[go: up one dir, main page]

EA201000946A1 - Бициклические производные для применения при лечении состояний, связанных с андрогенным рецептором - Google Patents

Бициклические производные для применения при лечении состояний, связанных с андрогенным рецептором

Info

Publication number
EA201000946A1
EA201000946A1 EA201000946A EA201000946A EA201000946A1 EA 201000946 A1 EA201000946 A1 EA 201000946A1 EA 201000946 A EA201000946 A EA 201000946A EA 201000946 A EA201000946 A EA 201000946A EA 201000946 A1 EA201000946 A1 EA 201000946A1
Authority
EA
Eurasian Patent Office
Prior art keywords
conditions associated
androgen receptor
treatment
bicyclic derivatives
relates
Prior art date
Application number
EA201000946A
Other languages
English (en)
Other versions
EA017144B1 (ru
Inventor
Роберт Хью Брэдбери
Нил Джеймс Хейлс
Алфред Артур Рейбоу
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201000946A1 publication Critical patent/EA201000946A1/ru
Publication of EA017144B1 publication Critical patent/EA017144B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение касается бициклических соединений формулы Iгде переменные X, X, X, кольцо A, R, Rи m определены в описании. Настоящее изобретение также относится к способам получения таких соединений, фармацевтическим композициям, содержащим их, и к их применению для изготовления лекарственного средства для применения для предотвращения или лечения состояний, связанных с андрогенным рецептором.
EA201000946A 2007-12-21 2008-12-18 N-содержащие бициклические производные для применения при лечении состояний, связанных с андрогенным рецептором EA017144B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1575507P 2007-12-21 2007-12-21
US9609008P 2008-09-11 2008-09-11
US10780408P 2008-10-23 2008-10-23
PCT/GB2008/051206 WO2009081197A1 (en) 2007-12-21 2008-12-18 Bicyclic derivatives for use in the treatment of androgen receptor associated conditions

Publications (2)

Publication Number Publication Date
EA201000946A1 true EA201000946A1 (ru) 2010-12-30
EA017144B1 EA017144B1 (ru) 2012-10-30

Family

ID=40428336

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000946A EA017144B1 (ru) 2007-12-21 2008-12-18 N-содержащие бициклические производные для применения при лечении состояний, связанных с андрогенным рецептором

Country Status (23)

Country Link
US (1) US8003649B2 (ru)
EP (1) EP2235010A1 (ru)
JP (1) JP2011507824A (ru)
KR (1) KR20100099742A (ru)
CN (1) CN101952286A (ru)
AR (1) AR069911A1 (ru)
AU (1) AU2008339572B2 (ru)
BR (1) BRPI0821676A2 (ru)
CA (1) CA2709514A1 (ru)
CL (1) CL2008003846A1 (ru)
CO (1) CO6331441A2 (ru)
CR (1) CR11524A (ru)
DO (1) DOP2010000195A (ru)
EA (1) EA017144B1 (ru)
EC (1) ECSP10010291A (ru)
IL (1) IL206284A0 (ru)
NI (1) NI201000110A (ru)
NZ (1) NZ586913A (ru)
PE (1) PE20091157A1 (ru)
TW (1) TW200927121A (ru)
UY (1) UY31559A1 (ru)
WO (1) WO2009081197A1 (ru)
ZA (1) ZA201004227B (ru)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
US8188083B2 (en) * 2007-06-28 2012-05-29 Abbott Laboratories Triazolopyridazines
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
BRPI0907844B8 (pt) 2008-02-22 2021-05-25 Radius Health Inc compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
US8586599B2 (en) 2008-12-22 2013-11-19 Merck Patent Gmbh Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
WO2010092371A1 (en) * 2009-02-10 2010-08-19 Astrazeneca Ab Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer
CN102482280A (zh) * 2009-05-11 2012-05-30 阿斯利康(瑞典)有限公司 作为雄激素受体的配体的[1，2，4]三唑并[4，3-b]哒嗪
WO2011008543A2 (en) * 2009-06-29 2011-01-20 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
ME02437B (me) 2009-10-23 2016-09-20 Janssen Pharmaceutica Nv Disupstituirani oktahidropirolo[3,4-c]piroli kao modulatori oreksin receptora
US8680275B2 (en) 2009-10-23 2014-03-25 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
EP2491031B1 (en) 2009-10-23 2013-08-07 Janssen Pharmaceutica N.V. Fused heterocyclic compounds as orexin receptor modulators
WO2011082271A2 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted triazolo-pyrimidine compounds
EP2531029B1 (en) 2010-02-04 2016-10-19 Radius Health, Inc. Selective androgen receptor modulators
SI2568806T1 (sl) 2010-05-12 2016-09-30 Radius Health, Inc. Režimi zdravljenja
WO2011143365A1 (en) 2010-05-13 2011-11-17 Amgen Inc. Nitrogen heterocyclic compounds useful as pde10 inhibitors
US9006450B2 (en) * 2010-07-01 2015-04-14 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
EP2621901B1 (en) 2010-09-28 2015-07-29 Radius Health, Inc Selective androgen receptor modulators
US9586962B2 (en) 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression
US9422290B2 (en) * 2012-11-13 2016-08-23 Boehringer Ingelheim International Gmbh Triazolopyridazine
US9266891B2 (en) 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
HUP1300139A2 (en) * 2013-03-06 2014-09-29 Richter Gedeon Nyrt Phenoxypiperidine h3 antagonists
ES2718550T3 (es) 2013-05-13 2019-07-02 Glaxosmithkline Llc Análogos de urea con puente sustituidos como moduladores de sirtuinas
JP5924453B2 (ja) * 2013-06-10 2016-05-25 アステラス製薬株式会社 二環式含窒素芳香族ヘテロ環アミド化合物
NO2719005T3 (ru) 2014-07-28 2018-01-20
EP3034499A1 (en) * 2014-12-17 2016-06-22 Gilead Sciences, Inc. Novel FXR (NR1H4) modulating compounds
EP3034501A1 (en) * 2014-12-17 2016-06-22 Gilead Sciences, Inc. Hydroxy containing FXR (NR1H4) modulating compounds
US10363254B2 (en) * 2015-03-31 2019-07-30 University Of Vermont And State Agricultural College Methods for treating cryptosporidiosis using triazolopyridazines
IL288321B2 (en) 2016-03-10 2025-08-01 Janssen Pharmaceutica Nv Methods of treating depression using orexin-2 receptor antagonists
SG11201810600WA (en) 2016-06-13 2018-12-28 Gilead Sciences Inc Fxr (nr1h4) modulating compounds
CA2968836C (en) 2016-06-13 2025-09-02 Gilead Sciences, Inc. FXR MODULATING COMPOUNDS (NR1H4)
PL3474841T3 (pl) 2016-06-22 2022-07-11 Ellipses Pharma Ltd Sposoby leczenia nowotworu złośliwego piersi ar+
EP4122464B1 (en) 2017-03-28 2024-05-15 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases
CN110997670B (zh) * 2017-08-04 2022-11-01 百时美施贵宝公司 [1,2,4]三唑并[4,3-a]吡啶基取代的吲哚化合物
GB201716871D0 (en) 2017-10-13 2017-11-29 Inst Of Cancer Research: Royal Cancer Hospital Compounds
GB201806663D0 (en) * 2018-04-24 2018-06-06 Avexxin As 2-Oxothiazole compositions for treatment of fibrotic disease
RS65638B1 (sr) 2018-11-14 2024-07-31 Janssen Pharmaceutica Nv Unapređene sintetičke metode pravljenja fuzionisanih heterocikličnih jedinjenja kao modulatora receptora oreksina
WO2020123670A1 (en) * 2018-12-11 2020-06-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of the androgen receptor activity and/or expression and uses thereof
CN109942574B (zh) * 2019-01-11 2022-04-01 成都阿奇生物医药科技有限公司 天奇替尼及其制备方法和用途
BR112021011762A2 (pt) 2019-01-15 2021-11-03 Gilead Sciences Inc Compostos para modulação de fxr (nr1h4)
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
WO2020172075A1 (en) 2019-02-19 2020-08-27 Gilead Sciences, Inc. Solid forms of fxr agonists
CN114685601B (zh) * 2020-12-30 2024-10-18 财团法人工业技术研究院 雄性激素受体结合分子及其用途
MX2023012882A (es) * 2021-04-30 2024-01-17 Vanqua Bio Inc Moduladores de moleculas peque?as de la actividad de la glucocerebrosidasa y sus usos.
WO2024189472A1 (en) 2023-03-14 2024-09-19 Janssen Pharmaceutica Nv Improved synthetic methods of making substituted pyrimidine intermediates for synthesis of orexin receptor modulators
WO2025099660A1 (en) * 2023-11-10 2025-05-15 Suven Life Sciences Limited Piperidine substituted compounds as muscarinic m4 receptor positive allosteric modulators (m4 pams)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000017163A1 (en) 1998-09-22 2000-03-30 Yamanouchi Pharmaceutical Co., Ltd. Cyanophenyl derivatives
US6472415B1 (en) 1998-12-18 2002-10-29 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
US6184249B1 (en) 1998-12-18 2001-02-06 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
ATE481969T1 (de) 2004-10-01 2010-10-15 Merck Sharp & Dohme Aminopiperidine als dipeptidylpeptidase-iv- inhibitoren zur behandlung oder prävention von diabetes
WO2008109104A1 (en) * 2007-03-07 2008-09-12 The Regents Of The University Of California Bivalent inhibitors of akt protein kinase

Also Published As

Publication number Publication date
AU2008339572B2 (en) 2012-05-10
ZA201004227B (en) 2011-10-26
CN101952286A (zh) 2011-01-19
NI201000110A (es) 2012-05-14
WO2009081197A1 (en) 2009-07-02
US20100016279A1 (en) 2010-01-21
KR20100099742A (ko) 2010-09-13
UY31559A1 (es) 2009-08-03
EP2235010A1 (en) 2010-10-06
IL206284A0 (en) 2010-12-30
AR069911A1 (es) 2010-03-03
CL2008003846A1 (es) 2010-02-05
CR11524A (es) 2010-08-05
TW200927121A (en) 2009-07-01
PE20091157A1 (es) 2009-09-03
CO6331441A2 (es) 2011-10-20
NZ586913A (en) 2012-06-29
CA2709514A1 (en) 2009-07-02
DOP2010000195A (es) 2010-08-31
JP2011507824A (ja) 2011-03-10
AU2008339572A1 (en) 2009-07-02
US8003649B2 (en) 2011-08-23
EA017144B1 (ru) 2012-10-30
ECSP10010291A (es) 2010-07-30
BRPI0821676A2 (pt) 2015-06-16

Similar Documents

Publication Publication Date Title
EA201000946A1 (ru) Бициклические производные для применения при лечении состояний, связанных с андрогенным рецептором
EA200900023A1 (ru) Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли
EA201001639A1 (ru) Композиции и способы их получения и применения
EA201101583A1 (ru) Ингибиторы pi3 киназы или mtor
MA32784B1 (fr) Composes aryles substitues par heterocycle comme inhibiteurs de hif
UA107783C2 (en) Isoindoline compounds for use in treating cancer
CY1118362T1 (el) Ανταγωνιστες υποδοχεων cgrp αζαϊνδανιου καρβοξαμιδιου πιπεριδινονης
EA201001847A1 (ru) Соединения и композиции, применяемые для лечения малярии
MX2011009796A (es) Inhibidores de la cinasa pi3.
EA201200471A1 (ru) Простые эфирные производные бициклических гетероарилов
EA201200174A1 (ru) Производные оксазина и их применение в качестве ингибиторов bace для лечения неврологических нарушений
CY1111702T1 (el) Τα παραγωγα ινδολης ως αγωνιστες υποδοχεων s1p1
ATE517882T1 (de) Chinolinderivate
EA201200176A1 (ru) Производные оксазина и их применение для лечения неврологических нарушений
MX2012001419A (es) Compuestos biciclicos novedosos de urea.
UA96785C2 (ru) Замещенные производные оксиндола и их применение как лигандов рецептора вазопрессина
EA201100750A1 (ru) Замещенные диоксопиперидинилфталимидные производные
EA201100161A1 (ru) Производные хинуклидина карбоната и их медицинские композиции
BRPI0908635A8 (pt) composto, composição farmacêutica e método de tratamento de câncer
EA200971106A1 (ru) Соединения с семичленным кольцом и их фармацевтические применения для предупреждения и лечения диабета и метаболического синдрома
ATE542531T1 (de) Nitrofuran-verbindungen zur behandlung von krebs und angiogenese
ATE554076T1 (de) Sulfoximinsubstituierte chinazolinderivate als immunmodulatoren, ihre herstellung und ihre verwendung als medikamente
UA107183C2 (uk) Феніламіно-ізонікотинамідні сполуки, їх застосування, фармацевтична композиція, що їх містить, та спосіб лікування гіперпроліферативних захворювань
ATE430744T1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
MA32943B1 (fr) Piperidine spiro pyrrolidione et piperidinone substituees, leur preparation et leur utilisation therapeutique

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU