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PE20080319A1 - Dihidrotienopirimidinas como agentes inhibidores de pde-4 - Google Patents

Dihidrotienopirimidinas como agentes inhibidores de pde-4

Info

Publication number
PE20080319A1
PE20080319A1 PE2007000470A PE2007000470A PE20080319A1 PE 20080319 A1 PE20080319 A1 PE 20080319A1 PE 2007000470 A PE2007000470 A PE 2007000470A PE 2007000470 A PE2007000470 A PE 2007000470A PE 20080319 A1 PE20080319 A1 PE 20080319A1
Authority
PE
Peru
Prior art keywords
5lambda4
pyrimidin
dihydro
phenyl
oxo
Prior art date
Application number
PE2007000470A
Other languages
English (en)
Inventor
Pascale Pouzet
Christoph Hoenke
Rolf Goeggel
Birgit Jung
Peter Nickolaus
Thomas Fox
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20080319A1 publication Critical patent/PE20080319A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE TIENOPIRIMIDINA DE FORMULA 1, DONDE X ES SO O SO2; R1 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ARILO C6-C10, ENTRE OTROS; R2 ES H, ALQUILO C1-C10, ALQUENILO C2-C6, ENTRE OTROS; R3 ES OH, Cl, NITRILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: {2-[4-(4-CLORO-FENIL)-PIPERAZINI-1-IL]-5-OXO-6,7-DIHIDRO-5H,5LAMBDA4-TIENO[3,2-d]PIRIMIDIN-4-IL}-(3-MORFOLIN-4-ILMETIL-FENIL)-AMINA, TRIFLUOROACETATO DE (R)-N2-{2-[4-(4-CLORO-FENIL)-PIPERAZIN-1-IL]-5-OXO-6,7-DIHIDRO-5H,5LAMBDA4-TIENO[3,2-d]PIRIMIDIN-4-IL)-3-METIL-BUTAN-1,2-DIAMINA, 4-{4-[4-(3-FLUORO-FENILAMINO)-5-OXO-6,7-DIHIDRO-5H,5LAMBDA4-TIENO[3,2-d]PIRIMIDIN-2-IL]-PIPERAZIN-1-IL}-N,N-DIMETILBENCENSULFONAMIDA, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE PDE-4 Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS GASTROINTESTINALES O DE LAS VIAS RESPIRATORIAS, ENFERMEDADES INFLAMATORIAS DE LAS ARTICULACIONES, PIEL, OJOS, ENTRE OTRAS
PE2007000470A 2006-04-19 2007-04-17 Dihidrotienopirimidinas como agentes inhibidores de pde-4 PE20080319A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112779A EP1847543A1 (de) 2006-04-19 2006-04-19 Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen

Publications (1)

Publication Number Publication Date
PE20080319A1 true PE20080319A1 (es) 2008-05-13

Family

ID=36847643

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000470A PE20080319A1 (es) 2006-04-19 2007-04-17 Dihidrotienopirimidinas como agentes inhibidores de pde-4

Country Status (20)

Country Link
US (3) US8114878B2 (es)
EP (2) EP1847543A1 (es)
JP (1) JP5214588B2 (es)
KR (1) KR20090009885A (es)
CN (1) CN101426505A (es)
AR (1) AR060516A1 (es)
AU (1) AU2007239573A1 (es)
BR (1) BRPI0710459A2 (es)
CA (1) CA2647243A1 (es)
CO (1) CO6140032A2 (es)
EA (1) EA200802051A1 (es)
EC (1) ECSP088738A (es)
IL (1) IL194739A0 (es)
MX (1) MX2008012915A (es)
NO (1) NO20083710L (es)
PE (1) PE20080319A1 (es)
TW (1) TW200808811A (es)
UY (1) UY30287A1 (es)
WO (1) WO2007118793A1 (es)
ZA (1) ZA200807015B (es)

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KR20250046278A (ko) * 2022-08-09 2025-04-02 시젱 하이스코 파마수티칼 씨오., 엘티디. Pde4b 억제제 및 이의 용도
CN119947728A (zh) 2022-09-28 2025-05-06 勃林格殷格翰国际有限公司 生物标志物在用pde4b抑制剂治疗纤维化病症中的用途
WO2024067660A1 (zh) 2022-09-29 2024-04-04 苏州爱科百发生物医药技术有限公司 氮杂稠环类化合物、其制备方法及其在医药上的应用
EP4678644A1 (en) 2023-04-13 2026-01-14 Shanghai Yidi Biotechnology Co., Ltd. Substituted dihydrothienopyrimidine compound, preparation method therefor, and use thereof
WO2025067168A1 (zh) * 2023-09-25 2025-04-03 苏州爱科百发生物医药技术有限公司 氮杂稠环类化合物及其制备方法和用途
WO2025092985A1 (zh) * 2023-11-03 2025-05-08 合肥医工医药股份有限公司 磷酸二酯酶4b抑制剂及其制备方法与用途
WO2025162431A1 (zh) * 2024-02-04 2025-08-07 西藏海思科制药有限公司 一种pde4b抑制剂化合物的口服药物组合物及其制备方法
WO2025162289A2 (zh) * 2024-02-04 2025-08-07 西藏海思科制药有限公司 一种pde4b抑制剂的晶型及其在医药上的用途
CN118324664A (zh) * 2024-03-14 2024-07-12 四川鸿日医药科技有限公司 一种丝氨酸衍生物的制备方法

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EP2010185B1 (de) 2012-06-13
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CA2647243A1 (en) 2007-10-25
US20140005154A1 (en) 2014-01-02
AR060516A1 (es) 2008-06-25
US8822474B2 (en) 2014-09-02
JP2010523467A (ja) 2010-07-15
US20080096882A1 (en) 2008-04-24
NO20083710L (no) 2008-11-18
WO2007118793A1 (de) 2007-10-25
ZA200807015B (en) 2010-01-27
IL194739A0 (en) 2009-08-03
US20120108534A1 (en) 2012-05-03
US8114878B2 (en) 2012-02-14
MX2008012915A (es) 2008-10-15
CO6140032A2 (es) 2010-03-19
EP1847543A1 (de) 2007-10-24
EP2010185A1 (de) 2009-01-07
CN101426505A (zh) 2009-05-06
EA200802051A1 (ru) 2009-04-28
AU2007239573A1 (en) 2007-10-25
BRPI0710459A2 (pt) 2011-08-16
TW200808811A (en) 2008-02-16
KR20090009885A (ko) 2009-01-23
ECSP088738A (es) 2008-10-31
US8604039B2 (en) 2013-12-10

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