PE20061181A1 - Proceso para la purificacion de compuestos benzoxazol substituidos - Google Patents
Proceso para la purificacion de compuestos benzoxazol substituidosInfo
- Publication number
- PE20061181A1 PE20061181A1 PE2006000257A PE2006000257A PE20061181A1 PE 20061181 A1 PE20061181 A1 PE 20061181A1 PE 2006000257 A PE2006000257 A PE 2006000257A PE 2006000257 A PE2006000257 A PE 2006000257A PE 20061181 A1 PE20061181 A1 PE 20061181A1
- Authority
- PE
- Peru
- Prior art keywords
- solution
- carbon atoms
- compound
- halogen
- hydroxyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical class C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 229940011871 estrogen Drugs 0.000 abstract 2
- 239000000262 estrogen Substances 0.000 abstract 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- MQIMZDXIAHJKQP-UHFFFAOYSA-N 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol Chemical compound N=1C2=CC(O)=CC(C=C)=C2OC=1C1=CC=C(O)C(F)=C1 MQIMZDXIAHJKQP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008395 clarifying agent Substances 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000012454 non-polar solvent Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 230000006916 protein interaction Effects 0.000 abstract 1
- 239000012264 purified product Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/42—One oxygen atom attached in position 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES ALQUENILO DE 2-7 ATOMOS DE CARBONO, HIDROXILO, -CN, HALOGENO, ENTRE OTROS; R2 Y R2a SON H, HIDROXILO, HALOGENO, ALQUILO DE 1-6 ATOMOS DE CARBONO, ENTRE OTROS; R3 Y R3a SON H, HALOGENO, ALCOXI DE 1-4 ATOMOS DE CARBONO, ENTRE OTROS; X ES O, S, o NR7; R7 ES H, ALQUILO DE 1-6 ATOMOS DE CARBONO, ARILO DE 6 -10 ATOMOS DE CARBONO , ENTRE OTROS. SIENDO COMPUESTO PREFERIDO 2-(3-FLUORO-4-HIDROXI-FENIL)-7-VINIL-BENZOXAZOL-5-OL. SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO PREPARACION QUE COMPRENDE LAS ETAPAS DE a) RECRISTALIZACION DE DICHO COMPUESTO DESDE UNA SOLUCION QUE COMPRENDE ACETONA Y ACETONITRILO PARA PROPORCIONAR UN PRODUCTO PURIFICADO CRUDO; b) DISOLVER DICHO PRODUCTO EN UNA SOLUCION DE ACETATO DE ETILO; c) TRATAR DICHA SOLUCION CON UN AGENTE CLARIFICANTE; d) CONCENTRAR DICHA SOLUCION CLARIFICADA PARA FORMAR UNA SOLUCION CLARIFICADA CONCENTRADA; e) AGREGAR UN SOLVENTE NO POLAR Y FORMAN UNA SOLUCION SOLVENTE Y FINALMENTE RECOLECTAR EL COMPUESTO PURIFICADO DESDE DICHA SOLUCION. EL COMPUESTO TIENE ACTIVIDAD A NIVEL DEL ESTROGENO EN LA INTERACCION RECEPTOR- PROTEINA CO-REGULADORA Y ES UTIL PARA EL REGULAR LOS EFECTOS PLEITROPICOS DE LOS ESTROGENOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65921205P | 2005-03-07 | 2005-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061181A1 true PE20061181A1 (es) | 2006-12-19 |
Family
ID=36579426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000257A PE20061181A1 (es) | 2005-03-07 | 2006-03-07 | Proceso para la purificacion de compuestos benzoxazol substituidos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7579478B2 (es) |
| EP (1) | EP1856068A1 (es) |
| JP (1) | JP2008531748A (es) |
| KR (1) | KR20070111515A (es) |
| CN (1) | CN101128443A (es) |
| AR (1) | AR052934A1 (es) |
| AU (1) | AU2006220680A1 (es) |
| BR (1) | BRPI0607816A2 (es) |
| CA (1) | CA2601975A1 (es) |
| GT (1) | GT200600104A (es) |
| IL (1) | IL185146A0 (es) |
| MX (1) | MX2007010895A (es) |
| NI (1) | NI200700206A (es) |
| NO (1) | NO20074103L (es) |
| PA (1) | PA8665701A1 (es) |
| PE (1) | PE20061181A1 (es) |
| RU (1) | RU2007130408A (es) |
| SG (1) | SG160352A1 (es) |
| TW (1) | TW200643017A (es) |
| WO (1) | WO2006096624A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080146630A1 (en) * | 2006-11-21 | 2008-06-19 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
| US20080139633A1 (en) * | 2006-11-21 | 2008-06-12 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
| US20080132554A1 (en) * | 2006-11-21 | 2008-06-05 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
| US20080176914A1 (en) * | 2006-11-21 | 2008-07-24 | Wyeth | Crystal form of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83620C2 (ru) * | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| CA2601973A1 (en) * | 2005-03-07 | 2006-09-14 | Wyeth | Process for the preparation of substituted benzoxazole compounds |
-
2006
- 2006-03-06 MX MX2007010895A patent/MX2007010895A/es unknown
- 2006-03-06 CA CA002601975A patent/CA2601975A1/en not_active Abandoned
- 2006-03-06 CN CNA2006800063536A patent/CN101128443A/zh active Pending
- 2006-03-06 AU AU2006220680A patent/AU2006220680A1/en not_active Abandoned
- 2006-03-06 WO PCT/US2006/007887 patent/WO2006096624A1/en not_active Ceased
- 2006-03-06 EP EP06737106A patent/EP1856068A1/en not_active Withdrawn
- 2006-03-06 US US11/369,113 patent/US7579478B2/en not_active Expired - Fee Related
- 2006-03-06 RU RU2007130408/04A patent/RU2007130408A/ru not_active Application Discontinuation
- 2006-03-06 BR BRPI0607816-8A patent/BRPI0607816A2/pt not_active IP Right Cessation
- 2006-03-06 KR KR1020077020451A patent/KR20070111515A/ko not_active Withdrawn
- 2006-03-06 SG SG201001457-9A patent/SG160352A1/en unknown
- 2006-03-06 JP JP2008500797A patent/JP2008531748A/ja active Pending
- 2006-03-07 TW TW095107504A patent/TW200643017A/zh unknown
- 2006-03-07 PE PE2006000257A patent/PE20061181A1/es not_active Application Discontinuation
- 2006-03-07 GT GT200600104A patent/GT200600104A/es unknown
- 2006-03-07 PA PA20068665701A patent/PA8665701A1/es unknown
- 2006-03-07 AR ARP060100852A patent/AR052934A1/es unknown
-
2007
- 2007-08-08 NO NO20074103A patent/NO20074103L/no not_active Application Discontinuation
- 2007-08-09 IL IL185146A patent/IL185146A0/en unknown
- 2007-08-14 NI NI200700206A patent/NI200700206A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NI200700206A (es) | 2008-07-03 |
| KR20070111515A (ko) | 2007-11-21 |
| US7579478B2 (en) | 2009-08-25 |
| AR052934A1 (es) | 2007-04-11 |
| GT200600104A (es) | 2006-10-25 |
| US20060199967A1 (en) | 2006-09-07 |
| EP1856068A1 (en) | 2007-11-21 |
| CN101128443A (zh) | 2008-02-20 |
| WO2006096624A1 (en) | 2006-09-14 |
| IL185146A0 (en) | 2007-12-03 |
| SG160352A1 (en) | 2010-04-29 |
| NO20074103L (no) | 2007-12-05 |
| AU2006220680A1 (en) | 2006-09-14 |
| TW200643017A (en) | 2006-12-16 |
| BRPI0607816A2 (pt) | 2010-03-23 |
| MX2007010895A (es) | 2007-12-05 |
| PA8665701A1 (es) | 2007-01-17 |
| JP2008531748A (ja) | 2008-08-14 |
| CA2601975A1 (en) | 2006-09-14 |
| RU2007130408A (ru) | 2009-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |