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PE20071023A1 - Azaciclilaminas-n-sustituidas como antagonistas de histamina-3 - Google Patents

Azaciclilaminas-n-sustituidas como antagonistas de histamina-3

Info

Publication number
PE20071023A1
PE20071023A1 PE2007000268A PE2007000268A PE20071023A1 PE 20071023 A1 PE20071023 A1 PE 20071023A1 PE 2007000268 A PE2007000268 A PE 2007000268A PE 2007000268 A PE2007000268 A PE 2007000268A PE 20071023 A1 PE20071023 A1 PE 20071023A1
Authority
PE
Peru
Prior art keywords
halogen
oxo
nitro
alkyl
optionally substituted
Prior art date
Application number
PE2007000268A
Other languages
English (en)
Inventor
Derek Cecil Cole
Magda Asselin
Joseph Raymond Stock
Albert Jean Robichaud
Ji-In Kim
William Ronald Solvibile
Jonathan Laird Gross
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20071023A1 publication Critical patent/PE20071023A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE AZACICLILAMINA N-SUSTITUIDOS DE FORMULA (I) DONDE X ES CO, CH2 O SOm, DONDE m ES DE 0 A 2; n Y p SON CADA UNO DE 1 A 3; R1 Y R2 SON CADA UNO H, ALQUILO(C1-C10) O R1 Y R2 SON TOMADOS JUNTO AL ATOMO AL CUAL ESTAN UNIDOS PARA FORMAR UN ANILLO DE 4 A 7 MIEMBROS QUE TIENE DE 1 A 2 HETEROATOMOS SELECCIONADOS DE N, O U S, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, NITRO, CN, OXO, OH, ENTRE OTROS; R3 ES NR4R5, ARILO(C6-C20) O HETEROARILO DE 5 A 11 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON HALOGENO, NITRO, CN, OXO, OH, ENTRE OTROS, DONDE R4 Y R5 SON TOMADOS JUNTO CON EL ATOMO AL CUAL ESTAN UNIDOS PARA FORMAR UN ANILLO BICICLICO, TRICICLICO O TETRACICLICO DE 9 A 15 MIEMBROS QUE CONTIENE DE 1 A 3 HETEROATOMOS SELECCIONADOS DE N, O U S; R6 Y R7 SON CADA UNO H, HALOGENO, ALQUILO(C1-C10), CICLOALQUILO(C3-C10), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, NITRO, CN, OXO, OH, ENTRE OTROS; R8 Y R9 SON CADA UNO H, ALQUILO(C1-C10), CICLOALQUILO(C3-C10) O ARILO(C6-C20) OPCIONALMENTE SUSTITUIDOS CON HALOGENO, NITRO, CN, OXO, OH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N,N-DIMETIL-1-{4-[(2-FENIL-1H-BENCIMIDAZOL-1-IL)METIL]-BENZOIL}PIRROLIDIN-3-ILAMINA, N,N-DIMETIL-1-{4-[(6-FLUORO-1H-BENCIMIDAZOL-1-IL)METIL]-BENZOIL}PIRROLIDIN-3-ILAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR DE HISTAMINA H3 SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER
PE2007000268A 2006-03-15 2007-03-13 Azaciclilaminas-n-sustituidas como antagonistas de histamina-3 PE20071023A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78251306P 2006-03-15 2006-03-15
US85907906P 2006-11-15 2006-11-15

Publications (1)

Publication Number Publication Date
PE20071023A1 true PE20071023A1 (es) 2007-10-03

Family

ID=38353957

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000268A PE20071023A1 (es) 2006-03-15 2007-03-13 Azaciclilaminas-n-sustituidas como antagonistas de histamina-3

Country Status (11)

Country Link
US (1) US7820825B2 (es)
EP (1) EP1994022A2 (es)
JP (1) JP2009530274A (es)
AR (1) AR059905A1 (es)
AU (1) AU2007227681A1 (es)
BR (1) BRPI0709612A2 (es)
CA (1) CA2645731A1 (es)
MX (1) MX2008011791A (es)
PE (1) PE20071023A1 (es)
TW (1) TW200800958A (es)
WO (1) WO2007108936A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2561791A1 (en) * 2004-03-31 2005-10-20 Janssen Pharmaceutica, N.V. Non-imidazole heterocyclic compounds
JP2009530274A (ja) 2006-03-15 2009-08-27 ワイス ヒスタミン−３アンタゴニストとしてのｎ−置換−アザシクリルアミン化合物
ATE533744T1 (de) 2006-05-19 2011-12-15 Wyeth Llc N-benzoypyrrolidin-3-ylamine als histamin-3 antagonisten
JP5285603B2 (ja) * 2006-05-30 2013-09-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ３受容体のモジュレーターとしての置換ピリジルアミド化合物
US20080045507A1 (en) * 2006-06-29 2008-02-21 Allison Brett D Substituted benzamide modulators of the histamine h3 receptor
PE20081152A1 (es) 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
PE20090720A1 (es) * 2007-05-24 2009-06-11 Wyeth Corp Derivados de azaciclilbenzamida como antagonistas de histamina-3
EP2170875A1 (en) 2007-07-16 2010-04-07 Wyeth LLC Aminoalkylazole derivatives as histamine-3 antagonists
EP2220045A1 (en) * 2007-11-20 2010-08-25 Janssen Pharmaceutica, N.V. Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
EP2222664B1 (en) * 2007-11-20 2014-10-29 Janssen Pharmaceutica, N.V. Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor
SG176645A1 (en) * 2009-06-26 2012-01-30 Sanofi Sa Novel fumarate salts of a histamine h3 receptor antagonist
EP2669271A4 (en) 2011-01-25 2014-08-13 Kissei Pharmaceutical INDOLE DERIVATIVE AND PHARMACEUTICAL ACCEPTABLE SALT THEREOF
EP2875013B1 (en) * 2012-07-17 2017-11-29 Glaxosmithkline Intellectual Property (No. 2) Limited Indolecarbonitriles as selective androgen receptor modulators
JP6549735B2 (ja) 2015-06-09 2019-07-24 アッヴィ・インコーポレイテッド 核内受容体調節剤
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1416872A (en) 1972-03-10 1975-12-10 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US3933829A (en) 1974-08-22 1976-01-20 John Wyeth & Brother Limited 4-Aminoquinoline derivatives
US4159331A (en) 1978-05-05 1979-06-26 The Upjohn Company Antihypertensive 4-aminoquinolines
US4166853A (en) 1978-05-05 1979-09-04 The Upjohn Company Antihypertensive 7-trifluoromethyl-4-aminoquinolones
EP0525129A4 (en) 1990-04-13 1993-03-24 Smith-Kline Beecham Corporation Substituted benzimidazoles
DE69430861T2 (de) 1993-04-07 2003-01-23 Otsuka Pharmaceutical Co., Ltd. N-acylierte 4-aminopiperidin derivate als aktive bestandteile von peripher gefässerweiternden wikstoffen
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US6034093A (en) * 1995-06-07 2000-03-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted sulfonic acid N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
DE69819539T2 (de) 1997-05-01 2004-09-30 Eli Lilly And Co., Indianapolis Antithrombotische mittel
US6699873B1 (en) * 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US7375125B2 (en) * 1999-08-04 2008-05-20 Ore Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
AU1734401A (en) 1999-12-09 2001-06-18 Mitsubishi Pharma Corporation Carboxyamido derivatives
DE60138605D1 (de) 2000-03-31 2009-06-18 Ortho Mcneil Pharm Inc Phenyl-substituierte indole als h3 histaminrezeptorantagonisten
EP1341768A1 (en) 2000-12-07 2003-09-10 AstraZeneca AB Therapeutic benzimidazole compounds
HN2002000156A (es) 2001-07-06 2003-11-27 Inc Agouron Pharmaceuticals Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
ATE447404T1 (de) 2002-03-29 2009-11-15 Novartis Vaccines & Diagnostic Substituierte benzazole und ihre verwendung als raf-kinase-hemmer
KR101133959B1 (ko) 2003-03-14 2012-04-09 메디진 아게 면역조절 헤테로고리 화합물
JP4777974B2 (ja) * 2004-04-01 2011-09-21 イーライ リリー アンド カンパニー ヒスタミンｈ３受容体作用物質、製剤および治療的使用
CN104193750B (zh) 2004-05-14 2018-04-27 千禧药品公司 通过抑制极光激酶抑制有丝分裂的化合物和方法
TW200602314A (en) 2004-05-28 2006-01-16 Tanabe Seiyaku Co A novel pyrrolidine compound and a process for preparing the same
US20060014733A1 (en) 2004-07-19 2006-01-19 Pfizer Inc Histamine-3 agonists and antagonists
ES2325865T3 (es) 2004-07-26 2009-09-22 Eli Lilly And Company Derivados de oxazol como agentes receptores de histamina h3, preparacion y usos terapeuticos.
EP1784400B1 (en) 2004-08-23 2015-01-14 Eli Lilly And Company Histamine h3 receptor agents, preparation and therapeutic uses
US20080015202A1 (en) * 2004-09-09 2008-01-17 Astellas Pharma Inc. Thiazole Derivatives Having Vap-1 Inhibitory Activity
UY29149A1 (es) 2004-10-07 2006-05-31 Boehringer Ingelheim Int Tiazolil-dihidro-indazoles
US7381732B2 (en) 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
JP2008526895A (ja) 2005-01-21 2008-07-24 シェーリング コーポレイション ヒスタミンｈ３アンタゴニストとして有用なイミダゾールおよびベンゾイミダゾール誘導体
WO2006113140A2 (en) 2005-04-15 2006-10-26 Elan Pharmaceuticals, Inc. Novel compounds useful for bradykinin b1 receptor antagonism
JP2009530274A (ja) 2006-03-15 2009-08-27 ワイス ヒスタミン−３アンタゴニストとしてのｎ−置換−アザシクリルアミン化合物
JP2009531320A (ja) 2006-03-20 2009-09-03 グラクソ グループ リミテッド Ａｍｐａ受容体を強化する化合物および医薬におけるその使用
US20070238718A1 (en) 2006-04-06 2007-10-11 Matthias Grauert Thiazolyl-dihydro-indazole
ATE533744T1 (de) * 2006-05-19 2011-12-15 Wyeth Llc N-benzoypyrrolidin-3-ylamine als histamin-3 antagonisten
PE20081152A1 (es) * 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3

Also Published As

Publication number Publication date
EP1994022A2 (en) 2008-11-26
JP2009530274A (ja) 2009-08-27
US20070219240A1 (en) 2007-09-20
CA2645731A1 (en) 2007-09-27
WO2007108936A2 (en) 2007-09-27
WO2007108936A3 (en) 2007-11-01
MX2008011791A (es) 2008-09-25
US7820825B2 (en) 2010-10-26
BRPI0709612A2 (pt) 2011-07-19
TW200800958A (en) 2008-01-01
AU2007227681A1 (en) 2007-09-27
AR059905A1 (es) 2008-05-07

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