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PE20090480A1 - Derivados de lactama tetraciclicos - Google Patents

Derivados de lactama tetraciclicos

Info

Publication number
PE20090480A1
PE20090480A1 PE2008001178A PE2008001178A PE20090480A1 PE 20090480 A1 PE20090480 A1 PE 20090480A1 PE 2008001178 A PE2008001178 A PE 2008001178A PE 2008001178 A PE2008001178 A PE 2008001178A PE 20090480 A1 PE20090480 A1 PE 20090480A1
Authority
PE
Peru
Prior art keywords
isoquinolin
dihydro
amino
methyl
carboxyl
Prior art date
Application number
PE2008001178A
Other languages
English (en)
Inventor
Achim Schlapbach
Laszlo Revesz
Guido Koch
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20090480A1 publication Critical patent/PE20090480A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
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  • Oncology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
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  • Psychiatry (AREA)
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE LACTAMA TETRACICLICOS DE FORMULA (IA) O (IB) DONDE R ES H, HALOGENO, ARILO(C6-C18), ALQUILO(C1-C7), ENTRE OTROS; A ES -CH2-, -CH2-CH2-, -CH2-CH2-CH2- O -CH=CH-; D ES UN ENLACE, ENTRE OTROS; R2 Y R3 SON CADA UNO H O FORMAN JUNTOS UN PUENTE DE ETILENO O TRIMETILENO; X ES CH O N; Y ES O, S O NR7, EN DONDE R7 ES H, ALQUILO(C1-C20), CICLOALQUILO(C3-C12), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: LACTAMA DEL ACIDO 2-(1-AMINO-METIL-CICLOPROPIL)-8-[5-(2-METOXI-ETOXI)-PIRIDIN-3-IL]-4,5-DIHIDRO-1H-PIRROLO-[2,3-f]-ISOQUINOLIN-3-CARBOXILICO, LACTAMA DEL ACIDO 2-(1-AMINO-METIL-CICLOPROPIL)-8-((E)-ESTIRIL)-4,5-DIHIDRO-1H-PIRROLO-[2,3-f]-ISOQUINOLIN-3-CARBOXILICO, LACTAMA DEL ACIDO 2-(1-AMINO-CICLOBUTIL-METIL)-8-[5-(2-METOXI-ETOXI)-PIRIDIN-3-IL]-4,5-DIHIDRO-1H-PIRROLO-[2,3-f]-ISOQUINOLIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA CINASA-2 DE PROTEINA ACTIVADA POR CINASA DE PROTEINA ACTIVADA POR MITOGENO (MK2 O MAPKAP CINASA-2) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ESPONDILITIS ANQUILOSANTE, ENFERMEDAD DE CROHN
PE2008001178A 2007-07-16 2008-07-14 Derivados de lactama tetraciclicos PE20090480A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07112549 2007-07-16

Publications (1)

Publication Number Publication Date
PE20090480A1 true PE20090480A1 (es) 2009-05-24

Family

ID=38792023

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001178A PE20090480A1 (es) 2007-07-16 2008-07-14 Derivados de lactama tetraciclicos

Country Status (15)

Country Link
US (2) US7838674B2 (es)
EP (1) EP2178874A1 (es)
JP (1) JP2010533674A (es)
KR (1) KR20100031619A (es)
CN (1) CN101687869A (es)
AR (1) AR067535A1 (es)
AU (1) AU2008277676A1 (es)
BR (1) BRPI0814426A2 (es)
CA (1) CA2693904A1 (es)
CL (1) CL2008002073A1 (es)
EA (1) EA201000100A1 (es)
MX (1) MX2009014247A (es)
PE (1) PE20090480A1 (es)
TW (1) TW200904818A (es)
WO (1) WO2009010488A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8494544B2 (en) * 2009-12-03 2013-07-23 Osocad Remote Limited Liability Company Method, apparatus and computer program to perform location specific information retrieval using a gesture-controlled handheld mobile device
AU2014277711B2 (en) * 2009-12-14 2016-10-27 Merck Sharp & Dohme B.V. MK2 inhibitors
MX2012006778A (es) * 2009-12-14 2012-07-23 Msd Oss Bv Inhibidores de proteina cinasa 2 activada por proteina cinasa activada por mitogeno.
WO2011123674A1 (en) 2010-03-31 2011-10-06 Array Biopharma Inc. Compounds for treating neurodegenerative diseases
EP2619181A1 (en) 2010-09-23 2013-07-31 Syngenta Participations AG Novel microbiocides
JP5925808B2 (ja) * 2011-01-26 2016-05-25 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 三環式誘導体、これらの調製方法およびこれらのキナーゼ阻害剤としての使用
JP5925809B2 (ja) * 2011-01-26 2016-05-25 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 三環系ピロロ誘導体、その調製方法およびそのキナーゼ阻害剤としての使用
WO2012117021A2 (en) 2011-03-03 2012-09-07 Syngenta Participations Ag Novel microbiocidal oxime ethers
BR112013028895A2 (pt) 2011-05-10 2016-08-09 Bayer Ip Gmbh (tio)carbonilamidinas bicíclicas
WO2013092460A1 (en) 2011-12-20 2013-06-27 Syngenta Participations Ag Cyclic bisoxime microbicides
EP2641901A1 (en) 2012-03-22 2013-09-25 Syngenta Participations AG. Novel microbiocides
KR101561330B1 (ko) 2012-09-19 2015-10-16 주식회사 두산 인돌로인돌계 유기 발광 화합물 및 이를 이용한 유기 전계 발광 소자
CN102936216B (zh) * 2012-12-05 2015-03-04 南京药石药物研发有限公司 7,9-二氧代-2,6-氮杂-螺[3.5]壬-2-甲酸叔丁酯及其中间体的制备方法
WO2014122083A1 (de) 2013-02-06 2014-08-14 Bayer Cropscience Ag Halogensubstituierte pyrazolderivate als schädlingsbekämpfungsmittel
MX380146B (es) 2013-03-15 2025-03-12 Celgene Car Llc Inhibidores mk2 y usos de los mismos.
WO2016044463A2 (en) 2014-09-17 2016-03-24 Celgene Avilomics Research, Inc. Mk2 inhibitors and uses thereof
CN105348263B (zh) * 2015-12-15 2018-03-23 乐普药业股份有限公司 一种达比加群酯中间体的制备方法
EA201992153A1 (ru) * 2016-10-05 2020-02-25 Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. Гетероарилтрифторборатные соединения для лечения микобактериальных инфекций
MX387359B (es) 2017-03-16 2025-03-18 Bristol Myers Squibb Co Inhibidores de cinasa activada por mitógeno 2 (mk2), síntesis de los mismos, e intermediarios de los mismos.
MX393600B (es) 2017-03-16 2025-03-24 Bristol Myers Squibb Co Formas y composiciones de un inhibidor de proteina cinasa 2 activada por la proteina cinasa activada por mitogeno (mk2).
US11124525B2 (en) 2017-03-16 2021-09-21 Celgene Car Llc Heteroaryl compounds useful as MK2 inhibitors
US11230551B2 (en) 2017-03-16 2022-01-25 Celgene Car Llc Deuterated analogs of MK2 inhibitors and uses thereof
EP3596084A4 (en) 2017-03-16 2020-12-23 Celgene CAR LLC 9,10,11,12-TETRAHYDRO-8H- [1,4] DIAZEPINO [5 ', 6': 4,5] THIÉNO [3,2-F] QUINOLIN-8-ONE COMPOUNDS AND THEIR USES
CN107383026B (zh) * 2017-06-29 2019-04-30 武汉药明康德新药开发有限公司 一种7-羟甲基-2,5-二氮杂螺[3,4]辛烷-2-甲酸叔丁酯的合成方法
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用
CN109678878A (zh) * 2019-02-27 2019-04-26 陕西科技大学 一种苯并噻吩并香豆素类化合物及其合成方法
CN109678879A (zh) * 2019-02-27 2019-04-26 陕西科技大学 一种苯并噻吩并吡喃酮类化合物及其合成方法
CN110563726A (zh) * 2019-07-23 2019-12-13 上海合全药业股份有限公司 叔丁基-7,9-二氧亚基-2,6-二氮杂螺[4.5]癸烷-2-甲酸基酯的制备方法
EP4284805A1 (en) 2021-02-01 2023-12-06 Celgene Corporation Mk2 inhibitors, the synthesis thereof, and intermediates thereto
CN117940433A (zh) * 2021-08-27 2024-04-26 瑞石生物医药有限公司 喹啉并呋喃衍生物及其用途
WO2024167950A1 (en) * 2023-02-07 2024-08-15 Celgene Corporation Compounds and compositions useful as degraders of mk2 kinase
WO2025096869A1 (en) * 2023-11-01 2025-05-08 Matchpoint Therapeutics Inc. Pyrrolo-isoquinoline compounds and their use in therapy

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
AU2003218989A1 (en) * 2002-02-19 2003-09-09 Pharmacia Italia S.P.A. Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents
CA2509565A1 (en) * 2002-12-20 2004-07-15 Pharmacia Corporation Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds

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