PE20090496A1 - Derivados de espirociclopentano como antagonistas del receptor h1 - Google Patents
Derivados de espirociclopentano como antagonistas del receptor h1Info
- Publication number
- PE20090496A1 PE20090496A1 PE2008001269A PE2008001269A PE20090496A1 PE 20090496 A1 PE20090496 A1 PE 20090496A1 PE 2008001269 A PE2008001269 A PE 2008001269A PE 2008001269 A PE2008001269 A PE 2008001269A PE 20090496 A1 PE20090496 A1 PE 20090496A1
- Authority
- PE
- Peru
- Prior art keywords
- spirocyclopentane
- dibenzo
- alkyl
- antagonists
- receptor
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 5 ', 11'-DIHYDROSPIRO [CYCLOPENTAN-1,10'-DIBENZO [a, d] CYCLOHEPTEN] Chemical compound 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/94—Spiro compounds containing "free" spiro atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS DE ESPIROCICLOPENTANO DE FORMULA (I) DONDE X ES CH2, C=O, O O S; R1 ES ALQUILO(C1-C4), ALCOXI(C1-C4) O HALOGENO; R2 ES ALQUILO(C1-C4), ALCOXI(C1-C4) O HALOGENO; R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6), CARBOXIALQUILO(C1-C6), ENTRE OTROS; R5 ES H U OXO; n ES DE 0 A 2; m ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: SAL FORMIATO DE N-(5',11'-DIHIDROESPIRO[CICLOPENTANO-1,10'-DIBENZO[a,d]CICLOHEPTEN]-3-IL)-b-ALANINA, ACIDO (-) 1-(5',11'-DIHIDROESPIRO[CICLOPENTANO-1,10'-DIBENZO[a,d]CICLOHEPTEN]-3-IL)-4-PIPERIDINACARBOXILICO, ACIDO 1-(2'-FLUORO-11'-OXO-11'H-ESPIRO[CICLOPENTANO-1,10'-DIBENZO[b,f]TIEPIN]-3-IL)-4-PIPERIDINACARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR H1 SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SUENO
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0714712A GB0714712D0 (en) | 2007-07-27 | 2007-07-27 | Novel compounds |
| GB0723318A GB0723318D0 (en) | 2007-11-28 | 2007-11-28 | Novel compounds |
| GB0806289A GB0806289D0 (en) | 2008-04-07 | 2008-04-07 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090496A1 true PE20090496A1 (es) | 2009-05-30 |
Family
ID=39956342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001269A PE20090496A1 (es) | 2007-07-27 | 2008-07-25 | Derivados de espirociclopentano como antagonistas del receptor h1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100190764A1 (es) |
| EP (1) | EP2178823A1 (es) |
| JP (1) | JP2010534704A (es) |
| AR (1) | AR067689A1 (es) |
| CL (1) | CL2008002195A1 (es) |
| PE (1) | PE20090496A1 (es) |
| TW (1) | TW200914010A (es) |
| WO (1) | WO2009016084A1 (es) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4198418A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Spiro[dibenz(b,f)oxepin-piperidine]s |
| US4198420A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Spiro[dibenz(b,f)thiepin-piperidine]s |
| US6806283B2 (en) * | 2002-05-06 | 2004-10-19 | Virginia Commonwealth University | Selective serotonin receptor antagonists and therapeutic applications thereof |
-
2008
- 2008-07-24 JP JP2010518623A patent/JP2010534704A/ja active Pending
- 2008-07-24 WO PCT/EP2008/059682 patent/WO2009016084A1/en not_active Ceased
- 2008-07-24 EP EP08786374A patent/EP2178823A1/en not_active Withdrawn
- 2008-07-24 US US12/670,712 patent/US20100190764A1/en not_active Abandoned
- 2008-07-25 AR ARP080103234A patent/AR067689A1/es unknown
- 2008-07-25 CL CL2008002195A patent/CL2008002195A1/es unknown
- 2008-07-25 PE PE2008001269A patent/PE20090496A1/es not_active Application Discontinuation
- 2008-07-25 TW TW097128221A patent/TW200914010A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR067689A1 (es) | 2009-10-21 |
| CL2008002195A1 (es) | 2009-01-30 |
| JP2010534704A (ja) | 2010-11-11 |
| EP2178823A1 (en) | 2010-04-28 |
| TW200914010A (en) | 2009-04-01 |
| US20100190764A1 (en) | 2010-07-29 |
| WO2009016084A1 (en) | 2009-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |