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PE20061012A1 - Derivados piperidinil piperazina como inhibidores de receptores quiomicina - Google Patents

Derivados piperidinil piperazina como inhibidores de receptores quiomicina

Info

Publication number
PE20061012A1
PE20061012A1 PE2006000210A PE2006000210A PE20061012A1 PE 20061012 A1 PE20061012 A1 PE 20061012A1 PE 2006000210 A PE2006000210 A PE 2006000210A PE 2006000210 A PE2006000210 A PE 2006000210A PE 20061012 A1 PE20061012 A1 PE 20061012A1
Authority
PE
Peru
Prior art keywords
alkyl
receptors
inhibitors
chiomycin
piperazine derivatives
Prior art date
Application number
PE2006000210A
Other languages
English (en)
Inventor
Tze-Ming Chan
Kathleen Cox
Wenqing Feng
Michael W Miller
Daniel Weston
Stuart W Mccombie
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36540289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20061012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20061012A1 publication Critical patent/PE20061012A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA IA, DONDE R1 ES SELECCIONADO DE R9-FENILO, R9-PIRIDILO, R9-TIOFENILO, ENTRE OTROS; R2 ES H, ALQUILO; R3 ES H, ALQUILO, ALCOXIALQUIL-CICLOALQUILO, CICLOALQUILALQUIL-, ENTRE OTROS; R4, R5, R6 Y R7 SONCADA UNO H, ALQUILO; R8 ES A, B, C; R9 ES 1-3 SUSTITUYENTES SELECCIONADOS DE H, HALOGENO, ALQUILO, ALCOXI, -OCF3, -CN, ENTRE OTROS; R15 Y R16 SON CADA UNO ALQUILO, HALOGENO, -OH, -CF3, -O-ACILO, ENTRE OTROS; R17 ES H2N, O-ALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: D, E, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UNA PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LOS RECEPTORES DE QUIMOCINA ESPECIALMENTE CCR5, QUE EM COMBINACION CON AGENTES ANTIVIRALES TALES COMO LAMIVUDINA, ZIDOVUDINA, ABACABIR, ENTRE OTROS, SON UTILES EN EL TRATAMIENTO DEL SIDA
PE2006000210A 2005-02-23 2006-02-21 Derivados piperidinil piperazina como inhibidores de receptores quiomicina PE20061012A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65557205P 2005-02-23 2005-02-23

Publications (1)

Publication Number Publication Date
PE20061012A1 true PE20061012A1 (es) 2006-10-03

Family

ID=36540289

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000210A PE20061012A1 (es) 2005-02-23 2006-02-21 Derivados piperidinil piperazina como inhibidores de receptores quiomicina

Country Status (17)

Country Link
US (1) US7659275B2 (es)
EP (1) EP1858887A1 (es)
JP (1) JP4769257B2 (es)
KR (1) KR20070107085A (es)
CN (1) CN101163695A (es)
AR (1) AR054740A1 (es)
AU (1) AU2006216731A1 (es)
BR (1) BRPI0609251A2 (es)
CA (1) CA2598651A1 (es)
IL (1) IL185395A0 (es)
MX (1) MX2007010258A (es)
NO (1) NO20074825L (es)
PE (1) PE20061012A1 (es)
RU (1) RU2411241C2 (es)
TW (1) TW200640910A (es)
WO (1) WO2006091692A1 (es)
ZA (1) ZA200707019B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA015517B1 (ru) 2004-04-13 2011-08-30 Инсайт Корпорейшн Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора
RU2334515C2 (ru) * 2006-10-02 2008-09-27 ГОУ ВПО Военно-медицинская академия им. С.М. Кирова Применение "дневного" транквилизатора фенибута и антидепрессанта - селективного ингибитора обратного захвата серотонина триттико - при лечении псориаза
KR100861024B1 (ko) * 2007-07-20 2008-09-30 세크론 주식회사 반도체 제조 장치

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ514519A (en) * 1999-05-04 2003-07-25 Schering Corp Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
US6387930B1 (en) * 1999-05-04 2002-05-14 Schering Corporation Piperidine derivatives useful as CCR5 antagonists
CZ20013940A3 (cs) * 1999-05-04 2002-04-17 Schering Corporation Piperazinové deriváty uľitečné jako CCR5 antagonisté
US6689765B2 (en) * 1999-05-04 2004-02-10 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
US6391865B1 (en) * 1999-05-04 2002-05-21 Schering Corporation Piperazine derivatives useful as CCR5 antagonists
EP1659111A3 (en) * 1999-05-04 2007-05-09 Schering Corporation Piperidine derivatives useful as ccr5 antagonists
AR033517A1 (es) * 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
ATE418542T1 (de) * 2001-03-29 2009-01-15 Schering Corp Als ccr5-antagonisten verwendbare aryloxim- piperazine
AU2002255947B8 (en) * 2001-03-29 2005-11-17 Schering Corporation CCR5 antagonists useful for treating AIDS
GB0223223D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds
PE20040769A1 (es) * 2002-12-18 2004-11-06 Schering Corp Derivados de piperidina utiles como antagonisas ccr5
JO2525B1 (en) * 2004-04-08 2010-03-17 شركة جانسين فارماسوتيكا ان. في Derived 4-alkyl-and-4-canoelperidine derivatives and their use as anti-neroquin

Also Published As

Publication number Publication date
RU2411241C2 (ru) 2011-02-10
EP1858887A1 (en) 2007-11-28
TW200640910A (en) 2006-12-01
CN101163695A (zh) 2008-04-16
RU2007135126A (ru) 2009-03-27
BRPI0609251A2 (pt) 2010-03-09
NO20074825L (no) 2007-10-17
WO2006091692A1 (en) 2006-08-31
AR054740A1 (es) 2007-07-11
JP4769257B2 (ja) 2011-09-07
ZA200707019B (en) 2008-10-29
AU2006216731A1 (en) 2006-08-31
MX2007010258A (es) 2007-09-11
JP2008531575A (ja) 2008-08-14
US7659275B2 (en) 2010-02-09
US20060223821A1 (en) 2006-10-05
IL185395A0 (en) 2008-02-09
CA2598651A1 (en) 2006-08-31
KR20070107085A (ko) 2007-11-06

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FD Application declared void or lapsed