PE20090505A1 - Proceso para preparar oxazolidina- y oxazolidinona-aminodioles - Google Patents
Proceso para preparar oxazolidina- y oxazolidinona-aminodiolesInfo
- Publication number
- PE20090505A1 PE20090505A1 PE2008001251A PE2008001251A PE20090505A1 PE 20090505 A1 PE20090505 A1 PE 20090505A1 PE 2008001251 A PE2008001251 A PE 2008001251A PE 2008001251 A PE2008001251 A PE 2008001251A PE 20090505 A1 PE20090505 A1 PE 20090505A1
- Authority
- PE
- Peru
- Prior art keywords
- oxazolidine
- compound
- prepare
- methylsulfonil
- hydroximethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 AMINODIOL COMPOUND Chemical class 0.000 abstract 3
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
REFERIDA PROCESO PARA PREPARAR COMPUESTO DE AMINODIOL DE FORMULA (VI) QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (VII), DONDE R1 ES H, METILO, METILSULFOXI, ENTRE OTROS; R2, R3 Y R4 SON CADA UNO H, ALQUILO (C1-C9), CICLOALQUILO (C3-C8), ENTRE OTROS CON UN SOLVENTE FORMADOR DE AXOZOLIDINA; B) ADICIONAR UN COMPUESTO DE OXAZOLIDINA Y UN COMPUESTO PROMOTOR DE OXAZOLIDINA A LA MEZCLA DE REACCION. UN COMPUESTO OBTENIDO ES: 3-(DICLOROACETIL)-4(R)-(HIDROXIMETIL)-2,2.DIMETIL-5(R)-[4-(METILSULFONIL)FENIL]OXAZOLIDINA; 3-(DICLOROACETIL)-4(R)-(HIDROXIMETIL)-2,2-DIEMETIL-5(R)-[4-METILSULFONIL)FENIL] OXAZOLIDINA; ENTRE OTROS. TAMBIEN SE REFIERE UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INTERMEDIARIOS PARA ELABORAR FLORFENICOL, SIENDO UN PROCESO EFICIENTE Y CON MENORES COSTOS UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95181607P | 2007-07-25 | 2007-07-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090505A1 true PE20090505A1 (es) | 2009-04-29 |
Family
ID=40019364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001251A PE20090505A1 (es) | 2007-07-25 | 2008-07-23 | Proceso para preparar oxazolidina- y oxazolidinona-aminodioles |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100210851A1 (es) |
| EP (1) | EP2173726A2 (es) |
| JP (1) | JP2010534667A (es) |
| KR (1) | KR20100046217A (es) |
| CN (1) | CN101796037A (es) |
| AR (1) | AR068325A1 (es) |
| AU (1) | AU2008279308A1 (es) |
| BR (1) | BRPI0814581A2 (es) |
| CA (1) | CA2693922A1 (es) |
| CL (1) | CL2008002174A1 (es) |
| PE (1) | PE20090505A1 (es) |
| RU (1) | RU2010106607A (es) |
| TW (1) | TW200925153A (es) |
| WO (1) | WO2009015111A2 (es) |
| ZA (1) | ZA201000397B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200505425A (en) * | 2003-05-29 | 2005-02-16 | Schering Plough Ltd | Compositions and method for treating infection in cattle and swine |
| WO2008076256A1 (en) * | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
| US8314252B2 (en) | 2008-07-30 | 2012-11-20 | Intervet Inc. | Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol |
| MX2013012820A (es) | 2011-05-02 | 2014-02-10 | Zoetis Llc | Cefalosporinas novedosas utiles como agentes antibacteriales. |
| CN108299330B (zh) * | 2018-02-06 | 2021-02-12 | 桂林医学院 | 去氢枞酸噁唑烷酮衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5105009A (en) * | 1983-06-02 | 1992-04-14 | Zambon S.P.A. | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives |
| IT1237798B (it) * | 1989-10-20 | 1993-06-17 | Zambon Spa | Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). |
| IT1249048B (it) * | 1991-02-21 | 1995-02-11 | Zambon Spa | Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite |
| US5663361A (en) * | 1996-08-19 | 1997-09-02 | Schering Corporation | Process for preparing intermediates to florfenicol |
| US7126005B2 (en) * | 2003-10-06 | 2006-10-24 | Aurobindo Pharma Limited | Process for preparing florfenicol |
| JP5113754B2 (ja) * | 2005-09-07 | 2013-01-09 | シェーリング−プラウ・リミテッド | エステルオキサゾリジン化合物を調製するためのプロセスおよびそれらのフロルフェニコールへの変換 |
-
2008
- 2008-07-22 JP JP2010518325A patent/JP2010534667A/ja not_active Withdrawn
- 2008-07-22 CA CA2693922A patent/CA2693922A1/en not_active Abandoned
- 2008-07-22 WO PCT/US2008/070696 patent/WO2009015111A2/en not_active Ceased
- 2008-07-22 CN CN200880100313A patent/CN101796037A/zh active Pending
- 2008-07-22 EP EP08796389A patent/EP2173726A2/en not_active Withdrawn
- 2008-07-22 AU AU2008279308A patent/AU2008279308A1/en not_active Abandoned
- 2008-07-22 US US12/669,645 patent/US20100210851A1/en not_active Abandoned
- 2008-07-22 BR BRPI0814581A patent/BRPI0814581A2/pt not_active IP Right Cessation
- 2008-07-22 RU RU2010106607/04A patent/RU2010106607A/ru not_active Application Discontinuation
- 2008-07-22 KR KR1020107003970A patent/KR20100046217A/ko not_active Withdrawn
- 2008-07-23 AR ARP080103191A patent/AR068325A1/es not_active Application Discontinuation
- 2008-07-23 PE PE2008001251A patent/PE20090505A1/es not_active Application Discontinuation
- 2008-07-24 TW TW097128165A patent/TW200925153A/zh unknown
- 2008-07-24 CL CL2008002174A patent/CL2008002174A1/es unknown
-
2010
- 2010-01-19 ZA ZA201000397A patent/ZA201000397B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200925153A (en) | 2009-06-16 |
| WO2009015111A3 (en) | 2009-03-26 |
| AR068325A1 (es) | 2009-11-11 |
| JP2010534667A (ja) | 2010-11-11 |
| CA2693922A1 (en) | 2009-01-29 |
| KR20100046217A (ko) | 2010-05-06 |
| CN101796037A (zh) | 2010-08-04 |
| CL2008002174A1 (es) | 2008-11-21 |
| US20100210851A1 (en) | 2010-08-19 |
| RU2010106607A (ru) | 2011-08-27 |
| AU2008279308A1 (en) | 2009-01-29 |
| WO2009015111A8 (en) | 2010-03-04 |
| EP2173726A2 (en) | 2010-04-14 |
| BRPI0814581A2 (pt) | 2017-05-09 |
| ZA201000397B (en) | 2010-09-29 |
| WO2009015111A2 (en) | 2009-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |