AR060535A1 - Pirido-piridazinonas y ftalazinonas como antagonistas duales de los receptores h1 y h3 de histamina - Google Patents
Pirido-piridazinonas y ftalazinonas como antagonistas duales de los receptores h1 y h3 de histaminaInfo
- Publication number
- AR060535A1 AR060535A1 ARP070101668A ARP070101668A AR060535A1 AR 060535 A1 AR060535 A1 AR 060535A1 AR P070101668 A ARP070101668 A AR P070101668A AR P070101668 A ARP070101668 A AR P070101668A AR 060535 A1 AR060535 A1 AR 060535A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- formula
- piridazinonas
- ftalazinonas
- pirido
- Prior art date
Links
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 2
- 239000005557 antagonist Substances 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 229960001340 histamine Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente se refiere a procedimientos para su preparacion, a composiciones que los contienen y a su uso en el tratamiento de diversas enfermedades tales como rinitis alérgica. Reivindicacion 1: Un compuesto de formula (1) en la que A representa N o CH; R1 y R2 representan independientemente cada uno halogeno, alquilo C1-6, alcoxi C1-6, hidroxilo o trifluorometilo; y y z representan independientemente cada uno 0, 1 o 2; R3 representa el grupo -(CH2)aNR4R5 o un grupo de formula (2) en la que a representa 1, 2 o 3; b representa 0 o 1; c representa 0, 1 o 2 y d representa 0, 1, 2 o 3, de tal modo que c y d no puedan ser ambos 0; R4 representa hidrogeno o alquilo C1-6; y R5 y R6 representan independientemente cada uno un grupo seleccionado de las formulas (3), (4) o (5) en las que, para la formula (3) e representa 1 a 6; e' representa 2 a 4; f representa 0, 1 o 2 y g representa 0, 1, 2 o 3, de tal modo que f y g no puedan ser ambos 0; h representa 0, 1 o 2; R7 representa alquilo C1-3 en las que, para la formula (4) i representa 1 a 6; X representa un enlace, O o -N(R10)C(O)-, en el que R10 representa hidrogeno o alquilo C1-6; j y k representan cada uno 1 o representan cada uno 2; R8 representa hidrogeno, cicloalquilo C3-6 o alquilo C1-6; en las que, para la formula (5) l representa 1 a 6; l' representa 0 a 3; m representa 0, 1 o 2 y n representa 0, 1 2 o 3, de tal modo que m y n no puedan ser ambos 0, y de tal modo que l' más n deben representar 1, 2 o 3; R9 representa hidrogeno, cicloalquilo C3-6 o alquilo C1-6; o una sal del mismo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0607839A GB0607839D0 (en) | 2006-04-20 | 2006-04-20 | Compounds |
| GB0706160A GB0706160D0 (en) | 2007-03-29 | 2007-03-29 | Compounds |
| GB0706176A GB0706176D0 (en) | 2007-03-29 | 2007-03-29 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060535A1 true AR060535A1 (es) | 2008-06-25 |
Family
ID=38226516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101668A AR060535A1 (es) | 2006-04-20 | 2007-04-18 | Pirido-piridazinonas y ftalazinonas como antagonistas duales de los receptores h1 y h3 de histamina |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20090105225A1 (es) |
| EP (1) | EP2007735B1 (es) |
| JP (1) | JP4489143B2 (es) |
| KR (1) | KR20090007604A (es) |
| AR (1) | AR060535A1 (es) |
| AT (1) | ATE486063T1 (es) |
| AU (1) | AU2007242842A1 (es) |
| BR (1) | BRPI0710156A2 (es) |
| CA (1) | CA2649029A1 (es) |
| CO (1) | CO6140030A2 (es) |
| CR (1) | CR10356A (es) |
| DE (1) | DE602007010118D1 (es) |
| EA (1) | EA200801996A1 (es) |
| MA (1) | MA30405B1 (es) |
| MX (1) | MX2008013406A (es) |
| NO (1) | NO20084363L (es) |
| PE (1) | PE20080360A1 (es) |
| TW (1) | TW200811116A (es) |
| WO (1) | WO2007122156A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR058109A1 (es) | 2005-12-20 | 2008-01-23 | Glaxo Group Ltd | Acido 3 - (4 - {[4 -(4 -{[3 - (3, 3 - dimetil - 1 - piperidinil)propil]oxi}fenil) - 1 - piperidinil]carbonil} - 1 - naftalenil)propanoico como antagonistas de los receptotres de histamina h1/h3, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamie |
| JP2010513393A (ja) * | 2006-12-20 | 2010-04-30 | グラクソ グループ リミテッド | Ｈ１受容体アンタゴニストとしての４−ベンジル−ｌ（２ｈ）−フタラジノン |
| PE20091089A1 (es) * | 2007-10-16 | 2009-08-24 | Glaxo Group Ltd | Composiciones farmaceuticas que comprenden 4-[(4-clorofenil)metil]-2-({(2r)-1-[4-(4{[3-(hexahidro-1h-azepin-1-il)propil]oxi}fenil)butil]-2-pirrolidinil}metil)-1(2h)-ftalazinona y furoato de fluticasona |
| MX2010012814A (es) | 2008-05-23 | 2010-12-20 | Amira Pharmaceuticals Inc | Inhibidor de proteina activadora de 5-lipoxigenasa. |
| GB0811447D0 (en) * | 2008-06-20 | 2008-07-30 | Glaxo Group Ltd | Formulations |
| WO2010094643A1 (en) | 2009-02-17 | 2010-08-26 | Glaxo Group Limited | Quinoline derivatives and their uses for rhinitis and urticaria |
| US20120157446A1 (en) * | 2009-06-29 | 2012-06-21 | Glaxo Group Limited | Medical use |
| BR112012029226A2 (pt) | 2010-05-19 | 2015-10-20 | Sandoz Ag | processo para a preparação de um composto quiral, composto quiral cristalino, sal de hcl do composto quiral cristalino, composto quiral e uso do composto |
| CN102892763B (zh) * | 2010-05-19 | 2016-03-09 | 桑多斯股份公司 | 泊沙康唑及泊沙康唑中间体的纯化 |
| BR112012029225B1 (pt) | 2010-05-19 | 2020-10-27 | Sandoz Ag | processo para a preparação de um composto quiral, composto quiral e uso de um composto quiral |
| WO2012045729A1 (en) | 2010-10-05 | 2012-04-12 | Glaxo Group Limited | Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists |
| WO2012072512A1 (en) | 2010-11-29 | 2012-06-07 | Glaxo Group Limited | N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists |
| WO2012139963A1 (en) | 2011-04-11 | 2012-10-18 | Glaxo Group Limited | N- cyclobutyl - imidazopyridine - methylamine as trpv1 antagonists |
| WO2012172015A1 (en) | 2011-06-16 | 2012-12-20 | Sandoz Ag | Process for the preparation of a chiral compound |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| TW201625247A (zh) | 2014-05-12 | 2016-07-16 | 葛蘭素史密斯克藍智慧財產權有限公司 | 用於治療傳染性疾病之醫藥組合物 |
| WO2021191875A1 (en) | 2020-03-26 | 2021-09-30 | Glaxosmithkline Intellectual Property Development Limited | Cathepsin inhibitors for preventing or treating viral infections |
| US20240279221A1 (en) * | 2021-05-27 | 2024-08-22 | Schrödinger, Inc. | Heterocyclic compounds and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH572914A5 (es) * | 1971-01-22 | 1976-02-27 | Asta Werke Ag Chem Fab | |
| US3813384A (en) * | 1972-01-17 | 1974-05-28 | Asta Werke Ag Chem Fab | Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof |
| ATE49205T1 (de) * | 1984-09-14 | 1990-01-15 | Asta Pharma Ag | Substituierte benzylphthalazinon-derivate. |
| ATE60598T1 (de) * | 1985-11-11 | 1991-02-15 | Asta Pharma Ag | 4-benzyl-1-(2h)-phthalazinon-derivate. |
| EP0289939A1 (de) * | 1987-05-08 | 1988-11-09 | ASTA Pharma AG | Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest |
| CZ199593A3 (en) * | 1992-10-02 | 1994-04-13 | Asta Medica Ag | Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr) |
| US6180629B1 (en) * | 1998-08-14 | 2001-01-30 | Cell Pathways, Inc. | [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia |
| PT997474E (pt) * | 1998-08-14 | 2004-01-30 | Pfizer | Agentes antitromboticos |
| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| CA2519220A1 (en) * | 2003-03-18 | 2004-09-30 | Merck & Co., Inc. | Amino cyclobutylamide modulators of chemokine receptor activity |
| CN1812981A (zh) * | 2003-06-27 | 2006-08-02 | 万有制药株式会社 | 杂芳氧基含氮饱和杂环衍生物 |
-
2007
- 2007-04-18 PE PE2007000478A patent/PE20080360A1/es not_active Application Discontinuation
- 2007-04-18 CA CA002649029A patent/CA2649029A1/en not_active Abandoned
- 2007-04-18 BR BRPI0710156-2A patent/BRPI0710156A2/pt not_active Application Discontinuation
- 2007-04-18 EP EP07728235A patent/EP2007735B1/en active Active
- 2007-04-18 MX MX2008013406A patent/MX2008013406A/es not_active Application Discontinuation
- 2007-04-18 KR KR1020087028456A patent/KR20090007604A/ko not_active Withdrawn
- 2007-04-18 US US12/297,458 patent/US20090105225A1/en not_active Abandoned
- 2007-04-18 AU AU2007242842A patent/AU2007242842A1/en not_active Abandoned
- 2007-04-18 AR ARP070101668A patent/AR060535A1/es not_active Application Discontinuation
- 2007-04-18 AT AT07728235T patent/ATE486063T1/de not_active IP Right Cessation
- 2007-04-18 TW TW096113665A patent/TW200811116A/zh unknown
- 2007-04-18 JP JP2009505878A patent/JP4489143B2/ja not_active Expired - Fee Related
- 2007-04-18 WO PCT/EP2007/053773 patent/WO2007122156A1/en not_active Ceased
- 2007-04-18 DE DE602007010118T patent/DE602007010118D1/de active Active
- 2007-04-18 EA EA200801996A patent/EA200801996A1/ru unknown
- 2007-04-18 US US11/736,602 patent/US20080039444A1/en not_active Abandoned
-
2008
- 2008-10-07 CR CR10356A patent/CR10356A/es not_active Application Discontinuation
- 2008-10-15 CO CO08110028A patent/CO6140030A2/es unknown
- 2008-10-17 NO NO20084363A patent/NO20084363L/no not_active Application Discontinuation
- 2008-11-10 MA MA31370A patent/MA30405B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2008013406A (es) | 2008-11-04 |
| MA30405B1 (fr) | 2009-05-04 |
| EP2007735A1 (en) | 2008-12-31 |
| WO2007122156A9 (en) | 2008-01-24 |
| US20090105225A1 (en) | 2009-04-23 |
| ATE486063T1 (de) | 2010-11-15 |
| KR20090007604A (ko) | 2009-01-19 |
| DE602007010118D1 (de) | 2010-12-09 |
| EA200801996A1 (ru) | 2009-04-28 |
| CO6140030A2 (es) | 2010-03-19 |
| TW200811116A (en) | 2008-03-01 |
| PE20080360A1 (es) | 2008-05-22 |
| WO2007122156A1 (en) | 2007-11-01 |
| US20080039444A1 (en) | 2008-02-14 |
| EP2007735B1 (en) | 2010-10-27 |
| JP2009534351A (ja) | 2009-09-24 |
| JP4489143B2 (ja) | 2010-06-23 |
| CR10356A (es) | 2008-11-26 |
| NO20084363L (no) | 2008-11-17 |
| AU2007242842A1 (en) | 2007-11-01 |
| CA2649029A1 (en) | 2007-11-01 |
| BRPI0710156A2 (pt) | 2012-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |