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PE20060837A1 - 3H-OXAZOLE AND 3H-THIAZOLE [4,5-d] PYRIMIDIN-2-ONA 3,5-DISUSTITUIDE AND 3,5,7-TRISUSTITUIDE COMPOUNDS AND PROPHARMACES OF THE SAME - Google Patents

3H-OXAZOLE AND 3H-THIAZOLE [4,5-d] PYRIMIDIN-2-ONA 3,5-DISUSTITUIDE AND 3,5,7-TRISUSTITUIDE COMPOUNDS AND PROPHARMACES OF THE SAME

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Publication number
PE20060837A1
PE20060837A1 PE2006000034A PE2006000034A PE20060837A1 PE 20060837 A1 PE20060837 A1 PE 20060837A1 PE 2006000034 A PE2006000034 A PE 2006000034A PE 2006000034 A PE2006000034 A PE 2006000034A PE 20060837 A1 PE20060837 A1 PE 20060837A1
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Peru
Prior art keywords
ona
pyrimidin
compounds
trisustituide
propharmaces
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Application number
PE2006000034A
Other languages
Spanish (es)
Inventor
Stephen E Webber
Gregory J Haley
Alan X Xiang
Erik J Rueden
Joseph R Lennox
Original Assignee
Anadys Pharmaceuticals Inc
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Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Publication of PE20060837A1 publication Critical patent/PE20060837A1/en

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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE PIRIMIDINONA DE FORMULA (I), DONDE X ES O O S; Y ES O S; R1 ES H, ARILO, CICLOALQUILO, ENTRE OTROS; R2 ES NH2, -NHC(O)R4, -NHR5, ENTRE OTROS; R4 ES ALQUILO C1-C7 O -O(ALQUILO C1-C7); R5 ES ALQUILO C1-C7; R3 ES H, Cl, Br, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-AMINO-3-(2'-C-METIL-b-D-RIBOFURANOSIL)-3H-TIAZOLO[4,5-d]PIRIMIDIN-2-ONA, 5-AMINO-3-(2'-DESOXI-b-D-RIBOFURANOSIL)-3H-TIAZOLO[4,5-d]PIRIMIDIN-2-ONA, 5-AMINO-3-(2'-O-ACETIL-3'-DESOXI-b-D-RIBOFURANOSIL)-3H-TIAZOLO[4,5-d]PIRIMIDIN-2-ONA, ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE INFECCIONES CAUSADAS POR ADENOVIRUS, CITOMEGALOVIRUS, VIRUS DE LA HEPATITIS C, ENTRE OTROSREFERRING TO A COMPOUND DERIVED FROM PYRIMIDINONE OF FORMULA (I), WHERE X IS OR OR S; Y IS O S; R1 IS H, ARYL, CYCLOALKYL, AMONG OTHERS; R2 IS NH2, -NHC (O) R4, -NHR5, AMONG OTHERS; R4 IS C1-C7 ALKYL OR -O (C1-C7 ALKYL); R5 IS C1-C7 ALKYL; R3 IS H, Cl, Br, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 5-AMINO-3- (2'-C-METHYL-bD-RIBOFURANOSIL) -3H-THIAZOLO [4,5-d] PYRIMIDIN-2-ONA, 5-AMINO-3- (2'-DEOXY -bD-RIBOFURANOSIL) -3H-THIAZOLO [4,5-d] PYRIMIDIN-2-ONA, 5-AMINO-3- (2'-O-ACETYL-3'-DEOXY-bD-RIBOFURANOSIL) -3H-THIAZOLO [ 4,5-d] PYRIMIDIN-2-ONA, AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE USEFUL IN THE TREATMENT OF INFECTIONS CAUSED BY ADENOVIRUS, CYTOMEGALOVIRUS, HEPATITIS C VIRUS, AMONG OTHERS

PE2006000034A 2004-12-17 2006-01-03 3H-OXAZOLE AND 3H-THIAZOLE [4,5-d] PYRIMIDIN-2-ONA 3,5-DISUSTITUIDE AND 3,5,7-TRISUSTITUIDE COMPOUNDS AND PROPHARMACES OF THE SAME PE20060837A1 (en)

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US63663404P 2004-12-17 2004-12-17
US63663304P 2004-12-17 2004-12-17

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EP (2) EP1824482B1 (en)
JP (1) JP5303149B2 (en)
KR (1) KR101320008B1 (en)
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IL (2) IL183512A (en)
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