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PE20091963A1 - Anticuerpos anti-flt3 - Google Patents

Anticuerpos anti-flt3

Info

Publication number
PE20091963A1
PE20091963A1 PE2009000733A PE2009000733A PE20091963A1 PE 20091963 A1 PE20091963 A1 PE 20091963A1 PE 2009000733 A PE2009000733 A PE 2009000733A PE 2009000733 A PE2009000733 A PE 2009000733A PE 20091963 A1 PE20091963 A1 PE 20091963A1
Authority
PE
Peru
Prior art keywords
seq
sequence
human
flt3
seqgsyinpsk
Prior art date
Application number
PE2009000733A
Other languages
English (en)
Inventor
Yiwen Li
Dan Lu
David Surguladze
James R Tonra
Original Assignee
Imclone Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41092183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091963(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imclone Llc filed Critical Imclone Llc
Publication of PE20091963A1 publication Critical patent/PE20091963A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

REFERIDA A UN ANTICUERPO QUE ENLAZA ESPECIFICAMENTE EL FLT3 HUMANO (RECEPTOR TIROSINA CINASA 3 TIPO Fms HUMANO) (SEC ID NO. 43) QUE COMPRENDE CDRH1 QUE TIENE LA SECUENCIA SYYMH (SEQ ID NO:2), UN CDRH2 DE SECUENCIA IINPSGGSTSYAQKFQG (SEQ ID NO:3), UN CDRH3 DE SECUENCIA GVGAHDAFDI (SEQ ID NO:4) O VVAAAVADY (SEQ ID NO:5), UN CDRL1 DE SECUENCIA RSSQSLLHSNGNNYLD (SEQ ID NO:6) O RSSQSLLHSNGYNYLD (SEQ ID NO:7), UN CDRL2 DE SECUENCIA LGSNRAS (SEQ ID NO:8) Y UN CDRL3 DE SECUENCIA MQGTHPAIS (SEQ ID NO:9) O MQSLQTPFT (SEQ ID NO:11). TAMBIEN ESTA REFERIDA A UN VECTOR, UNA CELULA RECOMBINANTEUN ACIDO POLINUCLEICO AISLADO Y A UNA COMPOSICION FARMACEUTICA QUE ADEMAS PUEDE CONTENER UN AGENTE ANTI-CANCER TAL COMO METOTREXATO
PE2009000733A 2008-05-30 2009-05-25 Anticuerpos anti-flt3 PE20091963A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13053908P 2008-05-30 2008-05-30
US13039408P 2008-05-30 2008-05-30
US13039508P 2008-05-30 2008-05-30

Publications (1)

Publication Number Publication Date
PE20091963A1 true PE20091963A1 (es) 2010-01-15

Family

ID=41092183

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000733A PE20091963A1 (es) 2008-05-30 2009-05-25 Anticuerpos anti-flt3

Country Status (18)

Country Link
US (3) US20110091470A1 (es)
EP (1) EP2300500A1 (es)
JP (1) JP2011521647A (es)
KR (1) KR20110004455A (es)
CN (1) CN102046659A (es)
AR (1) AR071891A1 (es)
AU (1) AU2009260517B2 (es)
BR (1) BRPI0912173A2 (es)
CA (1) CA2726522A1 (es)
CL (1) CL2009001277A1 (es)
EA (1) EA201071421A1 (es)
IL (1) IL209142A0 (es)
MX (1) MX2010013144A (es)
NZ (1) NZ588791A (es)
PE (1) PE20091963A1 (es)
TW (1) TWI374032B (es)
WO (1) WO2009155015A1 (es)
ZA (1) ZA201008024B (es)

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Also Published As

Publication number Publication date
EP2300500A1 (en) 2011-03-30
NZ588791A (en) 2012-05-25
MX2010013144A (es) 2010-12-21
TW201010722A (en) 2010-03-16
CA2726522A1 (en) 2009-12-23
AU2009260517A1 (en) 2009-12-23
TWI374032B (en) 2012-10-11
BRPI0912173A2 (pt) 2016-07-26
KR20110004455A (ko) 2011-01-13
CN102046659A (zh) 2011-05-04
US8071099B2 (en) 2011-12-06
CL2009001277A1 (es) 2010-10-08
IL209142A0 (en) 2011-01-31
JP2011521647A (ja) 2011-07-28
US20110008355A1 (en) 2011-01-13
AU2009260517B2 (en) 2012-12-06
WO2009155015A1 (en) 2009-12-23
US20090297529A1 (en) 2009-12-03
ZA201008024B (en) 2012-04-25
AR071891A1 (es) 2010-07-21
EA201071421A1 (ru) 2011-08-30
US20110091470A1 (en) 2011-04-21

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