PE20080898A1 - Derivados de quinolina como moduladores de 5-ht5a - Google Patents
Derivados de quinolina como moduladores de 5-ht5aInfo
- Publication number
- PE20080898A1 PE20080898A1 PE2007001313A PE2007001313A PE20080898A1 PE 20080898 A1 PE20080898 A1 PE 20080898A1 PE 2007001313 A PE2007001313 A PE 2007001313A PE 2007001313 A PE2007001313 A PE 2007001313A PE 20080898 A1 PE20080898 A1 PE 20080898A1
- Authority
- PE
- Peru
- Prior art keywords
- amine
- ht5a
- modulators
- quinoline derivatives
- penethyl
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title abstract 2
- 102100040370 5-hydroxytryptamine receptor 5A Human genes 0.000 title 1
- 101710138069 5-hydroxytryptamine receptor 5A Proteins 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 2-METHOXY-BENZYL Chemical class 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108010006590 serotonin 5 receptor Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
REFERIDA A UN DERIVADO DE QUINOLINA DE FORMULA (I), DONDE X ES UN ENLACE, -CH2CH2-, -CH=CH-, ENTRE OTROS; Y ES UN ENLACE, -CHR- O -OCH2CH2-; R ES H O ALQUILO C1-C7; Ar1 Y Ar2 SON ARILO O HETEROARILO DE 5 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON ALQUILO C1-C7, HALOGENO, CF3, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2-METOXI-BENCIL)-(5-FENETIL-QUINOLIN-2-IL)-AMINA, (2-METOXI-BENCIL)-[5-(2-PIRIDIN-3-IL-ETIL)-QUINOLIN-2-IL]-AMINA, (5-METIL-FURAN-2-ILMETIL)-(5-FENETIL-QUINOLIN-2-IL)-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE EL RECEPTOR 5-HT5A Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DE ANSIEDAD, DEPRESION, PSICOTICOS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06121449 | 2006-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080898A1 true PE20080898A1 (es) | 2008-08-06 |
Family
ID=38925599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001313A PE20080898A1 (es) | 2006-09-28 | 2007-09-27 | Derivados de quinolina como moduladores de 5-ht5a |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7825253B2 (es) |
| EP (1) | EP2076495B1 (es) |
| JP (1) | JP5111509B2 (es) |
| KR (1) | KR101088451B1 (es) |
| CN (1) | CN101516852B (es) |
| AR (1) | AR062994A1 (es) |
| AT (1) | ATE478050T1 (es) |
| AU (1) | AU2007302061B2 (es) |
| BR (1) | BRPI0717140A2 (es) |
| CA (1) | CA2664031A1 (es) |
| CL (1) | CL2007002768A1 (es) |
| DE (1) | DE602007008597D1 (es) |
| ES (1) | ES2347193T3 (es) |
| IL (1) | IL197301A0 (es) |
| MX (1) | MX2009003170A (es) |
| PE (1) | PE20080898A1 (es) |
| TW (1) | TW200819433A (es) |
| WO (1) | WO2008037626A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE477243T1 (de) | 2006-12-07 | 2010-08-15 | Hoffmann La Roche | 2-aminochinoline als 5-ht(5a)- rezeptorantagonisten |
| MX2010003001A (es) * | 2007-09-27 | 2010-04-01 | Hoffmann La Roche | Derivados de quinolina como antagonistas del receptor de la 5-hidroxitriptamina 5a. |
| CA2715842A1 (en) | 2008-03-07 | 2009-09-11 | F. Hoffmann-La Roche Ag | 2-aminoquinoline derivatives |
| CA2717453A1 (en) | 2008-03-07 | 2009-09-11 | F. Hoffmann-La Roche Ag | 2-aminoquinolines |
| EP2254666A1 (en) * | 2008-03-12 | 2010-12-01 | F. Hoffmann-La Roche AG | 2-aminoquinolines as 5-ht5a receptor antagonists |
| AR116628A1 (es) | 2018-10-18 | 2021-05-26 | Syngenta Crop Protection Ag | Compuestos microbiocidas |
| GB201903942D0 (en) | 2019-03-22 | 2019-05-08 | Syngenta Crop Protection Ag | Microbiocidal compounds |
| US20230131427A1 (en) | 2020-03-05 | 2023-04-27 | Syngenta Crop Protection Ag | Fungicidal compositions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0103648D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinolone compounds |
| SE0103649D0 (sv) | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
| US7084156B2 (en) * | 2001-11-27 | 2006-08-01 | Merck & Co., Inc. | 2-Aminoquinoline compounds |
| SE0202134D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Therapeutic agents |
| GB0309781D0 (en) | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
| GB0312609D0 (en) * | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| JP2005154434A (ja) * | 2003-11-05 | 2005-06-16 | Kyowa Hakko Kogyo Co Ltd | ２−アミノキナゾリン誘導体 |
-
2007
- 2007-09-18 CA CA002664031A patent/CA2664031A1/en not_active Abandoned
- 2007-09-18 MX MX2009003170A patent/MX2009003170A/es active IP Right Grant
- 2007-09-18 BR BRPI0717140-4A2A patent/BRPI0717140A2/pt not_active IP Right Cessation
- 2007-09-18 EP EP07803542A patent/EP2076495B1/en not_active Not-in-force
- 2007-09-18 ES ES07803542T patent/ES2347193T3/es active Active
- 2007-09-18 AT AT07803542T patent/ATE478050T1/de active
- 2007-09-18 WO PCT/EP2007/059840 patent/WO2008037626A1/en not_active Ceased
- 2007-09-18 JP JP2009529658A patent/JP5111509B2/ja not_active Expired - Fee Related
- 2007-09-18 KR KR1020097005608A patent/KR101088451B1/ko not_active Expired - Fee Related
- 2007-09-18 CN CN2007800353406A patent/CN101516852B/zh not_active Expired - Fee Related
- 2007-09-18 AU AU2007302061A patent/AU2007302061B2/en not_active Ceased
- 2007-09-18 DE DE602007008597T patent/DE602007008597D1/de active Active
- 2007-09-21 US US11/859,045 patent/US7825253B2/en not_active Expired - Fee Related
- 2007-09-26 CL CL200702768A patent/CL2007002768A1/es unknown
- 2007-09-26 AR ARP070104247A patent/AR062994A1/es unknown
- 2007-09-27 PE PE2007001313A patent/PE20080898A1/es not_active Application Discontinuation
- 2007-09-27 TW TW096135979A patent/TW200819433A/zh unknown
-
2009
- 2009-02-26 IL IL197301A patent/IL197301A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080081907A1 (en) | 2008-04-03 |
| US7825253B2 (en) | 2010-11-02 |
| KR20090042977A (ko) | 2009-05-04 |
| EP2076495A1 (en) | 2009-07-08 |
| ATE478050T1 (de) | 2010-09-15 |
| ES2347193T3 (es) | 2010-10-26 |
| AR062994A1 (es) | 2008-12-17 |
| KR101088451B1 (ko) | 2011-12-01 |
| CN101516852A (zh) | 2009-08-26 |
| TW200819433A (en) | 2008-05-01 |
| IL197301A0 (en) | 2009-12-24 |
| CA2664031A1 (en) | 2008-04-03 |
| CL2007002768A1 (es) | 2008-04-18 |
| AU2007302061B2 (en) | 2012-01-19 |
| CN101516852B (zh) | 2011-11-16 |
| DE602007008597D1 (de) | 2010-09-30 |
| JP2010504939A (ja) | 2010-02-18 |
| JP5111509B2 (ja) | 2013-01-09 |
| WO2008037626A1 (en) | 2008-04-03 |
| BRPI0717140A2 (pt) | 2013-10-22 |
| MX2009003170A (es) | 2009-04-03 |
| AU2007302061A1 (en) | 2008-04-03 |
| EP2076495B1 (en) | 2010-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |