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PE20090948A1 - Inhibidor de la proteina activadora de la 5-lipoxigenasa (flap) - Google Patents

Inhibidor de la proteina activadora de la 5-lipoxigenasa (flap)

Info

Publication number
PE20090948A1
PE20090948A1 PE2008001818A PE2008001818A PE20090948A1 PE 20090948 A1 PE20090948 A1 PE 20090948A1 PE 2008001818 A PE2008001818 A PE 2008001818A PE 2008001818 A PE2008001818 A PE 2008001818A PE 20090948 A1 PE20090948 A1 PE 20090948A1
Authority
PE
Peru
Prior art keywords
flap
activating protein
lipoxygenase activating
refers
protein inhibitor
Prior art date
Application number
PE2008001818A
Other languages
English (en)
Inventor
Melissa Virginia Rewolinski
Kevin Murray Schaab
Christopher David King
Jillian F Evans
Petpiboon Peppi Prasit
John Howard Hutchinson
Nicholas Simon Stock
Original Assignee
Amira Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amira Pharmaceuticals Inc filed Critical Amira Pharmaceuticals Inc
Publication of PE20090948A1 publication Critical patent/PE20090948A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE: A) UN INHIBIDOR DE LA PROTEINA ACTIVADORA DE LA 5-LIPOXIGENASA (FLAP) TAL COMO UN ACIDO 3-[5-(PIRIDIN-2-ILMETOXI)-3-(2-METIL-2-PROPILTIO)-1-[4-(2-METOXIPIRIDIN-5-IL)BENCIL]-INDOL-2-IL]-2,2-DIMETIL-PROPIONICO, O UNA SAL DE SODIO DEL MISMO COMPUESTO QUE SE ENCUENTRA EN FORMA AMORFA O CRISTALINA QUE SE ENCUENTRA EN UNA CANTIDAD DE 50MG A 1000MG EN LA COMPOSICION; B) UN INGREDIENTE INACTIVO TAL COMO CELULOSA MICROCRISTALINA SILICIFICADA, MANITOL, CROSPOVIDONA, ESTEARATO DE MAGNESIO; C) UN EDULCORANTE TAL COMO ASPARTAMO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DEL COMPUESTO ACTIVO. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE ASMA, RINITIS ALERGICA, FIBROSIS PULMONAR
PE2008001818A 2007-10-26 2008-10-23 Inhibidor de la proteina activadora de la 5-lipoxigenasa (flap) PE20090948A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98312407P 2007-10-26 2007-10-26
US98311907P 2007-10-26 2007-10-26

Publications (1)

Publication Number Publication Date
PE20090948A1 true PE20090948A1 (es) 2009-07-27

Family

ID=40580422

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001818A PE20090948A1 (es) 2007-10-26 2008-10-23 Inhibidor de la proteina activadora de la 5-lipoxigenasa (flap)

Country Status (17)

Country Link
US (1) US8697730B2 (es)
EP (1) EP2212312A4 (es)
JP (1) JP2011500846A (es)
KR (1) KR20100080561A (es)
CN (1) CN101910154A (es)
AR (1) AR068947A1 (es)
AU (1) AU2008316615A1 (es)
BR (1) BRPI0818831A2 (es)
CA (1) CA2702798A1 (es)
CL (1) CL2008003181A1 (es)
EA (1) EA201000486A1 (es)
MX (1) MX2010004501A (es)
PE (1) PE20090948A1 (es)
TW (1) TW200920369A (es)
UY (1) UY31431A1 (es)
WO (1) WO2009055721A2 (es)
ZA (1) ZA201002692B (es)

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GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
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KR101137929B1 (ko) * 2010-05-31 2012-05-09 에스케이하이닉스 주식회사 비휘발성 메모리 장치 및 그 제조 방법
WO2014031586A2 (en) * 2012-08-20 2014-02-27 Tallikut Pharmaceuticals, Inc. Methods for treating cardiovascular diseases
WO2014204511A2 (en) 2013-06-18 2014-12-24 Isonea Limited Compliance monitoring for asthma inhalers
CN105722834B (zh) 2013-12-13 2017-12-22 豪夫迈·罗氏有限公司 酪氨酸蛋白激酶抑制剂
WO2015086635A1 (en) 2013-12-13 2015-06-18 F. Hoffmann-La Roche Ag Inhibitors of bruton's tyrosine kinase
RU2648236C2 (ru) 2013-12-13 2018-03-23 Ф. Хоффманн-Ля Рош Аг Ингибиторы тирозинкиназы брутона
CN106456624B (zh) 2014-02-04 2020-05-22 生物制药合伙公司 Flap抑制剂的降低中枢神经系统内的神经炎症介导的损伤的应用
KR102589056B1 (ko) * 2015-12-08 2023-10-12 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
CN112126986B (zh) * 2020-04-30 2023-07-18 苏州京脉生物科技有限公司 一种定量miRNA的测序文库制备和分析方法
CN115267002A (zh) * 2022-08-08 2022-11-01 江苏慧聚药业股份有限公司 Gc-ms/ms联用测定醰露替尼中游离肼的方法
CN117665187B (zh) * 2023-11-23 2024-08-16 宁波大红鹰药业股份有限公司 一种舒林酸中间体杂质的测定方法

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