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PE20061060A1 - Derivados de taxanos como agentes citotoxicos - Google Patents

Derivados de taxanos como agentes citotoxicos

Info

Publication number
PE20061060A1
PE20061060A1 PE2005001385A PE2005001385A PE20061060A1 PE 20061060 A1 PE20061060 A1 PE 20061060A1 PE 2005001385 A PE2005001385 A PE 2005001385A PE 2005001385 A PE2005001385 A PE 2005001385A PE 20061060 A1 PE20061060 A1 PE 20061060A1
Authority
PE
Peru
Prior art keywords
desphenyl
desbenzoyl
isobutenyl
docetaxel
aryl
Prior art date
Application number
PE2005001385A
Other languages
English (en)
Inventor
Michael L Miller
Ravi V J Chari
Alain Commercon
Erkan Baloglu
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34931583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20061060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PE20061060A1 publication Critical patent/PE20061060A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE Z ES H O UN COMPUESTO DE FORMULA (II), DONDE R1 ES ALQUILO(C1-C10), ARILO, CICLOALQUILO(C3-C10), ENTRE OTROS, R3 ES ALQUILO(C1-C10), ARILO, CICLOALQUENILO(C3-C10), ENTRE OTROS; R4 ES H, OH, ALCOXI, ENTRE OTROS; R5, R6 Y R7 SON H o R7 Y R FORMAN UN ETER CICLICO; R8 ES ARILO O HETEROCICLICO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2'-(TRIISOPROPILSILILOXI)-3'-DESFENIL-3'(ISOBUTENIL)-2-DESBENZOIL-2-(2,5-DIMETOXIBENZOIL)-DOCETAXEL; 7-(TRIFLUOROMETANOSULFONILOXI)-2'-(TRIISOPROPILSILILOXI)-3'-DESFENIL-3'(ISOBUTENIL)-2-DESBENZOIL-2-(2,5-DIMETOXIBENZOIL)-DOCETAXEL; 7-(TRIFLUOROMETANOSULFONILOXI)-3'-DESFENIL-3'(ISOBUTENIL)-10-OXO-2-DESBENZOIL-2-(2,5-DIMETOXIBENZOIL)-DOCETAXEL; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN AGENTE DE UNION A LA CELULA ENLAZADO COVALENTEMENTE TALES COMO ANTICUERPOS O FRAGMENTOS DE ANTICUERPO, INTERFERONAS, HORMONAS, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DEL CANCER
PE2005001385A 2004-12-07 2005-11-29 Derivados de taxanos como agentes citotoxicos PE20061060A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04292898A EP1669358A1 (en) 2004-12-07 2004-12-07 Cytotoxic agents comprising new taxanes

Publications (1)

Publication Number Publication Date
PE20061060A1 true PE20061060A1 (es) 2006-11-14

Family

ID=34931583

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2010000952A PE20110001A1 (es) 2004-12-07 2005-11-29 Derivados de taxanos como agentes citotoxicos
PE2005001385A PE20061060A1 (es) 2004-12-07 2005-11-29 Derivados de taxanos como agentes citotoxicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2010000952A PE20110001A1 (es) 2004-12-07 2005-11-29 Derivados de taxanos como agentes citotoxicos

Country Status (22)

Country Link
US (1) US7667054B2 (es)
EP (2) EP1669358A1 (es)
JP (1) JP2008523019A (es)
KR (1) KR20070085781A (es)
CN (1) CN101094857A (es)
AR (1) AR054100A1 (es)
AU (1) AU2005313444B2 (es)
BR (1) BRPI0518869A2 (es)
CA (1) CA2588587A1 (es)
DO (1) DOP2005000248A (es)
EA (1) EA012625B1 (es)
IL (1) IL183404A0 (es)
MA (1) MA29103B1 (es)
MX (1) MX2007006765A (es)
MY (1) MY144632A (es)
NO (1) NO20073033L (es)
NZ (1) NZ555406A (es)
PE (2) PE20110001A1 (es)
TW (1) TW200637836A (es)
UY (1) UY29249A1 (es)
WO (1) WO2006061258A2 (es)
ZA (1) ZA200704790B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE446317T1 (de) 2001-05-11 2009-11-15 Ludwig Inst For Cancer Res Ltd Spezifische bindungsproteine und ihre verwendung
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
CN110613845B (zh) * 2007-01-25 2025-08-26 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
ES2542152T3 (es) * 2007-03-15 2015-07-31 Ludwig Institute For Cancer Research Ltd. Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
FR2947269B1 (fr) 2009-06-29 2013-01-18 Sanofi Aventis Nouveaux composes anticancereux
FR2949469A1 (fr) 2009-08-25 2011-03-04 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
US20110076232A1 (en) * 2009-09-29 2011-03-31 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
TW201117814A (en) 2009-10-02 2011-06-01 Sanofi Aventis New maytansinoids and the use of said maytansinoids to prepare conjugates with an antibody
CN101851231A (zh) * 2010-05-27 2010-10-06 东北林业大学 一种多西紫杉醇新衍生物的合成方法及其在制备抗肿瘤药物中的应用
FR2963007B1 (fr) 2010-07-26 2013-04-05 Sanofi Aventis Derives anticancereux, leur preparation et leur application therapeutique
ES2939836T3 (es) 2012-07-12 2023-04-27 Hangzhou Dac Biotech Co Ltd Conjugados de moléculas de unión celular con agentes citotóxicos
CN105849086B (zh) 2012-11-24 2018-07-31 杭州多禧生物科技有限公司 亲水性链接体及其在药物分子和细胞结合分子共轭反应上的应用
CN114262344A (zh) 2014-02-28 2022-04-01 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
CN104693156A (zh) * 2014-10-22 2015-06-10 上海大学 9,10-二羟基-1-去氧紫杉醇类似物及其制备方法
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
NZ752394A (en) 2016-11-14 2021-07-30 Hangzhou Dac Biotech Co Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
KR20240095442A (ko) 2021-11-03 2024-06-25 항저우 디에이씨 바이오테크 씨오, 엘티디 항체의 특이적 접합

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703247A (en) * 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
FR2742751B1 (fr) * 1995-12-22 1998-01-30 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
AU765588C (en) * 1999-11-24 2004-12-16 Immunogen, Inc. Cytotoxic agents comprising taxanes and their therapeutic use
US6596757B1 (en) * 2002-05-14 2003-07-22 Immunogen Inc. Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
AU2003247587B2 (en) * 2002-08-02 2009-07-09 Immunogen, Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use

Also Published As

Publication number Publication date
IL183404A0 (en) 2007-10-31
EP1669358A1 (en) 2006-06-14
NO20073033L (no) 2007-08-28
KR20070085781A (ko) 2007-08-27
CN101094857A (zh) 2007-12-26
JP2008523019A (ja) 2008-07-03
ZA200704790B (en) 2008-08-27
NZ555406A (en) 2011-02-25
AU2005313444A1 (en) 2006-06-15
US20060178427A1 (en) 2006-08-10
US7667054B2 (en) 2010-02-23
AU2005313444B2 (en) 2011-11-10
UY29249A1 (es) 2006-06-30
MA29103B1 (fr) 2007-12-03
TW200637836A (en) 2006-11-01
EP1824858A2 (en) 2007-08-29
MY144632A (en) 2011-10-14
AR054100A1 (es) 2007-06-06
WO2006061258A2 (en) 2006-06-15
EA200701251A1 (ru) 2007-12-28
DOP2005000248A (es) 2007-02-15
EA012625B1 (ru) 2009-10-30
BRPI0518869A2 (pt) 2008-12-16
WO2006061258A3 (en) 2006-09-28
PE20110001A1 (es) 2011-01-21
MX2007006765A (es) 2007-08-16
CA2588587A1 (en) 2006-06-15

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