[go: up one dir, main page]

PE20060173A1 - Polimorfo cristalino de acetato de bazedoxifeno - Google Patents

Polimorfo cristalino de acetato de bazedoxifeno

Info

Publication number
PE20060173A1
PE20060173A1 PE2005000385A PE2005000385A PE20060173A1 PE 20060173 A1 PE20060173 A1 PE 20060173A1 PE 2005000385 A PE2005000385 A PE 2005000385A PE 2005000385 A PE2005000385 A PE 2005000385A PE 20060173 A1 PE20060173 A1 PE 20060173A1
Authority
PE
Peru
Prior art keywords
crystalline polymorph
deficiency
refers
polymorph
syndrome
Prior art date
Application number
PE2005000385A
Other languages
English (en)
Inventor
Kadum A Ali
Malama K Chibwe
Carl E Longfellow
Aldo Belli
Vincenzo Cannata
Giorgio Soriato
Joseph Peter Sabatucci
Fei Ye
Massimo Verzini
Livius Cotarca
Roberto Brescello
Pietro Allegrini
Shridhar G Gangolli
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34965585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060173(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20060173A1 publication Critical patent/PE20060173A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN POLIMORFO CRISTALINO (FORMA B) DE ACETATO DE BASEDOXIFENO (1-[4-(2-AZEPAN-1-IL-ETOXI)-BENCIL]-2-(4-HIDROXI-FENIL)-3-METIL-1H-INDOL-5-OL ACETICO, CARACTERIZADO POR UN PATRON DE DIFRACCION DE RAYOS X EN POLVO QUE COMPRENDE PICOS CARACTERISTICOS , EN TERMINOS DE 2 THETA, A ALREDEDOR DE 13,3 Y 20,8° Y TIENE UN TRAZADO DE CALORIMETRIA DIFERENCIAL DE BARRIDO QUE MUESTRA UN MAXIMO ALREDEDOR DE 181°C. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHO POLIMORFO ES MODULADOR SELECTIVO DEL RECEPTOR DE ESTROGENO UTILES EN EL TRATAMIENTO DE SINDROME ASOCIADO CON DEFICIENCIA O EXCESO DE ESTROGENO, DESARROLLO ANORMAL DE TEJIDOS ENDOMETRIALES, DISMINUCION DE COLESTEROL, CANCER MAMARIO, ENTRE OTROS
PE2005000385A 2004-04-07 2005-04-06 Polimorfo cristalino de acetato de bazedoxifeno PE20060173A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56058404P 2004-04-07 2004-04-07

Publications (1)

Publication Number Publication Date
PE20060173A1 true PE20060173A1 (es) 2006-04-12

Family

ID=34965585

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000385A PE20060173A1 (es) 2004-04-07 2005-04-06 Polimorfo cristalino de acetato de bazedoxifeno

Country Status (20)

Country Link
US (1) US7683052B2 (es)
EP (1) EP1732889A1 (es)
JP (2) JP2007532548A (es)
KR (1) KR20070004815A (es)
CN (1) CN1938271A (es)
AR (1) AR048683A1 (es)
AU (1) AU2005233114A1 (es)
BR (1) BRPI0509257A (es)
CA (1) CA2561296A1 (es)
EC (1) ECSP066910A (es)
GT (1) GT200500080A (es)
IL (1) IL178101A0 (es)
NO (1) NO20065046L (es)
PA (1) PA8629201A1 (es)
PE (1) PE20060173A1 (es)
RU (1) RU2006132352A (es)
TW (1) TW200536845A (es)
UA (1) UA86055C2 (es)
WO (1) WO2005100314A1 (es)
ZA (1) ZA200608361B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080031037A (ko) * 2005-06-29 2008-04-07 와이어쓰 결합형 에스트로겐과 바제독시펜의 제형
RU2417084C2 (ru) 2005-08-24 2011-04-27 Вайет Составы, содержащие базедоксифен ацетат
PE20090100A1 (es) * 2007-03-30 2009-02-26 Wyeth Corp Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas
CZ302358B6 (cs) * 2007-07-25 2011-03-30 Zentiva, A. S. Nové soli bazedoxifenu
WO2009102778A1 (en) * 2008-02-11 2009-08-20 Wyeth Amorphous polymorph of bazedoxifene acetate
JP5199395B2 (ja) * 2008-02-11 2013-05-15 ワイス・エルエルシー バゼドキシフェン酢酸塩の多形体ａの調製方法
ITMI20091109A1 (it) * 2009-06-23 2010-12-24 Wyeth Corp Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione
AR078785A1 (es) 2009-10-27 2011-11-30 Wyeth Llc Formulaciones de bazedoxifeno con antioxidantes
WO2012007453A1 (en) 2010-07-14 2012-01-19 Sandoz Ag Crystalline compound of 1-[4-(2-azepan-1-ylethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1h-indol-5-ol
EP2407467A1 (de) 2010-07-14 2012-01-18 Sandoz Ag Kristalline Verbindung von 1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol und Milchsäure
WO2012037187A2 (en) 2010-09-14 2012-03-22 Dr. Reddy's Laboratories Ltd. Preparation of crystalline bazedoxifene and its salts
EP2471770A1 (en) 2010-12-28 2012-07-04 Sandoz Ag Method of preparing polymorphic pure form A of bazedoxifene acetate
CN103864664A (zh) * 2012-12-18 2014-06-18 江苏柯菲平医药有限公司 巴多昔芬乙酸盐新晶型及其制备方法
WO2014186325A1 (en) 2013-05-15 2014-11-20 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
CN103864665B (zh) * 2014-03-04 2016-03-02 苏州特瑞药业有限公司 醋酸巴多昔芬的制备方法
CN104030963A (zh) * 2014-06-30 2014-09-10 四川大学 一种巴多昔芬醋酸盐晶型a的制备方法
CN111004165A (zh) * 2019-12-03 2020-04-14 南京正济医药研究有限公司 一种醋酸巴多昔芬晶型a的制备方法
US11246874B1 (en) 2021-04-20 2022-02-15 Oxygen Biotech LLC Treatment of COVID-19

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW397821B (en) 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
ATE206701T1 (de) 1996-04-19 2001-10-15 American Home Prod Östrogene verbindungen
US5780497A (en) * 1996-04-19 1998-07-14 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
US5998402A (en) * 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
US5880137A (en) * 1996-04-19 1999-03-09 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
US6005102A (en) * 1997-10-15 1999-12-21 American Home Products Corporation Aryloxy-alkyl-dialkylamines
AR015183A1 (es) * 1997-10-15 2001-04-18 Wyeth Corp Ariloxi-alquil-dialquilaminas y procesos para su produccion
US6479535B1 (en) * 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
EP1336602A1 (en) 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
MXPA04012419A (es) * 2002-06-25 2005-04-19 Wyeth Corp Uso de derivados de tio-oxindol en el tratamiento de condiciones relacionadas con la hormona.
US7683051B2 (en) 2004-04-07 2010-03-23 Wyeth Crystalline polymorph of bazedoxifene acetate

Also Published As

Publication number Publication date
AR048683A1 (es) 2006-05-17
WO2005100314A1 (en) 2005-10-27
JP2007532548A (ja) 2007-11-15
JP2009007361A (ja) 2009-01-15
US20050250762A1 (en) 2005-11-10
IL178101A0 (en) 2006-12-31
CA2561296A1 (en) 2005-10-27
GT200500080A (es) 2005-10-31
UA86055C2 (ru) 2009-03-25
NO20065046L (no) 2006-11-06
ZA200608361B (en) 2010-03-31
ECSP066910A (es) 2006-12-20
CN1938271A (zh) 2007-03-28
TW200536845A (en) 2005-11-16
BRPI0509257A (pt) 2007-09-11
PA8629201A1 (es) 2005-11-25
EP1732889A1 (en) 2006-12-20
RU2006132352A (ru) 2008-05-20
AU2005233114A1 (en) 2005-10-27
US7683052B2 (en) 2010-03-23
KR20070004815A (ko) 2007-01-09

Similar Documents

Publication Publication Date Title
PE20060173A1 (es) Polimorfo cristalino de acetato de bazedoxifeno
USD592830S1 (en) Tie towel
AR064014A1 (es) Tabletas bi-capa de estrogeno/moduladores selectivos de receptores de estrogeno (serm) y estrogeno/progestina
PE20060676A1 (es) Polimorfo cristalino de acetato de bazedoxifeno
HRP20130454T1 (en) Novel vanilloid receptor ligands and their use for producing medicaments
IL187235A0 (en) 2,6 quinolinyl derivatives, processes for preparing them and their use as medicament
AR077203A1 (es) Forma polimorfica d del acetato de bazedoxifeno, composiciones farmaceuticas que la contienen metodo para prepararla y uso del mismo para tratar enfermedades mediadas por moduladores selectivos de receptores estrogenicos (serms)
MX2010004323A (es) Formas de dosificacion oral que comprenden acetato de licarbazepina.
JP2015500331A5 (es)
EP2112907A4 (en) PEARL FOR SEWING, VACUUM CAP FOR SUCKING AN INNER ORGAN AND DEVICE FOR SEWING AN INNER ORGAN
JP2007532548A5 (es)
NZ587670A (en) Use of interleukin-1 conjugates in the treatment of diabetes
JP2008024962A5 (es)
AR061300A1 (es) Formas cristalinas de 6-metoxi -8- [4- (1- (5-fluoro) -quinolin -8-il-piperidin -4-il) -piperazin -1-il] -quinolina
JP2011511813A5 (es)
CL2008003055A1 (es) Compuestos derivados del 5-oxo-4-fenil-4,5-dihidro-imidazol-1-il; procedimiento de preparacion; composicion farmaceutica, y su uso en, osteoporosis, drogas de abuso, enfermedad cardiovascular, entre otras, a travez de la modulacion del receptor npy y2.
Muthu Balcanologie
PE20090167A1 (es) Sintesis y caracterizacion de la forma iii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo
NITHINN BA SAAAAS
TH36368S1 (th) อุปกรณ์ยึดโครงหลังคา
TH101728S (th) อุปกรณ์ยึดโครงหลังคา
TH33569S1 (th) ลวดลายบนแผ่นวัสดุปิดทับแถบกาวสำหรับผ้าอนามัย
RU2006140572A (ru) Композиция, проявляющая местноанестезирующую активность
TH88015S (th) โต๊ะ
TH28953S1 (th) โต๊ะ

Legal Events

Date Code Title Description
FC Refusal