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PE20091085A1 - NUEVOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA E IMIDAZO[1,2-b]-PIRIDAZINA - Google Patents

NUEVOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA E IMIDAZO[1,2-b]-PIRIDAZINA

Info

Publication number
PE20091085A1
PE20091085A1 PE2008002052A PE2008002052A PE20091085A1 PE 20091085 A1 PE20091085 A1 PE 20091085A1 PE 2008002052 A PE2008002052 A PE 2008002052A PE 2008002052 A PE2008002052 A PE 2008002052A PE 20091085 A1 PE20091085 A1 PE 20091085A1
Authority
PE
Peru
Prior art keywords
imidazo
pyridazin
pyridin
pyridazine
aryl
Prior art date
Application number
PE2008002052A
Other languages
English (en)
Inventor
Noal James Dewdney
Yan Lou
Michael Soth
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40428199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091085(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20091085A1 publication Critical patent/PE20091085A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA E IMIDAZO[1,2-b]-PIRIDAZINA DE FORMULA (X) DONDE Z ES C O N; R* ES H, -R1, -R1-R2-R3, -R1-R3 O -R2-R3, EN DONDE R1 ES ARILO, HETEROARILO, CICLOALQUILO, ENTRE OTROS; R2 ES -C(=O), -C(=O)O, -C(=O)NH, ENTRE OTROS; R3 ES H O R4, DONDE R4 ES ALQUILO INFERIOR, ALCOXI INFERIOR, ARILO, ENTRE OTROS; R** ES (I*) O (II*), EN DONDE Q ES PIRROLILO, CICLOALQUILO O CICLOALQUENILO; X ES H, HALOGENO, ALQUILO INFERIOR, OH, ENTRE OTROS; Y ES H, -R5-R6, -R6, ENTRE OTROS, DONDE R5 ES -NHC(=O), -NH, -(CH2)n-C(=O), ENTRE OTROS, DONDE n ES DE 0 A 2; R6 ES ALQUILO INFERIOR, ARILO, ARILALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (6-FENIL-IMIDAZO[1,2-b]PIRIDAZIN-8-IL)-PIRIDIN-2-IL-AMINA, [6-(1-METIL-1H-PIRROL-2-IL)-IMIDAZO[1,2-b]PIRIDAZIN-8-IL]-PIRIDIN-2-IL-AMINA, (6-CICLOHEX-1-ENIL-IMIDAZO[1,2-b]-PIRIDAZIN-8-IL)-PIRIDIN-2-IL-AMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA-QUINASA DE BRUTON (Btk) SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES AUTOINMUNES E INFLAMATORIAS TAL COMO ARTRITIS
PE2008002052A 2007-12-14 2008-12-11 NUEVOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA E IMIDAZO[1,2-b]-PIRIDAZINA PE20091085A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1376207P 2007-12-14 2007-12-14

Publications (1)

Publication Number Publication Date
PE20091085A1 true PE20091085A1 (es) 2009-07-23

Family

ID=40428199

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002052A PE20091085A1 (es) 2007-12-14 2008-12-11 NUEVOS DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA E IMIDAZO[1,2-b]-PIRIDAZINA

Country Status (10)

Country Link
EP (1) EP2229390B1 (es)
JP (2) JP5643105B2 (es)
CN (1) CN101952283B (es)
AR (1) AR069666A1 (es)
CA (1) CA2708361C (es)
CL (1) CL2008003698A1 (es)
ES (1) ES2462642T3 (es)
PE (1) PE20091085A1 (es)
TW (1) TW200930720A (es)
WO (1) WO2009077334A1 (es)

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Also Published As

Publication number Publication date
EP2229390A1 (en) 2010-09-22
TW200930720A (en) 2009-07-16
WO2009077334A1 (en) 2009-06-25
CA2708361C (en) 2016-06-07
JP2011506378A (ja) 2011-03-03
CA2708361A1 (en) 2009-06-25
CN101952283A (zh) 2011-01-19
CN101952283B (zh) 2013-04-17
JP5643105B2 (ja) 2014-12-17
ES2462642T3 (es) 2014-05-26
EP2229390B1 (en) 2014-04-09
JP5871992B2 (ja) 2016-03-01
AR069666A1 (es) 2010-02-10
CL2008003698A1 (es) 2010-02-19
JP2014196316A (ja) 2014-10-16

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