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PE20080938A1 - SUBSTITUTE DERIVATIVES OF PIRROL - Google Patents

SUBSTITUTE DERIVATIVES OF PIRROL

Info

Publication number
PE20080938A1
PE20080938A1 PE2007000737A PE2007000737A PE20080938A1 PE 20080938 A1 PE20080938 A1 PE 20080938A1 PE 2007000737 A PE2007000737 A PE 2007000737A PE 2007000737 A PE2007000737 A PE 2007000737A PE 20080938 A1 PE20080938 A1 PE 20080938A1
Authority
PE
Peru
Prior art keywords
optionally substituted
methyl
pirrol
cyane
pyrrol
Prior art date
Application number
PE2007000737A
Other languages
Spanish (es)
Inventor
Mitsuhiro Ito
Nobuyuki Matsunaga
Masami Yamada
Takenori Hitaka
Satoshi Yamamoto
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20080938A1 publication Critical patent/PE20080938A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRROL DE FORMULA (I), EN DONDE R1 ES H, CIANO, ALQUILO(C1-C6) OPCIONALMENTE HALOGENADO O UN ALCOXI-CARBONILO(C1-C6) OPCIONALMENTE SUSTITUIDOS; R2 y R4 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C6), ALQUENILO(C1-C6) SUSTITUIDO CON HIDROXI, TIOL OPCIONALMENTE SUSTITUIDO U OXIDADO, CICLOALQUILO(C1-C6), ENTRE OTROS; R3 ES TIAZOLILO, PIRAZOLILO, OXAZOLILO, ENTRE OTROS OPCIONALMENTE SUSTITUIDOS; R5 ES FENILO OPCIONALMENTE SUSTITUIDO QUE TIENE UN CIANO EN LA POSICION 4 O 3. SON SELECCIONADOS: 4-(2,5-DIMETIL-1-{[3-(TRIFLUOROMETIL)-1H-PIRAZOL-5-IL]METIL}-1H-PIRROL-3-IL)BENZONITRILO; 3-(4-CIANOFENIL)-5-METIL-1-{[3-(TRIFLUROMETIL)-1H-PIRAZOL-5-IL-]METIL}-1H-PIRROL-2-CARBONITRILO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE ANDROGENOS SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE PROSTATAREFERS TO COMPOUNDS DERIVED FROM PIRROL OF FORMULA (I), WHERE R1 IS H, CYANE, ALKYL (C1-C6) OPTIONALLY HALOGENATED OR AN ALCOXY-CARBONYL (C1-C6) OPTIONALLY SUBSTITUTED; R2 and R4 ARE INDEPENDENTLY H, ALKYL (C1-C6), ALKENYL (C1-C6) SUBSTITUTED WITH HYDROXY, OPTIONALLY SUBSTITUTED OR OXIDATED THIOL, CYCLOALKYL (C1-C6), AMONG OTHERS; R3 IS THIAZOLIL, PYRAZOLIL, OXAZOLIL, AMONG OTHERS, OPTIONALLY SUBSTITUTED; R5 IS OPTIONALLY SUBSTITUTED PHENYL WHICH HAS A CYANE IN POSITION 4 OR 3. THEY ARE SELECTED: 4- (2,5-DIMETHYL-1 - {[3- (TRIFLUORomethyl) -1H-PIRAZOL-5-IL] METHYL} -1H -PYRROL-3-IL) BENZONITRILE; 3- (4-CYANOPHENYL) -5-METHYL-1 - {[3- (TRIFLUROMETHYL) -1H-PYRAZOLE-5-IL-] METHYL} -1H-PYRROL-2-CARBONITRILE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS ARE ANTAGONISTS OF THE ANDROGEN RECEPTOR BEING USEFUL IN THE TREATMENT OF PROSTATE CANCER

PE2007000737A 2006-06-13 2007-06-12 SUBSTITUTE DERIVATIVES OF PIRROL PE20080938A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006163992 2006-06-13

Publications (1)

Publication Number Publication Date
PE20080938A1 true PE20080938A1 (en) 2008-09-02

Family

ID=38832218

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000737A PE20080938A1 (en) 2006-06-13 2007-06-12 SUBSTITUTE DERIVATIVES OF PIRROL

Country Status (4)

Country Link
AR (1) AR061439A1 (en)
PE (1) PE20080938A1 (en)
TW (1) TW200813007A (en)
WO (1) WO2007145349A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2413504T3 (en) 2007-12-21 2013-07-16 Ligand Pharmaceuticals Inc. Selective androgen receptor modulators (SARM) and uses thereof
CN103102325B (en) * 2013-01-16 2014-11-12 浙江大学宁波理工学院 Synthetic method of 2-bromomethyl-4-carboxylate imidazole
BR112021020864A2 (en) 2019-04-19 2021-12-14 Ligand Pharm Inc Crystalline forms and methods of producing crystalline forms of a compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057669A1 (en) * 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Androgen receptor antagonists

Also Published As

Publication number Publication date
WO2007145349A3 (en) 2008-04-03
AR061439A1 (en) 2008-08-27
WO2007145349A2 (en) 2007-12-21
TW200813007A (en) 2008-03-16

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