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PE20060099A1 - Dispositivo para administrar en forma transdermica un agente anticoagulante mediante electrotransporte - Google Patents

Dispositivo para administrar en forma transdermica un agente anticoagulante mediante electrotransporte

Info

Publication number
PE20060099A1
PE20060099A1 PE2005000616A PE2005000616A PE20060099A1 PE 20060099 A1 PE20060099 A1 PE 20060099A1 PE 2005000616 A PE2005000616 A PE 2005000616A PE 2005000616 A PE2005000616 A PE 2005000616A PE 20060099 A1 PE20060099 A1 PE 20060099A1
Authority
PE
Peru
Prior art keywords
amidinophenyl
propenyl
electronic transport
anticoagulating agent
refers
Prior art date
Application number
PE2005000616A
Other languages
English (en)
Inventor
Sudeep Takhar
Rama V Padmanabhan
Janardhanan A Subramony
Joseph B Phipps
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of PE20060099A1 publication Critical patent/PE20060099A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/044—Shape of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN DISPOSITIVO PARA ADMINISTRAR EN FORMA TRANSDERMICA UN AGENTE ANTICOAGULANTE QUE INCLUYE UN DERIVADO DE BENZAMIDINA SELECCIONADO DE 2-[3-[4-(4-PIPERIDINILOXI)ANILINO]-1-PROPENIL]BENZAMIDINA, ACIDO N-[4-(1-ACETIMIDOILPIPERIDIN-4-ILOXI)-3-CLOROFENIL]-N-(3-(3-AMIDINOFENIL)-2-(E)-PROPENIL]SULFAMOILACETICO, ENTRE OTROS. EL AGENTE ANTICOAGULANTE INCLUYE UN DERIVADO DE ANFTAMIDINA. EL DISPOSITIVO INCLUYE UN RESERVORIO DONANTE QUE POSEE UNA FUENTE DE DICHO AGENTE ANTICOAGULANTE QUE INCLUYE UNA FORMULACION DE HIDROGEL, UN CONTRA RESERVORIO, UNA FUENTE DE ENERGIA ELECTRICA, UN CIRCUITO QUE CONTROLA LA CORRIENTE DE ELECTROTRANSPORTE QUE SE CONFIGURA PARA MANTENER UNA CONCENTRACION PLASMATICA DE 20-80 ng/ml. SE REFIERE A UN DISPOSITIVO UTILIZADO EN EL TRATAMIENTO DE ENFERMEDADES TROMBOEMBOLICAS Y LA INHIBICION DEL FACTOR XA
PE2005000616A 2004-06-03 2005-06-01 Dispositivo para administrar en forma transdermica un agente anticoagulante mediante electrotransporte PE20060099A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57690504P 2004-06-03 2004-06-03

Publications (1)

Publication Number Publication Date
PE20060099A1 true PE20060099A1 (es) 2006-02-18

Family

ID=35033286

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000616A PE20060099A1 (es) 2004-06-03 2005-06-01 Dispositivo para administrar en forma transdermica un agente anticoagulante mediante electrotransporte

Country Status (18)

Country Link
US (1) US20050273047A1 (es)
EP (1) EP1758568A1 (es)
JP (1) JP2008501434A (es)
KR (1) KR20070027582A (es)
CN (1) CN1972681A (es)
AR (1) AR049434A1 (es)
AU (1) AU2005251772A1 (es)
BR (1) BRPI0511740A (es)
CA (1) CA2568625A1 (es)
IL (1) IL179675A0 (es)
MX (1) MXPA06014082A (es)
NO (1) NO20065985L (es)
NZ (1) NZ551359A (es)
PE (1) PE20060099A1 (es)
RU (1) RU2006147274A (es)
UY (1) UY28935A1 (es)
WO (1) WO2005120482A1 (es)
ZA (1) ZA200700051B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007120747A2 (en) * 2006-04-13 2007-10-25 Nupathe Inc. Transdermal methods and systems for the delivery of anti-migraine compounds
US20070249988A1 (en) * 2006-04-21 2007-10-25 Alza Corporation Electrotransport Delivery of Nesiritide
EP2310091B1 (en) * 2008-05-09 2014-07-16 Wetling Holding ApS Ionized gas for medical treatment
US8428708B1 (en) * 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
US8428709B1 (en) 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
EP3342452A1 (en) * 2017-01-03 2018-07-04 L'oreal Systems including association of ellagic acid and microcurrent
IL285942B2 (en) * 2019-03-18 2025-08-01 Rambam Medtech Ltd Alternating charge to inhibit sorption to surfaces exposed to biological materials
US20240299372A1 (en) * 2023-03-07 2024-09-12 Pike Therapeutics Inc. Transdermal Drug Delivery Systems for Administration of a Therapeutically Effective Amount of Apixaban and Other Direct Oral Anticoagulants

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4340047A (en) * 1978-10-18 1982-07-20 Robert Tapper Iontophoretic treatment apparatus
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4382529A (en) * 1980-12-15 1983-05-10 Drdlik Frank J Sanitary dispensing closure
US4406658A (en) * 1981-03-06 1983-09-27 Medtronic, Inc. Iontophoretic device with reversible polarity
US4456012A (en) * 1982-02-22 1984-06-26 Medtronic, Inc. Iontophoretic and electrical tissue stimulation device
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US5047007A (en) * 1989-12-22 1991-09-10 Medtronic, Inc. Method and apparatus for pulsed iontophoretic drug delivery
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
EP0950407B1 (en) * 1998-04-14 2002-09-04 Hisamitsu Pharmaceutical Co., Inc. The use of a GP IIb/IIIa antagonist for the manufacture of a medicament suitable for transdermal application by iontophoresis
JP2001055332A (ja) * 1999-06-07 2001-02-27 Saitama Daiichi Seiyaku Kk 芳香族アミジン誘導体類含有のイオントフォレ−シス用製剤
US6496728B2 (en) * 2000-02-18 2002-12-17 University Of Utah Research Foundation Methods for extracting substances using alternating current
US7137975B2 (en) * 2001-02-13 2006-11-21 Aciont, Inc. Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
US6775570B2 (en) * 2002-02-04 2004-08-10 Ceramatec, Inc. Iontophoretic treatment device
WO2005051485A1 (en) 2003-11-19 2005-06-09 Alza Corporation Peptidically buffered formulations for electrotransport applications and methods of making

Also Published As

Publication number Publication date
BRPI0511740A (pt) 2008-01-08
NO20065985L (no) 2007-02-28
US20050273047A1 (en) 2005-12-08
AR049434A1 (es) 2006-08-02
IL179675A0 (en) 2008-03-20
CA2568625A1 (en) 2005-12-22
EP1758568A1 (en) 2007-03-07
WO2005120482A1 (en) 2005-12-22
UY28935A1 (es) 2005-07-29
JP2008501434A (ja) 2008-01-24
RU2006147274A (ru) 2008-07-20
AU2005251772A1 (en) 2005-12-22
NZ551359A (en) 2009-03-31
KR20070027582A (ko) 2007-03-09
MXPA06014082A (es) 2007-05-09
ZA200700051B (en) 2008-04-30
CN1972681A (zh) 2007-05-30

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed