|
US3894037A
(en)
*
|
1971-05-24 |
1975-07-08 |
Ciba Geigy Corp |
Certain isothiocyanobenzimidazoles
|
|
US4197307A
(en)
*
|
1977-04-12 |
1980-04-08 |
Ciba-Geigy Corporation |
2-Alkylthio-, 2-alkylsulphinyl- and 2-alkylsulfonyl-6-phenylbenzimidazoles as anthelmintic agents
|
|
US4294926A
(en)
*
|
1979-06-15 |
1981-10-13 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
|
US4319039A
(en)
*
|
1979-06-15 |
1982-03-09 |
Merck & Co., Inc. |
Preparation of ammonium salt of hypocholesteremic fermentation product
|
|
US4444784A
(en)
*
|
1980-08-05 |
1984-04-24 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
|
DK149080C
(da)
*
|
1980-06-06 |
1986-07-28 |
Sankyo Co |
Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
|
|
JPS5889191A
(ja)
|
1981-11-20 |
1983-05-27 |
Sankyo Co Ltd |
３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
|
|
US4430502A
(en)
*
|
1982-08-13 |
1984-02-07 |
The Upjohn Company |
Pyridinyl substituted benzimidazoles and quinoxalines
|
|
US5354772A
(en)
*
|
1982-11-22 |
1994-10-11 |
Sandoz Pharm. Corp. |
Indole analogs of mevalonolactone and derivatives thereof
|
|
AU570021B2
(en)
|
1982-11-22 |
1988-03-03 |
Novartis Ag |
Analogs of mevalolactone
|
|
US4911165A
(en)
*
|
1983-01-12 |
1990-03-27 |
Ethicon, Inc. |
Pliabilized polypropylene surgical filaments
|
|
GB8307865D0
(en)
*
|
1983-03-22 |
1983-04-27 |
Fujisawa Pharmaceutical Co |
Benzimidazole derivatives
|
|
US4681893A
(en)
*
|
1986-05-30 |
1987-07-21 |
Warner-Lambert Company |
Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
|
|
US4782084A
(en)
*
|
1987-06-29 |
1988-11-01 |
Merck & Co., Inc. |
HMG-COA reductase inhibitors
|
|
US4885314A
(en)
|
1987-06-29 |
1989-12-05 |
Merck & Co., Inc. |
Novel HMG-CoA reductase inhibitors
|
|
US4820850A
(en)
*
|
1987-07-10 |
1989-04-11 |
Merck & Co., Inc. |
Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
|
|
US5180589A
(en)
*
|
1988-03-31 |
1993-01-19 |
E. R. Squibb & Sons, Inc. |
Pravastatin pharmaceuatical compositions having good stability
|
|
US5030447A
(en)
*
|
1988-03-31 |
1991-07-09 |
E. R. Squibb & Sons, Inc. |
Pharmaceutical compositions having good stability
|
|
US4916239A
(en)
*
|
1988-07-19 |
1990-04-10 |
Merck & Co., Inc. |
Process for the lactonization of mevinic acids and analogs thereof
|
|
US5290946A
(en)
*
|
1988-10-13 |
1994-03-01 |
Sandoz Ltd. |
Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
|
|
US5118853A
(en)
*
|
1988-10-13 |
1992-06-02 |
Sandoz Ltd. |
Processes for the synthesis of 3-disubstituted aminoacroleins
|
|
US4929437A
(en)
*
|
1989-02-02 |
1990-05-29 |
Merck & Co., Inc. |
Coenzyme Q10 with HMG-CoA reductase inhibitors
|
|
US5189164A
(en)
*
|
1989-05-22 |
1993-02-23 |
Sandoz Ltd. |
Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
|
|
FI94339C
(fi)
|
1989-07-21 |
1995-08-25 |
Warner Lambert Co |
Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
|
|
PH27357A
(en)
*
|
1989-09-22 |
1993-06-21 |
Fujisawa Pharmaceutical Co |
Pyrazole derivatives and pharmaceutical compositions comprising the same
|
|
JPH06759B2
(ja)
*
|
1989-09-22 |
1994-01-05 |
ファイザー製薬株式会社 |
新規なベンゾイミダゾール化合物
|
|
US5420245A
(en)
*
|
1990-04-18 |
1995-05-30 |
Board Of Regents, The University Of Texas |
Tetrapeptide-based inhibitors of farnesyl transferase
|
|
US5041453A
(en)
*
|
1990-05-30 |
1991-08-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
|
|
FR2677020B1
(fr)
*
|
1991-05-31 |
1993-08-27 |
Cird Galderma |
Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
|
|
HU9203780D0
(en)
*
|
1991-12-12 |
1993-03-29 |
Sandoz Ag |
Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
|
|
US5612360A
(en)
|
1992-06-03 |
1997-03-18 |
Eli Lilly And Company |
Angiotensin II antagonists
|
|
US5604260A
(en)
*
|
1992-12-11 |
1997-02-18 |
Merck Frosst Canada Inc. |
5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
|
|
EP0604181A1
(en)
|
1992-12-21 |
1994-06-29 |
Eli Lilly And Company |
Antitumor compositions and method of treatment
|
|
CA2297592A1
(en)
|
1993-01-15 |
1994-07-21 |
G.D. Searle & Co. |
Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
|
|
WO1994019357A1
(en)
|
1993-02-23 |
1994-09-01 |
Merrell Dow Pharmaceuticals Inc. |
Farnesyl:protein transferase inhibitors as anticancer agents
|
|
US5298627A
(en)
|
1993-03-03 |
1994-03-29 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
|
US5409944A
(en)
*
|
1993-03-12 |
1995-04-25 |
Merck Frosst Canada, Inc. |
Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
|
|
CA2118985A1
(en)
|
1993-04-02 |
1994-10-03 |
Dinesh V. Patel |
Heterocyclic inhibitors of farnesyl protein transferase
|
|
EP0763537A3
(en)
*
|
1993-05-14 |
1997-10-22 |
Genentech Inc |
Non-peptides farnesyl transfer inhibitors
|
|
US5602098A
(en)
*
|
1993-05-18 |
1997-02-11 |
University Of Pittsburgh |
Inhibition of farnesyltransferase
|
|
US5380738A
(en)
*
|
1993-05-21 |
1995-01-10 |
Monsanto Company |
2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
|
|
US5474995A
(en)
*
|
1993-06-24 |
1995-12-12 |
Merck Frosst Canada, Inc. |
Phenyl heterocycles as cox-2 inhibitors
|
|
GB9602877D0
(en)
|
1996-02-13 |
1996-04-10 |
Merck Frosst Canada Inc |
3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
|
|
US5436265A
(en)
*
|
1993-11-12 |
1995-07-25 |
Merck Frosst Canada, Inc. |
1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
|
|
EP0639573A1
(de)
|
1993-08-03 |
1995-02-22 |
Hoechst Aktiengesellschaft |
Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
|
|
US5852046A
(en)
|
1993-08-03 |
1998-12-22 |
Hoechst Aktiengesellschaft |
Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
|
|
WO1995008542A1
(en)
|
1993-09-22 |
1995-03-30 |
Kyowa Hakko Kogyo Co., Ltd. |
Farnesyltransferase inhibitor
|
|
AU698960B2
(en)
|
1993-10-15 |
1998-11-12 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
US5661152A
(en)
*
|
1993-10-15 |
1997-08-26 |
Schering Corporation |
Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL111235A
(en)
|
1993-10-15 |
2001-03-19 |
Schering Plough Corp |
Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
|
|
US5719148A
(en)
|
1993-10-15 |
1998-02-17 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
US5721236A
(en)
|
1993-10-15 |
1998-02-24 |
Schering Corporation |
Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
ZA947970B
(en)
|
1993-10-15 |
1996-07-12 |
Schering Corp |
Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
ATE200677T1
(de)
|
1993-10-25 |
2001-05-15 |
Parke Davis & Co |
Substituierte tetra- und pentapeptid hemmstoffe der farnesyl protein transferase
|
|
US5344991A
(en)
|
1993-10-29 |
1994-09-06 |
G.D. Searle & Co. |
1,2 diarylcyclopentenyl compounds for the treatment of inflammation
|
|
JPH08505646A
(ja)
|
1993-11-04 |
1996-06-18 |
アボツト・ラボラトリーズ |
スクアレンシンテターゼ及びプロテインファルネシルトランスフェラーゼのインヒビターとしてのシクロブタン誘導体
|
|
US5783593A
(en)
|
1993-11-04 |
1998-07-21 |
Abbott Laboratories |
Inhibitors of squalene synthetase and protein farnesyltransferase
|
|
AU681454B2
(en)
|
1993-11-05 |
1997-08-28 |
Warner-Lambert Company |
Substituted DI- and tripeptide inhibitors of protein:farnesyl transferase
|
|
US5466823A
(en)
*
|
1993-11-30 |
1995-11-14 |
G.D. Searle & Co. |
Substituted pyrazolyl benzenesulfonamides
|
|
US5484799A
(en)
|
1993-12-09 |
1996-01-16 |
Abbott Laboratories |
Antifungal dorrigocin derivatives
|
|
US5393790A
(en)
*
|
1994-02-10 |
1995-02-28 |
G.D. Searle & Co. |
Substituted spiro compounds for the treatment of inflammation
|
|
AU2122795A
(en)
|
1994-03-15 |
1995-10-03 |
Eisai Co. Ltd. |
Isoprenyl transferase inhibitors
|
|
RU95104898A
(ru)
|
1994-03-31 |
1996-12-27 |
Бристоль-Мейерз Сквибб Компани (US) |
Имидазолсодержащие ингибиторы фарнезид-протеинтрансферазы, способ лечения связанных с ней заболеваний
|
|
US5523430A
(en)
*
|
1994-04-14 |
1996-06-04 |
Bristol-Myers Squibb Company |
Protein farnesyl transferase inhibitors
|
|
US5510510A
(en)
*
|
1994-05-10 |
1996-04-23 |
Bristol-Meyers Squibb Company |
Inhibitors of farnesyl protein transferase
|
|
US6358932B1
(en)
*
|
1994-05-31 |
2002-03-19 |
Isis Pharmaceticals, Inc. |
Antisense oligonucleotide inhibition of raf gene expression
|
|
US6391636B1
(en)
*
|
1994-05-31 |
2002-05-21 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
US5563255A
(en)
|
1994-05-31 |
1996-10-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of raf gene expression
|
|
CZ361996A3
(en)
|
1994-06-10 |
1997-04-16 |
Rhone Poulenc Rorer Sa |
Inhibitors of farnesyl-transferase, process of their preparation and pharmaceutical compositions containing thereof
|
|
US5571792A
(en)
*
|
1994-06-30 |
1996-11-05 |
Warner-Lambert Company |
Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
|
|
WO1996005529A1
(en)
|
1994-08-09 |
1996-02-22 |
Micron Optics, Inc. |
Temperature compensated fiber fabry-perot filters
|
|
ATE188464T1
(de)
|
1994-08-11 |
2000-01-15 |
Banyu Pharma Co Ltd |
Substituierte amidderivate
|
|
CA2155448A1
(en)
|
1994-08-11 |
1996-02-12 |
Katerina Leftheris |
Inhibitors of farnesyl protein transferase
|
|
AU3192495A
(en)
|
1994-08-12 |
1996-03-07 |
Banyu Pharmaceutical Co., Ltd. |
N,n-disubstituted amic acid derivative
|
|
DE4429506B4
(de)
|
1994-08-19 |
2007-09-13 |
Degussa Gmbh |
Verfahren zur Extraktion natürlicher Carotinoid-Farbstoffe
|
|
DE4429653C2
(de)
|
1994-08-20 |
1997-04-03 |
Anton Dr More |
Konverter und Verfahren zum Frischen von Metallschmelzen insbesondere von Roheisen zu Stahl
|
|
EP0701907A1
(en)
|
1994-09-13 |
1996-03-20 |
Agfa-Gevaert N.V. |
A dye donor element for use in a thermal dye transfer process
|
|
US6037136A
(en)
*
|
1994-10-24 |
2000-03-14 |
Cold Spring Harbor Laboratory |
Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto
|
|
DE69507284T2
(de)
|
1994-11-22 |
1999-07-01 |
Philips Electronics N.V., Eindhoven |
Halbleiter mit einem träger auf dem ein substrat mit einem halbleiter-element mittels einer klebeschicht und ein leiterbahn-muster befestigt sind
|
|
WO1996017861A1
(en)
|
1994-12-09 |
1996-06-13 |
Warner-Lambert Company |
Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
|
|
AU703440B2
(en)
|
1995-01-09 |
1999-03-25 |
Magla International Ltd. |
Wear resistant image printing on latex surfaces
|
|
WO1996021456A1
(en)
|
1995-01-12 |
1996-07-18 |
University Of Pittsburgh |
Inhibitors of prenyl transferases
|
|
US5741789A
(en)
*
|
1995-01-17 |
1998-04-21 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
FR2729390A1
(fr)
|
1995-01-18 |
1996-07-19 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730491B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2730492B1
(fr)
|
1995-02-09 |
1997-03-14 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5633272A
(en)
|
1995-02-13 |
1997-05-27 |
Talley; John J. |
Substituted isoxazoles for the treatment of inflammation
|
|
US5700806A
(en)
|
1995-03-24 |
1997-12-23 |
Schering Corporation |
Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
US5684013A
(en)
|
1995-03-24 |
1997-11-04 |
Schering Corporation |
Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
|
|
IL117580A0
(en)
|
1995-03-29 |
1996-07-23 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
|
|
US5891872A
(en)
|
1995-04-07 |
1999-04-06 |
Schering Corporation |
Tricyclic compounds
|
|
US5712280A
(en)
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
IL117798A
(en)
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
|
ATE242231T1
(de)
|
1995-04-07 |
2003-06-15 |
Schering Corp |
Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase
|
|
US5831115A
(en)
|
1995-04-21 |
1998-11-03 |
Abbott Laboratories |
Inhibitors of squalene synthase and protein farnesyltransferase
|
|
IL118101A0
(en)
|
1995-05-03 |
1996-09-12 |
Abbott Lab |
Inhibitors of farnesyltransferase
|
|
WO1997000252A1
(en)
|
1995-06-16 |
1997-01-03 |
Warner-Lambert Company |
Tricyclic inhibitors of protein farnesyltransferase
|
|
FR2736641B1
(fr)
|
1995-07-10 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
AT402617B
(de)
|
1995-07-11 |
1997-07-25 |
Datacon Schweitzer & Zeindl Gm |
Anlage zum automatisierten, hermetischen anlage zum automatisierten, hermetischen verschliessen von gehäusen verschliessen von gehäusen
|
|
FR2736638B1
(fr)
|
1995-07-12 |
1997-08-22 |
Rhone Poulenc Rorer Sa |
Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9514265D0
(en)
|
1995-07-13 |
1995-09-13 |
Wellcome Found |
Hetrocyclic compounds
|
|
CH690163A5
(fr)
|
1995-07-28 |
2000-05-31 |
Symphar Sa |
Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
|
|
US6001866A
(en)
|
1995-10-05 |
1999-12-14 |
Warner-Lambert Company |
Method for treating and preventing inflammation and atherosclerosis
|
|
WO1997012613A1
(en)
|
1995-10-05 |
1997-04-10 |
Warner-Lambert Company |
Method for treating and preventing inflammation and atherosclerosis
|
|
US5717100A
(en)
*
|
1995-10-06 |
1998-02-10 |
Merck & Co., Inc. |
Substituted imidazoles having anti-cancer and cytokine inhibitory activity
|
|
US6020343A
(en)
*
|
1995-10-13 |
2000-02-01 |
Merck Frosst Canada, Inc. |
(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
|
|
ATE236632T1
(de)
|
1995-11-06 |
2003-04-15 |
Univ Pittsburgh |
Inhibitoren der protein-isoprenyl-transferase
|
|
EP1186606B2
(de)
*
|
1995-11-17 |
2011-09-07 |
Gesellschaft für Biotechnologische Forschung mbH (GBF) |
Epothilon-Derivate, ihre Herstellung und Verwendung
|
|
EP0862435A4
(en)
|
1995-11-22 |
1999-02-03 |
Merck & Co Inc |
Inhibitors of farnesyl-protein transferase
|
|
EA000710B1
(ru)
|
1995-12-08 |
2000-02-28 |
Жансен Фармасетика Н.В. |
(имидазол-5-ил)метил-2-хинолиноновые производные, ингибирующие фарнезилпротеин-трансферазу
|
|
EP1380581A1
(en)
|
1995-12-22 |
2004-01-14 |
Schering Corporation |
Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative diseases
|
|
DK0882718T3
(da)
*
|
1995-12-28 |
2005-12-12 |
Astellas Pharma Inc |
Benzimidazolderivater
|
|
AU1529997A
(en)
|
1996-01-16 |
1997-08-11 |
Warner-Lambert Company |
Substituted histidine inhibitors of protein farnesyltransferase
|
|
GB9602029D0
(en)
*
|
1996-02-01 |
1996-04-03 |
Fujisawa Pharmaceutical Co |
New heterocyclic compounds
|
|
US6673927B2
(en)
|
1996-02-16 |
2004-01-06 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Farnesyl transferase inhibitors
|
|
JP2001519766A
(ja)
|
1996-04-03 |
2001-10-23 |
メルク エンド カンパニー インコーポレーテッド |
ファルネシルタンパク質トランスフェラーゼの阻害剤
|
|
TR199802049T2
(xx)
*
|
1996-04-12 |
1999-01-18 |
G.D.Searle & Co. |
COX-2 Inhibit�rlerinin �nilac� olarak s�bstit�e edilmi� benzens�lfonamid t�revleri.
|
|
NZ332712A
(en)
|
1996-05-22 |
2000-07-28 |
Warner Lambert Co |
Polypeptide inhibitors of protein farnesyl transferase
|
|
WO1997044058A1
(en)
*
|
1996-05-23 |
1997-11-27 |
Applied Research Systems Ars Holding N.V. |
Compounds that inhibit the binding of raf-1 or 14-3-3 proteins to the beta chain of il-2 receptor, and pharmaceutical compositions containing same
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
JP2000514456A
(ja)
|
1996-07-15 |
2000-10-31 |
ブリストル―マイヤーズ・スクイブ・カンパニー |
ファルネシルプロテイントランスフェラーゼのチアジオキソベンゾジアゼピン阻害剤
|
|
US5861419A
(en)
*
|
1996-07-18 |
1999-01-19 |
Merck Frosst Canad, Inc. |
Substituted pyridines as selective cyclooxygenase-2 inhibitors
|
|
FR2751649B1
(fr)
*
|
1996-07-26 |
1998-08-28 |
Adir |
Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
DE69734362T2
(de)
*
|
1996-12-03 |
2006-07-20 |
Sloan-Kettering Institute For Cancer Research |
Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
|
|
CA2276081A1
(en)
|
1996-12-30 |
1998-07-09 |
Lekhanh O. Tran |
Inhibitors of farnesyl-protein transferase
|
|
EP0951285A1
(en)
|
1996-12-30 |
1999-10-27 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US6127380A
(en)
*
|
1997-02-18 |
2000-10-03 |
American Home Products Corporation |
4-aminoalkoxy-1H-benzoimidazoles
|
|
US5932600A
(en)
*
|
1997-03-14 |
1999-08-03 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
ATE244717T1
(de)
*
|
1997-03-14 |
2003-07-15 |
Vertex Pharma |
Inhibitoren des impdh-enzyms
|
|
AR012634A1
(es)
*
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
|
US6187799B1
(en)
*
|
1997-05-23 |
2001-02-13 |
Onyx Pharmaceuticals |
Inhibition of raf kinase activity using aryl ureas
|
|
IL133731A0
(en)
*
|
1997-07-03 |
2001-04-30 |
Neurogen Corp |
Certain diarylimidazole derivatives, a new class of npy specific ligands
|
|
SI9700186B
(sl)
*
|
1997-07-14 |
2006-10-31 |
Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. |
Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin
|
|
FR2766822B1
(fr)
*
|
1997-07-30 |
2001-02-23 |
Adir |
Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9716557D0
(en)
*
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
|
US6022884A
(en)
*
|
1997-11-07 |
2000-02-08 |
Amgen Inc. |
Substituted pyridine compounds and methods of use
|
|
US6204467B1
(en)
*
|
1998-03-24 |
2001-03-20 |
Ford Global Technologies, Inc. |
Method and apparatus for resistive welding
|
|
PL344330A1
(en)
*
|
1998-05-22 |
2001-10-22 |
Smithkline Beecham Corp |
Novel 2-alkyl substituted imidazole compounds
|
|
US6420555B1
(en)
*
|
1998-06-16 |
2002-07-16 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Imidazolyl derivatives
|
|
FR2780973B1
(fr)
*
|
1998-07-09 |
2001-10-05 |
Hoechst Marion Roussel Inc |
Procede de preparation du 4-(3-pyridinyl)-1h-imidazole, et les intermediaires mis en oeuvre
|
|
DE19834751A1
(de)
*
|
1998-08-01 |
2000-02-03 |
Boehringer Ingelheim Pharma |
Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
|
|
BR9915401B1
(pt)
|
1998-11-17 |
2011-04-19 |
|
derivados de pirimidinilbenzimidazol ou triazinilbenzimidazol, de anilinotriazina e de anilinopirimidina, bem como fungicida agrìcola/hortìcola.
|
|
US6211177B1
(en)
*
|
1998-11-24 |
2001-04-03 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives
|
|
US6339083B1
(en)
|
1998-12-14 |
2002-01-15 |
Bayer Aktiengesellschaft |
Multiheterocyclic pharmAceuticals
|
|
RU2319693C9
(ru)
*
|
1999-01-13 |
2008-08-20 |
Байер Копэрейшн |
Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты)
|
|
AU3475100A
(en)
|
1999-01-29 |
2000-08-18 |
Imclone Systems Incorporated |
Antibodies specific to kdr and uses thereof
|
|
GB9904387D0
(en)
|
1999-02-25 |
1999-04-21 |
Pharmacia & Upjohn Spa |
Antitumour synergistic composition
|
|
WO2000061186A1
(en)
|
1999-04-08 |
2000-10-19 |
Arch Development Corporation |
Use of anti-vegf antibody to enhance radiation in cancer therapy
|
|
IL145748A0
(en)
|
1999-04-12 |
2002-07-25 |
Aventis Pharma Ltd |
Substituted bicyclic heteroaryl compounds as integrin antagonists
|
|
AU777275B2
(en)
|
1999-07-02 |
2004-10-07 |
Stuart A. Lipton |
Method of reducing neuronal injury or apoptosis
|
|
ES2263501T3
(es)
|
1999-10-27 |
2006-12-16 |
Cytokinetics, Inc. |
Procedimiento y composiciones que utilizan quinazolinonas.
|
|
US6545004B1
(en)
|
1999-10-27 |
2003-04-08 |
Cytokinetics, Inc. |
Methods and compositions utilizing quinazolinones
|
|
JP2003525936A
(ja)
|
2000-03-06 |
2003-09-02 |
スミスクライン ビーチャム パブリック リミテッド カンパニー |
Ｒａｆキナーゼ阻害物質としてのイミダゾール誘導体
|
|
EP1272483A2
(en)
|
2000-03-24 |
2003-01-08 |
Millenium Pharmaceuticals, Inc. |
OXINDOLE INHIBITORS OF FACTOR Xa
|
|
AU2001249399A1
(en)
|
2000-03-24 |
2001-10-08 |
Cor Therapeutics, Inc. |
Isoquinolone inhibitors of factor xa
|
|
JP2001322903A
(ja)
|
2000-05-15 |
2001-11-20 |
Kumiai Chem Ind Co Ltd |
農園芸用殺菌剤組成物
|
|
AU7804501A
(en)
*
|
2000-07-27 |
2002-02-13 |
Pharmacia Corp |
Epoxy-steroidal aldosterone antagonist and calcium channel blocker combination therapy for treatment of congestive heart failure
|
|
AU2001285349A1
(en)
*
|
2000-08-30 |
2002-03-13 |
The Board Of Trustees Of The University Of Arkansas |
Induction of ldl receptor expression by extracellular-signal regulated kinase, erk-1/2
|
|
JP4734705B2
(ja)
|
2000-10-31 |
2011-07-27 |
三菱化学株式会社 |
リチウム二次電池用正極材料、リチウム二次電池用正極及びリチウム二次電池
|
|
DE10060292A1
(de)
*
|
2000-12-05 |
2002-06-20 |
Aventis Pharma Gmbh |
Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament
|
|
EP1341769B1
(en)
*
|
2000-12-15 |
2007-10-17 |
Vertex Pharmaceuticals Incorporated |
Bacterial gyrase inhibitors and uses thereof
|
|
TW593278B
(en)
*
|
2001-01-23 |
2004-06-21 |
Wyeth Corp |
1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
|
|
AU2002237298B2
(en)
*
|
2001-02-08 |
2006-08-03 |
Karo Bio Ab |
Phenoxy substituted benzocondensed heteroaryl derivatives as thyroid receptor ligands
|
|
EP1379242B1
(en)
*
|
2001-03-26 |
2012-08-15 |
Newsouth Innovations Pty Limited |
Method for treatment of cancer and compositions for use therein
|
|
US20040106540A1
(en)
|
2001-04-10 |
2004-06-03 |
Barnett Stanley F |
Method of treating cancer
|
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
WO2002083140A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
CA2442270C
(en)
|
2001-04-10 |
2009-09-08 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
BR0208956A
(pt)
|
2001-04-16 |
2004-07-13 |
Tanabe Seiyaku Co |
Abridor de canais de k ativados por cálcio de grande condutância
|
|
US6855714B2
(en)
*
|
2001-07-06 |
2005-02-15 |
Schering Aktiengesellschaft |
1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
|
|
WO2003013526A1
(en)
|
2001-08-08 |
2003-02-20 |
Merck & Co. Inc. |
Anticoagulant compounds
|
|
WO2003024899A2
(en)
|
2001-09-17 |
2003-03-27 |
Bristol-Myers Squibb Company |
CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE)
|
|
US7132438B2
(en)
*
|
2001-10-09 |
2006-11-07 |
Amgen Inc. |
Benzimidazole derivatives
|
|
US7039413B2
(en)
*
|
2001-10-24 |
2006-05-02 |
Ntt Docomo, Inc. |
Mobile station transfer control system, cell transfer control method, mobile station, cell transfer control method at mobile station, cell transfer control program, control apparatus, and allocating method of communication resources
|
|
JP2005511581A
(ja)
|
2001-11-07 |
2005-04-28 |
メルク エンド カムパニー インコーポレーテッド |
有糸分裂キネシン阻害剤
|
|
TW200300140A
(en)
|
2001-11-14 |
2003-05-16 |
Novartis Ag |
Organic compounds
|
|
TW200303742A
(en)
|
2001-11-21 |
2003-09-16 |
Novartis Ag |
Organic compounds
|
|
UA83620C2
(ru)
*
|
2001-12-05 |
2008-08-11 |
Уайт |
Замещенные бензоксазолы и их аналоги как эстрогенные агенты
|
|
WO2003049679A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
DE60232994D1
(de)
|
2001-12-06 |
2009-08-27 |
Merck & Co Inc |
Inhibitoren von mitotischem kinesin
|
|
DE60222302T2
(de)
|
2001-12-06 |
2008-05-29 |
Merck & Co., Inc. |
Inhibitoren von mitotischem kinesin
|
|
WO2003049678A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
WO2003050122A2
(en)
|
2001-12-06 |
2003-06-19 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
JP4136395B2
(ja)
|
2002-02-22 |
2008-08-20 |
クミアイ化学工業株式会社 |
農園芸用殺菌剤組成物
|
|
EP1492487B1
(en)
|
2002-03-08 |
2009-11-11 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
US8299108B2
(en)
|
2002-03-29 |
2012-10-30 |
Novartis Ag |
Substituted benzazoles and methods of their use as inhibitors of raf kinase
|
|
US7071216B2
(en)
*
|
2002-03-29 |
2006-07-04 |
Chiron Corporation |
Substituted benz-azoles and methods of their use as inhibitors of Raf kinase
|
|
AU2003231359B2
(en)
|
2002-04-16 |
2009-04-30 |
Teijin Limited |
Piperidine derivatives having CCR3 antagonism
|
|
KR20040104596A
(ko)
|
2002-04-25 |
2004-12-10 |
데이진 가부시키가이샤 |
Ｃｃｒ３ 길항 작용을 갖는 ４,４-２치환 피페리딘 유도체
|
|
EP1509507A4
(en)
|
2002-05-23 |
2006-09-13 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
|
EP1517904A4
(en)
|
2002-05-23 |
2007-02-21 |
Merck & Co Inc |
INHIBITORS OF MITOTIC KINESINE
|
|
US7348440B2
(en)
|
2002-06-14 |
2008-03-25 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
ES2282647T3
(es)
|
2002-06-14 |
2007-10-16 |
MERCK & CO., INC. |
Inhibidores de cinesina mitotica.
|
|
TW200400816A
(en)
*
|
2002-06-26 |
2004-01-16 |
Lilly Co Eli |
Tricyclic steroid hormone nuclear receptor modulators
|
|
JP4637578B2
(ja)
|
2002-08-09 |
2011-02-23 |
アストラゼネカ アクチボラグ |
代謝調節型グルタミン酸受容体−５の調節因子としての１，２，４−オキサジアゾール類
|
|
KR20050057392A
(ko)
*
|
2002-09-18 |
2005-06-16 |
화이자 프로덕츠 인크. |
전환성장인자(ｔｇｆ) 억제제로서의 신규한 이미다졸 화합물
|
|
AU2003271548A1
(en)
|
2002-10-13 |
2004-05-04 |
Neurosearch A/S |
Use of skca channel blocking drugs for combating parkinson's disease
|
|
CA2502356A1
(en)
|
2002-10-15 |
2004-04-29 |
Synta Pharmaceuticals Corp. |
Aromatic bicyclic heterocyles to modulate 1l - 12 production
|
|
US20050054705A1
(en)
*
|
2003-02-04 |
2005-03-10 |
Aventis Pharma Deutschland Gmbh |
N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
|
|
US7531553B2
(en)
*
|
2003-03-21 |
2009-05-12 |
Amgen Inc. |
Heterocyclic compounds and methods of use
|
|
CA2520124A1
(en)
*
|
2003-03-28 |
2004-10-14 |
Chiron Corporation |
Use of benzazole compounds for immunopotentiation
|
|
AR044399A1
(es)
|
2003-05-20 |
2005-09-14 |
Novartis Ag |
Compuestos heterociclicos y su uso como activadores de receptores de ppar. composiciones farmaceuticas que los contienen
|
|
TW200510394A
(en)
|
2003-05-29 |
2005-03-16 |
Synta Pharmaceuticals Corp |
Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss
|
|
WO2005005421A1
(en)
|
2003-07-08 |
2005-01-20 |
Novartis Ag |
Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds
|
|
WO2005016914A1
(en)
|
2003-08-14 |
2005-02-24 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
PT2213661E
(pt)
|
2003-09-26 |
2011-12-15 |
Exelixis Inc |
Moduladores de c-met e métodos de uso
|
|
AU2004281151A1
(en)
*
|
2003-10-16 |
2005-04-28 |
Novartis Vaccines And Diagnostics, Inc. |
Substituted benzazoles and use thereof as inhibitors of Raf kinase
|
|
US7470712B2
(en)
|
2004-01-21 |
2008-12-30 |
Bristol-Myers Squibb Company |
Amino-benzazoles as P2Y1 receptor inhibitors
|
|
WO2005073224A2
(en)
|
2004-01-23 |
2005-08-11 |
Amgen Inc |
Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
|
|
TWI387592B
(zh)
*
|
2005-08-30 |
2013-03-01 |
Novartis Ag |
經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法
|
|
AU2007275634B2
(en)
*
|
2006-07-21 |
2011-01-20 |
Novartis Ag |
Formulations for benzimidazolyl pyridyl ethers
|