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PE20090100A1 - Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas - Google Patents

Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas

Info

Publication number
PE20090100A1
PE20090100A1 PE2008000556A PE2008000556A PE20090100A1 PE 20090100 A1 PE20090100 A1 PE 20090100A1 PE 2008000556 A PE2008000556 A PE 2008000556A PE 2008000556 A PE2008000556 A PE 2008000556A PE 20090100 A1 PE20090100 A1 PE 20090100A1
Authority
PE
Peru
Prior art keywords
acetate
bacedoxifen
components
separation
detection
Prior art date
Application number
PE2008000556A
Other languages
English (en)
Inventor
Wei Tong
Carl E Longfellow
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20090100A1 publication Critical patent/PE20090100A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/34—Chemical or biological purification of waste gases
    • B01D53/92—Chemical or biological purification of waste gases of engine exhaust gases
    • B01D53/94—Chemical or biological purification of waste gases of engine exhaust gases by catalytic processes
    • B01D53/9445—Simultaneously removing carbon monoxide, hydrocarbons or nitrogen oxides making use of three-way catalysts [TWC] or four-way-catalysts [FWC]
    • B01D53/945—Simultaneously removing carbon monoxide, hydrocarbons or nitrogen oxides making use of three-way catalysts [TWC] or four-way-catalysts [FWC] characterised by a specific catalyst
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02T—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
    • Y02T10/00—Road transport of goods or passengers
    • Y02T10/10—Internal combustion engine [ICE] based vehicles
    • Y02T10/12—Improving ICE efficiencies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Environmental & Geological Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Combustion & Propulsion (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA SEPARAR Y DETECTAR UNA COMPOSICION QUE CONTIENE ACETATO DE BACEDOXIFENO, EL CUAL PUEDE ESTAR EN FORMA A CARACTERIZADO CON UN PICO EN 2? DE 12.8 ± 0.2º; FORMA B CON PICO EN 2? DE 12.0 ± 0.2º Y 13.3 ± 0.2º Y OTROS COMPONENTES CON PICOS DE DIFRACCION PARECIDOS A ESTE. DICHO METODO COMPRENDE: a)PONER EN CONTACTO POR 1-120 MINUTOS LA COMPOSICION FARMACEUTICA CON UN MEDIO DE EXTRACCION, TALES COMO SALES DE ACETATO CON 0.05-0.75M Y PH DE 5-10, EN CANTIDAD DE 0,2 ml POR UNIDAD DE DOSIFICACION, PARA PRODUCIR UNA SUSPENSION; b)FILTRAR DICHA SUSPENSION, DONDE UNO O MAS COMPONENTES SE ENCUENTRAN EN EL FILTRADO; c)SECAR EL FILTRANDO PARA OBTENER UNO O MAS COMPONENTES QUE PRODUCEN PATRONES DE DIFRACCION DE RAYOS X QUE TIENEN UNO O MAS PICOS DE INTERFERENCIA, TALES COMO LACTOSA, SACAROSA O MEZCLAS DE LAS MISMAS, CON PICOS EN 2? DE 11.6 ± 0.2º HASTA 13.7 ± 0.2º
PE2008000556A 2007-03-30 2008-03-27 Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas PE20090100A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90911307P 2007-03-30 2007-03-30

Publications (1)

Publication Number Publication Date
PE20090100A1 true PE20090100A1 (es) 2009-02-26

Family

ID=39671954

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000556A PE20090100A1 (es) 2007-03-30 2008-03-27 Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas

Country Status (17)

Country Link
US (1) US20080249303A1 (es)
EP (1) EP2132172A1 (es)
JP (1) JP2010523982A (es)
KR (1) KR20090127431A (es)
CN (1) CN101657421A (es)
AR (1) AR065875A1 (es)
AU (1) AU2008232666A1 (es)
BR (1) BRPI0809950A2 (es)
CA (1) CA2682185A1 (es)
CL (1) CL2008000922A1 (es)
IL (1) IL201043A0 (es)
MX (1) MX2009010508A (es)
PA (1) PA8773701A1 (es)
PE (1) PE20090100A1 (es)
RU (1) RU2009135267A (es)
TW (1) TW200902023A (es)
WO (1) WO2008121800A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833645C (en) * 2011-05-17 2019-09-17 Zach System S.P.A. Method of detecting polymorphs using synchrotron radiation
CN106198827B (zh) * 2016-08-11 2018-03-27 齐鲁制药有限公司 高效测定醋酸巴多昔芬及其杂质的药物分析方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1553781A (en) * 1976-08-05 1979-10-10 Exxon Research Engineering Co Bisphenol derivatives and their use as stabilizers
ATE76435T1 (de) * 1985-06-26 1992-06-15 Upjohn Co Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen.
US5298397A (en) * 1989-10-19 1994-03-29 Yamasa Shoyu Kabushiki Kaisha Method of assaying d-vanillylmandelic acid
US5998402A (en) * 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
US6479535B1 (en) * 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
US6441144B1 (en) * 1999-05-20 2002-08-27 Alpha Therapeutic Corporation Method for repairing dual virally inactivated immune globulin for intravenous administration
WO2003087796A1 (en) * 2002-04-10 2003-10-23 Bristol-Myers Squibb Company High throughput x-ray diffraction filter sample holder
PA8629201A1 (es) * 2004-04-07 2005-11-25 Wyeth Corp Polimorfo cristalino de acetato de bazedoxifeno
US7683051B2 (en) * 2004-04-07 2010-03-23 Wyeth Crystalline polymorph of bazedoxifene acetate
KR20080031037A (ko) * 2005-06-29 2008-04-07 와이어쓰 결합형 에스트로겐과 바제독시펜의 제형

Also Published As

Publication number Publication date
AU2008232666A1 (en) 2008-10-09
PA8773701A1 (es) 2008-11-19
EP2132172A1 (en) 2009-12-16
CA2682185A1 (en) 2008-10-09
AR065875A1 (es) 2009-07-08
BRPI0809950A2 (pt) 2014-10-07
IL201043A0 (en) 2010-05-17
KR20090127431A (ko) 2009-12-11
US20080249303A1 (en) 2008-10-09
TW200902023A (en) 2009-01-16
MX2009010508A (es) 2009-10-19
JP2010523982A (ja) 2010-07-15
RU2009135267A (ru) 2011-05-10
WO2008121800A1 (en) 2008-10-09
CN101657421A (zh) 2010-02-24
CL2008000922A1 (es) 2009-01-16

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