PE20071323A1 - {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-((R)-1-FENIL-ETIL)-AMINA EN EL TRATAMIENTO DE CANCER - Google Patents
{6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-((R)-1-FENIL-ETIL)-AMINA EN EL TRATAMIENTO DE CANCERInfo
- Publication number
- PE20071323A1 PE20071323A1 PE2007000072A PE2007000072A PE20071323A1 PE 20071323 A1 PE20071323 A1 PE 20071323A1 PE 2007000072 A PE2007000072 A PE 2007000072A PE 2007000072 A PE2007000072 A PE 2007000072A PE 20071323 A1 PE20071323 A1 PE 20071323A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- ethyl
- ilmrtil
- piperazin
- amine
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 abstract 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000001672 ovary Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UNA FORMA CRISTALINA DE {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDN-4-IL}-((R)-1-FENIL-ETIL)-AMINA, CARACTERIZADA POR UN PATRON DE DIFRACCION DE RAYOS X, EXPRESADO EN TERMINOS DE 2 THETA ANGULOS, QUE INCLUYE 5 O MAS PICOS SELECCIONADOS DE 4.4; 8.8; 9.1; 13.2; 14.2; 17.2; 18.2; 19.4+-0.2. Y UN ESPECTRO DE ABSORCION INFRARROJA CON BANDAS DE ABSORCION A APROXIMADAMENTE 695, 802, 836, 923, 1013, 1095, 1146, 1165, 1207, 1229, 1292, 1300, 1310, 1348, 1358, 1507, 1546, 1595, Y 3269 +-2 cm-1. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHO COMPUESTO INHIBE A EFG Y VEGF UTILES EN EL CANCER DE MAMA, CANCER DE COLON, OVARIO, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76122406P | 2006-01-23 | 2006-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071323A1 true PE20071323A1 (es) | 2008-02-15 |
Family
ID=37946476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000072A PE20071323A1 (es) | 2006-01-23 | 2007-01-23 | {6-[4-(4-ETIL-PIPERAZIN-1-ILMRTIL)-FENIL]-7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL}-((R)-1-FENIL-ETIL)-AMINA EN EL TRATAMIENTO DE CANCER |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1979357A1 (es) |
| JP (1) | JP2009523768A (es) |
| KR (1) | KR20080095859A (es) |
| CN (1) | CN101370814A (es) |
| AR (1) | AR059090A1 (es) |
| AU (1) | AU2007206925A1 (es) |
| BR (1) | BRPI0706729A2 (es) |
| CA (1) | CA2636954A1 (es) |
| PE (1) | PE20071323A1 (es) |
| RU (1) | RU2008134314A (es) |
| TN (1) | TNSN08312A1 (es) |
| TW (1) | TW200738719A (es) |
| WO (1) | WO2007082946A1 (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20011349A1 (es) * | 2000-06-16 | 2002-01-19 | Upjohn Co | 1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales |
| GB0119249D0 (en) * | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| JP2005507424A (ja) * | 2001-10-29 | 2005-03-17 | ノバルティス アクチエンゲゼルシャフト | 固形腫瘍の処置における７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の使用 |
| US20080227980A1 (en) * | 2005-08-05 | 2008-09-18 | Novartis Ag | Preparation of a 7H-Pyrrolo [2,3-D] Pyrimidine Derivative |
-
2007
- 2007-01-19 EP EP07704035A patent/EP1979357A1/en not_active Withdrawn
- 2007-01-19 RU RU2008134314/04A patent/RU2008134314A/ru not_active Application Discontinuation
- 2007-01-19 CN CNA2007800022653A patent/CN101370814A/zh active Pending
- 2007-01-19 JP JP2008550775A patent/JP2009523768A/ja active Pending
- 2007-01-19 KR KR1020087017912A patent/KR20080095859A/ko not_active Withdrawn
- 2007-01-19 WO PCT/EP2007/050567 patent/WO2007082946A1/en not_active Ceased
- 2007-01-19 AU AU2007206925A patent/AU2007206925A1/en not_active Abandoned
- 2007-01-19 CA CA002636954A patent/CA2636954A1/en not_active Abandoned
- 2007-01-19 AR ARP070100240A patent/AR059090A1/es not_active Application Discontinuation
- 2007-01-19 BR BRPI0706729-1A patent/BRPI0706729A2/pt not_active IP Right Cessation
- 2007-01-22 TW TW096102341A patent/TW200738719A/zh unknown
- 2007-01-23 PE PE2007000072A patent/PE20071323A1/es not_active Application Discontinuation
-
2008
- 2008-07-22 TN TNP2008000312A patent/TNSN08312A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101370814A (zh) | 2009-02-18 |
| AU2007206925A1 (en) | 2007-07-26 |
| WO2007082946A1 (en) | 2007-07-26 |
| JP2009523768A (ja) | 2009-06-25 |
| TNSN08312A1 (en) | 2009-12-29 |
| CA2636954A1 (en) | 2007-07-26 |
| BRPI0706729A2 (pt) | 2011-04-05 |
| EP1979357A1 (en) | 2008-10-15 |
| KR20080095859A (ko) | 2008-10-29 |
| TW200738719A (en) | 2007-10-16 |
| AR059090A1 (es) | 2008-03-12 |
| RU2008134314A (ru) | 2010-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |