PE20080539A1 - MACROCYCLIC PYRIDAZINONYLS AS SERINE PROTEASE INHIBITORS OF HEPATITIS C - Google Patents
MACROCYCLIC PYRIDAZINONYLS AS SERINE PROTEASE INHIBITORS OF HEPATITIS CInfo
- Publication number
- PE20080539A1 PE20080539A1 PE2007001036A PE2007001036A PE20080539A1 PE 20080539 A1 PE20080539 A1 PE 20080539A1 PE 2007001036 A PE2007001036 A PE 2007001036A PE 2007001036 A PE2007001036 A PE 2007001036A PE 20080539 A1 PE20080539 A1 PE 20080539A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- substituted
- hepatitis
- serine protease
- pyridazinonyls
- Prior art date
Links
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES -(C=O)-O-R1, -(C=O)-R2, S(O)2-R1, ENTRE OTROS; R1 ES ARILO SUSTITUIDO O NO, HETEROARILO SUSTITUIDO O NO, HETEROCICLOALQUILO, CICLOALQUILO C1-C8, ENTRE OTROS; R2 ES H, ARILO SUSTITUIDO O NO, HETEROCICLOALQUILO SUSTITUIDO, -ALQUENILO C2-C8, ENTRE OTROS; G ES -NHS(O)2-R3 Y -NH(SO2)NR4R5; R3 ES ARILO SUSTITUIDO O NO, HETEROARILO, ALQUILO C1-C8, -CICLOALQUENILO -C3-C12, ENTRE OTROS; R4 Y R5 SON CADA UNO H, ARILO, HETEROARILO, HETEROCICLOALQUILO, ENTRE OTROS; L ES -CH2-, -O-, -S- Y S(O)2-; X, Y y Z SON CADA UNO H, -CN, -N3, HALOGENO, ARILO, ENTRE OTROS; ----DENOTA UN ENLACE CARBONO-CARBONO SIMPLE O DOBLE; j ES 0-4; k ES 1-3; m ES 0-2; n ES 1-3. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD SERINA PROTEASA, PARTICULARMENTE NS3-NS4A PROTEASA DEL VIRUS DE LA HEPATITIS C (VHC)REFERS TO A COMPOUND OF FORMULA I, WHERE A IS - (C = O) -O-R1, - (C = O) -R2, S (O) 2-R1, AMONG OTHERS; R1 IS ARYL, SUBSTITUTED OR NOT, HETEROARYL, SUBSTITUTED OR NOT, HETEROCICLOALKYL, CYCLOALKYL C1-C8, AMONG OTHERS; R2 IS H, ARYL SUBSTITUTED OR NOT, HETEROCYCLALKYL SUBSTITUTED, -ALKENYL C2-C8, AMONG OTHERS; G IS -NHS (O) 2-R3 AND -NH (SO2) NR4R5; R3 IS ARYL, SUBSTITUTED OR NOT, HETEROARYL, C1-C8 ALKYL, -CYCLOALKENYL -C3-C12, AMONG OTHERS; R4 AND R5 ARE EACH H, ARYL, HETEROARYL, HETEROCICLOALKYL, AMONG OTHERS; L IS -CH2-, -O-, -S- AND S (O) 2-; X, Y and Z ARE EACH H, -CN, -N3, HALOGEN, ARYL, AMONG OTHERS; ---- DENOTES A SIMPLE OR DOUBLE CARBON-CARBON LINK; j IS 0-4; k IS 1-3; m IS 0-2; n IS 1-3. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITORS OF SERINE PROTEASE ACTIVITY, PARTICULARLY NS3-NS4A PROTEASE OF THE HEPATITIS C VIRUS (HCV)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49984406A | 2006-08-04 | 2006-08-04 | |
| US11/832,893 US7718612B2 (en) | 2007-08-02 | 2007-08-02 | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080539A1 true PE20080539A1 (en) | 2008-05-16 |
Family
ID=39033583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001036A PE20080539A1 (en) | 2006-08-04 | 2007-08-06 | MACROCYCLIC PYRIDAZINONYLS AS SERINE PROTEASE INHIBITORS OF HEPATITIS C |
Country Status (4)
| Country | Link |
|---|---|
| CO (1) | CO6020004A1 (en) |
| EC (1) | ECSP077649A (en) |
| PE (1) | PE20080539A1 (en) |
| WO (1) | WO2008019303A2 (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| AR057456A1 (en) | 2005-07-20 | 2007-12-05 | Merck & Co Inc | HCV PROTEASA NS3 INHIBITORS |
| CN101415705B (en) | 2005-10-11 | 2011-10-26 | 因特蒙公司 | Compounds and methods for inhibiting hepatitis c viral replication |
| KR20090024834A (en) | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | New Inhibitors of Hepatitis C Virus Replication |
| US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
| UY32099A (en) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | HEPATITIS C SERINA PROTEASAS MACROCYCLIC INHIBITORS |
| EP2417134B1 (en) | 2009-04-08 | 2017-05-17 | Idenix Pharmaceuticals LLC. | Macrocyclic serine protease inhibitors |
| US8703700B2 (en) * | 2009-05-22 | 2014-04-22 | Sequoia Pharmaceuticals, Inc. | Bimacrocylic HCV NS3 protease inhibitors |
| US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
| TW201117812A (en) | 2009-08-05 | 2011-06-01 | Idenix Pharmaceuticals Inc | Macrocyclic serine protease inhibitors |
| US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| JP2013518060A (en) | 2010-01-25 | 2013-05-20 | エナンタ ファーマシューティカルズ インコーポレイテッド | Hepatitis C virus inhibitor |
| WO2012092409A2 (en) | 2010-12-30 | 2012-07-05 | Enanta Phararmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
| CA2821340A1 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc. | Phenanthridine macrocyclic hepatitis c serine protease inhibitors |
| TW201309690A (en) | 2011-02-10 | 2013-03-01 | Idenix Pharmaceuticals Inc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| SG11201502802PA (en) | 2012-10-19 | 2015-05-28 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2914598B1 (en) | 2012-11-02 | 2017-10-18 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9598433B2 (en) | 2012-11-02 | 2017-03-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9310374B2 (en) | 2012-11-16 | 2016-04-12 | Redwood Bioscience, Inc. | Hydrazinyl-indole compounds and methods for producing a conjugate |
| CN105164148A (en) | 2013-03-07 | 2015-12-16 | 百时美施贵宝公司 | Hepatitis c virus inhibitors |
| EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
| KR102783230B1 (en) | 2015-11-09 | 2025-03-19 | 알.피.쉐러 테크놀러지즈 엘엘씨 | Anti-CD22 antibody-maytansine conjugate and method of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601709B2 (en) * | 2003-02-07 | 2009-10-13 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis C serine protease inhibitors |
| AU2004211637C1 (en) * | 2003-02-07 | 2010-08-19 | Enanta Pharmaceuticals, Inc. | Macrocyclic hepatitis C serine protease inhibitors |
| US20040180815A1 (en) * | 2003-03-07 | 2004-09-16 | Suanne Nakajima | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors |
-
2007
- 2007-08-03 WO PCT/US2007/075146 patent/WO2008019303A2/en not_active Ceased
- 2007-08-06 PE PE2007001036A patent/PE20080539A1/en not_active Application Discontinuation
- 2007-08-06 EC EC2007007649A patent/ECSP077649A/en unknown
- 2007-08-06 CO CO07080060A patent/CO6020004A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008019303A2 (en) | 2008-02-14 |
| CO6020004A1 (en) | 2009-03-31 |
| WO2008019303A3 (en) | 2008-10-30 |
| ECSP077649A (en) | 2008-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |