PE20090964A1 - Derivados de pirrolo[2,3-d]pirimidina como inhibidores de proteina quinasa b - Google Patents
Derivados de pirrolo[2,3-d]pirimidina como inhibidores de proteina quinasa bInfo
- Publication number
- PE20090964A1 PE20090964A1 PE2008001748A PE2008001748A PE20090964A1 PE 20090964 A1 PE20090964 A1 PE 20090964A1 PE 2008001748 A PE2008001748 A PE 2008001748A PE 2008001748 A PE2008001748 A PE 2008001748A PE 20090964 A1 PE20090964 A1 PE 20090964A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- protein kinase
- pyrolo
- pyrimidine derivatives
- pyrrolo
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 239000003197 protein kinase B inhibitor Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 1- (4-CHLOROPHENYL) ETHYL Chemical class 0.000 abstract 2
- 108091008611 Protein Kinase B Proteins 0.000 abstract 2
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 abstract 2
- HKSQZEGSMBFHGC-UHFFFAOYSA-N pyrimidine-4-carboxamide Chemical compound NC(=O)C1=CC=NC=N1 HKSQZEGSMBFHGC-UHFFFAOYSA-N 0.000 abstract 2
- DPBWFNDFMCCGGJ-UHFFFAOYSA-N 4-Piperidine carboxamide Chemical compound NC(=O)C1CCNCC1 DPBWFNDFMCCGGJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Y ES CH, N; Z1-Z2 ES C(R6)=CH, N=CH, C(R6)=N; R6 ES H, F, Cl, CIANO, ENTRE OTROS; n ES 0-2; R1 ES ALQUILO C1-C4, ALCOXI C1-C4, METOCIALQUILO C1-C4, CICLOALQUILO C3-C6, ENTRE OTROS; R4 ES H, F, Cl, CIANO, CF3, Br; R5 ES H, F, Cl, Br. SON COMPUESTOS PREFERIDOS:4-AMINO-N-(1-(4-CLOROFENIL)ETIL)-1-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)PIPERIDINA-4-CARBOXAMIDA; (S)-4-AMINO-N-(1-(4-CLOROFENIL)PROPIL)-1-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)PIRIMIDINA-4-CARBOXAMIDA; (R)-4-AMINO-N-(1-(4-CLOROFENIL)-4-HIDROXIBUTIL)-1-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)PIRIMIDINA-4-CARBOXAMIDA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA U UN PROCESO. DICHOS COMPUESTOS SON INHIBIDORES DE PKB (PROTEINA QUINASA B) UTILES EN EL TRATAMIENTO DE CANCER
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97919207P | 2007-10-11 | 2007-10-11 | |
| US4786208P | 2008-04-25 | 2008-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090964A1 true PE20090964A1 (es) | 2009-08-15 |
Family
ID=40251789
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001748A PE20090964A1 (es) | 2007-10-11 | 2008-10-10 | Derivados de pirrolo[2,3-d]pirimidina como inhibidores de proteina quinasa b |
| PE2012002041A PE20130152A1 (es) | 2007-10-11 | 2008-10-10 | Derivados de heterociclo biciclicos como inhibidores de proteina quinasa b |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012002041A PE20130152A1 (es) | 2007-10-11 | 2008-10-10 | Derivados de heterociclo biciclicos como inhibidores de proteina quinasa b |
Country Status (43)
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