y SON CADA UNO H, F, ALQUILO, OH, ENTRE OTROS; Z ES O, S, SO2, NH, ENTRE OTROS; R ES ALQUILO, CICLOALQUILO, ARILO, HETEROARILO, ALQUILHETEROCICLILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES A. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASA DE PUNTO DE CONTROL Chk1 Y Chk2 UTILES EN EL TRATAMIENTO DE CANCER, INFLAMACION, ARTRITIS, ENTRE OTROS
PE2008001894A 2007-11-07 2008-11-05 Nuevos moduladores de los puntos de control del ciclo celular y su uso en combinacion con inhibidores de quinasa de punto de control PE20091195A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98608907P 2007-11-07 2007-11-07

Publications (1)

Publication Number Publication Date
PE20091195A1 true PE20091195A1 (es) 2009-08-06

Family

ID=40351703

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001894A PE20091195A1 (es) 2007-11-07 2008-11-05 Nuevos moduladores de los puntos de control del ciclo celular y su uso en combinacion con inhibidores de quinasa de punto de control

Country Status (11)

Country Link
US (1) US8603998B2 (es)
EP (1) EP2217611B1 (es)
JP (1) JP2011503084A (es)
CN (1) CN101903396A (es)
AR (1) AR069198A1 (es)
CA (1) CA2705092A1 (es)
CL (1) CL2008003309A1 (es)
MX (1) MX2010005095A (es)
PE (1) PE20091195A1 (es)
TW (1) TW200927130A (es)
WO (1) WO2009061781A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8603998B2 (en) 2007-11-07 2013-12-10 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
KR20100095020A (ko) 2007-12-19 2010-08-27 암젠 인크 세포 주기 억제제로서의 융합된 피리딘, 피리미딘 및 트리아진 화합물
CA2711614A1 (en) 2008-01-08 2009-07-16 Array Biopharma Inc. Pyrrolopyridines as kinase inhibitors
ES2392014T3 (es) 2008-01-09 2012-12-03 Array Biopharma, Inc. Pirazolopiridinas como inhibidores de la cinasa
AU2009233951B2 (en) 2008-04-07 2014-02-27 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
AR071717A1 (es) 2008-05-13 2010-07-07 Array Biopharma Inc Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.
WO2010108140A1 (en) * 2009-03-20 2010-09-23 Alios Biopharma, Inc. Substituted nucleoside and nucleotide analogs
US8993535B2 (en) 2009-09-04 2015-03-31 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
WO2011090935A1 (en) * 2010-01-19 2011-07-28 Merck Sharp & Dohme Corp. PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS
MY161199A (en) 2011-03-23 2017-04-14 Amgen Inc Fused tricyclic dual inhibitors of cdk 4/6 and flt3
WO2013009737A1 (en) * 2011-07-13 2013-01-17 Merck Sharp & Dohme Corp. 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases
WO2014062454A1 (en) * 2012-10-15 2014-04-24 Merck Sharp & Dohme Corp. Compositions and methods for treating cancer
CA2890359A1 (en) * 2012-11-07 2014-05-15 Zucai SUO Substituted gemcitabine aryl amide analogs and treatment methods using same
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
US20180044368A1 (en) * 2015-02-25 2018-02-15 Ligand Pharmaceuticals, Inc. Gemcitabine derivatives
US10472364B2 (en) 2016-09-09 2019-11-12 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
US10570167B2 (en) 2016-12-22 2020-02-25 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
EP3618837A4 (en) 2017-04-26 2020-11-04 Thomas I. Kalman MULTI-DIRECTIONAL NUCLEOSIDE DERIVATIVES
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
CA3088287A1 (en) 2018-01-10 2019-07-18 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
WO2019246403A1 (en) 2018-06-21 2019-12-26 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
AU2020315394A1 (en) 2019-07-17 2022-02-17 Nucorion Pharmaceuticals, Inc. Cyclic deoxyribonucleotide compounds
US12428433B2 (en) * 2019-12-13 2025-09-30 Scinnohub Pharmaceutical Co., Ltd Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof
EP4143199B1 (en) 2020-04-21 2025-11-19 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
WO2024118503A1 (en) 2022-11-28 2024-06-06 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5168578A (ja) * 1974-12-10 1976-06-14 Mitsubishi Chem Ind Nukureoshidojudotaino seizoho
ATE92499T1 (de) 1984-12-04 1993-08-15 Lilly Co Eli Tumorbehandlung bei saeugetieren.
US6749988B2 (en) 2000-11-29 2004-06-15 Shin-Etsu Chemical Co., Ltd. Amine compounds, resist compositions and patterning process
US7521557B2 (en) 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
TWI421078B (zh) * 2005-10-06 2014-01-01 Merck Sharp & Dohme 關卡激酶抑制劑及其用途
ATE533770T1 (de) * 2005-10-06 2011-12-15 Schering Corp Pyrazolopyrimidine als proteinkinaseinhibitoren
AU2006315718B2 (en) * 2005-11-10 2012-10-04 Merck Sharp & Dohme Corp. Imidazopyrazines as protein kinase inhibitors
MX2008014824A (es) * 2006-05-22 2008-12-01 Schering Corp Pirazolo[1,5-a]pirimidinas como inhibidores de quinasas dependientes de ciclina.
US8603998B2 (en) 2007-11-07 2013-12-10 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
US8993535B2 (en) 2009-09-04 2015-03-31 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors

Also Published As

Publication number Publication date
EP2217611B1 (en) 2013-07-31
US20110183933A1 (en) 2011-07-28
AR069198A1 (es) 2010-01-06
MX2010005095A (es) 2010-08-03
WO2009061781A1 (en) 2009-05-14
TW200927130A (en) 2009-07-01
CN101903396A (zh) 2010-12-01
EP2217611A1 (en) 2010-08-18
CA2705092A1 (en) 2009-05-14
US8603998B2 (en) 2013-12-10
CL2008003309A1 (es) 2010-01-04
JP2011503084A (ja) 2011-01-27

Similar Documents

Publication Publication Date Title
PE20091195A1 (es) Nuevos moduladores de los puntos de control del ciclo celular y su uso en combinacion con inhibidores de quinasa de punto de control
PE20200387A1 (es) Proceso novedoso para la elaboracion de compuestos para su uso en el tratamiento del cancer
ECSP18094790A (es) Piridinas sustituidas con heteroarilo y métodos de uso referencia cruzada a solicitudes relacionadas
PE20190326A1 (es) Isoquinolin-3-il-carboxamidas y preparacion y uso de las mismas
SV2009002865A (es) Uso de oxazolidinonas para el tratamiento y profilaxis de microangiopatias
PE20141678A1 (es) Indazol-3-carboxamidas y su uso como inhibidores de la ruta de senalizacion de wnt/b-catenina
PE20150684A1 (es) Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr)
SG10201806965XA (en) 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer
MX384087B (es) Piperidinas como inhibidores de menina.
TN2015000175A1 (en) Heteroaryl substituted pyridyl compounds useful as kinase modulators
UY31148A1 (es) Compuestos de piperazina con accion herbicida (ii)
PE20180231A1 (es) Compuestos nucleosidos 5'-sustituidos
PE20151752A1 (es) Amidas heterociclicas como inhibidores de cinasas
CY1109911T1 (el) Πυρρολοβενζοδιαζεπινες
PE20130306A1 (es) Morfolinopirimidinas y su uso en terapia
PE20121087A1 (es) Compuestos antiproliferativos, conjugados de los mismos, procedimientos para estos, y usos de los mismos
PE20080928A1 (es) Derivados de anilinopiperazina como inhibidores de proteina quinasa
CO6491116A2 (es) Derivados de 5-fluoropirimidinona
PE20160523A1 (es) Derivados de arilo o heteroarilo como inhibidores de moleculas pequenas de fibrosis
ECSP10010058A (es) Derivados de quinazolinadiona, su preparación y sus aplicaciones terapéuticas
AR068538A1 (es) Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido
PE20152007A1 (es) Entidades quimicas
EA201170154A1 (ru) Производные пиридинопиридинонов, способ их получения и применение в терапии
UY31750A (es) Compuestos y composiciones como inhibidores de quinasa
PE20160689A1 (es) Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas

Legal Events

Date Code Title Description
FD Application declared void or lapsed