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PE20080151A1 - Formulaciones farmaceuticas de fenilefrina y composiciones para su absorcion en el colon - Google Patents

Formulaciones farmaceuticas de fenilefrina y composiciones para su absorcion en el colon

Info

Publication number
PE20080151A1
PE20080151A1 PE2007000684A PE2007000684A PE20080151A1 PE 20080151 A1 PE20080151 A1 PE 20080151A1 PE 2007000684 A PE2007000684 A PE 2007000684A PE 2007000684 A PE2007000684 A PE 2007000684A PE 20080151 A1 PE20080151 A1 PE 20080151A1
Authority
PE
Peru
Prior art keywords
composition
weight
amount
phenylphrine
colon
Prior art date
Application number
PE2007000684A
Other languages
English (en)
Inventor
David Monteith
John O'mullane
Joseph P Reo
Robert T Nowak
Jiansheng Wan
Mohammed A Kabir
Malaz A Abutarif
Glenn E Fritz
Original Assignee
Schering Plough Healthcare
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38659360&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080151(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Plough Healthcare filed Critical Schering Plough Healthcare
Publication of PE20080151A1 publication Critical patent/PE20080151A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN NUCLEO QUE CONTIENE i) FENILEFRINA EN UNA CANTIDAD DE 4 A 5% EN PESO DE LA COMPOSICION; ii) HIDROXIPROPIL DE CELULOSA DE 300 A 600 CPS EN UNA CANTIDAD DE 4 A 5% EN PESO DE LA COMPOSICION; iii) HIDROXIPROPIL DE CELULOSA DE 150 A 300 CPS EN UNA CANTIDAD DE 4 A 5% EN PESO DE LA COMPOSICION; iv) CARBOXIMETILCELULOSA EN UNA CANTIDAD DE 16 A 17% EN PESO DE LA COMPOSICION; v) CELULOSA MICROCRISTALINA EN UNA CANTIDAD DE 59 A 69% EN PESO DE LA COMPOSICION; vi) ESTEARATO DE MAGNESIO EN UNA CANTIDAD DE 0.9 A 1% EN PESO DE LA COMPOSICION; B) UNA CAPA EROSIONABLE QUE CONTIENE i) FENILEFRINA EN UNA CANTIDAD DE 1 A 2% EN PESO DE LA COMPOSICION; ii) ALCOHOL POLIVINILICO EN UNA CANTIDAD DE 6 A 10% EN PESO DE LA COMPOSICION; C) UNA CAPA SENSIBLE AL pH LA CUAL SE DESINTEGRA BAJO UNA CONDICION DE pH DE 5.5 A 7.0. DICHA COMPOSICION ADEMAS CONTIENE LORATADINA O DESLORATADINA SIENDO UTIL EN EL TRATAMIENTO DE GRIPE, ALERGIA, RINITIS
PE2007000684A 2006-06-01 2007-06-01 Formulaciones farmaceuticas de fenilefrina y composiciones para su absorcion en el colon PE20080151A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81002106P 2006-06-01 2006-06-01
US87483006P 2006-12-14 2006-12-14

Publications (1)

Publication Number Publication Date
PE20080151A1 true PE20080151A1 (es) 2008-02-25

Family

ID=38659360

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000684A PE20080151A1 (es) 2006-06-01 2007-06-01 Formulaciones farmaceuticas de fenilefrina y composiciones para su absorcion en el colon

Country Status (20)

Country Link
US (2) US8956662B2 (es)
EP (2) EP2366381A1 (es)
JP (2) JP5175278B2 (es)
KR (1) KR101643626B1 (es)
CN (1) CN104161736A (es)
AR (1) AR061169A1 (es)
AU (1) AU2007254821B2 (es)
BR (1) BRPI0712532A2 (es)
CA (1) CA2653953C (es)
CL (1) CL2007001584A1 (es)
ES (1) ES2391585T3 (es)
MX (1) MX2008015360A (es)
NO (1) NO20085420L (es)
NZ (1) NZ573173A (es)
PE (1) PE20080151A1 (es)
PL (1) PL2034970T3 (es)
RU (1) RU2454225C2 (es)
SG (1) SG172664A1 (es)
TW (1) TWI411451B (es)
WO (1) WO2007143158A2 (es)

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ES2391585T3 (es) 2012-11-28
SG172664A1 (en) 2011-07-28
CN104161736A (zh) 2014-11-26
EP2366381A1 (en) 2011-09-21
TWI411451B (zh) 2013-10-11
CA2653953A1 (en) 2007-12-13
AU2007254821B2 (en) 2013-11-14
AU2007254821A1 (en) 2007-12-13
WO2007143158A3 (en) 2008-11-27
JP2013006878A (ja) 2013-01-10
NO20085420L (no) 2008-12-30
KR101643626B1 (ko) 2016-07-29
RU2008151949A (ru) 2010-07-20
JP2009538920A (ja) 2009-11-12
PL2034970T3 (pl) 2012-12-31
JP5175278B2 (ja) 2013-04-03
CL2007001584A1 (es) 2008-01-25
MX2008015360A (es) 2009-03-06
US8956662B2 (en) 2015-02-17
KR20090014392A (ko) 2009-02-10
HK1121970A1 (en) 2009-05-08
NZ573173A (en) 2012-03-30
TW200815050A (en) 2008-04-01
CA2653953C (en) 2015-12-08
EP2034970B1 (en) 2012-08-01
US20080020055A1 (en) 2008-01-24
AR061169A1 (es) 2008-08-06
US20150290147A1 (en) 2015-10-15
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RU2454225C2 (ru) 2012-06-27
EP2034970A2 (en) 2009-03-18

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