PE20091825A1 - Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 - Google Patents
Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3Info
- Publication number
- PE20091825A1 PE20091825A1 PE2009000460A PE2009000460A PE20091825A1 PE 20091825 A1 PE20091825 A1 PE 20091825A1 PE 2009000460 A PE2009000460 A PE 2009000460A PE 2009000460 A PE2009000460 A PE 2009000460A PE 20091825 A1 PE20091825 A1 PE 20091825A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- methyl
- hydroxy
- hydroximethyl
- pyrrolidines
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE HIDROXIMETIL PIRROLIDINAS DE FORMULA (Ia), DONDE Y ES ALCANODIILO(C1-C5), ALQUENODIILO(C2-C5), UN ENLACE, FENILO SUSTITUIDO O NO, ENTRE OTROS; Z ES FENILO, ANILLO DE BENCENO CONDENSADO CON ANILLO CARBOCICLICO C5-C10, ANILLO HETEROCICLICO DE 5-6 MIEMBROS CON 1-4 HETROATOMOS DE O, S, N, ENTRE OTROS; R3 ES -CN, OXO, ALQUILO C1-C6 SUSTITUIDO O NO, ENTRE OTROS; n ES DE 0-5. SON COMPUESTOS SELECCIONADOS: 2-(2-AMINO-1,3-TIAZOL-4-IL)-N-[4-({(5R)-[(R)-HIDROXI(FENIL)METIL]PIRROLIDINIL}METIL)FENIL]ACETAMIDA; 2-(2-AMINO-1,3-TIAZOL-4-IL)-N-[4-({(2S,5R)-[(R)-HIDROXI(FENIL)METIL]PIRROLIDINIL}METIL)FENIL]ACETAMIDA; N-(4-(((2S,5R)-5-((R)-HIDROXI(FENIL)METIL)PIRROLIDIN-2-IL)METIL)FENIL)-2-(3-METIL-1H-1,2,4-TRIAZOL-1-IL)PROPANAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR ADRENERGICO BETA 3 SIENDO UTILES EN EL TRATAMIENTO DE VEJIGA SOBREACTIVA, INCONTINENCIA URINARIA, URGENCIA URINARIA, ENTRE OTROS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12306308P | 2008-04-04 | 2008-04-04 | |
| US20604309P | 2009-01-27 | 2009-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091825A1 true PE20091825A1 (es) | 2009-12-04 |
Family
ID=40671093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000460A PE20091825A1 (es) | 2008-04-04 | 2009-03-27 | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
Country Status (41)
Families Citing this family (66)
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| US4891872A (en) | 1988-05-09 | 1990-01-09 | Sussman Martin V | Apparatus for incrementally drawing fibers |
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| EP2470012B1 (en) * | 2009-08-27 | 2014-11-05 | Merck Sharp & Dohme Corp. | Novel pyrrolidine derived beta 3 adrenergic receptor agonists |
| NZ599233A (en) * | 2009-10-07 | 2013-04-26 | Merck Sharp & Dohme | Combination therapy using a beta 3 adrenergic receptor agonist and an antimuscarinic agent |
| WO2011137054A1 (en) | 2010-04-30 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel beta 3 adrenergic receptor agonists |
| CA2805427A1 (en) | 2010-07-23 | 2012-01-26 | Merck Sharp & Dohme Corp. | Novel pyrrolidine derived beta 3 adrenergic receptor agonists |
| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
| PH12013500221A1 (en) * | 2010-08-03 | 2017-08-23 | Altherx Inc | Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder |
| US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
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| US20150087832A1 (en) * | 2011-10-27 | 2015-03-26 | Merck Sharp & Dohme, Corp. | Process for making beta 3 agonists and intermediates |
| IN2014CN04470A (es) | 2011-11-18 | 2015-09-04 | Codexis Inc | |
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| JP2015178458A (ja) * | 2012-07-25 | 2015-10-08 | 杏林製薬株式会社 | ベンゼン環縮合含窒素５員複素環式化合物、またはその薬理学的に許容される塩 |
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| MX365950B (es) * | 2013-03-13 | 2019-06-19 | Flatley Discovery Lab Llc | Compuestos de piridazinona y metodos para el tratamiento de la fibrosis quistica. |
| DK2968269T3 (da) * | 2013-03-15 | 2019-10-07 | Merck Sharp & Dohme | Fremgangsmåde til fremstilling af beta-3-agonister og mellemprodukter |
| CN103232352B (zh) * | 2013-05-11 | 2015-12-23 | 苏州永健生物医药有限公司 | (r)-4-(2-(2-羟基-2-苯乙胺基)乙基)苯胺基甲酸叔丁基酯 |
| CN103760286A (zh) * | 2014-01-14 | 2014-04-30 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法测定琥珀酸索非那新中间体光学纯度的方法 |
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| IL310527A (en) | 2015-10-23 | 2024-03-01 | B3Ar Therapeutics Inc | Zwitterion solvegron and its uses |
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| EP4325281A3 (en) | 2019-07-02 | 2024-03-27 | RealD Spark, LLC | Directional display apparatus |
| US11294233B2 (en) | 2019-08-23 | 2022-04-05 | ReaID Spark, LLC | Directional illumination apparatus and privacy display |
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| US11016341B2 (en) | 2019-09-11 | 2021-05-25 | Reald Spark, Llc | Directional illumination apparatus and privacy display |
| WO2021067639A1 (en) | 2019-10-03 | 2021-04-08 | Reald Spark, Llc | Illumination apparatus comprising passive optical nanostructures |
| KR20220077914A (ko) | 2019-10-03 | 2022-06-09 | 리얼디 스파크, 엘엘씨 | 수동형 광학 나노구조를 포함하는 조명 장치 |
| WO2021168090A1 (en) | 2020-02-20 | 2021-08-26 | Reald Spark, Llc | Illumination and display apparatus |
| CA3189771A1 (en) * | 2020-07-22 | 2022-01-27 | Janssen Pharmaceutica Nv | Compounds useful as factor xia inhibitors |
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| US12158602B2 (en) | 2021-06-22 | 2024-12-03 | Reald Spark, Llc | Illumination apparatus |
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| US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| DOP2003000587A (es) | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
| BR0316080A (pt) * | 2002-11-07 | 2005-09-27 | Astellas Pharma Inc | Remédio para bexiga superativa compreendendo derivado de ácido acético anildo como o ingrediente ativo |
| FR2874011B1 (fr) * | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| PE20091825A1 (es) | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
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2009
- 2009-03-27 PE PE2009000460A patent/PE20091825A1/es active IP Right Grant
- 2009-03-30 AR ARP090101127A patent/AR072043A1/es active IP Right Grant
- 2009-04-02 JP JP2010543320A patent/JP4783867B2/ja active Active
- 2009-04-02 PT PT09726601T patent/PT2276756E/pt unknown
- 2009-04-02 KR KR1020107024750A patent/KR101331771B1/ko active Active
- 2009-04-02 BR BRPI0909768-6A patent/BRPI0909768B1/pt active IP Right Grant
- 2009-04-02 EP EP09726601A patent/EP2276756B9/en active Active
- 2009-04-02 US US12/417,239 patent/US8247415B2/en active Active
- 2009-04-02 CA CA2719876A patent/CA2719876C/en active Active
- 2009-04-02 EA EA201071169A patent/EA020135B1/ru not_active IP Right Cessation
- 2009-04-02 GE GEAP200911992A patent/GEP20125666B/en unknown
- 2009-04-02 HR HRP20120129AT patent/HRP20120129T2/hr unknown
- 2009-04-02 WO PCT/US2009/039253 patent/WO2009124167A1/en not_active Ceased
- 2009-04-02 SG SG2013017736A patent/SG188883A1/en unknown
- 2009-04-02 RS RS20120042A patent/RS52175B/sr unknown
- 2009-04-02 AU AU2009231714A patent/AU2009231714B2/en active Active
- 2009-04-02 PL PL09726601T patent/PL2276756T3/pl unknown
- 2009-04-02 CN CN201110265670.2A patent/CN102391255B/zh active Active
- 2009-04-02 KR KR1020127015876A patent/KR101288798B1/ko not_active Expired - Fee Related
- 2009-04-02 ME MEP-2012-549A patent/ME01988B/me unknown
- 2009-04-02 SI SI200930188T patent/SI2276756T1/sl unknown
- 2009-04-02 ES ES09726601T patent/ES2376278T3/es active Active
- 2009-04-02 WO PCT/US2009/039249 patent/WO2009124166A1/en not_active Ceased
- 2009-04-02 NZ NZ588266A patent/NZ588266A/en unknown
- 2009-04-02 US US12/936,221 patent/US8399480B2/en active Active
- 2009-04-02 AT AT09726601T patent/ATE535521T1/de active
- 2009-04-02 KR KR1020127026256A patent/KR20120118086A/ko not_active Withdrawn
- 2009-04-02 MX MX2010010929A patent/MX2010010929A/es active IP Right Grant
- 2009-04-02 CN CN200980121149.2A patent/CN102056917B/zh active Active
- 2009-04-03 CL CL2009000815A patent/CL2009000815A1/es unknown
- 2009-04-03 TW TW098111302A patent/TWI378098B/zh active
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2010
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- 2010-09-16 IL IL208215A patent/IL208215A/en active IP Right Grant
- 2010-09-20 ZA ZA2010/06720A patent/ZA201006720B/en unknown
- 2010-09-30 HN HN2010002030A patent/HN2010002030A/es unknown
- 2010-09-30 SV SV2010003687A patent/SV2010003687A/es unknown
- 2010-10-01 DO DO2010000294A patent/DOP2010000294A/es unknown
- 2010-10-01 NI NI201000164A patent/NI201000164A/es unknown
- 2010-10-04 EC EC2010010518A patent/ECSP10010518A/es unknown
- 2010-10-04 CO CO10122821A patent/CO6331440A2/es active IP Right Grant
- 2010-10-22 CR CR11751A patent/CR11751A/es unknown
- 2010-10-29 MA MA33292A patent/MA32257B1/fr unknown
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2011
- 2011-05-13 JP JP2011107738A patent/JP4783870B1/ja active Active
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2012
- 2012-02-29 CY CY20121100209T patent/CY1112552T1/el unknown
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- 2012-06-20 US US13/527,934 patent/US8653260B2/en active Active
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2013
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