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PE20070016A1 - Compuestos heterociclicos n-enlazados como antagonistas del receptor p2y1 - Google Patents

Compuestos heterociclicos n-enlazados como antagonistas del receptor p2y1

Info

Publication number
PE20070016A1
PE20070016A1 PE2006000739A PE2006000739A PE20070016A1 PE 20070016 A1 PE20070016 A1 PE 20070016A1 PE 2006000739 A PE2006000739 A PE 2006000739A PE 2006000739 A PE2006000739 A PE 2006000739A PE 20070016 A1 PE20070016 A1 PE 20070016A1
Authority
PE
Peru
Prior art keywords
aryl
ring
heterocyclic compounds
antagonists
receiver
Prior art date
Application number
PE2006000739A
Other languages
English (en)
Inventor
Jennifer X Qiao
Tammy C Wang
James C Sutton
Timur Gungor
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20070016A1 publication Critical patent/PE20070016A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS N-ARIL O N-HETEROARIL-SUSTITUIDOS DE FORMULA (I), EN DONDE EL ANILLO A ES ARILO(C6-C10), HETEROCICLO DE 5 A 10 MIEMBROS CON 1 A 4 HETEROATOMOS DE N, NR11, ENTRE OTROS, AMBOS OPCIONALMENTE SUSTITUIDOS DE 1 A 5 R1; EL ANILLO B ES ARILO(C6-C10), O HETEROARILO DE 5 A 6 MIEMBROS DE 1 A 4 HETEROATOMOS DE N, NR11, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO; EL ANILLO D ESTA SUSTITUIDO DE 0 A 5 R6a, SIENDO SELECCIONADOS DIHIDROQUINOLINIL, BENZILINDOLIL, BENZIL-1H-INDOLIL, DECAHIDROQUINOLINIL, ENTRE OTROS; W ES -NR18, -NHS02-, -NHSO2CH2-, ENTRE OTROS. SON PREFERIDOS: N-(2-(4,4-DIMETIL-3,4-DIHIDROQUINOLIN-1(2H)-IL)FENIL9-4-(TRIFLUOROMETIL)TIAZOL-2-AMINA, N-(2-(3,3-DIMETILINDOLIN-1-IL)FENIL)-4-TRIFLUOROMETIL)-TIAZOL-AMINA, 4-TER-BUTIL-N-(2-(3,3-DIMETILINDOLIN-1-IL)PIRIDIN-3-IL)BENCENSULFONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES SELECTIVOS DEL RECEPTOR PURINERGICO P2Y1 HUMANO, POR LO QUE SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS TROMBOTICOS O TROMBOEMBOLICOS
PE2006000739A 2005-06-27 2006-06-27 Compuestos heterociclicos n-enlazados como antagonistas del receptor p2y1 PE20070016A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69459605P 2005-06-27 2005-06-27
US79706406P 2006-05-02 2006-05-02

Publications (1)

Publication Number Publication Date
PE20070016A1 true PE20070016A1 (es) 2007-02-11

Family

ID=37087734

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000739A PE20070016A1 (es) 2005-06-27 2006-06-27 Compuestos heterociclicos n-enlazados como antagonistas del receptor p2y1

Country Status (13)

Country Link
US (2) US7728008B2 (es)
EP (1) EP1896466B1 (es)
JP (1) JP2008543972A (es)
KR (1) KR20080027890A (es)
AR (1) AR056867A1 (es)
AT (1) ATE505468T1 (es)
AU (1) AU2006261828A1 (es)
DE (1) DE602006021306D1 (es)
MX (1) MX2007016501A (es)
NO (1) NO20076424L (es)
PE (1) PE20070016A1 (es)
TW (1) TW200726764A (es)
WO (1) WO2007002637A1 (es)

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DE602006021306D1 (es) 2011-05-26
WO2007002637A1 (en) 2007-01-04
ATE505468T1 (de) 2011-04-15
US20100197716A1 (en) 2010-08-05
US8329718B2 (en) 2012-12-11
MX2007016501A (es) 2008-03-06
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EP1896466A1 (en) 2008-03-12
KR20080027890A (ko) 2008-03-28
JP2008543972A (ja) 2008-12-04
AR056867A1 (es) 2007-10-31
US20060293281A1 (en) 2006-12-28
AU2006261828A1 (en) 2007-01-04
TW200726764A (en) 2007-07-16

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